• Name

  5-ethoxymethyl-2-methylpyrimidin-4-ylamine

• EINECS
• CAS No. 73-66-5
• Article Data15
• CAS DataBase
• Density 1.113g/cm³
• Solubility
• Melting Point
• Formula C8H13 N3 O
• Boiling Point 276.4°C at 760 mmHg
• Molecular Weight 167.211
• Flash Point 121°C
• Transport Information
• Appearance
• Safety A poison by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x.
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Pyrimidine,4-amino-5-(ethoxymethyl)-2-methyl- (6CI,7CI,8CI);2-Methyl-4-amino-5-(ethoxymethyl)pyrimidine; 2-Methyl-5-(ethoxymethyl)-6-aminopyrimidine;4-Amino-2-methyl-5-(ethoxymethyl)pyrimidine;4-Amino-5-(ethoxymethyl)-2-methylpyrimidine; NSC 41790
• PSA 61.03000
• LogP 1.48490

Synthetic route

749835-80-1

2-methyl-5-ethoxymethyl-6-chloropyrimidine

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
With ammonia In methanol at 140℃; for 4.5h; Autoclave;	82%
With ethanol; ammonia at 140℃;

109-95-5

ethyl nitrite

874-43-1, 1195-07-9, 25449-06-3

5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
With ethanol at 90 - 100℃;

64-17-5

ethanol

3699-10-3

2-ethoxymethyl-3c-methoxy-acrylonitrile

124-42-5

acetamidine hydrochloride

141-52-6

sodium ethanolate

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

...Expand

3699-10-3

2-ethoxymethyl-3c-methoxy-acrylonitrile

143-37-3

acetamidine

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
With ethanol

3699-12-5

3c-ethoxy-2-ethoxymethyl-acrylonitrile

143-37-3

acetamidine

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
With ethanol

3-acetoxy-2-ethoxymethyl-acrylonitrile

143-37-3

acetamidine

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
With ethanol; benzene

64-17-5

ethanol

3-acetoxy-2-ethoxymethyl-acrylonitrile

143-37-3

acetamidine

71-43-2

benzene

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
Erwaermen des Reaktionsprodukts mit 10prozentig.KOH;
Erwaermen des Reaktionsprodukts mit 10prozentig.KOH;Geschwindigkeit;

...Expand

99764-73-5

3-t-butoxypropanenitrile

124-42-5

acetamidine hydrochloride

109-94-4

formic acid ethyl ester

A

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

B

127556-60-9

2-methyl-4-amino-5-tert-butoxymethylpyrimidine

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

2141-62-0

3-(ethoxy)propionitrile

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethyl formate; benzene / beim Erwaermen des Reaktionsgemisches mit Dimethylsulfat 2: ethanol View Scheme
Multi-step reaction with 2 steps 1: ethyl formate; benzene / beim Erwaermen des Reaktionsgemisches mit Diaethylsulfat 2: ethanol View Scheme

5423-97-2

5-ethoxymethyl-2-methyl-3H-pyrimidin-4-one

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: POCl3 2: ethanol; NH3 / 140 °C View Scheme

763-69-9

ethyl 3-ethoxypropionate

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium / diethyl ether / 8 h / 20 °C / Inert atmosphere 1.2: 80 °C / Inert atmosphere 2.1: triethylamine; trichlorophosphate / 3 h / 78 °C 3.1: ammonia / methanol / 4.5 h / 140 °C / Autoclave View Scheme

2-methyl-5-ethoxymethyl-6-hydroxypyrimidine

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; trichlorophosphate / 3 h / 78 °C 2: ammonia / methanol / 4.5 h / 140 °C / Autoclave View Scheme

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

2908-71-6

4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 20 - 100℃; for 2h;	81%

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

25526-81-2

5-bromomethyl-2-methyl-pyrimidin-4-ylamine

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

189745-28-6

5-(chloromethyl)-2-methyl-pyrimidin-4-amine

Conditions

Conditions	Yield
With hydrogenchloride; butan-1-ol

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

A

70476-08-3

4-Amino-5-chloromethyl-2-methylpyrimidinium hydrochloride

B

2-methyl-4-chloro-5-chloromethylpyrimidine hydrochloride

C

2-methyl-4-chloro-5-hydroxymethylpyrimidine hydrochloride

D

2-methyl-4-chloro-5-ethoxymethylpyrimidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 90 - 95℃; for 5h; Substitution; Title compound not separated from byproducts;

...Expand

137-00-8

5-hydroxyethyl-4-methylthiazole

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

67-03-8

Thiamine hydrochloride

Conditions

Conditions	Yield
Stage #1: 5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine With hydrogenchloride In water at 90 - 95℃; for 5h; Substitution; Stage #2: 5-hydroxyethyl-4-methylthiazole at 102℃; for 4h; Alkylation;	0.85 g

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

70-16-6

Aneurin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; HBr View Scheme

73-66-5

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

18F-deoxythiamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; hydrogen bromide / 2 h / 20 - 100 °C 2: acetonitrile / 0.33 h / 110 °C View Scheme

2-METHYL-4-AMINO-5-ETHOXYMETHYL-PYRIMIDINE Toxicity Data With Reference

2-METHYL-4-AMINO-5-ETHOXYMETHYL-PYRIMIDINE Safety Profile