4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride supplier

Name
4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride
EINECS 218-130-3
CAS No. 2051-79-8
Article Data2
CAS DataBase
Density
Solubility almost transparency
Melting Point 250 °C (dec.)(lit.)
Formula C₁₁H₁₈N₂^.HCl
Boiling Point 300.3 °C at 760 mmHg
Molecular Weight 214.738
Flash Point 122 °C
Transport Information UN 2811 6.1/PG 3
Appearance White to grey white crystal
Safety 22-26-36/37/39-45-61-60-37-24
Risk Codes 23/24/25-43-50/53-36-25
Molecular Structure
Hazard Symbols T,N
Synonyms 1,4-Benzenediamine,N4,N4-diethyl-2-methyl-, monohydrochloride (9CI);Toluene-2,5-diamine,N5,N5-diethyl-, monohydrochloride (8CI);2-Amino-5-(diethylamino)toluenemonohydrochloride;4-(Diethylamino)-2-methylaniline monohydrochloride;4-Amino-N,N-diethyl-m-toluidinehydrochloride;CD 2;CD 2 (amine);N',N'-Diethyl-2-methyl-1,4-phenylenediaminemonohydrochloride;PPD 2;
PSA 29.26000
LogP 3.80660

Synthetic route

: 64-67-5
diethyl sulfate

: 4-phthalamino-3-methylaniline

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

Conditions

Conditions	Yield
With sodium hydroxide; sulfuric acid In water

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 41279-57-6
1-naphthylcyanamide

: 124646-92-0
N-Cyano-N'-(4'-diethylamino-2'-methylphenyl)-1,4-naphthoquinone di-imine

Conditions

Conditions	Yield
With sodium hydroxide; ammonium peroxydisulfate In water at 5℃; for 0.5h;	97%
With sodium hydroxide; ammonium peroxydisulfate In water at 5℃; for 0.5h;	97%

: 148-24-3
8-quinolinol

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 54033-12-4
5-(4'-diethylamino-2'-methylphenylimino)quinolin-8-one

Conditions

Conditions	Yield
With ammonium peroxydisulfate In water at 5℃; for 0.166667h; NaOCl;	95%

: 773-76-2
chloroxine

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 120015-12-5
7-chloro-5-(4'-diethylamino-2'-methylphenylimino)quinoline-8-one

Conditions

Conditions	Yield
With ammonium peroxydisulfate In water at 60℃; for 0.166667h;	87%

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 89-25-8
edaravone

: 4719-41-9, 14071-75-1
4-Diethylamino-2-methyl-phenylimino-3-methyl-1-phenyl-2-pyrazolin-5-on

Conditions

Conditions	Yield
With potassium ferrocyanide In water at 40℃;	82%

: 248590-47-8
25,26,27,28-tetrakis(hydroxy)calix[4]arene

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 139056-17-0
23-((4'-(diethylamino)-2'-methylphenyl)imino)-26,27,28-trihydroxypentacyclo<19.3.13,7.19,13.115,19>-octacosa-1(24),3,5,7(28),9,11,13(27),15,17,19(26),21-undecaen-25-one

Conditions

Conditions	Yield
With potassium hexacyanoferrate(III) Ambient temperature; alkaline conditions;	74%

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 54033-12-4
5-(4'-diethylamino-2'-methylphenylimino)quinolin-8-one

Conditions

Conditions	Yield
With sodium hydroxide; sodium hypochlorite; sodium hydrogencarbonate In water	64.3%

: 148-24-3
8-quinolinol

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 5-(2'-methyl-4'-diethylaminophenylimino)quinoline-8-one

Conditions

Conditions	Yield
With sodium hypochlorite In sodium hydroxide at 5℃; for 0.166667h;	64%

: 25784-91-2
2-chloro-5-nitrobenzoylchloride

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 372095-03-9
N-[4-(Diethylamino)-2-methylphenyl]-(2-chloro-5-nitrophenyl)carboxamide

Conditions

Conditions	Yield
With 2,4-dichlorophenoxyacetic acid dimethylamine; triethylamine	60%

: 576-26-1
2.6-dimethylphenol

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 55303-18-9
4-((4-(diethylamino)-o-tolyl)imino)-2,6-dimethylcyclohexa-2,5-dienone

Conditions

Conditions	Yield
With sodium hydroxide; In ethanol for 0.25h; Ambient temperature;	55%

