3,4-DIFLUOROBENZYLAMINE supplier

Name
3,4-Difluorobenzylamine
EINECS 276-503-6
CAS No. 72235-53-1
Article Data7
CAS DataBase
Density 1.214 g/cm³
Solubility
Melting Point 31oC
Formula C₇H₇F₂N
Boiling Point 183.8 °C at 760 mmHg
Molecular Weight 143.136
Flash Point 79.4 °C
Transport Information UN 2735 8/PG 3
Appearance Clear light yellow liquid
Safety 26-27-36/37/39-45-25
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms (3,4-difluorophenyl)methylazanium;(3,4-difluorophenyl)methanamine;
PSA 26.02000
LogP 2.12380

Synthetic route

: 64248-62-0
3,4-Difluorobenzonitrile

: 72235-53-1
3,4-difluorobenzylamine

Conditions

Conditions	Yield
Stage #1: 3,4-Difluorobenzonitrile With cerium(III) chloride; methyllithium; lithium bromide In tetrahydrofuran; diethyl ether at -25℃; for 1h; Inert atmosphere; Stage #2: With ammonium hydroxide In tetrahydrofuran; diethyl ether; water at 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; diethyl ether
With formic acid; triethylamine at 40℃; for 3h;	96 %Chromat.

: C21H18F2N2

: 100-46-9
benzylamine

A: C21H20N2

B: 72235-53-1
3,4-difluorobenzylamine

Conditions

Conditions	Yield
In dimethylsulfoxide-d6 Equilibrium constant;

...Expand

: C21H18F2N2

: 109-73-9
N-butylamine

A: C18H22N2

B: 72235-53-1
3,4-difluorobenzylamine

Conditions

Conditions	Yield
In dimethylsulfoxide-d6 Equilibrium constant;

...Expand

: 64248-62-0
3,4-Difluorobenzonitrile

A: bis(3,4-difluorobenzyl)amine

B: 72235-53-1
3,4-difluorobenzylamine

Conditions

Conditions	Yield
With borane-ammonia complex In methanol; water at 40℃; for 3h; Sealed tube; Overall yield = 99 percentChromat.;

: 108-22-5
Isopropenyl acetate

: 72235-53-1
3,4-difluorobenzylamine

: 1343690-20-9
N-(3,4-difluorobenzyl)acetamide

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 2h; Green chemistry;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 72235-53-1
3,4-difluorobenzylamine

: 1441345-18-1
tert-butyl 3,4-difluorobenzylcarbamate

Conditions

Conditions	Yield
With Amberlyst A21 In neat (no solvent) at 20℃; for 0.0166667h; Solvent; Time; Concentration; Green chemistry;	98%

: 529-23-7
2-aminobenzaldehyde

: 72235-53-1
3,4-difluorobenzylamine

: 13-(3,4-difluorobenzyl)-5,6,11,12-tetrahydro-6,12-epiminodibenzo[b,f ][1,5]diazocine

Conditions

Conditions	Yield
With scandium pentafluorobenzoate In toluene at 90℃; for 12h;	98%

: 32137-76-1
benzothiazole-2-carboxylic acid ethyl ester

: 72235-53-1
3,4-difluorobenzylamine

: N-(3,4-difluorobenzyl)benzo[d]thiazole-2-carboxamide

Conditions

Conditions	Yield
In acetonitrile at 100℃; for 0.25h; Sealed tube; Microwave irradiation;	97%

: 119-61-9
benzophenone

: 72235-53-1
3,4-difluorobenzylamine

: 218451-54-8
benzhydrylidene-(3,4-difluoro-benzyl)-amine

Conditions

Conditions	Yield
boron trifluoride diethyl etherate In toluene for 12h; Heating / reflux;	95%
With boron trifluoride diethyl etherate In toluene for 12h; Addition; Heating;

: 814-49-3
diethyl chlorophosphate

: 72235-53-1
3,4-difluorobenzylamine

: diethyl N-(3,4-difluorobenzyl)phosphoramidate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 6h;	95%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 88333-03-3, 10340-91-7
Benzyl isocyanide

: 59768-74-0, 124184-67-4
(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester

: 72235-53-1
3,4-difluorobenzylamine

: methyl (S)-4-((1-benzyl-4-(benzylcarbamoyl)piperidin-4-yl)(3,4-difluorobenzyl)amino)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoate

Conditions

Conditions	Yield
In methanol at 20℃; for 96h; Ugi Condensation;	95%

...Expand

: 869297-03-0
ethyl 5-{[({4-[(ethyloxy)carbonyl]phenyl}methyl)oxy]methyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate

: 72235-53-1
3,4-difluorobenzylamine

: ethyl 4-[({[2-({[(3,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl}oxy)methyl]benzoate

