2-Ethyl-2-methyl-1,3-dioxolane supplier

Name
2-ETHYL-2-METHYL-1,3-DIOXOLANE
EINECS 204-785-2
CAS No. 126-39-6
Article Data46
CAS DataBase
Density 0.929
Solubility
Melting Point -81.9°C
Formula C6H12 O2
Boiling Point 116.2°Cat760mmHg
Molecular Weight 116.16
Flash Point 13 ºC
Transport Information UN 1993
Appearance Clear colourless liquid
Safety Moderately toxic by ingestion and inhalation. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Risk Codes R11;R36
Molecular Structure
Hazard Symbols
Synonyms 2-Butanoneethylene ketal;2-Butanone, cyclic 1,2-ethanediyl acetal;2-Ethyl-2-methyl-1,3-dioxolane;2-Ethyl-2-methyldioxolane;2-Methyl-2-ethyl-1,3-dioxolane;2-Methyl-2-ethyldioxolane;NSC 829;
PSA 18.46000
LogP 1.15940

Synthetic route

: 107-21-1
ethylene glycol

: 78-93-3
butanone

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux;	99%
With [CuI4CuII(mtpo)4(H2O)2Cl2]n In toluene at 110℃; for 24h;	97%
With polyacrylonitrile hybrid fiber mat supported solid acid catalyst In cyclohexane Reflux;	96.56%

: 497-26-7
2-methyl-1,3-dioxolane

: 74-85-1
ethene

A: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

B: 14447-27-9
2-n-butyl-2-methyl-1,3-dioxolane

C: 937-94-0
2-methyl-2-hexyl-1,3-dioxolane

D: 123-86-4
acetic acid butyl ester

E: 142-92-7
1-hexyl acetate

F: 112-14-1
n-octyl acetate

Conditions

Conditions	Yield
di-tert-butyl peroxide at 140 - 150℃; Product distribution;

...Expand

: 7381-30-8
2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

: 78-93-3
butanone

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

Conditions

Conditions	Yield
With NafionTMS at 70℃; for 20h; acetalisation;

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 123995-06-2
Toluene-4-sulfonic acid (1R,4aR,8aR)-8a-methyl-6-oxo-decahydro-naphthalen-1-yl ester

: 123995-05-1
(4'aα,5'α,8'aβ)-octahydro-4'a-methylspiro<1,3-dioxolane-2,2'(1'H)-naphthalene>-5'-ol 5'-(4-methylbenzenesulfonate)

Conditions

Conditions	Yield
toluene-4-sulfonic acid; ethylene glycol In dichloromethane for 24h; Ambient temperature;	100%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 89951-20-2
(1α,3aβ,7α,8aβ)-3,3a,6,7,8,8a-hexahydro-1,7-dimethyl-1,7-ethanoazulene-2(1H),5(4H)-dione

: 89951-21-3
(1'α,3'aβ,7'α,8'aβ)-1',2',3',3'a,6',7',8',8'a-octahydro-1',7'-dimethylspiro<1,3-dioxolane-2,2'-<1,7>ethanoazulen>-5(4H)-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; ethylene glycol for 8h; Ambient temperature;	100%
	90%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 137956-75-3
3-Oxo-bicyclo[3.2.1]octane-6,6-dicarbothioic acid di-S-ethyl ester

: 137956-77-5
C16H24O4S2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	100%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 111324-63-1
(R)-1β-<(tert-butyldimethylsilyl)oxy>-8aβ-methyl-1,2,3,4,4aα,5,8,8a-octahydro-6(7H)-naphthalenone

: 125489-04-5
tert-Butyl-dimethyl-((4'aR,5'R,8'aR)-4'a-methyl-octahydro-spiro[[1,3]dioxolane-2,2'-naphthalen]-5'-yloxy)-silane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; ethylene glycol at 25℃; for 8h;	100%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 117535-79-2
(E)-1-(4-methoxyphenyl)-4-phenylbut-3-en-2-one

