Product Name

  • Name

    3-Dimethylamino-2-methylpropyl chloride hydrochloride

  • EINECS 224-237-6
  • CAS No. 4261-67-0
  • Density
  • Solubility
  • Melting Point 169-173 °C
  • Formula C6H14ClN.ClH
  • Boiling Point 144.5 °C at 760 mmHg
  • Molecular Weight 172.098
  • Flash Point 41.2 °C
  • Transport Information
  • Appearance white to off-white powder
  • Safety 37/39-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 4261-67-0 (3-Dimethylamino-2-methylpropyl chloride hydrochloride)
  • Hazard Symbols IrritantXi
  • Synonyms 1-Propanamine,3-chloro-N,N,2-trimethyl-, hydrochloride (9CI);Propylamine, 3-chloro-N,N,2-trimethyl-,hydrochloride (7CI,8CI);(g-Chloro-b-methylpropyl)dimethylamine-hydrochloride;1-Chloro-2-methyl-3-(N,N-dimethylamino)propane hydrochloride;1-Chloro-3-(dimethylamino)-2-methylpropane hydrochloride;2,N,N-Trimethylaminopropyl chloride hydrochloride;2-Methyl-3-(dimethylamino)propyl chloride hydrochloride;
  • PSA 3.24000
  • LogP 2.22490

Synthetic route

2-methyl-3-dimethylaminopropanol
33622-41-2

2-methyl-3-dimethylaminopropanol

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

Conditions
ConditionsYield
With thionyl chloride In chloroform Reflux; Cooling with ice;
10H-dipyrido[3,4-b:3',4'-e][1,4]thiazine
503321-47-9

10H-dipyrido[3,4-b:3',4'-e][1,4]thiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

10-(3'-dimethylamino-2'-methylpropyl)-2,7-diazaphenothiazine

10-(3'-dimethylamino-2'-methylpropyl)-2,7-diazaphenothiazine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 5h; Heating;84%
5H-dipyrido[2,3-b:4',3'-e][1,4]thiazine

5H-dipyrido[2,3-b:4',3'-e][1,4]thiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

10-(3'-dimethylamino-2'-methylpropyl)-3,6-diazaphenothiazine

10-(3'-dimethylamino-2'-methylpropyl)-3,6-diazaphenothiazine

Conditions
ConditionsYield
Stage #1: 5H-dipyrido[2,3-b:4',3'-e][1,4]thiazine With sodium hydroxide In 1,4-dioxane for 2h; Reflux;
Stage #2: 1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride In 1,4-dioxane for 24h; Reflux;		82%
6H-9-chloroquino[3,2-b]benzo[1,4]thiazine
1192303-44-8

6H-9-chloroquino[3,2-b]benzo[1,4]thiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

6-(3-dimethylamino-2-methylpropyl)-9-chloroquinobenzothiazine
1443133-98-9

6-(3-dimethylamino-2-methylpropyl)-9-chloroquinobenzothiazine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 3h; Reflux;78%
9-methylthio-6H-quinobenzothiazine
1192303-47-1

9-methylthio-6H-quinobenzothiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

6-(3-dimethylamino-2-methylpropyl)-9-methylthioquinobenzothiazine
1443133-99-0

6-(3-dimethylamino-2-methylpropyl)-9-methylthioquinobenzothiazine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 3h; Reflux;76%
6H-quino[3,2-b]benzo[1,4]thiazine
158438-85-8

6H-quino[3,2-b]benzo[1,4]thiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

6-(3-dimethylamino-2-methylpropyl)quinobenzothiazine
1443133-97-8

6-(3-dimethylamino-2-methylpropyl)quinobenzothiazine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 3h; Reflux;74%
6H-9-fluoroquinobenzothiazine
1192303-46-0

6H-9-fluoroquinobenzothiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

C21H22FN3S

C21H22FN3S

Conditions
ConditionsYield
With sodium hydroxide for 3h; Reflux;71%
6H-diquino[3,2-b;2',3'-e][1,4]thiazine
911371-11-4