Conditions

Conditions	Yield
In ethanol at 80℃; for 15h;	94%
In ethanol at 80℃; for 15h;	94%

: 72235-53-1
3,4-difluorobenzylamine

: 3,4-difluoro-N,N-dichlorobenzylamine

Conditions

Conditions	Yield
With iron(III) chloride; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 3h; Inert atmosphere;	94%

: methyl 2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate

: 72235-53-1
3,4-difluorobenzylamine

: N-(3,4-difluorobenzyl)-2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90℃; Inert atmosphere;	93.3%

: (E)-7-bromo-4-chloro-2-styrylquinazoline

: 72235-53-1
3,4-difluorobenzylamine

: (E)-7-bromo-N-(3,4-difluorobenzyl)-2-styryl-4-aminoquinazoline

Conditions

Conditions	Yield
With dmap; triethylamine In toluene at 120℃;	93.2%

: 66003-76-7
Diphenyliodonium triflate

: 72235-53-1
3,4-difluorobenzylamine

: 923253-36-5
3,4-difluoro-N-phenylbenzamide

Conditions

Conditions	Yield
With 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate); potassium carbonate In dimethyl sulfoxide at 150℃; for 24h; Sealed tube; Green chemistry;	93%

: 69150-28-3
7-(3-bromopropoxy)−2H-chromen-2-one

: 72235-53-1
3,4-difluorobenzylamine

: 7-{3-[(3,4-difluorobenzyl)amino]propoxy}-2H-chromen-2-one

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 10h; Reflux;	93%

: 1021693-28-6
(S)-tert-butyl 3-((2-chloro-5-nitropyrimidin-4-ylamino)methyl)piperidine-1-carboxylate

: 72235-53-1
3,4-difluorobenzylamine

: 1021693-29-7
(S)-tert-butyl-3-((2-(3,4-difluorobenzylamino)-5-nitropyrimidin-4-ylamino)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 0.5h;	91%

: 72235-53-1
3,4-difluorobenzylamine

: 13623-94-4
1,1-di(methylsulfanyl)-2-nitroethylene

: N,N'-bis(3,4-difluorobenzyl)-2-nitroethylene-1,1-diamine

Conditions

Conditions	Yield
In ethanol for 12h; Reflux;	91%

: 72235-53-1
3,4-difluorobenzylamine

: 170899-08-8
N-(tert-butoxycarbonyl)-D-allylglycine

: 880169-75-5
{1-[(3,4-difluorobenzylamino)-methyl]-but-3-enyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4 A molecular sieve; sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 14h;	90%

: 41530-32-9
1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate

: 72235-53-1
3,4-difluorobenzylamine

: 1001413-01-9
1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate; 3,4-difluorobenzylamine In iso-butanol at 5 - 100℃; Stage #2: With water; sodium hydroxide In methanol; iso-butanol at 20℃; for 2h; Stage #3: With hydrogenchloride In methanol; water; iso-butanol	90%
Stage #1: 1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate; 3,4-difluorobenzylamine In iso-butanol at 5 - 100℃; Stage #2: With water; sodium hydroxide In methanol; iso-butanol at 20℃; for 2h; Stage #3: With hydrogenchloride In methanol; water; iso-butanol	90%
Stage #1: 1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate; 3,4-difluorobenzylamine In iso-butanol at 5 - 100℃; for 49h; Stage #2: With water; sodium hydroxide In methanol; iso-butanol at 20℃; for 2h; Stage #3: With hydrogenchloride In methanol; water; iso-butanol	90%

: 37783-33-8
7-(4-bromobutoxy)-2H-chromen-2-one

: 72235-53-1
3,4-difluorobenzylamine

: 7-{4-[(3,4-difluorobenzyl)amino]butoxy}-2H-chromen-2-one

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 10h; Reflux;	90%

: methyl (S)-3-(1-(4-chlorophenyl)-3-((4-methoxybenzyl)oxy)propyl)-2-oxo-2H-pyran-5-carboxylate

: 72235-53-1
3,4-difluorobenzylamine

: methyl (S)-5-(1-(4-chlorophenyl)-3-((4-methoxybenzyl)oxy)propyl)-1-(3,4-difluorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylate

Conditions

Conditions	Yield
In methanol at 23℃;	89%

: 72235-53-1
3,4-difluorobenzylamine

: 1105689-83-5
N-(3,4-difluorobenzyl)-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

Conditions

Conditions	Yield
	88%

: 72235-53-1
3,4-difluorobenzylamine

: 85118-04-3
(3,4-difluoro-phenyl)-amide

Conditions

Conditions	Yield
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); potassium tert-butylate In tert-butyl alcohol at 70℃; for 12h;	88%

