• Name

  3-FLUORO-2-METHOXYBENZALDEHYDE

• EINECS
• CAS No. 74266-68-5
• Article Data11
• CAS DataBase
• Density 1.192±0.06 g/cm3 (20 ºC 760 Torr)
• Solubility
• Melting Point 47-48℃
• Formula C8H7 F O2
• Boiling Point 238.7±20.0℃ (760 Torr)
• Molecular Weight 154.141
• Flash Point 95.4±16.7℃
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 3-Fluoro-2-methoxybenzaldehyde
• PSA 26.30000
• LogP 1.64680

Synthetic route

394-50-3

3-fluorosalicylaldehyde

77-78-1

dimethyl sulfate

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
With potassium carbonate In acetone	100%
With potassium carbonate In acetone at 60℃; for 2h;	100%

394-50-3

3-fluorosalicylaldehyde

74-88-4

methyl iodide

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	88%
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere;	57%
With potassium carbonate In acetonitrile at 20 - 90℃; for 3h;

Conditions

Conditions	Yield
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0℃; for 1.33333h;	75%

Conditions

Conditions	Yield
Yield given. Multistep reaction;

A

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

B

103438-88-6

2-fluoro-3-methoxybenzaldehyde

Conditions

Conditions	Yield
With sec.-butyllithium 1.) THF, from -78 to -70 deg C, 10 min, 2.) THF; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

2105-94-4

4-bromo-2-fluorophenol

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 3: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme

1526-17-6

2-fluoro-6-nitrophenol

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: 94 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h View Scheme

367-12-4

2-fluorophenol

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 47 percent / liquid nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 3: 94 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h View Scheme
Multi-step reaction with 7 steps 1: 49 percent / liquid nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 2: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 3: 2., HBr, CuBr 4: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 6: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme

403-19-0

2-fluoro-4-nitrophenol

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 2: 2., HBr, CuBr 3: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 5: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme

399-96-2

4-amino-2-fluorophenol

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 2., HBr, CuBr 2: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 4: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme

484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h View Scheme

320-76-3

2-fluoro-4-bromo-6-nitro-phenol

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme

74266-66-3

bromo-4 fluoro-2 nitro-6 anisole

74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme

3-FLUORO-2-METHOXYBENZALDEHYDE Chemical Properties