3-Hydroxyphenylphosphinyl-propanoic acid supplier

Name
3-Hydroxyphenylphosphinyl-propanoic acid
EINECS 411-200-6
CAS No. 14657-64-8
Article Data13
CAS DataBase
Density 1.358 g/cm³
Solubility 31.183g/L at 20℃
Melting Point 152oC
Formula C₉H₁₁O₄P
Boiling Point 526.605 °C at 760 mmHg
Molecular Weight 214.158
Flash Point 272.281 °C
Transport Information
Appearance white powder
Safety 26-39
Risk Codes 41
Molecular Structure
Hazard Symbols Xi
Synonyms Propionicacid, 3-(hydroxyphenylphosphinyl)- (8CI);2-Carboxyethyl(phenyl)phosphinicacid;3-(Hydroxyphenylphosphinyl)propanoic acid;3-(Phenylphosphinyl)propionic acid;H 205;H 205 (flame retardant);Hiretar 205;Phosgard PF 100;2-Carboxyethylphenylphosphinic acid;CEPPA;
PSA 84.41000
LogP 1.05700

Synthetic route

: 644-97-3
Dichlorophenylphosphine

: 79-10-7
acrylic acid

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
Stage #1: Dichlorophenylphosphine; acrylic acid at 80 - 110℃; for 3h; Stage #2: With water at 90℃; for 3h; Temperature; Concentration;	98%
With acetic anhydride	96.8%
	94.2%

: 14576-56-8
butyl 3-[butoxy(phenyl)phosphinyl]propionate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
With sulfuric acid In water	97.2%

: 2071-68-3
3-(chlorophenylphosphinyl)-propionyl chloride

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
With water In acetone for 0.5h; Heating;	92.6%
With water

: 857470-46-3
(2-cyano-ethyl)-phenyl-phosphinic acid butyl ester

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 202477-16-5
3-(butoxy-phenyl-phosphinoyl)-propionic acid methyl ester

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 644-97-3
Dichlorophenylphosphine

μ.μ-bis-diphenylacetylene-bis-Fe-Fe): μ.μ-bis-diphenylacetylene-bis-Fe-Fe)

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95.6 percent / 1.) -10 deg C, 2 h, 2.) 0 deg C, 1 h 2: 92.6 percent / water / acetone / 0.5 h / Heating View Scheme

: 6172-81-2
butyl phenylphosphinate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium 2: aqueous HCl View Scheme
Multi-step reaction with 2 steps 1: sodium 2: aqueous HCl View Scheme
Multi-step reaction with 2 steps 1: sodium; benzene 2: aqueous HCl View Scheme

: 644-97-3
Dichlorophenylphosphine

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: sodium 3: aqueous HCl View Scheme
Multi-step reaction with 3 steps 2: sodium 3: aqueous HCl View Scheme
Multi-step reaction with 3 steps 2: sodium; benzene 3: aqueous HCl View Scheme
Multi-step reaction with 2 steps 2: H2O View Scheme

: hydroxyethyl 3-[hydroxy(phenyl)phosphinyl]propionate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 556-52-5
oxiranyl-methanol

: C15H23O8P

Conditions

Conditions	Yield
In ethanol at 50℃; for 8.5h;	98%

: 124-09-4
1,6-Hexanediamine

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: (3-((6-aminohexyl)amino)-3-oxopropyl)(phenyl)phosphinic acid

Conditions

Conditions	Yield
In ethanol at 0 - 70℃; for 4h;	96.78%

: 108-78-1
2,4,6-triamino-s-triazine

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: C12H15N6O3P

Conditions

Conditions	Yield
In water at 20 - 70℃;	93%

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 13317-44-7
ethyl(phenyl)phosphinic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 50℃; for 40h; pH=3 - 4; Temperature; pH-value; Concentration;	92.8%

: aqueous cadmium chloride

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 2C9H9O4P(2-)*2HO(1-)*3Cd(2+)

Conditions

Conditions	Yield
With triethylamine at 160℃; for 72h; pH=5; Autoclave; High pressure;	87%

...Expand

: manganese(II) sulfate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 2C9H10O4P(1-)*Mn(2+)

