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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (1R)-3-Chloro-1-Phenyl-Propan-1-Ol supplier in China

Cas:100306-33-0

Min.Order:1 Metric Ton

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:A white or primrose yellow crystalline powder Storage:cool dry place Package:25kg/drum Application:fine chemical

Manufacturer high quality (1R)-3-Chloro-1-phenyl-propan-1-ol Cas 100306-33-0 with good price

Cas:100306-33-0

Min.Order:1 Kilogram

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Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (1R)-3-Chloro-1-Phenyl-Propan-1-Ol

Cas:100306-33-0

Min.Order:1

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Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(1R)-3-Chloro-1-phenyl-propan-1-ol Manufacturer/High quality/Best price/In stock

Cas:100306-33-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-(+)-3-Chloro-1-phenyl-1-propanol

Cas:100306-33-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--100306-33-0--High purity (1R)-3-Chloro-1-phenyl-propan-1-ol factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had esta

TIANFUCHEM--100306-33-0--High purity (1R)-3-Chloro-1-phenyl-propan-1-ol factory price

Cas:100306-33-0

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 100306-33-0 with best quality

Cas:100306-33-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name (1R)-3-Chloro-1-phenyl-propan-1-ol Synonyms (R)-(+)-3-Chloro-1-phenylpropanol CAS No. 100306-33-0 Molecular weight 170.64 Molecular For

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 100306-33-0 (1R)-3-Chloro-1-phenyl-propan-1-ol with best price

Cas:100306-33-0

Min.Order:10 Gram

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Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(1R)-3-Chloro-1-phenyl-propan-1-ol 100306-33-0

Cas:100306-33-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(1R)-3-Chloro-1-phenyl-propan-1-ol CAS:100306-33-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

(1R)-3-Chloro-1-phenyl-propan-1-ol CAS:100306-33-0

Cas:100306-33-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:100306-33-0

Cas:100306-33-0

Min.Order:0

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Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (1R)-3-Chloro-1-phenyl-propan-1-ol Synonyms: R-(+)-1-chloro-3-hydroxy-3-phenylpropane;(αR)-α-(2-Chloroethyl)benzeneMethanol;(R)-(+)-3-Chloro-1-phenyl-1-propanol 98%;(R)-(+)-3-CHLORO-1-PHENYLPROPANOL((R)-3-chloro-1-pheny

(1R)-3-Chloro-1-phenyl-propan-1-ol supplier best quality

Cas:100306-33-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(1R)-3-Chloro-1-Phenyl-Propan-1-Ol

Cas:100306-33-0

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

C9H11ClO (1R)-3-Chloro-1-phenyl-propan-1-ol 100306-33-0

Cas:100306-33-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:White to yellow powder Storage:Inert atmosphere,Room Temperature Application:Intermediate in the preparation of (S)-Norfluoxetine (R)-(+)-3-Chloro-1-phenyl-1-propanol may be used as a building block in the synthesis of antidepr

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)-(+)-3-Chloro-1-phenyl-1-propanol

Cas:100306-33-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

(1R)-3-Chloro-1-Phenyl-Propan-1-Ol CAS 100306-33-0

Cas:100306-33-0

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (1R)-3-Chloro-1-Phenyl-Propan-1-Ol

Cas:100306-33-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: (1R)-3-Chloro-1-Phenyl-Propan-1-Ol CAS No.:100306-33-0 Molecule Formula:C9H11ClO Molecule Weight:170.64 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Best Quality (1R)-3-Chloro-1-Phenyl-Propan-1-Ol

Cas:100306-33-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: (1R)-3-Chloro-1-phenyl-propan-1-ol Synonyms: (R)-(+)-3-CHLORO-1-PHENYL-1-PR;α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-3-Chloro-1-phenylpropanol;Dapoxetine hydrochloride Impurity

(1R)-3-Chloro-1-phenyl-propan-1-ol

Cas:100306-33-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

C9H11ClO (1R)-3-Chloro-1-phenyl-propan-1-ol 100306-33-0

Cas:100306-33-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(R)-3-Chloro-1-phenylpropan-1-ol

