2-Methylpyrrole supplier | CasNO.636-41-9

Name
2-METHYL-1H-PYRROLE
EINECS 211-255-4
CAS No. 636-41-9
Article Data96
CAS DataBase
Density 0.965 g/cm³
Solubility
Melting Point -35.6°C
Formula C₅H₇N
Boiling Point 147.5 °C at 760 mmHg
Molecular Weight 81.1173
Flash Point 47.2 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Methyl pyrrole;
PSA 15.79000
LogP 1.32310

Synthetic route

: 1003-29-8
2-pyrrole aldehyde

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With lithium aluminium tetrahydride	87%
Stage #1: 2-pyrrole aldehyde With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux; Stage #2: With water In tetrahydrofuran at 0℃;	77%
With lithium aluminium tetrahydride In tetrahydrofuran	75%

: 3284-51-3
ethyl 5-methyl-1H-pyrrole-2-carboxylate

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With sodium hydroxide In ethylene glycol at 180 - 185℃; for 6h; Decarboxylation;	81%
With phosphoric acid

: 74-86-2
acetylene

: 127-06-0
acetone oxime

A: 636-41-9
2-methyl-1H-pyrrole

B: 57807-64-4
1-vinyl-2-methylpyrrole

C: 5883-10-3
acetone oxime O-vinyl ether

Conditions

Conditions	Yield
Stage #1: acetone oxime With potassium hydroxide In dimethyl sulfoxide at 110 - 115℃; for 0.0833333h; Metallation; Stage #2: acetylene In dimethyl sulfoxide at 74℃; for 0.5h; Addition; Cyclisation; Vinylation;	A 8% B n/a C 65.9%
With potassium hydroxide In dimethyl sulfoxide at 77℃; for 0.1h; Addition; Cyclisation; Vinylation;	A 0.2% B 12.7% C 38.2%

...Expand

: 80288-20-6
(2Z,4Z)-6-Methanesulfonyloxy-3-methyl-hexa-2,4-dienoic acid methyl ester

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide for 20h; Ambient temperature;	48%

: 107-06-2
1,2-dichloro-ethane

: 127-06-0
acetone oxime

A: 636-41-9
2-methyl-1H-pyrrole

B: 57807-64-4
1-vinyl-2-methylpyrrole

C: 92670-19-4
2,9-dimethyl-4,7-dioxa-3,8-diaza-2,8-decadiene

Conditions

Conditions	Yield
In dimethyl sulfoxide at 112 - 125℃; for 3.5h; Product distribution; var. time, var. temperatures;	A 30% B 1% C 2%
With potassium hydroxide In dimethyl sulfoxide at 115 - 125℃; for 0.5h; Title compound not separated from byproducts;	A 24% B 8% C 1%

...Expand

: 124706-35-0
1-(1-Piperidin-1-yl-cyclopropyl)-ethylideneamine

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With tetrafluoroboric acid dimethyl ether complex In xylene for 0.25h; Heating;	10%

: 67-64-1
acetone

: 74-86-2
acetylene

: 127-06-0
acetone oxime

A: 636-41-9
2-methyl-1H-pyrrole

B: 5883-10-3
acetone oxime O-vinyl ether

C: 1169876-90-7
C8H13NO

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 70 - 90℃; Autoclave;	A n/a B n/a C 7%

...Expand

: 54565-19-4
propan-2-one oxime; potassium salt

: 74-86-2
acetylene

A: 636-41-9
2-methyl-1H-pyrrole

B: 57807-64-4
1-vinyl-2-methylpyrrole

C: 119830-62-5
1-(2-methyl-5-pyrrolyl)-1-(1-vinyl-2-methyl-5-pyrrolyl)ethane

D: 73649-00-0
1,1-di(2-methyl-5-pyrrolyl)ethane

Conditions

Conditions	Yield
In dimethyl sulfoxide at 95℃; atmospheric pressure;	A n/a B n/a C 0.08% D 0.09%

...Expand

: 54565-19-4
propan-2-one oxime; potassium salt

: 74-86-2
acetylene

A: 636-41-9
2-methyl-1H-pyrrole

B: 57807-64-4
1-vinyl-2-methylpyrrole

C: 73649-00-0
1,1-di(2-methyl-5-pyrrolyl)ethane

Conditions

Conditions	Yield
In dimethyl sulfoxide at 95℃; atmospheric pressure;	A n/a B n/a C 0.09%

