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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(R)-3-(Methylamino)-1-phenylpropanol Manufacturer/High quality/Best price/In stock

Cas:115290-81-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-3-(Methylamino)-1-phenylpropanol

Cas:115290-81-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

( R)-3-(Methylamino)-1-phenylpropanol CAS 115290-81-8

Cas:115290-81-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 115290-81-8 with best quality

Cas:115290-81-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

(R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine

Cas:115290-81-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL CAS:115290-81-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL CAS:115290-81-8

Cas:115290-81-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine

Cas:115290-81-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU-CHEM (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(1R)-3-(methylamino)-1-phenylpropan-1-ol

Cas:115290-81-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-3-(Methylamino)-1-phenylpropanol

Cas:115290-81-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(R)-3-(Methylamino)-1-phenylpropanol

Cas:115290-81-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory Sells(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU-CHEM (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU-CHEM (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU-CHEM (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFU-CHEM (R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(R)-3-(methylamino)-1-phenylpropanol cas no. 115290-81-8 98%

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-3-(Methylamino)-1-phenylpropanol

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

(1R)-3-(methylamino)-1-phenylpropan-1-ol

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Atomoxetine Related Compound A (10 mg) (3-(Methylamino)-1-phenylpropan-1-ol)

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

(R)-(+)-3-(N-METHYLAMINO)-1-PHENYL-1-PROPANOL

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(R)-(+)-N-methyl-3-phenyl-3-hydroxypropylamine

Cas:115290-81-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(R)-3-iodo-1-phenyl-1-propanol
127073-84-1

(R)-3-iodo-1-phenyl-1-propanol

methylamine
74-89-5

methylamine

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
In tetrahydrofuran; water at 23℃; for 2h;99%
In tetrahydrofuran; water at 25℃; for 12h; Inert atmosphere; enantioselective reaction;98%
In tetrahydrofuran; water at 20℃;85%
(R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester
502697-62-3

(R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating;93%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;89%
β-Methylaminoethyl phenyl ketone hydrochloride
2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With Rh[((R,R)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 48h; Autoclave; enantioselective reaction;93%
Multi-step reaction with 2 steps
1: potassium borohydride / tetrahydrofuran / 66 °C
2: sodium hydrogencarbonate / chloroform; water
View Scheme
(1R) 3-phenyl-3-hydroxypropyl methanesulfonate
115290-78-3

(1R) 3-phenyl-3-hydroxypropyl methanesulfonate

methylamine
74-89-5

methylamine

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
In tetrahydrofuran; water at 65℃; for 24h;91%
In tetrahydrofuran; water at 60 - 65℃; for 4h;80%
In tetrahydrofuran; water at 65℃; for 3h;837 mg
N-methyl-3-phenylprop-2-en-1-amine
60960-88-5

N-methyl-3-phenylprop-2-en-1-amine

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: N-methyl-3-phenylprop-2-en-1-amine With L-diisopinocampheylborane In 1,2-dimethoxyethane at 30℃; for 2h;
Stage #2: With dihydrogen peroxide; potassium hydroxide In 1,2-dimethoxyethane at 20℃; for 2h;
90.67%
(R)-6-phenyl-1,3-oxazinan-2-one R-7a
406218-18-6

(R)-6-phenyl-1,3-oxazinan-2-one R-7a

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;90%
(3R)-3-phenyl-3-hydroxypropionic acid methyl amide

(3R)-3-phenyl-3-hydroxypropionic acid methyl amide

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 6h; Reflux;86%
Phenyl vinyl ketone
768-03-6

Phenyl vinyl ketone

methylamine
74-89-5

methylamine

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: Phenyl vinyl ketone; methylamine With sodium carbonate In water; isopropyl alcohol at 20℃; for 2h; Inert atmosphere;
Stage #2: With chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II); sodium formate In water; isopropyl alcohol at 40℃; for 10h; pH=7; Inert atmosphere; enantioselective reaction;
79%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

methylamine
74-89-5

methylamine

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With potassium iodide In methanol; water at 80℃; for 8h;72%
With sodium iodide In water
3-methylamino-1-phenyl-propan-1-ol; hydrochloride
57256-92-5

