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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(1S)-3-(Methylamino)-1-phenylpropan-1-ol Manufacturer/High quality/Best price/In stock

Cas:114133-37-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(s)-3-(methylamino)-1-phenylpropanol (114133-37-8)

Cas:114133-37-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(1S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(s)-3-(methylamino)-1-phenylpropanol (114133-37-8)

Cas:114133-37-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(1S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(s)-3-(methylamino)-1-phenylpropanol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

(1S)-3-(Methylamino)-1-phenylpropan-1-ol Application:Organic Chemicals

114133-37-8

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

(1S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as pri

(S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

(1S)-3-(Methylamino)-1-phenylpropan-1-ol cas 114133-37-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(1S)-3-(Methylamino)-1-phenylpropan-1-ol cas 114133-37-8

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Other

inquiry

SAGECHEM LIMITED

laboratory Application:Synthetic building block

Benzenemethanol, a-[2-(methylamino)ethyl]-, (aS)-

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(s)-3-(methylamino)-1-phenylpropanol (114133-37-8)

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(s)-3-(methylamino)-1-phenylpropanol (114133-37-8)

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

ORCHID CHEMICAL SUPPLIES LTD

(1S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Other

inquiry

Finetech Industry Limited

High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate

FT-0771123

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

(S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Langchem

1.We are specializing in providing customers with complete chemical raw materials.2.Superior quality, moderate price & quick delivery.3. Extensive international cooperation experience.4. Outstanding communication skills. Application:contact us for de

(S)-3-(Methylamino)-1-phenylpropan-1ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Alchemist-pharm chemical Technology Co. Ltd.

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

114133-37-8

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

crucell inc

114133-37-8

(1S)-3-(Methylamino)-1-phenylpropan-1-ol

Cas:114133-37-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(S)-3-hydroxy-N-methyl-3-phenylpropanamide
76183-10-3, 134619-76-4

(S)-3-hydroxy-N-methyl-3-phenylpropanamide

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether98%
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating;97.6%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 25℃;90%
With lithium aluminium tetrahydride In tetrahydrofuran for 6h; Reflux;89%
(1S) 3-phenyl-3-hydroxypropyl methanesulfonate
115290-77-2

(1S) 3-phenyl-3-hydroxypropyl methanesulfonate

methylamine
74-89-5

methylamine

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
In tetrahydrofuran; water at 65℃; for 3h;96%
In tetrahydrofuran; water at 70℃;93%
In tetrahydrofuran; water at 70℃; for 4h;90%
In tetrahydrofuran; water at 60 - 65℃; for 4h;82%
β-Methylaminoethyl phenyl ketone hydrochloride
2538-50-3

β-Methylaminoethyl phenyl ketone hydrochloride

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With Rh[((S,S)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 20h; Autoclave; enantioselective reaction;92%
With hydrogen; potassium carbonate; [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h;90%
With [Rh((S,S)-BenzP*)(cod)]SbF6; hydrogen; magnesium sulfate; potassium carbonate In ethyl acetate at 50℃; under 37503.8 Torr; for 1h; enantioselective reaction;80%
3-(N-methylamino)propiophenone
27152-62-1

3-(N-methylamino)propiophenone

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) In acetonitrile at 20℃; for 5h; Solvent; Reagent/catalyst;89.93%
(S)-N-(ethoxycarbonyl)-3-amino-1-phenyl-1-propanol
502697-61-2

(S)-N-(ethoxycarbonyl)-3-amino-1-phenyl-1-propanol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Heating;88%
(S)-(-)-3-iodo-1-phenyl-1-propanol
114133-36-7

(S)-(-)-3-iodo-1-phenyl-1-propanol

methylamine
74-89-5

methylamine

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
In tetrahydrofuran; water Ambient temperature;86%
In tetrahydrofuran Ambient temperature;85%
In tetrahydrofuran; water for 22h;
(S)-(-)-N-(tert-butoxycarbonyl)-3-amino-1-phenylpropan-1-ol
762273-00-7

(S)-(-)-N-(tert-butoxycarbonyl)-3-amino-1-phenylpropan-1-ol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 5.5h; Heating;78%
3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

methylamine
74-89-5

methylamine

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With potassium iodide In methanol; water at 80℃; for 8h;75%
With sodium iodide In water
(6S)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinane

(6S)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinane

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 90℃; for 1.5h;67%
((S)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

((S)-3-Hydroxy-3-phenyl-propyl)-carbamic acid methyl ester

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Heating; Yield given;
With lithium aluminium tetrahydride
methylamine
74-89-5

methylamine

3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate
51699-49-1

3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate

A

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

B

(R)-N-methyl-3-phenyl-3-hydroxypropylamine
115290-81-8

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
Stage #1: 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate With 3 A molecular sieve; oxygen; (-)-sparteine; palladium diacetate In toluene at 80℃; under 760 Torr; for 36h;
Stage #2: methylamine With water In tetrahydrofuran at 65℃;
N-(3-hydroxy-3-phenyl-propyl)-formamide

