2-Nitro-5-(phenylthio)aniline supplier

Name
2-Nitro-5-(phenylthio)aniline
EINECS 256-121-6
CAS No. 43156-47-4
Article Data21
CAS DataBase
Density 1.37 g/cm³
Solubility
Melting Point 145-146 °C
Formula C₁₂H₁₀N₂O₂S
Boiling Point 472.503 °C at 760 mmHg
Molecular Weight 246.29
Flash Point 239.562 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1-Amino-2-nitro-5-phenylthiobenzene;2-Amino-4-phenylthio-1-nitrobenzene;Benzenamine,2-nitro-5-(phenylthio)-;
PSA 97.14000
LogP 4.43260

Synthetic route

: 1635-61-6
5-chloro-2-nitroaniline

: 108-98-5
thiophenol

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With ammonia In isopropyl alcohol	96.4%
With ammonia In 2-methyl-propan-1-ol	95.8%
With potassium hydroxide In ethanol for 4h; Heating;	83%

: 2-amino-4-mercapto-1-nitrobenzene

: 108-90-7
chlorobenzene

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With potassium carbonate at 130 - 135℃; Temperature; Inert atmosphere;	95.4%

: 108-86-1
bromobenzene

: 2-amino-4-mercapto-1-nitrobenzene

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With potassium carbonate at 150 - 160℃; Temperature; Inert atmosphere;	94.3%

: 2-chloro-4-phenylthio nitrobenzene

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With ammonia In methanol at 180 - 200℃; under 13501.4 - 26252.6 Torr; for 10h; Pressure; Solvent; Temperature; Autoclave;	93.1%

: 611-06-3
2,4-dichloronitrobenzene

: 108-98-5
thiophenol

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With ammonia In isopropyl alcohol	89.5%

: 1122-97-0
4-methylsulfanyl-thiophenol

A: 252019-48-0
2-Bromo-4-(4-methylsulphanylphenylsulphanyl)nitrobenzene

B: 43156-47-4
2-nitro-5-phenylthioaniline

: 1635-61-6
5-chloro-2-nitroaniline

: 43156-48-5
1,2-diamino-4-phenylthiobenzene

: 598-52-7
1-(methyl)-thiourea

: 108-98-5
thiophenol

: 79-22-1
methyl chloroformate

A 5-phenylmercapto-benzimidazole-2-methyl-carbaminate: 5-phenylmercapto-benzimidazole-2-methyl-carbaminate

B: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With sodium hydroxide In N-methyl-acetamide; water; potassium carbonate; acetic acid

...Expand

: 541-73-1
1,3-Dichlorobenzene

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: nitric acid; sulfuric acid / 3 h / 10 - 15 °C 2: potassium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / Reflux 3: ammonia / methanol / 10 h / 180 - 200 °C / 13501.4 - 26252.6 Torr / Autoclave View Scheme

: 611-06-3
2,4-dichloronitrobenzene

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / Reflux 2: ammonia / methanol / 10 h / 180 - 200 °C / 13501.4 - 26252.6 Torr / Autoclave View Scheme

: 108-42-9
3-chloro-aniline

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitric acid / acetic acid; sulfuric acid / 10.5 h / 20 - 25 °C 2: sodium hydroxide / methanol / 10.25 h / 90 - 95 °C View Scheme

: 108-98-5
thiophenol

: 89-63-4
4-Chloro-2-nitroaniline

: 43156-47-4
2-nitro-5-phenylthioaniline

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 90 - 95℃; for 10.25h; Temperature;

: 6290-49-9
methyl methoxyacetate

: 43156-47-4
2-nitro-5-phenylthioaniline

: 63470-85-9
2-methoxy-N-(2-nitro-5-(phenylsulfanyl)phenyl)acetamide

Conditions

Conditions	Yield
at 120 - 130℃; Temperature;	95.5%

: 43156-47-4
2-nitro-5-phenylthioaniline

: 625-45-6
2-methoxyacetic acid

: 63470-85-9
2-methoxy-N-(2-nitro-5-(phenylsulfanyl)phenyl)acetamide

Conditions

Conditions	Yield
With pyridine; thionyl chloride In toluene at 75 - 110℃; for 10.5h; Reagent/catalyst; Solvent; Temperature;	94.8%

: 38870-89-2
Methoxyacetyl chloride

: 43156-47-4
2-nitro-5-phenylthioaniline

: 59011-22-2
N-(2-Amino-5-benzenesulfinyl-phenyl)-2-methoxy-acetamide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 14077-58-8
ethoxyacetyl chloride

: 43156-47-4
2-nitro-5-phenylthioaniline

: 59011-18-6
N-(2-Amino-5-phenylsulfanyl-phenyl)-2-ethoxy-acetamide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 14077-58-8
ethoxyacetyl chloride

: 43156-47-4
2-nitro-5-phenylthioaniline

: 59011-24-4
N-(2-Amino-5-benzenesulfinyl-phenyl)-2-ethoxy-acetamide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 79-03-8
propionyl chloride

: 58306-64-2
2-propionamido-4-phenylthioaniline

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 79-03-8
propionyl chloride

: 58306-70-0
2-propionamido-4-phenylsulfinylaniline

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 541-41-3
chloroformic acid ethyl ester

: 58306-65-3
(2-Amino-5-phenylsulfanyl-phenyl)-carbamic acid ethyl ester

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 541-41-3
chloroformic acid ethyl ester

