4,4,5,5,5-Pentafluoro-1-pentanol supplier

Name
4,4,5,5,5-Pentafluoro-1-pentanol
EINECS 421-360-9
CAS No. 148043-73-6
Article Data7
CAS DataBase
Density 1.31 g/cm³
Solubility
Melting Point 236oC
Formula C₅H₇F₅O
Boiling Point 73.9 °C at 760 mmHg
Molecular Weight 178.102
Flash Point 145°F
Transport Information UN 1993
Appearance
Safety 26-36
Risk Codes 36-36/37/38
Molecular Structure
Hazard Symbols Xi, F
Synonyms 4,4,5,5,5-Pentafluoropentanol;
PSA 20.23000
LogP 1.95650

Synthetic route

: 172032-07-4
4,4,5,5,5-pentafluoro-2-iodopent-2-en-1-ol

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
With hydrogen; triethylamine; platinum(IV) oxide In ethyl acetate at 25℃; for 3h;	95%

: 148043-72-5
4,4,5,5,5-pentafluoropentyl acetate

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
With sodium hydroxide for 1h; Heating;	92%

: 1,1,1,2,2-pentafluoropentane

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
With Cumene hydroperoxide In isopropyl alcohol at 80℃; for 2h; Reagent/catalyst; Solvent; Temperature; Autoclave;	83.3%

: 148043-71-4
4,4,5,5,5-pentafluoro-2-iodopentyl acetate

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 78 percent / azoisobutyronitrile (AIBN), Bu3SnH / 55 - 65 °C 2: 92 percent / aq. NaOH / 1 h / Heating View Scheme

: 1634-04-4
tert-butyl methyl ether

: 757-06-2
4,4,5,5,5-pentafluoro-2-iodo-1-pentanol

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
With hydrogen; triethylamine; palladium

: 757-06-2
4,4,5,5,5-pentafluoro-2-iodo-1-pentanol

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
With triethylamine; palladium In water; ethyl acetate
With 2,2'-azobis(isobutyronitrile); palladium diacetate at 60 - 70℃; Reagent/catalyst;
With hydrogen; triethylamine In acetonitrile at 50℃; under 15001.5 Torr; for 0.5h; Flow reactor;

: 757-06-2
4,4,5,5,5-pentafluoro-2-iodo-1-pentanol

: 141-43-5
ethanolamine

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
palladium In water

: 4,4,5,5,5-pentafluoro-2-penten-1-ol

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

Conditions

Conditions	Yield
platinum (IV) oxide In ethyl acetate
platinum (IV) oxide In ethyl acetate

: 124-63-0
methanesulfonyl chloride

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 252947-01-6
1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3 - 12h; Product distribution / selectivity;	100%
With triethylamine In tetrahydrofuran at 0 - 20℃;	99%
With triethylamine In dichloromethane at 0℃; for 0.75h;	96%

: 98-91-9
thiobenzoic acid

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 862700-61-6
thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	99%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 17h;	75 g

: 5,10,15,20-tetrakis[2-fluoro-5-(chlorosulfonyl)phenyl]porphyrin

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 5,10,15,20-tetrakis[2-fluoro-5-(4,4,5,5,5-pentafluoropentyloxy)sulfonylphenyl]porphyrin

Conditions

Conditions	Yield
In tetrahydrofuran; water at 5 - 20℃;	95%

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 1,1,1,2,2-pentafluoro-5-chloro-n-pentane

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In dichloromethane at 0 - 20℃; Solvent; Reagent/catalyst;	95%
With thionyl chloride; triethylamine In dichloromethane at 0 - 20℃; for 2h; Solvent; Reagent/catalyst;	95%

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 1293408-08-8
C13H12ClF5O2

Conditions

Conditions	Yield
With triethylamine In acetone at 10 - 20℃; for 2h; Inert atmosphere;	93%
With triethylamine In acetone at 10 - 20℃; for 2h; Inert atmosphere;	93%

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

molecular sieve supported p-toluenesulfonic acid: molecular sieve supported p-toluenesulfonic acid

: 209325-64-4
4,4,5,5,5-pentafluoropentyl-4-methylbenzene sulphonate

Conditions

Conditions	Yield
at 65℃; for 1h; Temperature; Microwave irradiation; Molecular sieve;	91%