Cas:100306-33-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Synthetic route

3-chloropropiophenone
936-59-4

3-chloropropiophenone

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With borane; S-oxaborolidine In tetrahydrofuran at 0℃; for 0.833333h;99%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; C22H32N4O4S2; water; sodium formate at 40℃; for 0.25h; Air atmosphere; optical yield given as %ee; enantioselective reaction;99%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; (1R,2R)-9H-fluorene-2,7-disulfonic acid bis-[(2-amino-cyclohexyl)amide]; sodium formate In water at 40℃; for 0.25h; optical yield given as %ee; enantioselective reaction;99%
3-chloropropiophenone
936-59-4

3-chloropropiophenone

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With dimethylsulfide borane complex; C23H22BNO3 In tetrahydrofuran at 20℃; for 2h; Reagent/catalyst;A n/a
B 75%
With dimethylsulfide borane complex; (+)-3-exo-amino-7,7-dimethoxynorbornan-2-exo-ol In tetrahydrofuran at 25℃; for 2h;A 65%
B n/a
With dimethylsulfide borane complex; chiral diphenyloxazaborolidine In tetrahydrofuran at 25℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Isopropenyl acetate
108-22-5

Isopropenyl acetate

3-chloro-1-phenyl-propan-1-ol
18776-12-0

3-chloro-1-phenyl-propan-1-ol

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

C

(R)-3-chloro-1-phenyl-1-propyl acetate

(R)-3-chloro-1-phenyl-1-propyl acetate

Conditions
ConditionsYield
With Pseudomonas cepacia lipase immobilized on toyonite; potassium tert-butylate; sodium carbonate; [2,3,4,5-Ph4(η5-C4CNH(i-Pr))]Ru(CO)2Cl In toluene at 25℃; for 168h;A n/a
B n/a
C 31%
With Burkholderia species lipoprotein lipase; C51H77NO17; dextrin In toluene at 25℃; for 6h; Enzymatic reaction; enantioselective reaction;A n/a
B n/a
C n/a
vinyl acetate
108-05-4

vinyl acetate

3-chloro-1-phenyl-propan-1-ol
18776-12-0

3-chloro-1-phenyl-propan-1-ol

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

C

(R)-3-chloro-1-phenyl-1-propyl acetate

(R)-3-chloro-1-phenyl-1-propyl acetate

Conditions
ConditionsYield
With lipase from Pseudomonas fluorescens In hexane at 20℃; for 21h; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;A n/a
B n/a
C 25%
(R)-3-chloro-1-phenyl-1-propyl acetate

(R)-3-chloro-1-phenyl-1-propyl acetate

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With lipase from Candida rugosa at 20℃; for 5h; pH=8; aq. phosphate buffer; Enzymatic reaction; stereoselective reaction;23%
Phenyl-acetic acid 3-chloro-1-phenyl-propyl ester

Phenyl-acetic acid 3-chloro-1-phenyl-propyl ester

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
In acetonitrile at 27 - 28℃; 0.1 M aq. phosphate buffer (pH 8.0), penicillin G aminohydrolase (PGA);18%
1-Phenyl-3-chlor-propyl-monochloracetat
141987-54-4

1-Phenyl-3-chlor-propyl-monochloracetat

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With buffer pH 7 lipase from Pseudomonas fluorescens (SAM-2);
1-Phenyl-3-chlor-propyl-monochloracetat
141987-54-4

1-Phenyl-3-chlor-propyl-monochloracetat

A

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

B

Chloro-acetic acid (S)-3-chloro-1-phenyl-propyl ester
142037-19-2

Chloro-acetic acid (S)-3-chloro-1-phenyl-propyl ester

Conditions
ConditionsYield
pH 7, Pseudomonas sp. lipase (SAM-2);
3-Cloro-1-phenylpropyl butanoate
293322-40-4

3-Cloro-1-phenylpropyl butanoate

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With phosphate buffer; novozyme 435 at 30℃; for 288h; pH=7; Hydrolysis; Title compound not separated from byproducts;
3-chloropropiophenone
936-59-4