: 59011-21-1
(2-Amino-5-benzenesulfinyl-phenyl)-carbamic acid ethyl ester

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 638-29-9
n-valeryl chloride

: 59011-19-7
2-Amino-5-phenylthio-valeranilid

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 638-29-9
n-valeryl chloride

: 59011-25-5
Pentanoic acid (2-amino-5-benzenesulfinyl-phenyl)-amide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 142-61-0
Hexanoyl chloride

: 58306-66-4
Hexanoic acid (2-amino-5-phenylsulfanyl-phenyl)-amide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 142-61-0
Hexanoyl chloride

: 59011-26-6
Hexanoic acid (2-amino-5-benzenesulfinyl-phenyl)-amide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 75-36-5
acetyl chloride

: 58306-63-1
2-Amino-5-phenylthioacetanilid

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 75-36-5
acetyl chloride

: 54394-15-9
2-acetamido-1-amino-4-phenylsulfinylbenzene

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 141-75-3
butyryl chloride

: 58306-62-0
2-Amino-5-phenylthio-butyranilid

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 141-75-3
butyryl chloride

: 59011-17-5
2-butyramido-4-phenylsulfinylaniline

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 701-99-5
Phenoxyacetyl chloride

: 58306-68-6
N-(2-Amino-5-phenylsulfanyl-phenyl)-2-phenoxy-acetamide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2, Raney-Ni, THF; Multistep reaction;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 701-99-5
Phenoxyacetyl chloride

: 59011-23-3
N-(2-Amino-5-benzenesulfinyl-phenyl)-2-phenoxy-acetamide

Conditions

Conditions	Yield
(i) Py, benzene, (ii) H2O2, Ac2O, (iii) H2, Raney-Ni, THF; Multistep reaction;

: 35266-49-0
methoxycarbonylisothiocyanate

: 43156-47-4
2-nitro-5-phenylthioaniline

: 74-88-4
methyl iodide

: 65671-13-8
C16H17N3O2S2

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 35266-49-0
methoxycarbonylisothiocyanate

: 43156-47-4
2-nitro-5-phenylthioaniline

: 56069-34-2
2-nitro-5-phenylthiophenylallophanic acid methyl ester

Conditions

Conditions	Yield
In acetonitrile for 15h; Heating;	3.5 g
In acetonitrile
In acetonitrile

: 43156-47-4
2-nitro-5-phenylthioaniline

: 43156-48-5
1,2-diamino-4-phenylthiobenzene

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol under 2660 Torr; for 12h;
With hydrogen; palladium on activated charcoal In ethanol at 20℃; under 3102.89 Torr;
With platinum on activated charcoal; hydrogen In ethanol at 70 - 90℃; under 7500.75 - 15001.5 Torr; for 8h; Solvent; Reagent/catalyst;	21.2 g
With iron(III) chloride; hydrazine hydrate; pyrographite In methanol at 45 - 50℃; under 3750.38 - 7500.75 Torr; for 0.75h; Temperature; Pressure;

: 43156-47-4
2-nitro-5-phenylthioaniline

: 43210-67-9
Fenbendazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 2.1: NaOH / H2O / 0.67 h / 3 - 6 °C 2.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C View Scheme

: 43156-47-4
2-nitro-5-phenylthioaniline

: 68828-79-5
5-Phenylthiobenzimidazole-2-thione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / Raney-nickel / ethanol / 12 h / 2660 Torr 2: KOH / ethanol / 4 h / Heating View Scheme

2-Nitro-5-(phenylthio)aniline Chemical Properties

Molecular Structure of 2-Nitro-5-(phenylthio)aniline (CAS NO.43156-47-4):

IUPAC Name: 2-Nitro-5-phenylsulfanylaniline
Canonical SMILES: C1=CC=C(C=C1)SC2=CC(=C(C=C2)[N+](=O)[O-])N
InChI: InChI=1S/C12H10N2O2S/c13-11-8-10(6-7-12(11)14(15)16)17-9-4-2-1-3-5-9/h1-8H,13H2
InChIKey: AJGJUXSVUPXOHL-UHFFFAOYSA-N
Molecular Weight: 246.285 [g/mol]
Molecular Formula: C₁₂H₁₀N₂O₂S
XLogP3: 3.3
H-Bond Donor: 1
H-Bond Acceptor: 3
EINECS: 256-121-6
Index of Refraction: 1.696
Molar Refractivity: 69.12 cm³
Molar Volume: 179.5 cm³
Surface Tension: 67.5 dyne/cm
Density: 1.37 g/cm³
Flash Point: 239.6 °C
Enthalpy of Vaporization: 73.55 kJ/mol
Boiling Point: 472.5 °C at 760 mmHg
Vapour Pressure: 4.26E-09 mmHg at 25 °C
Product Categories: API intermediates

2-Nitro-5-(phenylthio)aniline Specification

2-Nitro-5-(phenylthio)aniline (CAS NO.43156-47-4), its Synonyms are 2-Nitro-5-(phenylthio)benzenamine ; 4-Phenylthio-2-aminonitrobenzene ; Benzenamine, 2-nitro-5-(phenylthio)- .

Product Name

2-Nitro-5-(phenylthio)aniline

Synthetic route

2-Nitro-5-(phenylthio)aniline Chemical Properties

2-Nitro-5-(phenylthio)aniline Specification

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