...Expand

: 765-38-8
2-methyl-1-pyrrolidine

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
leiten ueber ein Gemisch von Titan(IV)-oxid und Aluminiumoxid bei 600grad;

: 534-22-5
2-methylfuran

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With aluminium silicate; ammonia at 450℃;
With aluminium trichloride; ammonia at 450℃;
With aluminum oxide; steam; ammonia at 365 - 400℃;
With ammonium hydroxide; copper; copper(II) oxide at 300℃;

: 96-54-8
N-Methylpyrrole

A: 110-86-1
pyridine

B: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
beim Destillieren durch ein gluehendes Rohr;
beim Destillieren durch ein schwach gluehendes Rohr;

: 96-54-8
N-Methylpyrrole

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
bei der Destillation durch ein schwach gluehendes Rohr;
Leiten ueber schwach rotgluehende Tonscherben;

: 96-54-8
N-Methylpyrrole

A: 636-41-9
2-methyl-1H-pyrrole

B: 616-43-3
3-methylpyrrole

Conditions

Conditions	Yield
at 475 - 575℃; Rate constant; Isomerisierung;
at 826.9℃; under 9880 - 10640 Torr; Rate constant; Mechanism; Product distribution; var. temp.;

: 58518-63-1
2,5-dimethoxy-2-methyl-tetrahydro-furan

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With aluminium trichloride; ammonia at 250℃;

: 37102-48-0
2-methyl-1H-pyrrole-3-carboxylic acid

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
beim Erhitzen ueber den Schmelzpunkt;

: 79673-53-3
pyrrole-2-acetic acid

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
under 70 Torr;
Erhitzen unter vermindertem Druck;

: 67-56-1
methanol

: 109-97-7
pyrrole

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With zinc

: 936-12-9
2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With sodium hydroxide; hydrazine hydrate; ethylene glycol at 170℃;

: 120445-73-0
pyrrole-2-carbaldehyde semicarbazone

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With potassium hydroxide unter Stickstoff;

: 1071-73-4
5-Hydroxy-2-pentanone

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With aluminium trichloride; ammonia at 350℃;

: 927-56-0
levulinonitrile

A: 636-41-9
2-methyl-1H-pyrrole

B: 765-38-8
2-methyl-1-pyrrolidine

Conditions

Conditions	Yield
With cobalt catalyst at 100 - 200℃; under 73550.8 - 147102 Torr; Hydrogenation;
With nickel at 90 - 120℃; under 110326 Torr; Hydrogenation;

: 626-96-0
4-oxopentanal

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With diethyl ether; ammonia durch trockne Destillation oder Kochen mit verd. Essigsaeure;

: 66202-48-0
pyrrole-1,2-dicarboxylic acid diethyl ester

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With copper oxide-chromium oxide at 200℃; partielle Hydrierung;

: bis-(1-pyrrol-2-yl-ethylidene)-hydrazine

: 124-41-4
sodium methylate

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
at 200 - 210℃;

: 54677-53-1
2-methylpyrrolidine hydrochloride

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
With zinc Erhitzen im Wasserstoffstrom;

: 20246-37-1, 26372-13-4, 28223-46-3, 30516-86-0, 30923-13-8, 67337-08-0, 6422-34-0
L-rhamnonic acid

: 56-81-5
glycerol

: 636-41-9
2-methyl-1H-pyrrole

Conditions

Conditions	Yield
das Ammoniumsalz liefert bei der Destillation;

: 534-22-5
2-methylfuran

A: 636-41-9
2-methyl-1H-pyrrole

B: 109-97-7
pyrrole

Conditions

Conditions	Yield
With ammonia; zeolite HZSM-5 at 209.9℃; under 760 Torr; for 0.5h; other amines; var. temp. and reaction times;

: 109-97-7
pyrrole

: 593-53-3
Methyl fluoride

A: 636-41-9
2-methyl-1H-pyrrole

B: 96-54-8
N-Methylpyrrole

C: 616-43-3
3-methylpyrrole

Conditions

Conditions	Yield
With oxygen; trimethylamine at 37.5℃; Product distribution; Irradiation;	A 15 % Chromat. B 35 % Chromat. C 50 % Chromat.

