3-Bromo-5-chloroaniline supplier

Name
3-BROMO-5-CHLOROPHENYLAMINE
EINECS
CAS No. 96558-78-0
Article Data4
CAS DataBase
Density 1.722 g/cm³
Solubility
Melting Point
Formula C₆H₅BrClN
Boiling Point 284.132 °C at 760 mmHg
Molecular Weight 206.469
Flash Point 125.639 °C
Transport Information
Appearance
Safety
Risk Codes Xi:;
Molecular Structure
Hazard Symbols Xi
Synonyms 3-BROMO-5-CHLOROPHENYLAMINE;3-Bromo-5-chloroaniline;3-BROMO-5-CHLOROPHENYLAMINE, 95+%;3-BROMO-5-CHLOROPHEN;3-broMo-5-chlorobenzenaMine;BenzenaMine,3-broMo-5-chloro-
PSA 26.02000
LogP 3.26590

Synthetic route

: 1-bromo-3-chloro-5-nitrobenzene

: 96558-78-0
3-bromo-5-chlorophenylamine

Conditions

Conditions	Yield
With acetic acid; zinc for 4h;	99%
With sodium sulfide; zinc at 35 - 45℃; for 0.333333h; Temperature;	90%

: 96558-70-2
2,3-dibromo-5-chloroaniline

: 96558-78-0
3-bromo-5-chlorophenylamine

Conditions

Conditions	Yield
With hydrogenchloride; 2H(1+)2H3NCl3Cu(2-) In acetic acid at 90℃; Rate constant; other solvent, other temp., other Cu(I) complex;

5-chloro-3-bromo-1-nitrobenzene: 5-chloro-3-bromo-1-nitrobenzene

: 96558-78-0
3-bromo-5-chlorophenylamine

Conditions

Conditions	Yield
With hydrogenchloride; tin

: 98-11-3
benzenesulfonic acid

: 96558-78-0
3-bromo-5-chlorophenylamine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: nitric acid; manganese(IV) oxide / 0.75 h / 35 °C / 15001.5 Torr 2: N-Bromosuccinimide / 30 °C 3: hydrogenchloride / water / 1 h / 95 °C / 18751.9 Torr 4: acetic acid / 0.75 h / 20 - 25 °C / 15001.5 - 18751.9 Torr 5: zinc; sodium sulfide / 0.33 h / 35 - 45 °C View Scheme

: 138-42-1
p-nitrobenzenesulfonic acid

: 96558-78-0
3-bromo-5-chlorophenylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: N-Bromosuccinimide / 30 °C 2: hydrogenchloride / water / 1 h / 95 °C / 18751.9 Torr 3: acetic acid / 0.75 h / 20 - 25 °C / 15001.5 - 18751.9 Torr 4: zinc; sodium sulfide / 0.33 h / 35 - 45 °C View Scheme

: 2-bromo-p-nitrobenzenesulfonic acid

: 96558-78-0
3-bromo-5-chlorophenylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 1 h / 95 °C / 18751.9 Torr 2: acetic acid / 0.75 h / 20 - 25 °C / 15001.5 - 18751.9 Torr 3: zinc; sodium sulfide / 0.33 h / 35 - 45 °C View Scheme

: 1065010-87-8
potassium cyclopropyltrifluoroborate

: 96558-78-0
3-bromo-5-chlorophenylamine

: 3-chloro-5-cyclopropylaniline

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium tert-butylate In water; toluene at 90℃; for 16h; Inert atmosphere;	92.4%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 2-chloro-5-(1,1-dioxo-1,2-thiazolidin-2-yl)-3-fluorobenzoic acid

: C16H12BrCl2FN2O3S

Conditions

Conditions	Yield
With triethylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	88.3%

: 5600-21-5
2-amino-6-methyl-4-chloropyrimidine

: 96558-78-0
3-bromo-5-chlorophenylamine

: N4-(3-bromo-5-chlorophenyl)-6-methylpyrimidine-2,4-diamine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 140℃; for 1.5h; Microwave irradiation; Sealed tube;	87%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 3-chloro-5-(prop-1-en-2-yl)aniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 130℃; for 3h;	82%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 100℃; for 12h; Inert atmosphere;	51.1%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 73183-34-3
bis(pinacol)diborane

: 1269233-11-5
3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 110℃; for 5h;	81.4%

: 4,4,5,5-tetramethyl-2-[1-methylprop-1-enyl]-1,3,2-dioxaborolane

: 96558-78-0
3-bromo-5-chlorophenylamine

: 3-(but-2-en-2-yl)-5-chloroaniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 130℃; for 12h; Inert atmosphere;	81%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 3-bromo-5-chloro-benzenesulfonyl chloride

Conditions

Conditions	Yield
Stage #1: 3-bromo-5-chlorophenylamine With hydrogenchloride; sodium nitrite In water at 0℃; Cooling with ice/salt; Stage #2: With copper(II) choride dihydrate; sulfur dioxide In water; acetic acid at 20℃; Cooling with ice/salt;	78%
Stage #1: 3-bromo-5-chlorophenylamine With hydrogenchloride; sodium nitrite In water at 5℃; Sandmeyer reaction; Stage #2: With sulfur dioxide; acetic acid; copper(l) chloride In water at 20℃; for 2h; Sandmeyer reaction;
Stage #1: 3-bromo-5-chlorophenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: With sulfur dioxide; acetic acid; copper(l) chloride In water at 0 - 20℃; for 2h;

