3,3-Diethoxypropylazanium supplier

Name
1-AMINO-3,3-DIETHOXYPROPANE
EINECS
CAS No. 41365-75-7
Article Data13
CAS DataBase
Density 0.915 g/cm³
Solubility
Melting Point
Formula C₇H₁₇NO₂
Boiling Point 200.6 °C at 760 mmHg
Molecular Weight 147.217
Flash Point 79.3 °C
Transport Information
Appearance clear colourless to yellow liquid
Safety 26-27-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms 3,3-Diethoxy-1-propanamine;3,3-Diethoxypropylamine;3-AMINOPROPIONALDEHYDE DIETHYL ACETAL;3,3-DIETHOXY-1-PROPYLAMINE;1-AMINO-3,3-DIETHOXYPROPANE;APEA;RARECHEM AL BW 0123;TIMTEC-BB SBB005781
PSA 44.48000
LogP 1.43460

Synthetic route

: 107833-73-8
3-nitropropanal diethyl acetal

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 7600.51 Torr; for 12h;	98%

: 2453-90-9
N-(3,3-diethoxypropyl)phthalimide

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With hydrazine In methanol for 2h; Heating;	87%
With hydrazine In methanol; dichloromethane	70%

: 2032-34-0
3,3-bis(ethyloxy)propanenitrile

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 16h; Ambient temperature;	49%
With lithium aluminium tetrahydride

: 35573-93-4
3-chloro-1,1-diethoxy-propane

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With ethanol; ammonia
With sodium azide; hydrogen; palladium on activated charcoal 1.) DMF, 2.) C2H5OH, 4 d; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: NaN3 / dimethylsulfoxide / 16 h / 50 °C 2: 8.2 g / H2 / 5 percent Pd/C / methanol / 2 h / 20 °C / 2585.74 Torr View Scheme
Multi-step reaction with 2 steps 1: 83 percent / dimethylformamide / 5 h / 145 °C 2: 87 percent / hydrazine / methanol / 2 h / Heating View Scheme

: 35573-93-4
3-chloro-1,1-diethoxy-propane

A: 41365-75-7
aminopropane diethyl acetal

B: 854253-50-2
bis-(3,3-diethoxy-propyl)-amine

Conditions

Conditions	Yield
With ethanol; ammonia at 115 - 118℃;

: 41365-74-6
3,3-diethoxypropionic amide

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether

3-chloro-propionaldehyde diethyl acetate: 3-chloro-propionaldehyde diethyl acetate

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With ammonia at 80℃;

: 688317-69-3
3-azidopropanal diethyl acetal

: 41365-75-7
aminopropane diethyl acetal

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; 5% Pd on active carbon In methanol at 20℃; under 2585.74 Torr; for 2h;	8.2 g

: 10601-80-6
ethyl 3,3-diethoxypropanoate

A: 41365-75-7
aminopropane diethyl acetal

B 35 percent formaldehyde-solution: 35 percent formaldehyde-solution

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NH3 2: LiAlH4 / diethyl ether View Scheme

: 122-51-0
orthoformic acid triethyl ester

SOCl2 (1 mol): SOCl2 (1 mol)

A: 41365-75-7
aminopropane diethyl acetal

B 35 percent formaldehyde-solution: 35 percent formaldehyde-solution

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Zn / benzene 2: aq. NH3 3: LiAlH4 / diethyl ether View Scheme

...Expand

: 41365-75-7
aminopropane diethyl acetal

: 24424-99-5
di-tert-butyl dicarbonate

: 153815-24-8
1-(tert-butyloxycarbonylamino)-3,3-diethoxypropane

Conditions

Conditions	Yield
In acetonitrile	100%
In dichloromethane at 20℃; for 2h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 16.25h;	94%

: 41365-75-7
aminopropane diethyl acetal

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 380635-36-9
3-(2,2,2-trichloroethoxycarbonylamino)propionaldehyde diethyl acetal

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 2.16667h;	100%

: 41365-75-7
aminopropane diethyl acetal

: 922-67-8
propynoic acid methyl ester

: methyl 4-aza-7,7-diethoxyhept-2-enoate

Conditions

Conditions	Yield
	100%

: 41365-75-7
aminopropane diethyl acetal

: 98-59-9
p-toluenesulfonyl chloride

: 164532-58-5
N-(3,3-diethoxypropyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 10h;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;
With triethylamine In dichloromethane at 0 - 20℃;
With triethylamine In dichloromethane at 0℃; for 0.5h;
With triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 41365-75-7
aminopropane diethyl acetal