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 507-09-5
thioacetic acid

: 160598-75-4
1-(acetylsulfanyl)-4,4,5,5,5-pentafluoropentane

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran 1.) 0 deg C, 30 min; 2.) 0 deg C, 30 min then 25 deg C, 1 h;	88%

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: C11H10F5NO5S

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at -10℃; for 1h; Concentration;	85%

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 3637-31-8
4,4,5,5,5-pentafluoropentanoic acid

Conditions

Conditions	Yield
With Jones reagent In acetone at 0 - 20℃; for 1h;	82%
With sodium permanganate monohydrate; tetraethylammonium hydrogen sulphate In water at 65 - 75℃; for 6.5h; Large scale;	77%
With chromium(VI) oxide; acetic acid at 0 - 20℃; for 26h;	63%

: 5,10,15,20-tetrakis[2,6-difluoro-3-(chlorosulfonyl)phenyl]porphyrin

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 5,10,15,20-tetrakis[2,6-difluoro-3-(4,4,5,5,5-pentafluoropentyloxy)sulfonylphenyl]porphyrin

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 5 - 20℃;	82%

: C34H52N2O9S

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: C39H57F5N2O9S

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃; Mitsunobu reaction;	67%

: 4-[9-(N-t-butyloxycarbonylaminosulfonylamino)nonyl]-7-methoxymethoxy-3-(4-methoxymethoxyphenyl)-3-methylchroman

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 4-[9-(N-t-butyloxycarbonyl-N-4,4,5,5,5-pentafluoropentylaminosulfonylamino)nonyl]-7-methoxymethoxy-3-(4-methoxymethoxyphenyl)-3-methylchroman

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃;	67%

: 98-59-9
p-toluenesulfonyl chloride

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 209325-64-4
4,4,5,5,5-pentafluoropentyl-4-methylbenzene sulphonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 24h;	61%
With pyridine at 0 - 20℃;	53%
With pyridine at 0 - 20℃;	53%
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane
With triethylamine In dichloromethane at 20℃; for 18h;

: Gly-Ni-(S)-2-[N-(N-benzylpropyl)amino]benzophenone

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

A: C32H30F5N3NiO3

B: C32H30F5N3NiO3

Conditions

Conditions	Yield
With cyanomethylenetributyl-phosphorane at 105℃; Inert atmosphere; Sealed tube; diastereoselective reaction;	A 50% B n/a

...Expand

: Gly-Ni-(S)-2-[N-(N-benzylpropyl)amino]benzophenone

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

A: C32H30F5N3NiO3

B: C33H32F5N3NiO3

Conditions

Conditions	Yield
With cyanomethylenetributyl-phosphorane at 105℃; Mitsunobu Displacement; Sealed tube; Inert atmosphere; diastereoselective reaction;	A 50% B n/a

...Expand

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 151556-31-9
1,1,1,2,2-pentafluoro-5-iodo-pentane

Conditions

Conditions	Yield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; for 1.5h;	45%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; for 1.5h; Inert atmosphere;	45%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane for 2.5h;
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: sodium iodide / acetone / 12 h / Reflux View Scheme
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 2.5h; Inert atmosphere;

: 1308375-93-0
{(R)-2-[3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-piperazin-1-yl-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 1308380-96-2
(R)-tert-butyl-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-(4,4,5,5,5-pentafluoropentyl)-piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)carbamate

Conditions

Conditions	Yield
With potassium carbonate; methanesulfonyl chloride; triethylamine In dichloromethane; acetonitrile at 80℃; for 7h;	21%

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 530-62-1
1,1'-carbonyldiimidazole

: imidazole-1-carboxylic acid 4,4,5,5,5-pentafluoro-pentyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;
In tetrahydrofuran at 20℃; for 0.5h;

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 7-methoxy-3-(4-methoxyphenyl)-3-methyl-4-[8-(4,4,5,5,5-pentafluoropentylsulfanyl)octyl]thiochroman

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 76 percent / sodium methoxide / methanol; tetrahydrofuran / 12 h / 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 7-methoxy-3-(4-methoxyphenyl)-3-methyl-4-[8-(4,4,5,5,5-pentafluoropentylsulfanyl)octyl]thiochroman

