Product Name

  • Name

    3-Methylamino-1,2-propanediol

  • EINECS 254-809-0
  • CAS No. 40137-22-2
  • Article Data19
  • CAS DataBase
  • Density 1.064 g/cm3
  • Solubility miscible with water
  • Melting Point 69°C (estimate)
  • Formula C4H11NO2
  • Boiling Point 245.8 °C at 760 mmHg
  • Molecular Weight 105.137
  • Flash Point 142.7 °C
  • Transport Information UN 2735
  • Appearance clear colorless to pale yellow viscous liquid
  • Safety 26-36-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 40137-22-2 (3-Methylamino-1,2-propanediol)
  • Hazard Symbols IrritantXi
  • Synonyms (2,3-Dihydroxypropyl)methylamine;1-(Methylamino)-2,3-propanediol;1-(N-Methylamino)propane-2,3-diol;2,3-Dihydroxy-N-methylpropylamine;3-(Methylamino)-1,2-propanediol;Methyl(2,3-dihydroxypropyl)amine;N-Methyl-2,3-dihydroxy-1-propanamine;N-Methyl-2,3-dihydroxypropylamine;N-Methyl-N-(2,3-dihydroxypropyl)amine;N-Methyl-b,g-dihydroxypropylamine;N-Methylglycerylamine;
  • PSA 52.49000
  • LogP -1.05010

Synthetic route

oxiranyl-methanol
556-52-5

oxiranyl-methanol

methylamine
74-89-5

methylamine

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
at 55℃; under 225.023 - 31503.2 Torr; for 0.666667h; Pressure; Autoclave; Green chemistry;98.99%
In water at 30℃; for 4 - 5h;92.7%
unter Kuehlung;
potassium N-(1,2-dihydroxypropyl)-N-methylamidosulfonate

potassium N-(1,2-dihydroxypropyl)-N-methylamidosulfonate

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
With sulfuric acid; water at 100℃; for 8h; Hydrolysis;95%
3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

methylamine
74-89-5

methylamine

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
With sodium hydroxide In water at 17 - 42℃; for 0.270167h;82.4%
With sodium hydrogencarbonate; sodium hydroxide In water at 50 - 65℃; under 1125.11 Torr; for 4.33333h; Product distribution / selectivity;
oxiranyl-methanol
556-52-5

oxiranyl-methanol

methylamine
74-89-5

methylamine

A

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

B

2-(methylamino)-1,3-propanediol
77697-86-0

2-(methylamino)-1,3-propanediol

...Expand
3-(N-Benzyl-N-methylamino)-1,2-propanediol
60278-98-0

3-(N-Benzyl-N-methylamino)-1,2-propanediol

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
With hydrogen
With hydrogen; palladium on activated charcoal In methanol under 2585.7 Torr; for 18h;
N,N'-bis(2,3-dihydroxypropyl)-5-{2-[(2,3-dihydroxypropyl)methylamino]-2-oxoethoxy}-1,3-benzenedicarboxamide
193483-80-6

N,N'-bis(2,3-dihydroxypropyl)-5-{2-[(2,3-dihydroxypropyl)methylamino]-2-oxoethoxy}-1,3-benzenedicarboxamide

A

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

B

[3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid

[3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid

Conditions
ConditionsYield
With water at 95℃; Rate constant;
oxiranyl-methanol
556-52-5

oxiranyl-methanol

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
In water; methylamine
With methylamine In water25.6g (76%)
1-(2,2-dimethyl-1,3-dioxolan-4-yl)-N-methylmethanamine

1-(2,2-dimethyl-1,3-dioxolan-4-yl)-N-methylmethanamine

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
With carbon dioxide; water at 140℃; under 22502.3 Torr; for 12h; Autoclave;
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]
1067884-35-8

(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]

(2'Z-3'E)-6-bromoindirubin-3'-(O-{2-[N-methyl,N-(2,3-dihydroxypropyl)amino]ethyl}oxime)
1067884-44-9