: 1410040-78-6
N-(3,3-diethoxypropyl)-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Conditions

Conditions	Yield
With N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 15h;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;	1.6 g

: 41365-75-7
aminopropane diethyl acetal

: 1610535-31-3
N-(4-chloro-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)-O,N-dimethylhydroxylamine

: 1610534-70-7
N-[4-(3,3-diethoxypropylamino)-6-prop-2-ynylamino-[1,3,5]triazin-2-yl]-O,N-dimethylhydroxylamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 60℃; for 2h;	100%

: 41365-75-7
aminopropane diethyl acetal

: 1268621-10-8
5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid

: N-(3,3-diethoxypropyl)-5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

Conditions

Conditions	Yield
Stage #1: 5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: aminopropane diethyl acetal In N,N-dimethyl-formamide at 20℃; for 0.166667h;	100%

: 41365-75-7
aminopropane diethyl acetal

: (S*)-3-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid

: (S*)-N5-(3,3-diethoxypropyl)-N7,3-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 1h;	100%

: 41365-75-7
aminopropane diethyl acetal

: (S*)-3-ethyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid

: (S*)-N5-(3,3-diethoxypropyl)-3-ethyl-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 1h;	100%

: 41365-75-7
aminopropane diethyl acetal

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: N-Fmoc-1-amino-3,3-diethoxypropane

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;	100%

: 41365-75-7
aminopropane diethyl acetal

: 54814-41-4, 54640-00-5, 54910-31-5
3-(3,4-dimethoxy-phenyl)-2-hydroxy-propionic acid methyl ester

: 170801-80-6
(R)-(+)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 140℃; for 2h;	99%

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 41365-75-7
aminopropane diethyl acetal

: C12H20N2O3

Conditions

Conditions	Yield
In acetonitrile at 20℃; Inert atmosphere;	99%

: 41365-75-7
aminopropane diethyl acetal

: 1423-60-5
methyl ethynyl ketone

: (3Z)-4-[(3,3-diethoxypropyl)amino]but-3-en-2-one

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.2h;	99%

: 41365-75-7
aminopropane diethyl acetal

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 4-(chloromethyl)-N-(3,3-diethoxypropyl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	99%

: 41365-75-7
aminopropane diethyl acetal

: 2251-50-5
pentafluorobenzoylchloride

: 2,3,4,5,6-pentafluoro-N-(3-oxopropyl)benzamide

Conditions

Conditions	Yield
Stage #1: aminopropane diethyl acetal; pentafluorobenzoylchloride With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; Schlenk technique; Stage #2: With hydrogenchloride; water In acetone for 1h; Inert atmosphere; Schlenk technique;	99%

: 41365-75-7
aminopropane diethyl acetal

: 1613414-00-8
4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid

: (R)-quinuclidin-3-yl ((S)-(3-((4-((3,3-diethoxypropyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Conditions

Conditions	Yield
Stage #1: 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: aminopropane diethyl acetal at 20℃; for 18h;	99%

: 63810-78-6
4‑chloro‑5‑bromo‑2‑(methylthio)pyrimidine

: 41365-75-7
aminopropane diethyl acetal

: 5-bromo-N-(3,3-diethoxypropyl)-2-(methylsulfanyl)pyrimidin-4-amine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h;	98%

: 50-00-0
formaldehyd

: 41365-75-7
aminopropane diethyl acetal

: 14655-66-4
bis(4-methylphenyl)phosphinous acid

: (3,3-diethoxypropylaminomethyl)di-p-tolylphosphine oxide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Kabachnik-Fields Reaction; Dean-Stark; Reflux;	98%

...Expand

: 41365-75-7
aminopropane diethyl acetal

: 79878-15-2
2,4-di-(β,β,β-trifluoroethoxy)-5-nitropyridine

: 79878-17-4
4-(3',3'-diethoxypropylamino)-5-nitro-2-(β,β,β-trifluoroethoxy)-pyridine

Conditions

Conditions	Yield
In chloroform-d1 for 1h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 153381-08-9
Methyl (S)-(+)-3-(3,4 dimethoxyphenyl)-2-hydroxypropionate

: 153309-68-3
(S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 140℃; for 2h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 100-52-7
benzaldehyde

: 1099778-15-0
N-(3,3-diethoxypropyl)benzylamine hydrochloride

Conditions

Conditions	Yield
With chloroform; 10% Pd/C; hydrogen In ethanol at 20℃; under 1551.49 Torr; for 10h; chemoselective reaction;	97%