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 96107-95-8
calix[6]arene

: C53H50N2O6

Conditions

Conditions	Yield
With sodium carbonate; potassium hexacyanoferrate(III) Ambient temperature;	53%

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 321898-65-1
1-butyl-3-{3-[(3-butyl-thioureido)-methyl]-2-hydroxy-benzyl}-thiourea

: 1-butyl-3-[5-[(3-butyl-thioureido)-methyl]-3-(4-diethylamino-2-methyl-phenylimino)-6-oxo-cyclohexa-1,4-dienylmethyl]-thiourea

Conditions

Conditions	Yield
Stage #1: 4-diethylamino-2-methylaniline hydrochloride; 1-butyl-3-{3-[(3-butyl-thioureido)-methyl]-2-hydroxy-benzyl}-thiourea With sodium hydroxide In methanol at 20℃; Stage #2: With potassium hexacyanoferrate(III)	52%

: 5518-09-2
2-(naphthalen-1-yl)malononitrile

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 110930-60-4
4-(2'-methyl-4'-diethylaminophenylimino)-9,9-dicyano-1,4-naphthoquinone methide

Conditions

Conditions	Yield
With sodium hydroxide; sodium hypochlorite In water for 0.166667h; Ambient temperature;	51%
In water for 0.166667h; Product distribution; Ambient temperature; various oxidizing agents and molar ratio, various yield;

: 248590-47-8
25,26,27,28-tetrakis(hydroxy)calix[4]arene

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

A: 139056-17-0
23-((4'-(diethylamino)-2'-methylphenyl)imino)-26,27,28-trihydroxypentacyclo<19.3.13,7.19,13.115,19>-octacosa-1(24),3,5,7(28),9,11,13(27),15,17,19(26),21-undecaen-25-one

B: 148249-68-7
11,23-bis((4'-(diethylamino)-2'-methylphenyl)imino)-26,28-dihydroxypentacyclo<19.3.1.13,7.19,13.115,19>-octacosa-1(24),3,5,7(28),9,12,15,17,19(26),21-decaene-25,27-dione

C: 17,23-bis([4'-(diethylamino)-2'-methylphenyl]imino)-27,28-dihydroxypentacyclo[19.3.1.13,7.19,13.115,19]-octacosa-1(24),3,5,7(28),9,11,13(27),15,18,21-decaene-25,26-dione

D: 5,11,17,23-tetrakis([4'-(diethylamino)-2'-methylphenyl]imino)pentacyclo[19.3.1.13,7.19,13.115,19]-octacosa-1(24),3,6,9,12,15,18,21-octaene-25,26,27,28-tetraone

Conditions

Conditions	Yield
With sodium hydroxide; potassium hexacyanoferrate(III) In acetone for 2h; Product distribution; Ambient temperature;	A 50% B 8% C 11.5% D n/a
With sodium hydroxide; potassium hexacyanoferrate(III) In acetone for 2h; Ambient temperature;	A 50% B 8% C 11.5% D n/a
With sodium hydroxide; potassium hexacyanoferrate(III) In acetone for 0.166667h; Ambient temperature;	A 2% B 35% C 25% D n/a

...Expand

: silver(I) bromide

: 7732-18-5
water

: 10035-10-6, 12258-64-9
hydrogen bromide

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: N,N-diethyl-2-methyl-1,4-benzenediammonium hexabromodiargentate(I) monohydrate

Conditions

Conditions	Yield
In hydrogen bromide aq. HBr; dissolving of AgBr in warm 48% HBr; dissolving of N,N-diethyl-2-methyl-1,4-benzenediamine hydrogen chloride in HBr; combining of two solns. withstirring; gentle heating to 70°C; slow cooling to 0°C; crystn.; filtration, washing with a small amt. of 50:50 H2O:HBr; drying in desiccator under flowing N2; elem. anal.;	44.8%

...Expand

: 248590-47-8
25,26,27,28-tetrakis(hydroxy)calix[4]arene

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

A: 148249-68-7
11,23-bis((4'-(diethylamino)-2'-methylphenyl)imino)-26,28-dihydroxypentacyclo<19.3.1.13,7.19,13.115,19>-octacosa-1(24),3,5,7(28),9,12,15,17,19(26),21-decaene-25,27-dione

B: 17,23-bis([4'-(diethylamino)-2'-methylphenyl]imino)-27,28-dihydroxypentacyclo[19.3.1.13,7.19,13.115,19]-octacosa-1(24),3,5,7(28),9,11,13(27),15,18,21-decaene-25,26-dione

