2-Methyltetrahydrofuran-3-thiol supplier

Name
2-Methyltetrahydrofuran-3-thiol
EINECS 260-572-4
CAS No. 57124-87-5
Article Data3
CAS DataBase
Density 1.03 g/cm³
Solubility insoluble in water
Melting Point
Formula C₅H₁₀OS
Boiling Point 161.1 °C at 760 mmHg
Molecular Weight 118.2
Flash Point 51.3 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 37/39-26-16-36-24/25-23
Risk Codes 36/38-10-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3-Furanthiol,tetrahydro-2-methyl- (9CI);2-Methyl-3-mercaptotetrahydrofuran;2-Methyl-tetrahydrofuran-3-mercaptan;
PSA 48.03000
LogP 1.09360

Synthetic route

: C7H12O2S

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

Conditions

Conditions	Yield
With acetic acid at 20℃; for 0.5h;	87%

: 30672-41-4
2-methyl-3-chlorotetrahydrofuran

: 3-thioacetoxy-2-methyltetrahydrofuran

: 10387-40-3
potassium thioacetate

A: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

B: (2S,3S)-2-methyl-tetrahydrofuran-3-thiol

Conditions

Conditions	Yield
With sodium methylate In N-methyl-acetamide; methanol; water	A 0.72 g (67%) B n/a

...Expand

: 1071-73-4
5-Hydroxy-2-pentanone

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: phosphoric acid / 200 °C 2: piperidine / 1 h / 20 °C 3: acetic acid / 0.5 h / 20 °C View Scheme

: 16493-81-5
4-ethyloctanoyl chloride

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1236109-83-3
C15H28O2S

Conditions

Conditions	Yield
at 70℃; for 4h;	94%

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: (±)5-((2-methyltetrahydrofuran-3-yl)thio)furan-2-carbaldehyde

Conditions

Conditions	Yield
With {NiBr2phan2}; zinc; caesium carbonate In water at 45℃; for 24h; Inert atmosphere; Sealed tube;	74%

: 1454920-50-3
2-(3-chlorophenyl)-2H-1,2,3-triazole 1-oxide

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 2-(3-chlorophenyl)-4-(2-methyltetrahydrofuran-3-ylthio)-2H-1,2,3-triazole

Conditions

Conditions	Yield
With nickel(II) sulphate; caesium carbonate; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 60℃; for 18h; regioselective reaction;	73%

: 100-25-4
para-dinitrobenzene

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 2-methyl-3-((4-nitrophenyl)thio)tetrahydrofuran

Conditions

Conditions	Yield
With potassium phosphate; 18-crown-6 ether In tetrahydrofuran at 20℃; for 3h;	69%

: 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylicacid ethyl ester

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1309112-23-9
ethyl 3-(2-methyltetrahydrofuran-3-ylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate

Conditions

Conditions	Yield
In methanol; chloroform at 20℃;	65%

: 1431772-07-4
2-(4-methylphenyl)-1,2,3-triazole N-oxide

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 4-(2-methyltetrahydrofuran-3-ylthio)-2-p-tolyl-2H-1,2,3-triazole

Conditions

Conditions	Yield
With nickel(II) sulphate; caesium carbonate; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 60℃; for 12h; regioselective reaction;	63%

: 135248-89-4
Nα-fluoren-9-ylmethoxycarbonyl-L-cysteine

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: Fmoc-Cys(2-methyloxolane-3-thiol)-OH

Conditions

Conditions	Yield
Stage #1: 3-mercapto-2-methyltetrahydrofuran With N-chloro-succinimide In dichloromethane at -50℃; for 0.25h; Stage #2: Nα-fluoren-9-ylmethoxycarbonyl-L-cysteine In tetrahydrofuran; dichloromethane at -50℃; for 2h;	60.1%

: 6-amino-4-fluoronicotinonitrile

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 6-amino-4-((2-methyltetrahydrofuran-3-yl)thio)nicotinonitrile

Conditions

Conditions	Yield
Stage #1: 3-mercapto-2-methyltetrahydrofuran With potassium hexamethylsilazane In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: 6-amino-4-fluoronicotinonitrile In tetrahydrofuran at 20℃;	57%

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 6-methoxy-2-(2-methyltetrahydrofuran-3-ylsulfanyl)-3-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;	48%

: 846038-96-8
8-oxo-8H-acenaphthyleno[1,2-b]pyrrole-9-carbonitrile

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1309112-19-3
3-(2-methyltetrahydrofuran-3-ylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile

Conditions

Conditions	Yield
With triethylamine In methanol at 0 - 5℃;	42%

: 590371-90-7
4-chloro-3-iodoquinoline

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1268468-59-2
3-iodo-4-(2-methyltetrahydrofuran-3-ylsulfanyl)quinoline

Conditions

Conditions	Yield
With caesium carbonate In tetrahydrofuran; 1,4-dioxane at 20 - 90℃;
With caesium carbonate In tetrahydrofuran; 1,4-dioxane at 20 - 90℃; for 4h;

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1310801-64-9
(E)-3-[4-(2-methyltetrahydrofuran-3-sulfanyl)quinolin-3-yl]acrylic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: caesium carbonate / tetrahydrofuran; 1,4-dioxane / 4 h / 20 - 90 °C 2: palladium diacetate; potassium acetate; tetrabutyl-ammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C View Scheme