: cinnam-(p-methoxyphenyl)-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol; benzene for 4.5h; acetal formation; Heating;	100%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: C16(13)CH16O2

: C18(13)CH20O3

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol; benzene for 4.5h; acetal formation; Heating;	100%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 4-methoxy-r-1,c-2,c-9-trimethylbicyclo<4.3.0>non-4-en-7-one

: 100692-68-0
r-1,c-5,c-6-trimethylspirononane-3,2'-<1,3>dioxolan>-9-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 48h; Ambient temperature;	99%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 1018479-87-2
(4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde

: 1018479-88-3
(8S,1R,2R,5R,4aR)-2,5-di(1,3-dioxolan-2-yl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol at 40℃; for 7.5h; Inert atmosphere;	99%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 20599-03-5
2-(1-bromoethyl)-2-(bromomethyl)-1,3-dioxolane

Conditions

Conditions	Yield
With bromine In dichloromethane at 30℃; for 4.3h;	98%
With bromine In dichloromethane at 30℃;	98%
With bromine In dichloromethane Bromination;

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: C27H24N2O4

: 6-(2-(1,3-dioxolan-2-yl)ethyl)-1,4-dibenzyl-6-phenylpiperazine-2,3,5-trione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 16h; Inert atmosphere;	98%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 54100-20-8
5-methoxy-8a-methyl-3,4,8,8a-tetrahydro-2H,7H-naphthalene-1,6-dione

: 85532-84-9
C14H20O4

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 168h; Ambient temperature;	97%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 123994-89-8
(4aα,5α,8α,8aβ)-octahydro-5,8-dihydroxy-4a,8-dimethyl-2(1H)-naphthalenone 5-(4-methylbenzenesulfonate)

: 124095-81-4
(4'aα,5'α,8'α,8'aβ)-octahydro-4'a,8'-dimethylspiro<1,3-dioxolane-2,2'(1'H)-naphthalene>-5',8'-diol 5'-(4-methylbenzenesulfonate)

Conditions

Conditions	Yield
toluene-4-sulfonic acid; ethylene glycol In dichloromethane for 24h; Ambient temperature;	97%
With toluene-4-sulfonic acid Ambient temperature;

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 141871-31-0
(3S,4aR,5R,8aS)-5,8a-dimethyl-3-isopropenyl-2,3,4,4a,5,7,8,8a-octahydronaphthalene-1,6-dione

: 141871-25-2
(3S,4aR,5R,8aS)-5,8a-dimethyl-6-(1,3-dioxolan-2-yl)-3-isopropenyl-2,3,4,4a,5,7,8,8a-octahydronaphthalene-1(2H)-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; ethylene glycol for 0.25h;	97%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 1146894-85-0
cyclohepta-3,6-diene-1,2,5-trione-5-(O-methyloxime)

: 1101862-42-3
C12H15NO5

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 2h;	96%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 33878-99-8
(S)-8a-methyl-3,4,8,8a-tetrahydro-2H,7H-naphthalene-1,6-dione

: 61950-54-7
(8aS)-1,1-(1,2-ethylenedioxy)-1,2,3,4,6,7,8,8a-octahydro-8a-methyl-6-oxonaphthalene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol Inert atmosphere; regioselective reaction;	95%
With toluene-4-sulfonic acid; ethylene glycol	94%
With toluene-4-sulfonic acid In ethylene glycol for 30h; Ambient temperature;	79%
With toluene-4-sulfonic acid
With toluene-4-sulfonic acid In ethylene glycol

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 20007-99-2, 33878-99-8, 100348-93-4, 20007-72-1
Wieland-Miescher ketone

A: 42742-18-7
3',4',8',8'a-tetrahydro-8'a-methylspiro[1,3-dioxolane-2,1'(2'H)-naphthalen]-6'(7'H)-one