: 41365-75-7
aminopropane diethyl acetal

: 456-48-4
3-Fluorobenzaldehyde

: 1099778-13-8
3-fluoro-N-(3,3-diethoxypropyl)benzylamine hydrochloride

Conditions

Conditions	Yield
With chloroform; 10% Pd/C; hydrogen In ethanol at 20℃; under 1551.49 Torr; for 10h; chemoselective reaction;	97%

: 41365-75-7
aminopropane diethyl acetal

: 13049-86-0
diethyl 2-(ethoxycarbonylmethylene)malonate

: 1314160-55-8
C18H33NO8

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 18h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 1268619-84-6
5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid

: N-(3,3-diethoxypropyl)-5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxamide

Conditions

Conditions	Yield
Stage #1: 5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: aminopropane diethyl acetal In N,N-dimethyl-formamide for 0.166667h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 1268619-99-3
5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid

: N-(3,3-diethoxypropyl)-5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxamide

Conditions

Conditions	Yield
Stage #1: 5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: aminopropane diethyl acetal In N,N-dimethyl-formamide for 0.166667h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 98-09-9
benzenesulfonyl chloride

: N-(3,3-diethoxypropyl)benzenesulfonamide

Conditions

Conditions	Yield
With sodium carbonate In dichloromethane; water at 0℃; for 2h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 345-18-6
2-fluoro-5-chloronitrobenzene

: 4-chloro-N-(3,3-diethoxypropyl)-2-nitroaniline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 4.5h;	97%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 4.5h;	97%

: 41365-75-7
aminopropane diethyl acetal

: 4,7,10,13-tetraoxa-16-azaheneicosanoic acid 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-2,5-dioxo-1-pyrrolidinyl ester

: 1166397-67-6
C28H52N4O9S

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	96%

: 41365-75-7
aminopropane diethyl acetal

: 83-01-2
diphenylcarbamic chloride

: N'-(3,3-diethoxypropyl)-N,N-diphenylurea

Conditions

Conditions	Yield
With triethylamine In benzene	96%

3,3-Diethoxypropylazanium Specification

The 3,3-Diethoxypropylazanium is an organic compound with the formula C₇H₁₇NO₂. The IUPAC name of this chemical is 3,3-diethoxypropylazanium. With the CAS registry number 41365-75-7, it is also named as 1-Amino-3,3-diethoxypropane. Besides, it should be stored in a closed cool and dry place.

Physical properties about 3,3-Diethoxypropylazanium are: (1)ACD/LogP: 0.79; (2)ACD/LogD (pH 5.5): -2.14; (3)ACD/LogD (pH 7.4): -0.73; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1.92; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 7; (11)Polar Surface Area: 21.7 Å²; (12)Index of Refraction: 1.428; (13)Molar Refractivity: 41.46 cm³; (14)Molar Volume: 160.8 cm³; (15)Polarizability: 16.43×10^-24cm³; (16)Surface Tension: 29.9 dyne/cm; (17)Density: 0.915 g/cm³; (18)Flash Point: 79.3 °C; (19)Enthalpy of Vaporization: 43.68 kJ/mol; (20)Boiling Point: 200.6 °C at 760 mmHg; (21)Vapour Pressure: 0.321 mmHg at 25°C.

Preparation of 3,3-Diethoxypropylazanium: this chemical can be prepared by 3-Phthalimido-1,1-diethoxy-propan. This reaction will need reagent hydrazine and solvent methanol. The reaction time is 2 hours by heating. The yield is about 87%.

3,3-Diethoxypropylazanium can be prepared by 3-Phthalimido-1,1-diethoxy-propan

Uses of 3,3-Diethoxypropylazanium: it can be used to produce N,N'-bis-(3,3-diethoxy-propyl)-succinamide. It will need reagent Et₃N and solvent benzene.

3,3-Diethoxypropylazanium and succinyl dichloride can be used to produce N,N'-bis-(3,3-diethoxy-propyl)-succinamide

When you are using this chemical, please be cautious about it as the following:
This chemical can cause burns. When you are using it, wear suitable gloves and eye/face protection. Please take off immediately all contaminated clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O(CC)C(OCC)CCN
(2)InChI: InChI=1/C7H17NO2/c1-3-9-7(5-6-8)10-4-2/h7H,3-6,8H2,1-2H3
(3)InChIKey: PXXMSHBZYAOHBD-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C7H17NO2/c1-3-9-7(5-6-8)10-4-2/h7H,3-6,8H2,1-2H3
(5)Std. InChIKey: PXXMSHBZYAOHBD-UHFFFAOYSA-N

Product Name

1-AMINO-3,3-DIETHOXYPROPANE

Synthetic route

3,3-Diethoxypropylazanium Specification

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