Conditions

Conditions	Yield
In water at 120℃; for 48h; Autoclave; High pressure;	82%

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: lead(II) chloride

: [Pb(2-carboxyethyl(phenyl)phosphinate)2]

Conditions

Conditions	Yield
In water High Pressure; mixt. PbCl2 and 2-carboxyethyl(phenyl)phosphinic acid in water in Parr Teflon-lined autoclave was heated at 150°C for 3 days; elem. anal.;	81%

: 66-71-7
1,10-Phenanthroline

: cadmium(II) nitrate tetrhydrate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 1428102-03-7
C9H9O4P(2-)*Cd(2+)*C12H8N2

Conditions

Conditions	Yield
With urea In water at 150℃; for 72h; pH=7; Autoclave;	81%

...Expand

: 66-71-7
1,10-Phenanthroline

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 6046-93-1
copper(II) acetate monohydrate

: C9H9O4P(2-)*Cu(2+)*4H2O*C12H8N2

Conditions

Conditions	Yield
at 80 - 90℃; pH=4;	78%

...Expand

: 66-71-7
1,10-Phenanthroline

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 5743-04-4
cadmium(II) acetate dihydrate

: 3C9H9O4P(2-)*3Cd(2+)*3C12H8N2*6.5H2O

Conditions

Conditions	Yield
at 80 - 90℃; pH=5;	72%

...Expand

: 108-78-1
2,4,6-triamino-s-triazine

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: melaminium (2-carboxyethyl)(phenyl)phosphinate monohydrate

Conditions

Conditions	Yield
With water at 20℃; Heating;	70%

: 66-71-7
1,10-Phenanthroline

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 6156-78-1
manganese (II) acetate tetrahydrate

: 1428102-00-4
C9H9O4P(2-)*Mn(2+)*H2O*C12H8N2

Conditions

Conditions	Yield
With urea at 110℃; for 72h; pH=6; Autoclave;	70%

...Expand

: 69506-86-1
1,1'-(1,4-butanediyl)bis(imidazole)

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 5970-45-6
zinc(II) acetate dihydrate

: [Zn(1,4-bis(1H-imidazol-1-yl)butane)0.5(2-carboxyethyl(phenyl)phosphinate)]n

Conditions

Conditions	Yield
Stage #1: 1,1'-(1,4-butanediyl)bis(imidazole); 3-[hydroxy(phenyl)phosphinyl]propionic acid; zinc(II) acetate dihydrate With air In water at 20℃; for 0.5h; Stage #2: In water at 150℃; for 96h; Concentration; High pressure;	70%

...Expand

: aqueous cadmium chloride

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 2C9H9O4P(2-)*2H(1+)*Cd(2+)

Conditions

Conditions	Yield
In water at 160℃; for 72h; Autoclave; High pressure;	68%

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: {NaH(Ph-PO2-C2H4-COOH)2}∞

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 0.166667h;	66%

: 553-26-4
4,4'-bipyridine

: zinc(II) nitrate hexahydrate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 0.5C10H8N2*C9H9O4P(2-)*Zn(2+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 140℃; for 48h; pH=Ca. 6; Autoclave; High pressure;	65%

...Expand

: 66-71-7
1,10-Phenanthroline

: cadmium(II) nitrate tetrhydrate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: C9H9O4P(2-)*Cd(2+)*C12H8N2*3H2O

Conditions

Conditions	Yield
at 150℃; for 72h; pH=4; Autoclave;	61%

...Expand

: 288-32-4
1H-imidazole

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: uranyl(VI) acetate dihydrate

: Co(imidazole)2(UO2)3((2-carboxyethyl)(phenyl)phosphinic acid(-2H))4

Conditions

Conditions	Yield
In water at 160℃; for 72h; pH=4 - 5; Autoclave; High pressure;	61%

...Expand

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: uranyl(VI) acetate dihydrate

: 25372-07-0
1,4-bis-(1H-imidazol-1-yl)benzene

: [Ni(1,4-di(1H-imidazol-1-yl)benzene)2(H2O)2][(UO2)3((2-carboxyethyl)(phenyl)phosphinic acid(-2H))4]·2H2O