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 16 percent / sodium methoxide / methanol; tetrahydrofuran / 12 h / 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 3-(4-hydroxyphenyl)-3-methyl-4-[8-(4,4,5,5,5-pentafluoropentylsulfanyl)octyl]thiochroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 76 percent / sodium methoxide / methanol; tetrahydrofuran / 12 h / 20 °C 4: boron tribromide / CH2Cl2 / -78 - 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 3-(4-hydroxyphenyl)-3-methyl-4-[8-(4,4,5,5,5-pentafluoropentylsulfanyl)octyl]chroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 59 percent / sodium methoxide / methanol; tetrahydrofuran / 20 °C 4: hydrogen chloride / methanol / 0.25 h / 60 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 3-(4-hydroxyphenyl)-3-methyl-4-[8-(4,4,5,5,5-pentafluoropentylsulfinyl)octyl]chroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 59 percent / sodium methoxide / methanol; tetrahydrofuran / 20 °C 4: hydrogen chloride / methanol / 0.25 h / 60 °C 5: oxone(R) / tetrahydrofuran; H2O / 0.17 h / 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: (3S,4S)-3-(4-Hydroxy-phenyl)-3-methyl-4-[9-(4,4,5,5,5-pentafluoro-pentylsulfanyl)-nonyl]-thiochroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: sodium methoxide / methanol; tetrahydrofuran / 12 h / 20 °C 4: boron tribromide / CH2Cl2 / -78 - 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: (3R,4R)-3-(4-Hydroxy-phenyl)-3-methyl-4-[9-(4,4,5,5,5-pentafluoro-pentylsulfanyl)-nonyl]-thiochroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: sodium methoxide / methanol; tetrahydrofuran / 20 °C 4: boron tribromide / CH2Cl2 / -78 - 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 3-(4-hydroxyphenyl)-3-methyl-4-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]thiochroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 79 percent / sodium methoxide / methanol; tetrahydrofuran / 20 °C 4: 74 percent / boron tribromide / CH2Cl2 / -78 - 20 °C View Scheme

: 148043-73-6
4,4,5,5,5-pentafluorpentan-1-ol

: 3-(4-hydroxyphenyl)-3-methyl-4-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]thiochroman-7-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 33.9 g / triethylamine / CH2Cl2 / 0 - 20 °C 2: 51 percent / acetone / 12 h / 20 °C 3: 11 percent / sodium methoxide / methanol; tetrahydrofuran / 20 °C 4: boron tribromide / CH2Cl2 / -78 - 20 °C View Scheme

4,4,5,5,5-Pentafluoro-1-pentanol Chemical Properties

IUPAC Name: 4,4,5,5,5-Pentafluoropentan-1-ol
Systematic of 4,4,5,5,5-Pentafluoro-1-pentanol (CAS NO.148043-73-6): Pentafluoropentanol ; 4,4,5,5,5-Pentafluoropentan-1-ol 96% ; 4,4,5,5,5-Pentafluoropentan-1-ol96% ; 4,4,5,5,5-Pentafluoro-1-pentanol ,97%
CAS NO: 148043-73-6
Molecular Formula of 4,4,5,5,5-Pentafluoro-1-pentanol (CAS NO.148043-73-6): C₅H₇F₅O
Molecular Weight: 178.1005
Molecular Structure:

ProductCategories: AIndustrial/Fine Chemicals;Organic Fluorides;Alcohols;C2 to C6;Oxygen Compounds
Melting Point: 236 °C
Polar Surface Area: 9.23 Å²
Index of Refraction: 1.327
Molar Refractivity: 27.49 cm³
Molar Volume: 135.9 cm³
Surface Tension: 19.4 dyne/cm
Density of 4,4,5,5,5-Pentafluoro-1-pentanol (CAS NO.148043-73-6): 1.31 g/cm³
Flash Point: °C
Enthalpy of Vaporization: 36.74 kJ/mol
Boiling Point: 73.9 °C at 760 mmHg
Vapour Pressure: 78 mmHg at 25°C

4,4,5,5,5-Pentafluoro-1-pentanol Safety Profile

Hazard Codes: Irritant Xi, Flammable F
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
RIDADR: 1993
WGK Germany: 2
Hazard Note: Irritant
HazardClass: FLAMMABLE

Product Name

4,4,5,5,5-Pentafluoro-1-pentanol

Synthetic route

4,4,5,5,5-Pentafluoro-1-pentanol Chemical Properties

4,4,5,5,5-Pentafluoro-1-pentanol Safety Profile

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