• Name

  4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE HYDROCHLORIDE

• EINECS
• CAS No. 28783-38-2
• Article Data1
• CAS DataBase
• Density
• Solubility
• Melting Point
• Formula C₇H₉NS·ClH
• Boiling Point 278.3 °C at 760 mmHg
• Molecular Weight 175.682
• Flash Point 122.1 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Thieno[2,3-c]pyridine,4,5,6,7-tetrahydro-, hydrochloride (8CI,9CI);4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride (1:1);4,5,6,7-Tetrahydrothieno[2,3-c]pyridinhydrochlorid;4,5,6,7-Tetrahydrothieno[2,3-c]pyridine HCl;TL80073586;MFCD08448167;
• PSA 40.27000
• LogP 2.52460

Synthetic route

165947-52-4

6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol

24424-99-5

di-tert-butyl dicarbonate

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

165947-52-4

6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4.5h;	100%

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

2-bromo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrobromide

Conditions

Conditions	Yield
With bromine In acetic acid at 20℃; for 1.5h;	90%

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

40435-14-1

(S)-1-phenyl-2-(tosyloxy)ethanol

(S)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)-1-phenylethanol

Conditions

Conditions	Yield
With triethylamine at 80℃; for 4h;	90%

24424-99-5

di-tert-butyl dicarbonate

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Conditions

Conditions	Yield
With triethylamine; dmap In ethyl acetate; N,N-dimethyl-formamide	88%

1323407-86-8

3-[4-[[4-(bromomethyl)phenyl]methoxy]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

1323403-95-7

3-{4-[4-(4,7-Dihydro-5H-thieno[2,3-c]pyridin-6-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;	74%

1401031-28-4

(R)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decane-9-yl)acetaldehyde

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

(R)-6-(2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Conditions

Conditions	Yield
Stage #1: 2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]acetaldehyde; 4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride With sodium sulfate In dichloromethane at 20℃; Stage #2: With sodium tetrahydroborate In dichloromethane for 0.5h;	10%

2942-58-7

diethyl cyanophosphonate

5581-75-9

6-phenylhexanic acid

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

1-(5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl)-6-phenylhexan-1-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane

...Expand

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

1200131-56-1

2-bromo-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine / acetic acid / 1.5 h / 20 °C 2: sodium tetrahydroborate / tetrahydrofuran / 0 - 60 °C View Scheme

223123-46-4

methyl (R)-2-(2-chlorophenyl)-2-benzenesulfonyloxyacetate

28783-38-2

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride

113665-84-2

(S)-(+)-clopidogrel

Conditions

Conditions	Yield
With potassium carbonate at 25 - 40℃; for 24h; Temperature;

4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride Specification