3-chloropropiophenone

A

1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

B

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

C

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

D

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With Merulius tremellosus ono991 In acetone at 28℃; for 72h; Title compound not separated from byproducts;
3-chloro-1-phenyl-propan-1-ol
18776-12-0

3-chloro-1-phenyl-propan-1-ol

A

3-chloropropiophenone
936-59-4

3-chloropropiophenone

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With Sphingomonas paucimobilis NCIMB 8195 In water; N,N-dimethyl-formamide for 120h;A 21 % Chromat.
B 79 % Chromat.
3-chloro-1-phenyl-propan-1-ol
18776-12-0

3-chloro-1-phenyl-propan-1-ol

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

C

Isobutyric acid (S)-3-chloro-1-phenyl-propyl ester

Isobutyric acid (S)-3-chloro-1-phenyl-propyl ester

D

(1R)-3-chloro-1-phenylpropyl 2-methylpropanoate

(1R)-3-chloro-1-phenylpropyl 2-methylpropanoate

Conditions
ConditionsYield
With (-)-(Sa) 4-di-n-butylaminopyridine based biaryl; triethylamine In toluene at -95℃; for 15h; Title compound not separated from byproducts.;
3-chloro-1-phenyl-propan-1-ol
18776-12-0

3-chloro-1-phenyl-propan-1-ol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / pyridine; DMAP / CH2Cl2 / 0 - 20 °C
2: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7
View Scheme
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2
2: buffer pH 7 / lipase from Pseudomonas fluorescens (SAM-2)
View Scheme
3-chloro-1-phenyl-propan-1-ol
18776-12-0

3-chloro-1-phenyl-propan-1-ol

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
at 145 - 180℃; Gas phase; Resolution of racemate; Inert atmosphere;
With Candida antarctica lipase B (Novozym 435) at 45℃; under 150 Torr; for 144h; Resolution of racemate; Enzymatic reaction; Overall yield = 58 %;A n/a
B n/a
Stage #1: 3-chloro-1-phenyl-propan-1-ol With Candida antarctica lipase B (Novozym 435) at 45℃; under 150 Torr; for 144h; Resolution of racemate; Enzymatic reaction;
Stage #2: With ethanol; Candida antarctica lipase B (Novozym 435) for 24h; Enzymatic reaction; Overall yield = 33 %;
A n/a
B n/a
(RS)-3-chloro-1-phenyl-1-propyl acetate
22912-90-9

(RS)-3-chloro-1-phenyl-1-propyl acetate

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

C

(S)-3-chloro-1-phenyl-1-propyl acetate

(S)-3-chloro-1-phenyl-1-propyl acetate

D

(R)-3-chloro-1-phenyl-1-propyl acetate

(R)-3-chloro-1-phenyl-1-propyl acetate

Conditions
ConditionsYield
With Bacillus subtilis esterase In ethanol at 30℃; for 12h; pH=7.2; aq. phosphate buffer; optical yield given as %ee; enantioselective reaction;
3-chloropropiophenone
936-59-4

3-chloropropiophenone

A

(S)-1-phenyl-1-propanol
613-87-6

(S)-1-phenyl-1-propanol

B

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

C

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

D

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With yeast strain Aureobasidium pullulans CQA at 28℃; for 48h; Microbiological reaction; Enzymatic reaction;A n/a
B n/a
C n/a
D n/a
With yeast culture of Candida viswanathii KCh 120 In acetone at 25℃; for 6h; Microbiological reaction; enantioselective reaction;A 30 %Chromat.
B n/a
C n/a
D 23 %Chromat.
3-chloropropiophenone
936-59-4

