Product Name

  • Name

    2-NITRODIPHENYL ETHER

  • EINECS 218-684-6
  • CAS No. 2216-12-8
  • Article Data93
  • CAS DataBase
  • Density 1.23
  • Solubility
  • Melting Point <-20 °C
  • Formula C12H9 N O3
  • Boiling Point 184 ºC (8 mmHg)
  • Molecular Weight 215.208
  • Flash Point 181 ºC
  • Transport Information
  • Appearance CLEAR YELLOW TO BROWN LIQUID
  • Safety Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx. See also ETHERS and NITRO COMPOUNDS of AROMATIC HYDROCARBONS.
  • Risk Codes R36/37/38   
  • Molecular Structure Molecular Structure of 2216-12-8 (2-NITRODIPHENYL ETHER)
  • Hazard Symbols
  • Synonyms Ether,o-nitrophenyl phenyl (6CI,7CI,8CI); 1-Nitro-2-phenoxybenzene; 2-Nitrodiphenylether; 2-Nitrophenyl phenyl ether; 2-Phenoxy-1-nitrobenzene;2-Phenoxynitrobenzene; NSC 5419; NSC 642583; Phenyl o-nitrophenyl ether;o-Nitrodiphenyl ether; o-Nitrophenyl phenyl ether
  • PSA 55.05000
  • LogP 3.91030

2-Nitrophenyl phenyl ether Chemical Properties

IUPAC Name: 1-Nitro-2-phenoxybenzene
Synonyms of 2-Nitrophenyl phenyl ether (CAS NO.2216-12-8) : 1-Nitro-2-phenoxybenzene ; 2-Nitrophenyl phenyl ether ; Benzene, 1-nitro-2-phenoxy-
CAS NO:2216-12-8
Molecular Formula:C12H9NO3
Molecular Weight :215.2048
Molecular Structure :
EINECS: 218-684-6
Index of Refraction: 1.605
Surface Tension: 48.6 dyne/cm
Density: 1.252 g/cm3
Flash Point: 137.8 °C
Enthalpy of Vaporization: 53.45 kJ/mol
Boiling Point: 315.4 °C at 760 mmHg
Vapour Pressure: 0.000809 mmHg at 25°C 
Appearance: 2-Nitrophenyl phenyl ether (CAS NO.2216-12-8) is clear yellow to brown liquid .

2-Nitrophenyl phenyl ether Uses

 2-Nitrophenyl phenyl ether (CAS NO.2216-12-8) is used as  intermediate in organic synthesis.

2-Nitrophenyl phenyl ether Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 838mg/kg (838mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology. Vol. 8, Pg. 347, 1977.

2-Nitrophenyl phenyl ether Consensus Reports

Reported in EPA TSCA Inventory.

2-Nitrophenyl phenyl ether Safety Profile

Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx. See also ETHERS and NITRO COMPOUNDS of AROMATIC HYDROCARBONS.

Hazard Codes IrritantXi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 23-24/25-36/37/39-26
S23:Do not breathe vapour. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S24/25:Avoid contact with skin and eyes. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 3
RTECS KO2650000
F 9
Hazard Note Irritant

2-Nitrophenyl phenyl ether Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire. 
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

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