6H-diquino[3,2-b;2',3'-e][1,4]thiazine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

6-(3'-dimethylamino-2'-methylpropyl)diquinothiazine
1027333-79-4

6-(3'-dimethylamino-2'-methylpropyl)diquinothiazine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane for 3h; Heating;62%
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

1-azido-2-methyl-3-(N,N-dimethylamino)propane

1-azido-2-methyl-3-(N,N-dimethylamino)propane

Conditions
ConditionsYield
With sodium azide In water at 80℃; for 15h;45%
With sodium azide In water at 80℃;45%
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

1-benzyl-3-hydroxy-1H-indazole
2215-63-6

1-benzyl-3-hydroxy-1H-indazole

[3-(1-benzyl-1H-indazol-3-yloxy)-2-methyl-propyl]-dimethyl-amine

[3-(1-benzyl-1H-indazol-3-yloxy)-2-methyl-propyl]-dimethyl-amine

Conditions
ConditionsYield
Stage #1: 1-benzyl-3-hydroxy-1H-indazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride With sodium hydride In N,N-dimethyl-formamide at 100℃; for 12h; Further stages.;		45%
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

(3-Dimethylamino-2-methyl-propyl)-hydrazin
89600-39-5

(3-Dimethylamino-2-methyl-propyl)-hydrazin

Conditions
ConditionsYield
(i) N2H4*H2O, (ii) K2CO3; Multistep reaction;
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

1,1-Bis-(3-dimethylamino-2-methyl-propyl)-hydrazin
91695-34-0

1,1-Bis-(3-dimethylamino-2-methyl-propyl)-hydrazin

Conditions
ConditionsYield
(i) N2H4*H2O, (ii) K2CO3; Multistep reaction;
2,7-dihydroxy-9H-fluoren-9-one
42523-29-5

2,7-dihydroxy-9H-fluoren-9-one

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

2,7-Bis-(3-dimethylamino-2-methyl-propoxy)-fluoren-9-one

2,7-Bis-(3-dimethylamino-2-methyl-propoxy)-fluoren-9-one

Conditions
ConditionsYield
With potassium hydroxide In toluene
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-1H-quinolin-2-one
142326-67-8

7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-1H-quinolin-2-one

7-chloro-4-(3-dimethylamino-2-methyl-propoxy)-3-(3,5-dimethyl-phenyl)-1H-quinolin-2-one

7-chloro-4-(3-dimethylamino-2-methyl-propoxy)-3-(3,5-dimethyl-phenyl)-1H-quinolin-2-one

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 16h; Alkylation;
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

Phenyl-2-propanon-(2-methyl-3-dimethylamino-propylhydrazon)
106458-88-2

Phenyl-2-propanon-(2-methyl-3-dimethylamino-propylhydrazon)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) N2H4*H2O, (ii) K2CO3
2: benzene / Heating
View Scheme
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

1-(2-Methyl-3-dimethylaminopropyl)-2-(1-phenyl-2-propyl)hydrazin
92793-44-7

1-(2-Methyl-3-dimethylaminopropyl)-2-(1-phenyl-2-propyl)hydrazin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (i) N2H4*H2O, (ii) K2CO3
2: benzene / Heating
3: LiAlH4 / diethyl ether / Heating
View Scheme
2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
27068-88-8

2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

diethyl ether
60-29-7

diethyl ether

water
7732-18-5

water

potassium carbonate
584-08-7

potassium carbonate

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

Cis(+)-3-acetyloxy-2,3-dihydro-5-(2-methyl-3-dimethylaminopropyl)-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one oxalate

Cis(+)-3-acetyloxy-2,3-dihydro-5-(2-methyl-3-dimethylaminopropyl)-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one oxalate

Conditions
ConditionsYield
With oxalic acid; acetic anhydride In acetone
...Expand
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