B: 97194-25-7
9-Methyl-Δ4-octalindion-(3,8)-diethylenlactal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol for 30h; Ambient temperature; Title compound not separated from byproducts;	A 95% B 2%

...Expand

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 74877-23-9
ethyl 3,3a,6,6a-tetrahydro-2,5-dioxo-1H,4H-pentalene-4-carboxylate

: 74923-22-1
1,2,3,3a,6,6a-hexahydro-5'-oxo-4'-(carboethoxy)-1,3-dioxolane-2-spiro-2'(1'H)-pentalene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol for 3h;	95%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 80251-91-8
3-acetoxy-5-(4-methoxybenzocyclobutenyl)pentan-2-one

: 80251-92-9
3-acetoxy-5-(4-methoxybenzocyclobutenyl)pentan-2-one-2-ethylene ketal

Conditions

Conditions	Yield
With (1S)-10-camphorsulfonic acid In dichloromethane for 2h; Ambient temperature;	95%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: (3aSR,7aRS)-7a-acetyl-7,7-dimethylhexahydro-1H-inden-5(6H)-one

: 1-((3a'SR,7a'RS)-7',7'-dimethyloctahydrospiro[[1,3]dioxolane-2,5'-indene]-7a'-yl)ethanone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol at 22℃; for 0.75h;	95%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 124095-83-6
(4aα,5α,8α,8aβ)-octahydro-5,8-dihydroxy-4a-methyl-2(1H)-naphthalenone 5-(4-methylbenzenesulfonate)

: 124149-98-0
(4'aα,5'α,8'α,8'aβ)-octahydro-4'a-methylspiro<1,3-dioxolane-2,2'(1'H)-naphthalene>-5',8'-diol 5'-(4-methylbenzenesulfonate)

Conditions

Conditions	Yield
toluene-4-sulfonic acid; ethylene glycol In dichloromethane for 24h; Ambient temperature;	94%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 121537-74-4
1-carboxy-2-(3',4'-dimethoxyphenyl)-5-oxocyclohexanol

: 121537-75-5
8-(3,4-Dimethoxy-phenyl)-7-hydroxy-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform for 0.5h; Heating;	94%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 87262-30-4
4aβ,8α-Dimethyl-3,4,4a,5,6,8aα-hexahydronaphthalene-1(2H),7(8H)-dione

: 61302-40-7
4aβ,8α-Dimethyl-3,4,4a,5,6,8aα-hexahydronaphthalene-1(2H),7(8H)-dione 7-ethylene acetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; ethylene glycol; triethylamine 1) 3 h;	93%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: Acetic acid (4aR,8aR)-1,7-dioxo-1,3,4,7,8,8a-hexahydro-2H-naphthalen-4a-ylmethyl ester

: (1S*,6S*)-6-acetoxymethyl-10,10-ethylenedioxybicyclo<4.4.0>dec-4-en-3-one

Conditions

Conditions	Yield
at 23℃; for 16h;	93%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: (1R,6S)-6-(2-oxoethyl)cyclohex-3-en-1-yl 2-hydroxybenzoate

: (1R,6S)-6-((1,3-dioxalan-2-yl)methyl)cyclohex-3-en-1-yl 2-hydroxybenzoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 12h;	93%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 85096-80-6, 105999-76-6
7,7-dimethyl-8α-hydroxy-cis-bicyclo<3.3.0>octan-3-one

: 85082-87-7, 85115-21-5
7,7-dimethyl-8α-hydroxy-cis-bicyclo<3.3.0>octan-3-ethylene ketal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 3h; Heating;	92%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 175775-26-5
(2R,4R)-2-hydroxy-4-methylcyclohexanone

: 175775-27-6
(6R,8R)-8-methyl-1,4-dioxaspiro<4.5>decan-6-ol

Conditions

Conditions	Yield
With camphor-10-sulfonic acid; ethylene glycol for 1h; Ambient temperature;	92%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 17082-61-0
1,2-bis(trimethylsiloxy)cyclobutene