(2'Z-3'E)-6-bromoindirubin-3'-(O-{2-[N-methyl,N-(2,3-dihydroxypropyl)amino]ethyl}oxime)

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃;100%
In N,N-dimethyl-formamide at 90℃; for 0.666667h; Inert atmosphere; Microwave irradiation;
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

sodium 1-(N-methyl-N-2,3-dihydroxypropyl)diazen-1-ium-1,2-diolate

sodium 1-(N-methyl-N-2,3-dihydroxypropyl)diazen-1-ium-1,2-diolate

Conditions
ConditionsYield
With nitrogen(II) oxide; sodium methylate In methanol; diethyl ether at 20℃; under 4654.46 Torr;98.9%
With nitrogen(II) oxide; sodium methylate In methanol; diethyl ether
Na2CO3.10H2O

Na2CO3.10H2O

5-Acetoxyacetylamino-2,4,6-tribromo-3-[N-(2,3-diacetoxypropyl)carbamoyl] benzoyl chloride
403695-94-3

5-Acetoxyacetylamino-2,4,6-tribromo-3-[N-(2,3-diacetoxypropyl)carbamoyl] benzoyl chloride

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5-acetoxyacetylamino-2,4,6-tribromo-N,N'-bis-(2,3-diacetoxypropyl)-N-methylisophthalamide

5-acetoxyacetylamino-2,4,6-tribromo-N,N'-bis-(2,3-diacetoxypropyl)-N-methylisophthalamide

Conditions
ConditionsYield
In acetone98%
...Expand
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride
150928-21-5

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide
1193076-40-2

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl acetamide Product distribution / selectivity;98%
With triethylamine In ISOPROPYLAMIDE at 20℃; for 2h;
ethyl 1-imidazolecarboxylate
19213-72-0

ethyl 1-imidazolecarboxylate

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5‐(hydroxymethyl)‐3‐methyl‐1,3‐oxazolidin‐2‐one

5‐(hydroxymethyl)‐3‐methyl‐1,3‐oxazolidin‐2‐one

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran for 15h; Reflux;98%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

(R)-1-(3-((3'-(3-bromopropoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol

(R)-1-(3-((3'-(3-bromopropoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol

trifluoroacetic acid
76-05-1

trifluoroacetic acid

3-((3-((3'-(3-((R)-3-hydroxypyrrolidin-1-yl)propoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)(methyl)amino)propane-1,2-diol trifluoroacetate

3-((3-((3'-(3-((R)-3-hydroxypyrrolidin-1-yl)propoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)(methyl)amino)propane-1,2-diol trifluoroacetate

Conditions
ConditionsYield
Stage #1: 3-methylamino-propane-1,2-diol; (R)-1-(3-((3'-(3-bromopropoxy)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol With N-ethyl-N,N-diisopropylamine In methanol at 65℃; Inert atmosphere;
Stage #2: trifluoroacetic acid In water; acetonitrile		98%
...Expand
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl

3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl

3,3'-((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(oxy))bis(propane-3,1-diyl))bis(methylazanediyl))bis(propane-1,2-diol)

3,3'-((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(oxy))bis(propane-3,1-diyl))bis(methylazanediyl))bis(propane-1,2-diol)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; methanol at 65℃; for 72h; Inert atmosphere;98%
5-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride
250781-45-4

5-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5-Amino-3-acetoxymethyl-N-methyl-N-(2,3-dihydroxypropyl)-2,4,6-triiodo-benzamide

5-Amino-3-acetoxymethyl-N-methyl-N-(2,3-dihydroxypropyl)-2,4,6-triiodo-benzamide

Conditions
ConditionsYield
97%
97%
Na2CO3.10H2O

Na2CO3.10H2O

5-acetoxyacetylamino-2,4,6-tribromo-3-carbamoylbenzoyl chloride
403696-08-2

5-acetoxyacetylamino-2,4,6-tribromo-3-carbamoylbenzoyl chloride

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

Conditions
ConditionsYield
In acetone97%
...Expand

Conditions
ConditionsYield
With sulfuric acid; water at 100℃; for 8h; Hydrolysis;95%
Na2CO3.10H2O