3-chloropropiophenone

A

(R)-1-phenyl-1-propanol
1565-74-8

(R)-1-phenyl-1-propanol

B

(S)-1-phenyl-1-propanol
613-87-6

(S)-1-phenyl-1-propanol

C

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

D

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

E

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With yeast culture of Aphanocladium album KCh 417 In acetone at 25℃; for 144h; Microbiological reaction; enantioselective reaction;A n/a
B n/a
C n/a
D n/a
E 21 %Chromat.
With yeast culture of Saccharomyces cerevisiae KCh 464 In acetone at 25℃; for 144h; Microbiological reaction; enantioselective reaction;A n/a
B n/a
C n/a
D n/a
E 33 %Chromat.
With yeast culture of Saccharomyces pastorianus KCh 906 In acetone at 25℃; for 24h; Reagent/catalyst; Microbiological reaction; enantioselective reaction;A n/a
B n/a
C n/a
D n/a
E 33 %Chromat.
3-chloropropiophenone
936-59-4

3-chloropropiophenone

A

(R)-1-phenyl-1-propanol
1565-74-8

(R)-1-phenyl-1-propanol

B

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

C

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

D

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With yeast culture of Candida parapsilosis KCh 909 In acetone at 25℃; for 72h; Microbiological reaction; enantioselective reaction;A 29 %Chromat.
B n/a
C n/a
D 33 %Chromat.
With yeast culture of Candida viswanathii KCh 120 In acetone at 25℃; for 144h; Microbiological reaction; enantioselective reaction;A 28 %Chromat.
B n/a
C n/a
D 57 %Chromat.
3-chloropropiophenone
936-59-4

3-chloropropiophenone

A

3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

B

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

C

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
With yeast culture of Saccharomyces brasiliensis KCh 905 In acetone at 25℃; for 24h; Microbiological reaction; enantioselective reaction;A n/a
B n/a
C 61 %Chromat.
C15H22BClO3

C15H22BClO3

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

Conditions
ConditionsYield
With silica gel In toluene at 20℃; for 1h; Schlenk technique; Glovebox;
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

NaI

NaI

(R)-3-iodo-1-phenyl-1-propanol
127073-84-1

(R)-3-iodo-1-phenyl-1-propanol

Conditions
ConditionsYield
In acetone for 16h; Heating;99%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-3-iodo-1-phenyl-1-propanol
127073-84-1

(R)-3-iodo-1-phenyl-1-propanol

Conditions
ConditionsYield
With sodium iodide In acetone for 16h; Reflux; enantioselective reaction;99%
With sodium iodide In acetone for 16h; Finkelstein Reaction; Heating / reflux;98%
With sodium iodide In acetone for 16h; Reflux;91%
With sodium iodide
With sodium iodide In acetone
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-α-(2-azidoethyl)benzenemethanol
168465-69-8

(R)-α-(2-azidoethyl)benzenemethanol

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 25℃; for 18h;99%
With sodium azide99%
In dimethyl sulfoxide79%
With sodium azide In dimethyl sulfoxide at 40℃; for 1.5h;79%
Multi-step reaction with 2 steps
1: NaI
2: NaN3
View Scheme
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-4-(3-hydroxy-3-phenylpropoxy)benzaldehyde

(R)-4-(3-hydroxy-3-phenylpropoxy)benzaldehyde

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzaldehyde With caesium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; for 1h;
Stage #2: (1R)-3-chloro-1-phenylpropanol In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; for 16h; Inert atmosphere;
95%
With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 50℃;
2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide
387827-32-9

2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

N-(3-{1-[(3R)-3-HYDROXY-3-PHENYLPROPYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE
387826-71-3

N-(3-{1-[(3R)-3-HYDROXY-3-PHENYLPROPYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In DMF (N,N-dimethyl-formamide) at 100℃; for 3h;94.3%
With N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide In 1,4-dioxane34.2%
With N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide In 1,4-dioxane34.2%
With N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide In 1,4-dioxane at 90℃; for 72h;34.2%
3-Iodophenol
626-02-8

3-Iodophenol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene

(R)-1-(3-chloro-1-phenylpropoxy)-3-iodobenzene

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 20h; Mitsunobu Displacement;89%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(Z)-diphenyl[(Z)-2-phenyl-2-(phenylsulfonyl)vinyl]selenonium trifluoromethanesulfonate