...Expand

: 109-97-7
pyrrole

: 64710-12-9
dimethylfluoronium ion

A: 636-41-9
2-methyl-1H-pyrrole

B: 96-54-8
N-Methylpyrrole

C: 616-43-3
3-methylpyrrole

Conditions

Conditions	Yield
With oxygen; trimethylamine In gas under 760 Torr; Product distribution; other pressure; gas-phase methylation of pyrrole and N-methylpyrrole, pressure dependence, effect of partial pressure of NMe3, competition experiments in the presence of benzene; methylation by radiolytic CH3ClCH3+ ions; mechanism of methylation;

...Expand

: 636-41-9
2-methyl-1H-pyrrole

: 78115-49-8
2,3-dihydro-3-methylene-4H-benzopyran-4-one

: C15H15NO2

Conditions

Conditions	Yield
With C45H55O4P In chlorobenzene at -15℃; for 12h; Inert atmosphere; enantioselective reaction;	99%

: 636-41-9
2-methyl-1H-pyrrole

: 1227204-45-6
C22H23IN2O2

: 1227204-47-8
1-(5-((4-iodophenyl)(5-methyl-1H-pyrrol-2-yl)methyl)-2,4-dimethyl-1H-pyrrol-3-yl)ethanone

Conditions

Conditions	Yield
With acetyl chloride In methanol at -78 - 0℃; Inert atmosphere;	98%
With methanol; acetyl chloride at -78 - 0℃; for 1.5h;	98%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-hydroxy-1-(thiophen-2-yl)ethyl)phenol

A: (S)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-(thiophen-2-yl)ethyl)phenol

B: (R)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-(thiophen-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve;	A 98% B n/a

...Expand

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-hydroxy-1-(naphthalen-2-yl)ethyl)phenol

: (R)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-(naphthalen-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	98%

: 636-41-9
2-methyl-1H-pyrrole

: 1190957-91-5
4-(1-hydroxy-1-phenylethyl)-2-methylphenol

: (S)-2-methyl-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-phenylethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	98%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1-hydroxyethyl)phenol

: (R)-4-(1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1-(5-methyl-1H-pyrrol-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	98%

: 636-41-9
2-methyl-1H-pyrrole

: 474090-21-6
5-methoxy-2-methylene-2,3-dihydro-1H-inden-1-one

: C16H17NO2

Conditions

Conditions	Yield
With C45H55O4P In dichloromethane at -65℃; for 12h; Inert atmosphere; enantioselective reaction;	98%

: 636-41-9
2-methyl-1H-pyrrole

: C20H15F3O3

: C25H20F3NO2

Conditions

Conditions	Yield
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane at 20℃; for 48h; enantioselective reaction;	98%

: 636-41-9
2-methyl-1H-pyrrole

: 2,6-dimethyl-4-(2,2,2-trifluoro-1-phenylethylidene)cyclohexa-2,5-dienone

: 2,6-dimethyl-4-(2,2,2-trifluoro-1-(5-methyl-1H-pyrrol-2-yl)-1-phenylethyl)phenol

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In dichloromethane at 20℃; for 0.0333333h;	98%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-(4-fluorophenyl)-1-hydroxyethyl)phenol

: (R)-4-(1-(4-fluorophenyl)-1-(5-methyl-1H-pyrrol-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	97%

: 636-41-9
2-methyl-1H-pyrrole

: 1-(4-Chlorphenyl)-1-(4'-hydroxyphenyl)ethanol

: (R)-4-(1-(4-chlorophenyl)-1-(5-methyl-1H-pyrrol-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	97%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(hydroxy-(2-methoxyphenyl)(phenyl)methyl)phenol

: (R)-4-((2-methoxyphenyl)(5-methyl-1H-pyrrol-2-yl)(phenyl)methyl)phenol

Conditions

Conditions	Yield
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane at 0℃; for 48h; Green chemistry;	97%
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane for 48h; Reagent/catalyst; Solvent; enantioselective reaction;	97%