3-methylamino-1-phenyl-propan-1-ol; hydrochloride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: 3-methylamino-1-phenyl-propan-1-ol; hydrochloride With sodium hydrogencarbonate In chloroform; water
Stage #2: With (S)-Mandelic acid In acetone
46%
((R)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

((R)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;
(R)-3-(N-benzyl-N-methylamino)-1-phenylpropanol hydrochloride

(R)-3-(N-benzyl-N-methylamino)-1-phenylpropanol hydrochloride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol for 20h; Ambient temperature; Yield given;
methylamine
74-89-5

methylamine

3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate
51699-49-1

3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate

A

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

B

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate With 3 A molecular sieve; oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; for 36h;
Stage #2: methylamine With water In tetrahydrofuran at 65℃;
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinane
823182-36-1

(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinane

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 90℃; for 1.5h;
Benzoylacetonitrile
614-16-4

Benzoylacetonitrile

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / borane-dimethylsulfide complex; polymer-supported chiral sulfonamide / tetrahydrofuran / Heating
2: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C
3: 93 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating
View Scheme
(1R)-3-amino-1-phenyl-1-propanol
138750-31-9

(1R)-3-amino-1-phenyl-1-propanol

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C
2: 93 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C
2: 89 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
Multi-step reaction with 2 steps
1: NaHCO3 / tetrahydrofuran
2: LiAlH4 / tetrahydrofuran / Heating
View Scheme
butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester
118856-08-9

butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
4: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Ethyl 3-hydroxy-3-phenylpropanoate
5764-85-2

Ethyl 3-hydroxy-3-phenylpropanoate

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
3: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
5: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h
2.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C
3.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr
3.2: H2O / tetrahydrofuran / 65 °C
View Scheme
ethyl (R)-3-hydroxy-3-phenylpropanoate
72656-47-4

ethyl (R)-3-hydroxy-3-phenylpropanoate

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
3: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C
2: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C
3: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C
View Scheme
(R)-3-phenyl-1,3-dihydroxypropane
103548-16-9

(R)-3-phenyl-1,3-dihydroxypropane

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
2: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C
2: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C
View Scheme
Multi-step reaction with 2 steps
1: 74 percent / triethylamine / diethyl ether / 3 h / -10 - 0 °C
2: 837 mg / H2O; tetrahydrofuran / 3 h / 65 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

SASRIN-maleidobenzoic acid resin

SASRIN-maleidobenzoic acid resin

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
4.1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
6.1: 80 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-6-phenyl-1,3-oxazinan-4-one

(6R)-2-((S)-1-triisopropylsilyloxyethyl)-6-phenyl-1,3-oxazinan-4-one

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium hexamethyldisilazide / tetrahydrofuran / 2 h / 20 °C
2: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C
3: HCl / methanol; H2O / 1.5 h / 90 °C
View Scheme
(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinan-4-one
823182-35-0

(6R)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinan-4-one

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C
2: HCl / methanol; H2O / 1.5 h / 90 °C
View Scheme
styrene oxide
96-09-3

styrene oxide

1-chloro-1-phenylethene, 1,2-dichloro-1-phenyl-ethane, benzaldehyde, benzoic acid

1-chloro-1-phenylethene, 1,2-dichloro-1-phenyl-ethane, benzaldehyde, benzoic acid

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / ethanol; H2O / 20 °C
2: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C
3: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating
4: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C
5: 89 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
3-hydroxy-3-phenylpropanenitrile
73627-97-1, 121617-17-2, 132203-26-0, 17190-29-3

3-hydroxy-3-phenylpropanenitrile

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C
2: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating
3: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C
4: 89 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogen, NH3 / Raney Ni / ethanol / 90 °C / p(NH3) = 30 psi and p(H2) = 170 psi
2: NaHCO3 / tetrahydrofuran
3: LiAlH4 / tetrahydrofuran / Heating
View Scheme
(R)-3-acetyloxy-3-phenylpropanenitrile
198561-42-1