N-(3-hydroxy-3-phenyl-propyl)-formamide

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 8h; Heating;4.10 g
ethyl (3R)-3-hydroxy-3-phenylpropionate
33401-74-0

ethyl (3R)-3-hydroxy-3-phenylpropionate

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / tetrahydrofuran; H2O / 70 °C
2: 90 percent / LiAlH4 / tetrahydrofuran / 0 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1: 80 percent / LiAlH4 / diethyl ether / Ambient temperature
2: 85 percent / Et3N / diethyl ether / 2 h / 0 °C
3: 90 percent / NaI / acetone / Heating
4: 86 percent / tetrahydrofuran; H2O / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 80 percent / LiAlH4 / diethyl ether / Ambient temperature
2: 85 percent / Et3N / diethyl ether / 2 h / 0 °C
3: 90 percent / tetrahydrofuran; H2O / 4 h / 70 °C
View Scheme
(S)-3-hydroxy-3-phenylpropanenitrile
132203-26-0

(S)-3-hydroxy-3-phenylpropanenitrile

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / borane-dimethyl sulfide complex / tetrahydrofuran / 4 h / 70 °C
2: aq. K2CO3 / CH2Cl2 / 0.5 h / 20 °C
3: 4.10 g / LiAlH4 / tetrahydrofuran / 8 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 85 percent / BH3*SMe2 / tetrahydrofuran / 2 h / Heating
2: 90 percent / K2CO3 / CH2Cl2; H2O / 0.58 h / 20 °C
3: 88 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: BH3*SMe2 / tetrahydrofuran / 2.5 h / Heating
3: LAH
View Scheme
(1S)-3-amino-1-phenyl-1-propanol
130194-42-2

(1S)-3-amino-1-phenyl-1-propanol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. K2CO3 / CH2Cl2 / 0.5 h / 20 °C
2: 4.10 g / LiAlH4 / tetrahydrofuran / 8 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / K2CO3 / CH2Cl2; H2O / 0.58 h / 20 °C
2: 88 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
2: LAH
View Scheme
Multi-step reaction with 2 steps
1: NaHCO3
2: LiAlH4 / tetrahydrofuran / Heating
View Scheme
acetophenone
98-86-2

acetophenone

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / ethanol / 110 °C
2: 90 percent / hydrogen; K2CO3 / [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 / methanol / 12 h / 20 °C / 7500.6 Torr
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / ethanol / 20 h / 110 °C
2: Rh[((S,S)-BenzP*)(cod)]SbF6; zinc(II) chloride; caesium carbonate; hydrogen / methanol / 20 h / 20 °C / 19001.3 Torr / Autoclave
View Scheme
butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester
118856-08-9

butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
2: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
4: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
(3S) ethyl β-butyryloxy-β-phenyl propionate
838841-85-3

(3S) ethyl β-butyryloxy-β-phenyl propionate

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
3: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Ethyl 3-hydroxy-3-phenylpropanoate
5764-85-2

Ethyl 3-hydroxy-3-phenylpropanoate

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
3: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
5: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h
2.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C
3.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr
3.2: H2O / tetrahydrofuran / 65 °C
View Scheme
(S)-3-phenyl-1,3-propanediol
96854-34-1

(S)-3-phenyl-1,3-propanediol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
2: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 85 percent / Et3N / diethyl ether / 2 h / 0 °C
2: 90 percent / NaI / acetone / Heating
3: 86 percent / tetrahydrofuran; H2O / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / Et3N / diethyl ether / 2 h / 0 °C
2: 90 percent / tetrahydrofuran; H2O / 4 h / 70 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

SASRIN-maleidobenzoic acid resin

SASRIN-maleidobenzoic acid resin

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C
4.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling
6.1: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C
View Scheme
(6S)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinan-4-one

(6S)-2-((S)-1-triisopropylsilyloxyethyl)-3-methyl-6-phenyl-1,3-oxazinan-4-one

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diphenyl silane / tris(triphenylphosphine)rhodium(I) carbonyl hydride / tetrahydrofuran / 15 h / 20 °C
2: 67 percent / HCl / methanol; H2O / 1.5 h / 90 °C
View Scheme
3-hydroxy-3-phenylpropanenitrile
73627-97-1, 121617-17-2, 132203-26-0, 17190-29-3

3-hydroxy-3-phenylpropanenitrile

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: LiAlH4 / tetrahydrofuran / 5 h / Heating
2: 41 percent / Et3N / CH2Cl2 / 2 h / 23 °C
3: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr
4: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogen, NH3 / Raney Ni / ethanol / 90 °C / p(NH3) = 30 psi and p(H2) = 170 psi
2: NaHCO3
3: LiAlH4 / tetrahydrofuran / Heating
View Scheme
3-amino-1-phenylpropan-1-ol
5053-63-4