Na2CO3.10H2O

2,4,6-tribromo-5-bromomethanesulfonylamino-3-[N-(2,3-diacetoxypropyl)carbamoyl]benzoyl chloride

2,4,6-tribromo-5-bromomethanesulfonylamino-3-[N-(2,3-diacetoxypropyl)carbamoyl]benzoyl chloride

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

2,4,6-Tribromo-5-bromomethanesulfonylamino-N-(2,3-dihydroxypropyl)-N-methyl-N'-(2,3-diacetoxypropyl)-isophthalamide
403696-05-9

2,4,6-Tribromo-5-bromomethanesulfonylamino-N-(2,3-dihydroxypropyl)-N-methyl-N'-(2,3-diacetoxypropyl)-isophthalamide

Conditions
ConditionsYield
In acetone95%
...Expand
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

1,3-dimethyl 5-(2-methoxyacetamido)-2,4,6-triiodoisophthalate

1,3-dimethyl 5-(2-methoxyacetamido)-2,4,6-triiodoisophthalate

3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester

3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,2-dimethoxyethane for 18h; Reflux; Large scale;95%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester

3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine Large scale;95%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3-[(2,3-dihydroxypropylaminoformyl)]-5-[(methoxyacetyl)amino]benzoic acid methyl ester

3-[(2,3-dihydroxypropylaminoformyl)]-5-[(methoxyacetyl)amino]benzoic acid methyl ester

C18H27N3O8
1009809-16-8

C18H27N3O8

Conditions
ConditionsYield
With sodium t-butanolate In methanol for 48h; Reagent/catalyst; Reflux;92.3%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5-methoxyacetamido-3-allylcarbamoyl-2,4,6-triiodobenzoyl chloride

5-methoxyacetamido-3-allylcarbamoyl-2,4,6-triiodobenzoyl chloride

5-methoxyacetamido-2,4,6-triiodophthalic acid [(allylamino)-(2,3-dihydroxy-N-methylpropyl)]diamide

5-methoxyacetamido-2,4,6-triiodophthalic acid [(allylamino)-(2,3-dihydroxy-N-methylpropyl)]diamide

Conditions
ConditionsYield
In 1,4-dioxane; acetonitrile at 20℃;91%
In 1,4-dioxane; acetonitrile at 20℃;60 g
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3-nitro-5-(((2-oxo-1,3-dioxolan-4-yl)methyl)carbamoyl)benzoic acid

3-nitro-5-(((2-oxo-1,3-dioxolan-4-yl)methyl)carbamoyl)benzoic acid

N1-(2,3-dihydroxypropyl)-N1-methyl-5-nitro-N3-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

N1-(2,3-dihydroxypropyl)-N1-methyl-5-nitro-N3-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

Conditions
ConditionsYield
Stage #1: 3-nitro-5-(((2-oxo-1,3-dioxolan-4-yl)methyl)carbamoyl)benzoic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 1h;
Stage #2: 3-methylamino-propane-1,2-diol In ethanol; dichloromethane at -10℃; for 2.5h;		90%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5-methoxyacetamido-2,4,6-triiodoisophthalic acid [(2-oxo-1,3-dioxolan-4-yl)methyl]amide chloride

5-methoxyacetamido-2,4,6-triiodoisophthalic acid [(2-oxo-1,3-dioxolan-4-yl)methyl]amide chloride

5-methoxyacetamido-2,4,6-triiodoisophthalic acid {[(2-oxo-1,3-dioxolan-4-yl)methyl]-(2,3-dihydroxy-N-methylpropyl)}diamide