(Z)-diphenyl[(Z)-2-phenyl-2-(phenylsulfonyl)vinyl]selenonium trifluoromethanesulfonate

(Z)-β-[(1R)-3-chloro-1-phenylpropoxy]-α-(phenylsulfonyl)styrene

(Z)-β-[(1R)-3-chloro-1-phenylpropoxy]-α-(phenylsulfonyl)styrene

Conditions
ConditionsYield
With sodium hydride In acetonitrile at -30℃; for 2h; Substitution;88%
3-(4-hydroxynaphthalen-1-yl)-1-phenylpropan-1-one

3-(4-hydroxynaphthalen-1-yl)-1-phenylpropan-1-one

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

C28H26O3

C28H26O3

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 70℃; for 5h;87%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-(+)-2-Phenyloxetane
106760-61-6

(R)-(+)-2-Phenyloxetane

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 25℃; for 4h;86%
With potassium tert-butylate In tetrahydrofuran for 4h;82%
With potassium tert-butylate In tetrahydrofuran at 20℃; for 12h; Schlenk technique; Glovebox; enantioselective reaction;81%
With potassium hydride In tetrahydrofuran at 0 - 20℃; for 15h;76%
With potassium tert-butylate In tetrahydrofuran
morpholine
110-91-8

morpholine

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-3-morpholino-1-phenylpropan-1-ol
40116-81-2

(R)-3-morpholino-1-phenylpropan-1-ol

Conditions
ConditionsYield
at 80℃;86%
at 80℃;
α-naphthol
90-15-3

α-naphthol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(R)-(-)-3-(1-naphthalenyloxy)-1-phenyl-1-propanol

(R)-(-)-3-(1-naphthalenyloxy)-1-phenyl-1-propanol

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl acetamide at 60 - 80℃;85.6%
Stage #1: α-naphthol With sodium hydride In N,N-dimethyl-formamide for 1h; Cooling with ice;
Stage #2: (1R)-3-chloro-1-phenylpropanol In N,N-dimethyl-formamide for 1h; Cooling with ice;
74%
With sodium hydroxide In water; N,N-dimethyl-formamide; toluene at 90 - 95℃; for 2h; Large scale reaction;67.2%
With potassium hydroxide In acetone at 0℃; Inert atmosphere; Reflux;
2-bromo-p-cresol
6627-55-0

2-bromo-p-cresol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(S)-2-bromo-1-(3-chloro-1-phenylpropoxy)-4-methyl-benzene

(S)-2-bromo-1-(3-chloro-1-phenylpropoxy)-4-methyl-benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;82%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;82%
tert-Butyl N-hydroxycarbamate
36016-38-3

tert-Butyl N-hydroxycarbamate

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

tert-butyl N-[(3R)-3-hydroxy-3-phenylpropoxy]carbamate

tert-butyl N-[(3R)-3-hydroxy-3-phenylpropoxy]carbamate

Conditions
ConditionsYield
Stage #1: tert-Butyl N-hydroxycarbamate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: (1R)-3-chloro-1-phenylpropanol In N,N-dimethyl-formamide at 0 - 20℃; for 72h; Inert atmosphere;
82%
Stage #1: tert-Butyl N-hydroxycarbamate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: (1R)-3-chloro-1-phenylpropanol In N,N-dimethyl-formamide at 0 - 20℃; for 72h;
68%
Stage #1: tert-Butyl N-hydroxycarbamate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: (1R)-3-chloro-1-phenylpropanol In N,N-dimethyl-formamide at 0 - 20℃; for 72h;
2-bromo-4-chlorophenol
695-96-5

2-bromo-4-chlorophenol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(S)-2-bromo-4-chloro-1-(3-chloro-1-phenylpropoxy)-benzene

(S)-2-bromo-4-chloro-1-(3-chloro-1-phenylpropoxy)-benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;81%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;81%
2,4-dibromophenol
615-58-7

2,4-dibromophenol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene
319924-81-7

(S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;79%
2-hydroxybromobenzene
95-56-7