C: 5,11,17,23-tetrakis([4'-(diethylamino)-2'-methylphenyl]imino)pentacyclo[19.3.1.13,7.19,13.115,19]-octacosa-1(24),3,6,9,12,15,18,21-octaene-25,26,27,28-tetraone

Conditions

Conditions	Yield
With sodium hydroxide; potassium hexacyanoferrate(III) In acetone for 4h; Ambient temperature;	A 1% B 3% C 37.5%

...Expand

: 248590-47-8
25,26,27,28-tetrakis(hydroxy)calix[4]arene

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 148249-68-7
11,23-bis((4'-(diethylamino)-2'-methylphenyl)imino)-26,28-dihydroxypentacyclo<19.3.1.13,7.19,13.115,19>-octacosa-1(24),3,5,7(28),9,12,15,17,19(26),21-decaene-25,27-dione

Conditions

Conditions	Yield
With sodium hydroxide; potassium hexacyanoferrate(III) Ambient temperature;	35%

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 171006-80-7, 151598-45-7, 564467-64-7, 564467-65-8
C56H50O8

: C70H60N2O10

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hexacyanoferrate(III) In water; acetonitrile	34%

: 91822-53-6
1-naphthylcyanoacetamide

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 110930-62-6
4-(2'-methyl-4'-diethylaminophenylimino)-9-cyano-9-amide-1,4-naphthoquinone methide

Conditions

Conditions	Yield
With sodium hydroxide; sodium hypochlorite In water for 0.166667h; Ambient temperature;	3%

: 131543-46-9
Glyoxal

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 78991-03-4
glyoxal-bis-(4-diethylamino-2-methyl-phenylimine)

Conditions

Conditions	Yield
With sodium hydroxide

: 92963-33-2
3-(2-methoxy-phenyl)-3-oxo-propionic acid anilide

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 68854-62-6
2-(4-diethylamino-2-methyl-phenylimino)-3-(2-methoxy-phenyl)-3-oxo-propionic acid anilide

Conditions

Conditions	Yield
With ethanol; sodium carbonate; silver(I) chloride

: 109251-77-6
3-oxo-3-phenyl-propionic acid-(2-dimethylamino-anilide)

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 121791-72-8
2-(4-diethylamino-2-methyl-phenylimino)-3-oxo-3-phenyl-propionic acid-(2-dimethylamino-anilide)

Conditions

Conditions	Yield
With ethanol; sodium carbonate; potassium hexacyanoferrate(III)

: 152532-13-3
N-(2,5-dimethoxyphenyl)-3-phenyl-3-oxopropionamide

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 121848-86-0
2-(4-diethylamino-2-methyl-phenylimino)-3-oxo-3-phenyl-propionic acid-(2,5-dimethoxy-anilide)

Conditions

Conditions	Yield
With ethanol; sodium carbonate; potassium hexacyanoferrate(III)

: 109393-41-1
3-oxo-3-phenyl-propionic acid-(2,6-dimethoxy-anilide)

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 121848-87-1
2-(4-diethylamino-2-methyl-phenylimino)-3-oxo-3-phenyl-propionic acid-(2,6-dimethoxy-anilide)

Conditions

Conditions	Yield
With ethanol; sodium carbonate; potassium hexacyanoferrate(III)

: 109393-40-0
3-oxo-3-phenyl-propionic acid-(2,4-dimethoxy-anilide)

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 121813-41-0
2-(4-diethylamino-2-methyl-phenylimino)-3-oxo-3-phenyl-propionic acid-(2,4-dimethoxy-anilide)

Conditions

Conditions	Yield
With ethanol; sodium carbonate; potassium hexacyanoferrate(III)

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 120-46-7
1,3-diphenylpropanedione

: 4754-96-5
2-(4-diethylamino-2-methyl-phenylimino)-1,3-diphenyl-propane-1,3-dione

Conditions

Conditions	Yield
With ethanol; sodium carbonate; potassium hexacyanoferrate(III)
With ethanol; sodium carbonate; silver(I) chloride

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 123-63-7
paracetaldehyde

: 1-(4-diethylamino-2-methyl-anilino)-ethanesulfonic acid

Conditions

Conditions	Yield
With water; sodium hydrogensulfite

: 90-15-3
α-naphthol

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 2363-97-5
4-(4-diethylamino-2-methylphenylimino)-1,4-naphthoquinone