5-methoxyacetamido-2,4,6-triiodoisophthalic acid {[(2-oxo-1,3-dioxolan-4-yl)methyl]-(2,3-dihydroxy-N-methylpropyl)}diamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl acetamide at 20℃; for 10h;90%
With triethylamine In N,N-dimethyl acetamide at 20℃; for 10h;90%
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester
1955-46-0

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3-((2,3-dihydroxypropyl)methylcarbamoyl)-5-nitrobenzoic acid

3-((2,3-dihydroxypropyl)methylcarbamoyl)-5-nitrobenzoic acid

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Inert atmosphere; Reflux;89%
In acetonitrile at 75 - 80℃; for 5h;80%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

C23H26O8

C23H26O8

C27H37NO10

C27H37NO10

Conditions
ConditionsYield
In dichloromethane for 0.5h;88.9%
2-chloro-6-methoxy-3-nitropyridine
38533-61-8

2-chloro-6-methoxy-3-nitropyridine

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3-[(6-methoxy-3-nitro-pyridin-2-yl)methyl-amino]propane-1,2-diol
677277-91-7

3-[(6-methoxy-3-nitro-pyridin-2-yl)methyl-amino]propane-1,2-diol

Conditions
ConditionsYield
In ethanol for 2h; Heating / reflux;87.1%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

[(3-acetoxy-1-acetylindol-2-yl)methylene]malononitrile
1431945-57-1

[(3-acetoxy-1-acetylindol-2-yl)methylene]malononitrile

1-acetyl-2-[2-cyano-2-(5-hydroxymethyl-3-methyloxazolidin-2-ylidene)ethylidene]indolin-3-one
1431945-58-2

1-acetyl-2-[2-cyano-2-(5-hydroxymethyl-3-methyloxazolidin-2-ylidene)ethylidene]indolin-3-one

Conditions
ConditionsYield
In isopropyl alcohol for 1h; Reflux;86.7%
5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride
76350-03-3

5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

5-[(2-methoxy)acetamido]-3-(2,3-dihydroxy-N-propyl(methyl)carbamoyl)-2,4,6-triiodobenzoyl chloride

5-[(2-methoxy)acetamido]-3-(2,3-dihydroxy-N-propyl(methyl)carbamoyl)-2,4,6-triiodobenzoyl chloride

Conditions
ConditionsYield
With ZrO2-Cr2O3 solid base catalyst In N,N-dimethyl acetamide at 10 - 15℃; for 5h;85%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

α-isocyanato-L-O-methyltyrosine methyl ester
52177-38-5

α-isocyanato-L-O-methyltyrosine methyl ester

(2RS)-<<(2,3-dihydroxypropyl)methylamino>carbonyl>-O-methyltyrosine methyl ester
114359-43-2

(2RS)-<<(2,3-dihydroxypropyl)methylamino>carbonyl>-O-methyltyrosine methyl ester

Conditions
ConditionsYield
In 1,4-dioxane 1.) 0 deg C, 1 h, 2.) RT, 1 h;84%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

tert-butyl 1H-imidazole-1-carboxylate
49761-82-2

tert-butyl 1H-imidazole-1-carboxylate

C5H9NO3

C5H9NO3

Conditions
ConditionsYield
With potassium hydroxide In toluene Heating;82%
(3E)-5,6-difluoro-3-[4-(6-fluoropyridin-3-yl)-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

(3E)-5,6-difluoro-3-[4-(6-fluoropyridin-3-yl)-5,5-dimethylfuran-2(5H)-ylidene]-1,3-dihydro-2H-indol-2-one

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

(3E)-3-[4-{6-[(2,3-dihydroxypropyl)(methyl)amino]pyridin-3-yl}-5,5-dimethylfuran-2(5H)-ylidene]-5,6-difluoro-1,3-dihydro-2H-indol-2-one