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1268468-52-5
(E)-3-[4-(2-methyltetrahydrofuran-3-sulfonyl)quinolin-3-yl]acrylic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: caesium carbonate / tetrahydrofuran; 1,4-dioxane / 4 h / 20 - 90 °C 2: palladium diacetate; potassium acetate; tetrabutyl-ammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C 3: acetic acid; peracetic acid / dichloromethane / 0 - 20 °C View Scheme

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 3-(4-trifluoromethylphenyl)-4-(2-methyltetrahydrofuran-3-ylsulfanyl)quinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: caesium carbonate / tetrahydrofuran; 1,4-dioxane / 4 h / 20 - 90 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 16 h / 90 °C View Scheme

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 1268468-53-6
3-(4-trifluoromethylphenyl)-4-(2-methyltetrahydrofuran-3-sulfonyl)quinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: caesium carbonate / tetrahydrofuran; 1,4-dioxane / 4 h / 20 - 90 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 16 h / 90 °C 3: acetic acid; peracetic acid / dichloromethane / 0 - 20 °C View Scheme

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 6-methoxy-2-(2-methyltetrahydrofuran-3-ylsulfinyl)-3-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C View Scheme

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: 6-methoxy-2-((2-methyltetrahydrofuran-3-yl)sulfonyl)-3-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C View Scheme

: 26791-73-1, 30890-35-8, 119478-96-5
(-)-xanthatin

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: C20H28O4S

Conditions

Conditions	Yield
Stage #1: (-)-xanthatin With triethylamine In methanol at 0 - 5℃; for 0.166667h; Michael Addition; Stage #2: 3-mercapto-2-methyltetrahydrofuran In methanol at 0 - 5℃; Michael Addition;

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-60-0
Fmoc-Leu-OH

: 76880-29-0
N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine

: 35661-40-6
N-Fmoc L-Phe

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: Boc-Cys(2-methyloxolane-3-thiol)-Gly-Phe-Leu-NH2

Conditions

Conditions	Yield
Stage #1: Fmoc-Leu-OH With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Stage #2: With piperidine In N,N-dimethyl-formamide Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine; N-Fmoc L-Phe; 3-mercapto-2-methyltetrahydrofuran Further stages;

...Expand

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-60-0
Fmoc-Leu-OH

: 76880-29-0
N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine

: 35661-40-6
N-Fmoc L-Phe

: 57124-87-5
3-mercapto-2-methyltetrahydrofuran

: Cys-Gly-Phe-Leu-NH2

Conditions

Conditions	Yield
Stage #1: Fmoc-Leu-OH With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Stage #2: With piperidine In N,N-dimethyl-formamide Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine; N-Fmoc L-Phe; 3-mercapto-2-methyltetrahydrofuran Further stages;

...Expand

2-Methyltetrahydrofuran-3-thiol Chemical Properties

Molecular Structure of Pentitol,1,4-anhydro-2,5-dideoxy-3-thio- (CAS NO.57124-87-5):

IUPAC Name: (2S,3S)-2-Methyloxolane-3-thiol
Empirical Formula: C₅H₁₀OS
Molecular Weight: 118.1973
Einecs: 260-572-4
Product Categories: THIOL ; API intermediates ; thiol Flavor ; Alphabetical Listings ; Flavors and Fragrances ; M-N
storage temp.: Flammables area
Water Solubility: insoluble
Freely Rotating Bonds: 1
Polar Surface Area: 34.53 Å²
Index of Refraction: 1.484
Molar Refractivity: 32.69 cm³
Molar Volume: 114.2 cm³
Polarizability: 12.96 ×10^-24cm³
Surface Tension: 31.1 dyne/cm
Density: 1.03 g/cm³
Flash Point: 51.3 °C
Enthalpy of Vaporization: 38.14 kJ/mol
Boiling Point: 161.1 °C at 760 mmHg
Vapour Pressure: 3.01 mmHg at 25 °C
Appearance: Colorless to light yellow liquid

2-Methyltetrahydrofuran-3-thiol Uses

Pentitol,1,4-anhydro-2,5-dideoxy-3-thio- (CAS NO.57124-87-5) is used as food additives.

2-Methyltetrahydrofuran-3-thiol Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/38-10-36/37/38
R36/38: Irritating to eyes and skin.
R10: Flammable.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26-16-36-24/25-23
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S16: Keep away from sources of ignition.
S36: Wear suitable protective clothing.
S24/25: Avoid contact with skin and eyes.
S23: Do not breathe vapour.
RIDADR: 1993

2-Methyltetrahydrofuran-3-thiol Specification

Pentitol,1,4-anhydro-2,5-dideoxy-3-thio- (CAS NO.57124-87-5), its Synonyms are 2-Methyl-3-mercaptotetrahydrofuran ; 2-Methyl-3-tetrahydrofuranthiol ; 3-Furanthiol, tetrahydro-2-methyl- ; 2-Methyltetrahydrofuran-3-thiol .

Product Name

2-Methyltetrahydrofuran-3-thiol

Synthetic route

2-Methyltetrahydrofuran-3-thiol Chemical Properties

2-Methyltetrahydrofuran-3-thiol Uses

2-Methyltetrahydrofuran-3-thiol Safety Profile

2-Methyltetrahydrofuran-3-thiol Specification

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