3-(dimethylamino)-2-methylpropyl carbamimidothioate dihydrochloride
118646-15-4

3-(dimethylamino)-2-methylpropyl carbamimidothioate dihydrochloride

Conditions
ConditionsYield
With thiourea In ethanol; calcium chloride
sodium hydride-mineral oil

sodium hydride-mineral oil

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

4,9-Dihydro-4-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
56276-59-6

4,9-Dihydro-4-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

9-(3-Dimethylamino-2-methylpropyl)-4,9-dihydro-4-methyl-10H-thieno[3,4-b] [1,5]benzodiazepin-10-one, hydrochloride
59720-16-0

9-(3-Dimethylamino-2-methylpropyl)-4,9-dihydro-4-methyl-10H-thieno[3,4-b] [1,5]benzodiazepin-10-one, hydrochloride

Conditions
ConditionsYield
In N-methyl-acetamide; benzene
...Expand
1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

m,p-dichloroaniline
95-76-1

m,p-dichloroaniline

N'-(3,4-dichlorophenyl)-N,N,2-trimethylpropane-1,3-diamine

N'-(3,4-dichlorophenyl)-N,N,2-trimethylpropane-1,3-diamine

Conditions
ConditionsYield
With sodium hydroxide
N-(5-chloro-pyrimidin-2-yl)-acetamide
68303-37-7

N-(5-chloro-pyrimidin-2-yl)-acetamide

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

2-(2-methyl-3-dimethylaminopropylamino)-5-chloropyrimidine

2-(2-methyl-3-dimethylaminopropylamino)-5-chloropyrimidine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

N,N-dimethyl-N'-(2-methyl-3-dimethylaminopropyl)-N'-(5-chloro-2-pyrimidinyl)urea

N,N-dimethyl-N'-(2-methyl-3-dimethylaminopropyl)-N'-(5-chloro-2-pyrimidinyl)urea

maleic anhydride
108-31-6

maleic anhydride

1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride
4261-67-0

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

C22H41NO4

C22H41NO4

Conditions
ConditionsYield
Stage #1: maleic anhydride; 1-dodecyl alcohol In n-heptane at 15 - 80℃; for 6h;
Stage #2: With 18-crown-6 ether; potassium carbonate In chloroform at 60℃; for 4h;
Stage #3: 1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride In chloroform at 50℃; for 20h;
...Expand

3-Dimethylamino-2-methylpropyl chloride hydrochloride Specification

The cas register number of 3-Dimethylamino-2-methylpropyl chloride hydrochloride is 4261-67-0. It also can be called as 3-Chloro-2-methylpropyl(dimethyl)ammonium chloride and the Systematic name about this chemical is [(2R)-3-chloro-2-methylpropyl]-dimethylazanium.

Physical properties about 3-Dimethylamino-2-methylpropyl chloride hydrochloride are: (1)ACD/LogP: 1.40; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.6; (4)ACD/LogD (pH 7.4): -0.38; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 2.29; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 3.24Å2; (13)Flash Point: 41.2 °C; (14)Enthalpy of Vaporization: 38.16 kJ/mol; (15)Boiling Point: 144.5 °C at 760 mmHg; (16)Vapour Pressure: 5.07 mmHg at 25°C.

Uses of 3-Dimethylamino-2-methylpropyl chloride hydrochloride: It reacts to get (3-azido-2-methyl-propyl)-dimethyl-amine. This reaction needs solvent H2O. The reaction time is 15 hours. The yield is 45 %.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. People must wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

People can use the following data to convert to the molecule structure.
1.SMILES: Cl.ClCC(C)CN(C)C
2.InChI: InChI=1/C6H14ClN.ClH/c1-6(4-7)5-8(2)3;/h6H,4-5H2,1-3H3;1H 
3.InChIKey: SOMIBONUMGNAEP-UHFFFAOYAF
4.Std. InChI: InChI=1S/C6H14ClN.ClH/c1-6(4-7)5-8(2)3;/h6H,4-5H2,1-3H3;1H

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