: 25112-87-2
2-Ethyl-2-methyl-1,3-cyclopentanedione

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane -78 deg C -> r.t., overnight;	91.5%
With boron trifluoride diethyl etherate In dichloromethane -78 deg C -> r.t., overnight;	91.5%
With boron trifluoride diethyl etherate In dichloromethane at -78 - 20℃; Condensation;

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 74069-10-6
4-(1-Nitromethyl-3-oxo-butyl)-indole-1-carboxylic acid methyl ester

: 74323-13-0
4-[2-(2-Methyl-[1,3]dioxolan-2-yl)-1-nitromethyl-ethyl]-indole-1-carboxylic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene at 50 - 55℃;	91%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: (1S,2S,4S,7R)-2-Iodo-5-oxo-bicyclo[2.2.1]heptane-7-carboxylic acid methyl ester

: C11H15IO4

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Ambient temperature;	91%

2-Ethyl-2-methyl-1,3-dioxolane Chemical Properties

IUPAC Name: 2-Ethyl-2-methyl-1,3-dioxolane
The MF of 2-Ethyl-2-methyl-1,3-dioxolane (CAS NO.126-39-6) is C₆H₁₂O₂.

The MW of 2-Ethyl-2-methyl-1,3-dioxolane (CAS NO.126-39-6) is 116.16.
Synonyms of 2-Ethyl-2-methyl-1,3-dioxolane (CAS NO.126-39-6): 2-Butanone, cyclic 1,2-ethanediyl acetal ; 2-Ethyl-2-methyl-3-dioxolane ; 2-Ethyl-2-methyldioxolane ; 2-Methyl-2-ethyl-1,3-dioxolane ; 2-Methyl-2-ethyldioxolane
Product Categories: Dioxanes & Dioxolanes;Dioxolanes;Acetals/Ketals/Ortho Esters
Apperance: Clear colourless liquid
Index of Refraction: 1.403
EINECS: 204-785-2
Density: 0.916 g/ml
Flash Point: 12.8 °C
Boiling Point: 116.2 °C
Storage temp: Refrigerator

2-Ethyl-2-methyl-1,3-dioxolane Uses

2-Ethyl-2-methyl-1,3-dioxolane (CAS NO.126-39-6) is used in the manufacture of pesticides, pharmaceuticals and other chemical products.

2-Ethyl-2-methyl-1,3-dioxolane Toxicity Data With Reference

1.	skn-rbt 500 mg/24H MLD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,797.
2.	eye-rbt 500 mg/24H MLD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,797.
3.	orl-rat LDLo:2830 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
4.	ihl-rat LCLo:4000 ppm/4H	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.

2-Ethyl-2-methyl-1,3-dioxolane Consensus Reports

Reported in EPA TSCA Inventory.

2-Ethyl-2-methyl-1,3-dioxolane Safety Profile

Moderately toxic by ingestion and inhalation. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.Safety information of 2-Ethyl-2-methyl-1,3-dioxolane (CAS NO.126-39-6):
Hazard Codes F, Harmful Xn,Xi
Risk Statements
11 Highly Flammable
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
16 Keep away from sources of ignition - No smoking
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
38 In case of insufficient ventilation, wear suitable respiratory equipment
RIDADR UN 1993 3/PG 2
WGK Germany 3
RTECS JH7700000
HazardClass 3.1
PackingGroup II

Product Name

2-ETHYL-2-METHYL-1,3-DIOXOLANE

Synthetic route

2-Ethyl-2-methyl-1,3-dioxolane Chemical Properties

2-Ethyl-2-methyl-1,3-dioxolane Uses

2-Ethyl-2-methyl-1,3-dioxolane Toxicity Data With Reference

2-Ethyl-2-methyl-1,3-dioxolane Consensus Reports

2-Ethyl-2-methyl-1,3-dioxolane Safety Profile

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