2-hydroxybromobenzene

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(S)-1-bromo-2-(3-chloro-1-phenylpropoxy)-benzene
319924-80-6

(S)-1-bromo-2-(3-chloro-1-phenylpropoxy)-benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;78%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;78%
2,6-dibromophenol
608-33-3

2,6-dibromophenol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(S)-2,6-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene
319924-93-1

(S)-2,6-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;77%
2-bromo-3,5-dimethoxyphenol
121449-70-5

2-bromo-3,5-dimethoxyphenol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

(S)-2-bromo-1-(3-chloro-1-phenylpropoxy)-3,5-dimethoxy-benzene

(S)-2-bromo-1-(3-chloro-1-phenylpropoxy)-3,5-dimethoxy-benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;76%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;76%
3-Hydroxyacetophenone
121-71-1

3-Hydroxyacetophenone

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

1-(3-{[(1S)-3-chloro-1-phenylpropyl]oxy}phenyl)ethanone
487058-12-8

1-(3-{[(1S)-3-chloro-1-phenylpropyl]oxy}phenyl)ethanone

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran76%
4-Phenoxyphenol
831-82-3

4-Phenoxyphenol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

4-{[(1S)-3-chloro-1-phenylpropyl]oxy}-(4-phenoxy)benzene
387827-50-1

4-{[(1S)-3-chloro-1-phenylpropyl]oxy}-(4-phenoxy)benzene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 24h;75.7%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

benzylamine
100-46-9

benzylamine

(R)-3-(benzylamino)-1-phenylpropan-1-ol
185376-75-4

(R)-3-(benzylamino)-1-phenylpropan-1-ol

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 75℃; for 48h;75%
phthalimide
136918-14-4

phthalimide

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

2-[(1S)-3-chloro-1-phenylpropyl]-1H-isoindole-1,3(2H)-dione
387827-49-8

2-[(1S)-3-chloro-1-phenylpropyl]-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 4h;74%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 24h;50.2%
phthalimide
136918-14-4

phthalimide

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

diethylazodicarboxylate
1972-28-7

diethylazodicarboxylate

2-[(1S)-3-chloro-1-phenylpropyl]-1H-isoindole-1,3(2H)-dione
387827-49-8

2-[(1S)-3-chloro-1-phenylpropyl]-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran; hexane; ethyl acetate74%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

methylamine
74-89-5

methylamine

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With potassium iodide In methanol; water at 80℃; for 8h;72%
With sodium iodide In water
ortho-cresol
95-48-7

ortho-cresol

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

-(+)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane
114446-50-3

-(+)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Ambient temperature;68%
With triphenylphosphine; diethylazodicarboxylate In diethyl ether
With triphenylphosphine; diethylazodicarboxylate
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Ambient temperature;
4-hydroxybenzotrifluoride
402-45-9

4-hydroxybenzotrifluoride

(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

-(-)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane
114446-51-4

-(-)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane

Conditions
ConditionsYield
Stage #1: 4-hydroxybenzotrifluoride With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h; Mitsunobu reaction; Inert atmosphere;
Stage #2: (1R)-3-chloro-1-phenylpropanol In tetrahydrofuran at 20℃; Mitsunobu reaction; Inert atmosphere;
66%
With triphenylphosphine; diethylazodicarboxylate
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

α,α,α-trifluoro-p-cresol
402-45-9

α,α,α-trifluoro-p-cresol

-(-)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane
114446-51-4

-(-)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Ambient temperature;65%
(1R)-3-chloro-1-phenylpropanol
100306-33-0

(1R)-3-chloro-1-phenylpropanol

2-bromo-5,6,7,8-tetrahydronaphthalen-1-ol
319924-91-9

2-bromo-5,6,7,8-tetrahydronaphthalen-1-ol

6-Bromo-5-((S)-3-chloro-1-phenyl-propoxy)-1,2,3,4-tetrahydro-naphthalene

6-Bromo-5-((S)-3-chloro-1-phenyl-propoxy)-1,2,3,4-tetrahydro-naphthalene

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;64%

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