• Name

  3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

• EINECS C10H14ClNO
• CAS No. 2538-50-3
• Article Data6
• CAS DataBase
• Density 1.002g/cm³
• Solubility
• Melting Point 139-141 °C(Solv: acetone (67-64-1))
• Formula C₁₀H₁₄N.ClH
• Boiling Point 274.7°C at 760 mmHg
• Molecular Weight 199.68
• Flash Point 114.1°C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (9CI);Propiophenone,3-(methylamino)-, hydrochloride (6CI,7CI,8CI);3-(N-Methylamino)propiophenone hydrochloride;3-Methylaminopropiophenone;
• PSA 29.10000
• LogP 2.67170

Synthetic route

50-00-0

formaldehyd

593-51-1

methylamine hydrochloride

98-86-2

acetophenone

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 110℃; for 20h; Sealed tube;	70%
With hydrogenchloride In ethanol; water at 110℃; for 20h;	39.8%
With hydrogenchloride In ethanol at 110℃;
With toluene-4-sulfonic acid In ethanol at 110℃; for 20h;

...Expand

879-72-1

3-(dimethylamino)propiophenone hydrochloride

suitable amine

suitable amine

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions

Conditions	Yield
With Rh[((R,R)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 48h; Autoclave; enantioselective reaction;	93%
Multi-step reaction with 2 steps 1: potassium borohydride / tetrahydrofuran / 66 °C 2: sodium hydrogencarbonate / chloroform; water View Scheme

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions

Conditions	Yield
With Rh[((S,S)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 20h; Autoclave; enantioselective reaction;	92%
With hydrogen; potassium carbonate; [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h;	90%
With [Rh((S,S)-BenzP*)(cod)]SbF6; hydrogen; magnesium sulfate; potassium carbonate In ethyl acetate at 50℃; under 37503.8 Torr; for 1h; enantioselective reaction;	80%

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

42142-52-9

3-methylamino-1-phenylpropan-1-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 1h;	90%
With sodium tetrahydroborate In methanol at 20℃; for 1h;

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

57256-92-5

3-methylamino-1-phenyl-propan-1-ol; hydrochloride

Conditions

Conditions	Yield
With potassium borohydride In tetrahydrofuran at 66℃;	82%

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH4 / methanol / 1 h / 20 °C 2: CH2Cl2 / 0.17 h / 0 °C View Scheme

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

(S)-N-(3-hydroxy-3-phenylpropyl)-N-methylacetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Rh[((S,S)-BenzP*)(cod)]SbF6; zinc(II) chloride; caesium carbonate; hydrogen / methanol / 20 h / 20 °C / 19001.3 Torr / Autoclave 2: dichloromethane / 0.17 h / 0 °C View Scheme

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

54910-89-3, 57226-07-0, 100568-02-3, 100568-03-4, 59333-67-4

FLUOXETINE

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 55 °C / Inert atmosphere 2.2: 1 h / 90 °C View Scheme

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

1254705-11-7

4-(3-(methylamino)-1-phenylpropyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2: trifluoroacetic acid / 48 h / 20 °C View Scheme

2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

82248-59-7

atomoxetine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium borohydride / tetrahydrofuran / 66 °C 2.1: sodium hydrogencarbonate / chloroform; water 3.1: ethyl acetate / 77 °C 3.2: pH 1 - 2 View Scheme

3-Methylamino-1-phenylpropan-1-one hydrochloride Chemical Properties

3-Methylamino-1-phenylpropan-1-one hydrochloride Uses