: 636-41-9
2-methyl-1H-pyrrole

: 243121-09-7
(E)-3-(4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

: 3-[4,4,4-trifluoro-3-(5-methyl-1H-pyrrol-2-yl)butyryl]oxazolidin-2-one

Conditions

Conditions	Yield
With bis((1,1,1-trifluoro-N-(trifluoromethyl)sulfonyl)methylsulfonamido)zinc; Ph-dbfox In dichloromethane at -75℃; for 24h; Friedel Crafts alkylation; Inert atmosphere; Molecular sieve; optical yield given as %ee; enantioselective reaction;	96%

: 636-41-9
2-methyl-1H-pyrrole

: 243121-09-7
(E)-3-(4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

: 1350661-54-9
C12H13F3N2O3

Conditions

Conditions	Yield
With bis((1,1,1-trifluoro-N-(trifluoromethyl)sulfonyl)methylsulfonamido)zinc; (R,R)-4,6-dibenzofurandiyl-2,2'-bis(4-phenyloxazoline) In dichloromethane at -75℃; for 24h; Friedel Crafts alkylation; Inert atmosphere; Molecular sieve; optical yield given as %ee; enantioselective reaction;	96%

: 636-41-9
2-methyl-1H-pyrrole

: 243121-09-7
(E)-3-(4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

A: 1350661-54-9
C12H13F3N2O3

B: C12H13F3N2O3

Conditions

Conditions	Yield
With bis((1,1,1-trifluoro-N-(trifluoromethyl)sulfonyl)methylsulfonamido)zinc; (R,R)-4,6-dibenzofurandiyl-2,2'-bis(4-phenyloxazoline) In dichloromethane at -60℃; for 24h; Friedel Crafts alkylation; Inert atmosphere; Molecular sieve; optical yield given as %ee; enantioselective reaction;	A 96% B n/a

...Expand

: 636-41-9
2-methyl-1H-pyrrole

: 1-phenyl-2,3-dihydro-1H-indene-1,5-diol

A: (S)-1-(5-methyl-1H-pyrrol-2-yl)-1-phenyl-2,3-dihydro-1H-inden-5-ol

B: (R)-1-(5-methyl-1H-pyrrol-2-yl)-1-phenyl-2,3-dihydro-1H-inden-5-ol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve;	A 96% B n/a

...Expand

: 636-41-9
2-methyl-1H-pyrrole

: 80396-08-3
4-(1-hydroxy-1-phenylpropyl)phenol

: (S)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-phenylpropyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	96%

: 636-41-9
2-methyl-1H-pyrrole

: 92549-05-8
4-(1-(4-methoxyphenyl)vinyl)phenol

: (R)-4-(1-(4-methoxyphenyl)-1-(5-methyl-1H-pyrrol-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	96%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-hydroxy-1-(4-vinylphenyl)ethyl)phenol

: (S)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-(4-vinylphenyl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	96%

: 636-41-9
2-methyl-1H-pyrrole

: 1-{5-[(benzyl-hydroxy-amino)-phenyl-methyl]-2,4-dimethyl-1H-pyrrol-3-yl}-ethanone

: 1227204-46-7
1-(2,4-dimethyl-5-((5-methyl-1H-pyrrol-2-yl)(phenyl)methyl)-1H-pyrrol-3-yl)ethanone

Conditions

Conditions	Yield
With acetyl chloride In methanol at -78 - 0℃; Inert atmosphere;	95%
With methanol; acetyl chloride at -78 - 0℃; for 1h;	95%

: 636-41-9
2-methyl-1H-pyrrole

: 2-(tert-butyl)-4-(1-hydroxy-1-phenylethyl)phenol

: (S)-2-(tert-butyl)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-phenylethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	95%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(2-hydroxy-4-phenylbut-3-yn-2-yl)phenol

A: (R)-4-(2-(5-methyl-1H-pyrrol-2-yl)-4-phenylbut-3-yn-2-yl)phenol

B: (S)-4-(2-(5-methyl-1H-pyrrol-2-yl)-4-phenylbut-3-yn-2-yl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve;	A 94% B n/a

...Expand

: 636-41-9
2-methyl-1H-pyrrole

: 126597-34-0
1-p-hydroxyphenyl-1-phenyl-1-ethanol

: (S)-4-(1-(5-methyl-1H-pyrrol-2-yl)-1-phenylethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	94%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-hydroxy-1-(3-methoxyphenyl)ethyl)phenol