(3E)-3-[4-{6-[(2,3-dihydroxypropyl)(methyl)amino]pyridin-3-yl}-5,5-dimethylfuran-2(5H)-ylidene]-5,6-difluoro-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 16h;82%
4-[(5E)-5-(5,6-difluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]benzoic acid

4-[(5E)-5-(5,6-difluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]benzoic acid

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

4-[(5E)-5-(5,6-difluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]-N-(2,3-dihydroxypropyl)-N-methylbenzamide

4-[(5E)-5-(5,6-difluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]-N-(2,3-dihydroxypropyl)-N-methylbenzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h;81%
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

N-(2,3-dihydroxypropyl)-3-oxobutanamide
160173-41-1

N-(2,3-dihydroxypropyl)-3-oxobutanamide

Conditions
ConditionsYield
In tetrahydrofuran at -5 - 0℃; for 1h;79%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

4-[(3-bromophenyl)-amino]-6-fluoropyrido[3,4-d]pyrimidine
171179-03-6

4-[(3-bromophenyl)-amino]-6-fluoropyrido[3,4-d]pyrimidine

4-[(3-Bromophenyl)amino]-6-[N-(2,3-dihydroxy-propyl) methylamino]pyrido[3,4-d]pyrimidine

4-[(3-Bromophenyl)amino]-6-[N-(2,3-dihydroxy-propyl) methylamino]pyrido[3,4-d]pyrimidine

Conditions
ConditionsYield
In dimethyl sulfoxide at 80℃; for 24h;72%

3-Methylamino-1,2-Propanediol Chemical Properties

3-Methylamino-1,2-Propanediol(40137-22-2) is also named as N-METHYL-3-AMINO-1,2-PROPANEDIOL;3-(AMINOMETHYL)-1,2-PROPANEDIOL;2,3-Dihydroxy-N-methylpropylamine;3-Methylamino-1,2-Propandiol;N-Methyl-2,3-dihydroxypropylamine;1,2-Propanediol, 3-(methylamino)-;ZINC04283843;CID7167892,and so on.3-Methylamino-1,2-Propanediol(40137-22-2) at room temperature is usually a colorless to light yellow liquid.

CAS: 40137-22-2
Molecular Formula: C4H11NO2
Molecular Weight: 105.14
Molecular structure:
EINECS: 254-809-0
Water Solubility:  miscible
BRN:  1733341
ACD/LogD (pH 5.5): -4.63 
ACD/LogD (pH 7.4): -3.6 
ACD/BCF (pH 5.5): 1 
ACD/BCF (pH 7.4): 1 
ACD/KOC (pH 5.5): 1 
ACD/KOC (pH 7.4): 1 
H bond acceptors: 3 
H bond donors: 3 
Freely Rotating Bonds: 5 
Index of Refraction: 1.463 
Molar Refractivity: 27.2 cm3 
Molar Volume: 98.7 cm3 
Polarizability: 10.78 10-24cm3 
Surface Tension: 41.1 dyne/cm 
Density: 1.064 g/cm3 
Flash Point: 142.7 °C 
Enthalpy of Vaporization: 56.11 kJ/mol 
Boiling Point: 245.8 °C at 760 mmHg 
Vapour Pressure: 0.00467 mmHg at 25°C 

3-Methylamino-1,2-Propanediol Uses

3-Methylamino-1,2-Propanediol(40137-22-2) is mainly used for the production of non-ionic contrast agent iopromide.

3-Methylamino-1,2-Propanediol Safety Profile

Hazard Codes:  Xi
Risk Statements:  36/37/38 (36/37/38:  Irritating to eyes, respiratory system and skin)
Safety Statements:  26-36-37/39 (26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36:  Wear suitable protective clothing 37/39:  Wear suitable gloves and eye/face protection)
RIDADR:  2735
WGK Germany:  3
F:  3-10-34
HazardClass:  8
PackingGroup:  II
HS Code:  29221980

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