: 1749-68-4
4-amino-6-chloro-2-methylpyrimidine

: 96558-78-0
3-bromo-5-chlorophenylamine

: N4-(3-bromo-5-chlorophenyl)-2-methylpyrimidine-4,6-diamine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 18h; Reflux;	75%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 100-39-0
benzyl bromide

: N,N-dibenzyl-3-bromo-5-chloroaniline

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;	75%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 3-allyl-5-chloroaniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In water at 100℃; for 12h; Inert atmosphere;	54.2%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 1692-15-5
4-pyridylboronic acid

: 1426806-67-8
3-chloro-5-(pyridin-4-yl)aniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 100℃; for 12h; Inert atmosphere;	53.1%

: 96558-78-0
3-bromo-5-chlorophenylamine

: methyl 2-chloro-5-(1,1-dioxo-1,2-thiazolidin-2-yl)benzoate

: C16H13BrCl2N2O3S

Conditions

Conditions	Yield
With trimethylaluminum In toluene at 0 - 110℃; for 3h;	52.4%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 17997-47-6
2-tri-n-butylstannylpyridine

: C11H9ClN2

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 110℃; for 12h; Inert atmosphere;	50.4%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 1269233-11-5
3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Conditions

Conditions	Yield
In ethyl acetate	48%

: 10147-36-1
n-propanesulfonyl chloride

: 96558-78-0
3-bromo-5-chlorophenylamine

: N-(3-bromo-5-chlorophenyl)propane-1-sulfonamide

Conditions

Conditions	Yield
With pyridine at 20℃; for 48h;	48%

: 24424-99-5
di-tert-butyl dicarbonate

: 96558-78-0
3-bromo-5-chlorophenylamine

: C11H13BrClNO2

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 40℃; for 12h;	41.1%

: 1191-99-7
2,3-dihydro-2H-furan

: 96558-78-0
3-bromo-5-chlorophenylamine

A: 3-chloro-5-(2,3-dihydrofuran-5-yl)aniline

B: C10H10ClNO

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 110℃; for 12h; Inert atmosphere;	A 41.1% B 24.8%

...Expand

: 96558-78-0
3-bromo-5-chlorophenylamine

: 126689-00-7
2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-propene

: 3-chloro-5-(2-methylprop-1-enyl)aniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 120℃; for 12h; Inert atmosphere;	41%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 24850-33-7
allyltributylstanane

: 3-allyl-5-chloroaniline

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20 - 85℃; for 16h; Inert atmosphere;	38.7%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 3-bromo-4,5-dichloroaniline

Conditions

Conditions	Yield
With N-chloro-succinimide In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	34%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 75927-49-0
pinacol vinylboronate

: 3-chloro-5-ethenylaniline

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 100℃; for 22h; Inert atmosphere;	24%

: 96558-78-0
3-bromo-5-chlorophenylamine

: 13101-40-1
1-bromo-3-chloro-5-iodobenzene

Conditions

Conditions	Yield
ueber die Diazoverbindung;

: 96558-78-0
3-bromo-5-chlorophenylamine

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: sulfanilic acid-(3-bromo-5-chloro-anilide)

Conditions

Conditions	Yield
With pyridine; acetone Erwaermen des Reaktionsprodukts mit wss. Natronlauge;

: 463-71-8
thiophosgene

: 96558-78-0
3-bromo-5-chlorophenylamine

: C7H3BrClNS

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 96558-78-0
3-bromo-5-chlorophenylamine

: 1240523-63-0
(S)-tert-butyl 1-(3-bromo-5-chlorophenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide for 14h;

: 110-91-8
morpholine

: 96558-78-0
3-bromo-5-chlorophenylamine

: 1259440-76-0
3-chloro-5-morpholinoaniline

Conditions

Conditions	Yield
With lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2,4,6-triisopropylbiphenyl In tetrahydrofuran at 65℃; for 2.5h;

: 822-36-6
4-methyl-1H-imidazole

: 96558-78-0
3-bromo-5-chlorophenylamine

: 1290090-24-2
C10H10ClN3

Conditions

Conditions	Yield
With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 24h; Inert atmosphere;

3-Bromo-5-chloroaniline Specification

The IUPAC name of 3-Bromo-5-chloroaniline is 3-bromo-5-chloroaniline . The CAS registry number is 96558-78-0. It is also named as Benzenamine, 3-bromo-5-chloro- ; 3-Bromo-5-chlorophenylamine . It is pharmaceutical intermediates and can be used in pharmaceutical synthesis. People can use the following data to convert to the molecule structure. SMILES: c1c(cc(cc1Cl)Br)N; InChI: InChI=1/C6H5BrClN/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2; InChIKey:YYBRLVWWPRAQDX-UHFFFAOYAR; Std. InChI:
InChI=1S/C6H5BrClN/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2; Std. InChIKey: YYBRLVWWPRAQDX-UHFFFAOYSA-N.

Product Name

3-BROMO-5-CHLOROPHENYLAMINE

Synthetic route

3-Bromo-5-chloroaniline Specification

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