Conditions

Conditions	Yield
With ammonium hydroxide at 160℃; for 72h; pH=3.5 - 4.5; Autoclave; High pressure;	61%

...Expand

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: {[KH(Ph-PO2-C2H4-COOH)2]·H2O}∞

Conditions

Conditions	Yield
With potassium hydroxide In water at 20℃; for 0.166667h;	60%

: 66-71-7
1,10-Phenanthroline

: zinc(II) nitrate hexahydrate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: Zn(2-carboxyethyl(phenyl)phosphinate)(1,10-phenanthroline)*5H2O

Conditions

Conditions	Yield
With sodium hydroxide In water at 150℃; for 73h; pH=5; Autoclave;	60%

...Expand

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: uranyl(VI) acetate dihydrate

: 25372-07-0
1,4-bis-(1H-imidazol-1-yl)benzene

: [Co(1,4-di(1H-imidazol-1-yl)benzene)2(H2O)2][(UO2)3((2-carboxyethyl)(phenyl)phosphinic acid(-2H))4]·2H2O

Conditions

Conditions	Yield
With ammonium hydroxide at 160℃; for 72h; pH=3.5 - 5; Autoclave; High pressure;	59%

...Expand

: 66-71-7
1,10-Phenanthroline

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: 6156-78-1
manganese (II) acetate tetrahydrate

: C9H9O4P(2-)*Mn(2+)*3H2O*C12H8N2

Conditions

Conditions	Yield
at 20℃; for 24h; pH=5;	56%

...Expand

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 638-38-0, 993-02-2, 2180-18-9, 15411-95-7, 22981-23-3, 27004-39-3
manganese(II) acetate

: uranyl(VI) acetate dihydrate

: 25372-07-0
1,4-bis-(1H-imidazol-1-yl)benzene

: Mn(1,4-di(1H-imidazol-1-yl)benzene)(UO2)2((2-carboxyethyl)(phenyl)phosphinic acid(-2H))3

Conditions

Conditions	Yield
With ammonium hydroxide In water at 160℃; for 72h; pH=4 - 6; Autoclave; High pressure;	51%

...Expand

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: C9H9O4P(2-)*Li(1+)*H(1+)

Conditions

Conditions	Yield
With lithium hydroxide In water at 50℃;	45%

: 66-71-7
1,10-Phenanthroline

: cadmium(II) acetate monohydrate

: 14657-64-8
3-[hydroxy(phenyl)phosphinyl]propionic acid

: 7732-18-5
water

: C42H38Cd2N4O10P2*2H2O

Conditions

Conditions	Yield
at 20℃; for 48h;	45%

...Expand

3-Hydroxyphenylphosphinyl-propanoic acid Specification

The 3-Hydroxyphenylphosphinyl-propanoic acid, with the CAS registry number 14657-64-8, is also known as 2-Carboxyethyl(phenyl)phosphinic acid. It belongs to the product category of Flame retardant. This chemical's molecular formula is C₉H₁₁O₄P and molecular weight is 214.16. What's more, its systematic name is 3-[Hydroxy(phenyl)phosphoryl]propanoic acid.

Physical properties of 3-Hydroxyphenylphosphinyl-propanoic acid are: (1)ACD/LogP: -0.331; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.29; (4)ACD/LogD (pH 7.4): -5.07; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 84.41 Å²; (13)Index of Refraction: 1.554; (14)Molar Refractivity: 50.567 cm³; (15)Molar Volume: 157.658 cm³; (16)Polarizability: 20.046×10^-24cm³; (17)Surface Tension: 57.6 dyne/cm; (18)Density: 1.358 g/cm³; (19)Flash Point: 272.281 °C; (20)Enthalpy of Vaporization: 84.319 kJ/mol; (21)Boiling Point: 526.605 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical has a risk of serious damage to eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=P(O)(c1ccccc1)CCC(=O)O
(2)Std. InChI: InChI=1S/C9H11O4P/c10-9(11)6-7-14(12,13)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)(H,12,13)
(3)Std. InChIKey: MORLYCDUFHDZKO-UHFFFAOYSA-N

Product Name

3-Hydroxyphenylphosphinyl-propanoic acid

Synthetic route

3-Hydroxyphenylphosphinyl-propanoic acid Specification

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