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 41279-57-6
1-naphthylcyanamide

: 4-[(E)-4-Diethylamino-2-methyl-phenylimino]-4H-naphthalen-(1E)-ylidene-cyanamide

Conditions

Conditions	Yield
With ammonium peroxydisulfate Yield given;

: 37860-51-8
tetraethylene glycol di(p-toluenesulfonate)

: 248590-47-8
25,26,27,28-tetrakis(hydroxy)calix[4]arene

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: Calix[4]crown-5

Conditions

Conditions	Yield
Stage #1: tetraethylene glycol di(p-toluenesulfonate); 25,26,27,28-tetrakis(hydroxy)calix[4]arene Substitution; Stage #2: 4-diethylamino-2-methylaniline hydrochloride With potassium permanganate Condensation; alkaline condition;

...Expand

: 2051-79-8
4-diethylamino-2-methylaniline hydrochloride

: 11,23-bis((4'-(diethylamino)-2'-methylphenyl)imino)-26,28-bis((ethoxycarbonyl)methoxy)pentacyclo<19.3.1.13,7.19,13.115,19>-octacosa-1(24),3,5,7(28),9,12,15,17,19(26),21-decaene-25,27-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1 percent / NaOH, aq. K3 / acetone / 4 h / Ambient temperature 2: 62 percent / NaH / dimethylformamide / 1 h / 80 °C View Scheme
Multi-step reaction with 2 steps 1: 35 percent / NaOH, K3Fe(CN)6 / Ambient temperature 2: 62 percent View Scheme

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Chemical Properties

IUPAC Name: 4-N,4-N-Diethyl-2-methylbenzene-1,4-diamine hydrochloride
Canonical SMILES: CCN(CC)C1=CC(=C(C=C1)N)C.Cl
InChI: InChI=1S/C11H18N2.ClH/c1-4-13(5-2)10-6-7-11(12)9(3)8-10;/h6-8H,4-5,12H2,1-3H3;1H
Empirical Formula: C₁₁H₁₉ClN₂
Molecular Weight: 214.735
Flash Point: 122 °C
Enthalpy of Vaporization: 54.03 kJ/mol
Boiling Point: 300.3 °C at 760 mmHg
Vapour Pressure: 0.00113 mmHg at 25 °C
EINECS: 218-130-3
Product Categories: Industrial / Fine Chemicals
Melting Point of 4-Amino-3-methyl-N,N-diethylaniline hydrochloride (CAS NO.2051-79-8): 250 °C (dec.)(lit.)

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Uses

4-Amino-3-methyl-N,N-diethylaniline hydrochloride (CAS NO.2051-79-8) is used for color photographic contrast.

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	skin	> 1gm/kg (1000mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
rat	LD50	intraperitoneal	25mg/kg (25mg/kg)	Kodak Company Reports. Vol. 21MAY1971,
rat	LD50	oral	200mg/kg (200mg/kg)	Kodak Company Reports. Vol. 21MAY1971,

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of NO_x and HCl.
Hazard Codes : Toxic T, Dangerous N
WGK Germany: 3
HazardClass: 6.1(b)
RIDADR: UN 2811 6.1/PG 3
Risk Statements: 23/24/25-43-50/53-36-25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R43:May cause sensitization by skin contact.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R36:Irritating to eyes.
R25 :Toxic if swallowed.
Safety Statements: 22-26-36/37/39-45-61-60-37-24
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S37:Wear suitable gloves.
S24:Avoid contact with skin.

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Specification

4-Amino-3-methyl-N,N-diethylaniline hydrochloride (CAS NO.2051-79-8), its Synonyms are Toluene-2,5-diamine, N(sup 5),N(sup 5)-diethyl-, monohydrochloride ; 1,4-Benzenediamine, N(sup 4),N(sup 4)-diethyl-2-methyl-, monohydrochloride ; 2-Amino-5-diethylaminotoluene monohydrochloride ; 1,4-Benzenediamine, N4,N4-diethyl-2-methyl-, hydrochloride (1:1) ; N5,N5-Diethyltoluene-2,5-diamine monohydrochloride ; p-Phenylenediamine, N,N-diethyl-3-methyl-, hydrochloride ; CD-2 . It is white to grey white crystal.

Product Name

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride

Synthetic route

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Chemical Properties

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Uses

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Toxicity Data With Reference

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Consensus Reports

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Safety Profile

4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride Specification

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