: (R)-4-(1-(3-methoxyphenyl)-1-(5-methyl-1H-pyrrol-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	93%

: 636-41-9
2-methyl-1H-pyrrole

: 4-(1-(3,5-dimethylphenyl)-1-hydroxyethyl)phenol

: (R)-4-(1-(3,5-dimethylphenyl)-1-(5-methyl-1H-pyrrol-2-yl)ethyl)phenol

Conditions

Conditions	Yield
With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In chloroform at 0 - 20℃; for 48h; Molecular sieve; enantioselective reaction;	93%

: 636-41-9
2-methyl-1H-pyrrole

: (R)-2,2’-dimethoxy-[1,1’-binaphthalene]-3,3’-dicarbaldehyde

: C44H38N4O2

Conditions

Conditions	Yield
Stage #1: 2-methyl-1H-pyrrole; (1R)-2,2'-dimethoxy[1,1'-binaphthalene]-3,3'-dicarboxaldehyde With trifluoroacetic acid In dichloromethane at 20℃; Darkness; Stage #2: With chloranil In dichloromethane for 2h;	93%

: 636-41-9
2-methyl-1H-pyrrole

: 842169-80-6
1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine

: (+)-1,1,1-trifluoro-2-{(5-methyl)-2-pyrrolyl}-2-(4-bromophenyl)ethan-2-amine

Conditions

Conditions	Yield
With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid In toluene at -78℃; for 24h; Friedel-Crafts Alkylation; Inert atmosphere; Molecular sieve; enantioselective reaction;	93%

: 636-41-9
2-methyl-1H-pyrrole

: 4-((2-fluoro-4-methoxyphenyl)(hydroxy)(phenyl)methyl)phenol

: (R)-4-((2-fluoro-4-methoxyphenyl)-(5-methyl-1H-pyrrol-2-yl)(phenyl)methyl)phenol

Conditions

Conditions	Yield
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane at 20℃; for 48h; Green chemistry;	93%
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane for 48h; enantioselective reaction;	93%

: 636-41-9
2-methyl-1H-pyrrole

: C20H17FO3

: (S)-4-((4-fluorophenyl)-(2-methoxyphenyl)-(5-methyl-1H-pyrrol-2-yl)methyl)phenol

Conditions

Conditions	Yield
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane at 0℃; for 48h; Green chemistry;	93%

: 636-41-9
2-methyl-1H-pyrrole

: C23H24O3

: C28H29NO2

Conditions

Conditions	Yield
With (Ra)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide In 1,2-dichloro-ethane at 0℃; for 48h; enantioselective reaction;	93%

2-Methylpyrrole Specification

The 1H-Pyrrole, 2-methyl-, with the CAS registry number of 636-41-9, is also known as Methyl pyrrole. Its EINECS registry number is 211-255-4. This chemical's molecular formula is C₅H₇N and molecular weight is 81.12. What's more, its IUPAC name is 2-Methyl-1H-pyrrole.

Physical properties about the 1H-Pyrrole, 2-methyl- are: (1)ACD/LogP: 1.21; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.21; (4)ACD/LogD (pH 7.4): 1.21; (5)ACD/BCF (pH 5.5): 4.89; (6)ACD/BCF (pH 7.4): 4.89; (7)ACD/KOC (pH 5.5): 108.46; (8)ACD/KOC (pH 7.4): 108.46; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 4.93 Å²; (13)Index of Refraction: 1.519; (14)Molar Refractivity: 25.51 cm³; (15)Molar Volume: 84 cm³; (16)Surface Tension: 35 dyne/cm; (17)Density: 0.965 g/cm³; (18)Flash Point: 47.2 °C; (19)Enthalpy of Vaporization: 36.86 kJ/mol; (20)Boiling Point: 147.5 °C at 760 mmHg; (21)Vapour Pressure: 5.6 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: c1(cccn1)C
(2) InChI: InChI=1/C5H7N/c1-5-3-2-4-6-5/h2-4,6H,1H3
(3) InChIKey: TVCXVUHHCUYLGX-UHFFFAOYAZ

Product Name

2-METHYL-1H-PYRROLE

Synthetic route

2-Methylpyrrole Specification

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