(R)-3-acetyloxy-3-phenylpropanenitrile

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating
2: 88 percent / K2CO3 / CH2Cl2; H2O / 20 °C
3: 89 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / H2 / RuBr2((S)-(6,6'-(MeO)2-biphenyl-2,2'-diyl)bis(Ph2-phosphane) / ethanol / 18 h / 50 °C / 760.05 Torr
2: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C
3: 82 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C
4: 91 percent / tetrahydrofuran; H2O / 24 h / 65 °C
View Scheme
1-phenyl-1,3-propanediol
4850-49-1

1-phenyl-1,3-propanediol

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C
2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr
2.2: H2O / tetrahydrofuran / 65 °C
View Scheme
3-(benzyl methylamino)-1-phenylpropan-1-one hydrochloride
5409-62-1

3-(benzyl methylamino)-1-phenylpropan-1-one hydrochloride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2, 2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr
2: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature
View Scheme
acetophenone
98-86-2

acetophenone

sulfur

sulfur

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 50 percent / concd. HCl / ethanol / 4 h / Heating
2: H2, 2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr
3: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature
View Scheme
ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2;
Stage #3: With sodium hydroxide In water pH=11 - 12;
99%
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium carbonate; copper(l) iodide In toluene at 148℃; for 21h; Ullmann type reaction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2;
Stage #3: With sodium hydroxide In water pH=11 - 12;
94%
Stage #1: ortho-methylphenyl iodide; (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium phosphate; copper(l) iodide In toluene for 24h; Ullmann type reaction; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2;
Stage #3: With sodium hydroxide In water pH=12 - 14;
82%
4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide at 80 - 90℃; for 1h;92%
In N,N-dimethyl acetamide86%
In N,N-dimethyl acetamide86%
2-Fluorotoluene
95-52-3

2-Fluorotoluene

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium hydroxide In dimethyl sulfoxide at 130℃; for 1h;
Stage #2: 2-Fluorotoluene In dimethyl sulfoxide at 130℃;
89.51%
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In dimethyl sulfoxide for 0.25h;
Stage #2: With Potassium benzoate In dimethyl sulfoxide at 50 - 55℃; for 1h;
Stage #3: 2-Fluorotoluene In dimethyl sulfoxide at 50 - 120℃; for 6.25 - 7.25h;
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h;
4-Fluorobenzotrifluoride
402-44-8

4-Fluorobenzotrifluoride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In N,N-dimethyl acetamide; paraffin oil at 90℃; for 0.5h; Inert atmosphere;
Stage #2: 4-Fluorobenzotrifluoride In N,N-dimethyl acetamide; paraffin oil at 100℃; for 5h; Inert atmosphere;
88%
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

C7H7X

C7H7X

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine; C7H7X In ethyl acetate at 77℃;
Stage #2: With hydrogenchloride In water; acetone pH=1 - 2;
73%
2-Fluorotoluene
95-52-3

2-Fluorotoluene

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

rac-tomoxetine hydrochloride

rac-tomoxetine hydrochloride

Conditions
ConditionsYield
With sodium hydride 1) DMSO, 2) DMSO; Yield given. Multistep reaction;
2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction;
2-Chloroanisole
766-51-8

2-Chloroanisole

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

(R)-3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
112066-67-8

(R)-3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine

Conditions
ConditionsYield
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction;
ortho-cresol
95-48-7

ortho-cresol

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

atomoxetine hydrochloride
82248-59-7

atomoxetine hydrochloride

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate Yield given. Multistep reaction;
4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

(R)-fluoxetine hydrochloride
114247-09-5

(R)-fluoxetine hydrochloride

Conditions
ConditionsYield
With sodium hydride 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min; Yield given. Multistep reaction;
With sodium hydride 1.) N,N-dimethylacetamide, a) 0 deg C, 5 min, b) 70 deg C, 30 min, 2.) N,N-dimethylacetamide, 100 deg C, 3 h; Yield given. Multistep reaction;
With sodium hydride 1,) 0 deg C, then 70 deg C, 30 min; 2.) 2.5 h, 100 deg C; Yield given. Multistep reaction;

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