: 67498-38-8
α-ethoxycarbonyl-γ,γ-dimethyl-Δα,β-butenolide

: 72235-53-1
3,4-difluorobenzylamine

: ethyl 4-((3,4-difluorobenzyl)amino)-5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 20 - 50℃; for 10h;	88%

: 885679-07-2
2-([(5-chloro-2-methoxyphenyl)sulfonyl]amino)pent-4-enoic acid

: 72235-53-1
3,4-difluorobenzylamine

: 885679-09-4
2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(3,4-difluorobenzyl)pent-4-enamide

Conditions

Conditions	Yield
Stage #1: 2-([(5-chloro-2-methoxyphenyl)sulfonyl]amino)pent-4-enoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h; Stage #2: 3,4-difluorobenzylamine In dichloromethane at 20℃; for 12h;	87%

: 72235-53-1
3,4-difluorobenzylamine

: 351351-79-6
N-[9-chloro-6-(3-pyrrolidin-1-yl-propionylamino)-acridin-3-yl]-3-pyrrolidin-1-yl-propionoamide

: BSG-17

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 28h; Heating;	87%
With N-ethyl-N,N-diisopropylamine In ethanol	35%

: 1190707-76-6
tert-butyl 2-((2-chloro-6-(2,6-dichlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)thiomorpholine-4-carboxylate

: 72235-53-1
3,4-difluorobenzylamine

: 1300038-54-3
C29H29Cl2F2N5O2S

Conditions

Conditions	Yield
at 140℃; for 2h; Microwave irradiation;	86%

: 58711-31-2
(1-methyl-2-oxo-cyclohexyl)-acetic acid

: 72235-53-1
3,4-difluorobenzylamine

: 1057255-82-9
1-(3,4-difluoro-benzyl)-3a-methyl-1,3,3a,4,5,6-hexahydro-indol-2-one

Conditions

Conditions	Yield
In m-xylene for 3h; Reflux;	85%

: 99815-16-4
3,4-bis(tert-butyldimethylsilanyloxy)benzaldehyde

: 72235-53-1
3,4-difluorobenzylamine

: C26H39F2NO2Si2

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃;	83%

: 551-93-9
2-aminoacetophenone

: 72235-53-1
3,4-difluorobenzylamine

: 6-(3,4-difluorophenyl)-7-methyl-5,6-dihydrodibenzo[b,h][1,6]naphthayridine

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In neat (no solvent, solid phase) at 90℃; for 12h; Green chemistry;	82%

: 79-04-9
chloroacetyl chloride

: 72235-53-1
3,4-difluorobenzylamine

: 2-chloro-N-(3,4-difluorobenzyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	82%

: 1312012-32-0
3-bromo-2-(2-bromophenyl)pyridine

: 72235-53-1
3,4-difluorobenzylamine

: 5-(3,4-difluorobenzyl)-5H-pyrido[3,2-b]indole

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; L-proline In dimethyl sulfoxide at 120℃; for 24h;	80%

3,4-DIFLUOROBENZYLAMINE Chemical Properties

The molecular formula of 3,4-Difluorobenzylamine(72235-53-1) is C₇H₇F₂N and its formula weight is 143.13.
The density of 3,4-Difluorobenzylamine(72235-53-1) is 1.21 g/mL at 25 °C(lit.). The refractive index is about 1.493(lit.). Its flash point is 175 °F.
The chemical synonyms of 3,4-Difluorobenzylamine(72235-53-1) are (3,4-Difluorophenyl)methanamine;Benzenemethanamine, 3,4-difluoro-;RARECHEM AL BW 0298;3,4-DIFLUOROBENZYLAMINE;3,4-Difluorobenzylamine 99%;3,4-Difluorobenzylamine99%;3, 4-DIFLUOROBENZYLAMINE,98%;3,4-Difluorobenzenemethanamine
The molecular structure of 3,4-Difluorobenzylamine(72235-53-1):

3,4-DIFLUOROBENZYLAMINE Toxicity Data With Reference

RTECS#: CAS# 72235-53-1: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: 3,4-Difluorobenzylamine - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated.

3,4-DIFLUOROBENZYLAMINE Safety Profile

Hazard Codes C
Risk Statements 34
Safety Statements 26-27-36/37/39-45-25
RIDADR UN 2735 8/PG 3
WGK Germany 3
Hazard Note Corrosive
HazardClass 8
PackingGroup III

3,4-DIFLUOROBENZYLAMINE Specification

Chemical Stability: Stable.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents, strong acids.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization Will not occur.

Product Name

3,4-Difluorobenzylamine

Synthetic route

3,4-DIFLUOROBENZYLAMINE Chemical Properties

3,4-DIFLUOROBENZYLAMINE Toxicity Data With Reference

3,4-DIFLUOROBENZYLAMINE Safety Profile

3,4-DIFLUOROBENZYLAMINE Specification

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