3-amino-1-phenylpropan-1-ol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 41 percent / Et3N / CH2Cl2 / 2 h / 23 °C
2: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr
3: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating
View Scheme
(3-oxo-3-phenylpropyl)carbamic acid tert-butyl ester
333387-97-6

(3-oxo-3-phenylpropyl)carbamic acid tert-butyl ester

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / NaBH4 / ethanol / 3 h / 0 - 23 °C
2: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr
3: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating
View Scheme
(+/-)-N-(tert-butoxycarbonyl)-3-amino-1-phenylpropan-1-ol
257892-43-6

(+/-)-N-(tert-butoxycarbonyl)-3-amino-1-phenylpropan-1-ol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr
2: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating
View Scheme
1-phenyl-1,3-propanediol
4850-49-1

1-phenyl-1,3-propanediol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C
2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr
2.2: H2O / tetrahydrofuran / 65 °C
View Scheme
(R)-Styrene oxide
20780-53-4

(R)-Styrene oxide

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85.2 percent / Et3N / tetrahydrofuran / 18 h / Heating
2: BH3*SMe2 / tetrahydrofuran / 2.5 h / Heating
4: LAH
View Scheme
3-chloro-1-phenylpropanol
100306-34-1

3-chloro-1-phenylpropanol

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / NaI / acetone / Heating
2: 85 percent / tetrahydrofuran / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 17 h / Reflux
2: water; tetrahydrofuran / 22 h
View Scheme
hydrogenchloride
7647-01-0

hydrogenchloride

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine
134619-77-5

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; ethyl acetate97%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine
134619-77-5

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine

Conditions
ConditionsYield
In dichloromethane95%
In dichloromethane for 2h; Heating;95%
In tetrahydrofuran at 0 - 20℃;57%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 22h;
4-Fluorobenzotrifluoride
402-44-8

4-Fluorobenzotrifluoride

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

(S)-fluoxetine
100568-02-3

(S)-fluoxetine

Conditions
ConditionsYield
Stage #1: (S)-N-methyl-3-amino-1-phenyl-1-propanol With sodium hydride In N,N-dimethyl acetamide; paraffin oil at 90℃; for 0.5h; Inert atmosphere;
Stage #2: 4-Fluorobenzotrifluoride In N,N-dimethyl acetamide; paraffin oil at 100℃; for 5h; Inert atmosphere;
91%
With sodium hydride 1.) dimethylacetamide, 70 deg C, 30 min; 2) dimethylacetamide, 93 deg C, 2.25 h; Yield given. Multistep reaction;
(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

(S)-fluoxetine hydrochloride
114247-06-2

(S)-fluoxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (S)-N-methyl-3-amino-1-phenyl-1-propanol With sodium hydride In dimethyl sulfoxide at 70℃; for 0.5h;
Stage #2: 4-chlorobenzotrifluoride In dimethyl sulfoxide at 90℃; for 2h;
90%
With hydrogenchloride; sodium hydride 1) DMAC 2) EtOH; Multistep reaction;
1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min; Yield given. Multistep reaction;
With hydrogenchloride; N,N-dimethyl acetamide; sodium hydride Yield given;
(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

(S)-fluoxetine
100568-02-3

(S)-fluoxetine

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide at 90 - 100℃; for 1.5h;84%
With sodium hydride In dimethyl sulfoxide at 90 - 100℃; for 1h;71%
With sodium hydride 1.) N,N-dimethylacetamid (DMAC), 90 deg C, 2.) 100-105 deg C; Yield given. Multistep reaction;
(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

ortho-cresol
95-48-7

ortho-cresol

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In toluene at 120℃; for 2h; Solvent; Reagent/catalyst; Temperature; Mitsunobu Displacement;79.45%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 12h;67%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu Displacement;
2-Fluorotoluene
95-52-3

2-Fluorotoluene

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

rac-tomoxetine hydrochloride

rac-tomoxetine hydrochloride

Conditions
ConditionsYield
With sodium hydride 1) DMSO, 2) DMSO; Yield given. Multistep reaction;
2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

(S)-N-methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine
105314-53-2

(S)-N-methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine

Conditions
ConditionsYield
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction;
2-Chloroanisole
766-51-8

2-Chloroanisole

(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

(S)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine
112066-66-7

(S)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine

Conditions
ConditionsYield
With 2,4-dichlorophenoxyacetic acid dimethylamine; sodium hydride Multistep reaction;
(S)-N-methyl-3-amino-1-phenyl-1-propanol
114133-37-8

(S)-N-methyl-3-amino-1-phenyl-1-propanol

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

B

(S)-fluoxetine
100568-02-3

(S)-fluoxetine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl acetamide Title compound not separated from byproducts.;

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