4-Chloro-8-methoxy-2-methylquinoline supplier

Name
4-CHLORO-8-METHOXY-2-METHYLQUINOLINE
EINECS
CAS No. 64951-58-2
Article Data7
CAS DataBase
Density 1.228 g/cm³
Solubility
Melting Point 89-93℃
Formula C₁₁H₁₀ClNO
Boiling Point 308.8 °C at 760 mmHg
Molecular Weight 207.659
Flash Point 140.6 °C
Transport Information
Appearance
Safety 26-39-45
Risk Codes 25-41
Molecular Structure
Hazard Symbols Xi
Synonyms Quinaldine,4-chloro-8-methoxy- (6CI);4-Chloro-8-methoxy-2-methylquinoline;
PSA 22.12000
LogP 3.20520

Synthetic route

: 15644-89-0
8-methoxy-2-methyl-4-quinolinol

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
With N,N-dimethyl-aniline; trichlorophosphate for 2h; Heating;	81.9%
With trichlorophosphate for 3h; Reflux;	81%
With trichlorophosphate at 130℃;	61%

: 33267-45-7
ethyl 3-<(2-methoxyphenyl)amino>but-2-enoate

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C 2: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating View Scheme

: 90-04-0
2-methoxy-phenylamine

phenylmethanesulfonic acid chloride: phenylmethanesulfonic acid chloride

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 99.8 percent / AcOH / benzene / 8 h / Heating 2: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C 3: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating View Scheme

: 90-04-0
2-methoxy-phenylamine

potassium-<2.5-dichloro benzoate>: potassium-<2.5-dichloro benzoate>

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) HCl, 2.) acetic anhydride, sulphuric acid 2: phosphorous oxychloride / 75 °C View Scheme

: 90-04-0
2-methoxy-phenylamine

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 336 h / 20 °C 1.2: 0.5 h / Reflux 2.1: trichlorophosphate / 15 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: polyphosphoric acid / 5 h / 120 °C 2: trichlorophosphate / 4 h / 130 °C View Scheme
Multi-step reaction with 3 steps 1: hydrogenchloride / 25 °C 2: diethyl ether / 1 h / 235 °C 3: trichlorophosphate / 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: polyphosphoric acid / 120 °C 2: trichlorophosphate / 130 °C View Scheme

: 50553-62-3
2-methyl-8-methoxy-1H-quinolin-4-one

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
With trichlorophosphate for 15h; Reflux;	2.28 g

: ethyl (E)-3-((2-methoxyphenyl)amino)but-2-enoate

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether / 1 h / 235 °C 2: trichlorophosphate / 3 h / Reflux View Scheme

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 137-07-5
2-amino-benzenethiol

: (4E)-4-[(2-mercaptophenyl)imino]-2-methyl-8-methoxy-1,4-dihydroquinoline dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 5 - 6h; Heating on water bath;	97%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 17356-08-0
thiourea

: S-(2-methyl-8-methoxy-4-quinolyl)thiouronium chloride

Conditions

Conditions	Yield
In acetone Heating;	94%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 541-69-5
m-phenylenediamine dihydrochloride

: N-(3-aminophenyl)-8-methoxy-2-methylquinolin-4-amine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 8h; Heating;	94%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 16245-77-5
p-phenylenediammonium sulfate

: N-(4-aminophenyl)-8-methoxy-2-methylquinolin-4-amine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 8h; Heating;	94%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 591-27-5
m-Hydroxyaniline

: 3-(8-methoxy-2-methylquinolin-4-ylamino)phenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Heating;	92%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 4-hydrazino-8-methoxy-2-methylquinoline dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrazine In ethanol; water for 15h; Heating;	92%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 137-07-5
2-amino-benzenethiol

: 1126485-27-5
4-[(2-aminophenyl)thio]-2-methyl-8-methoxyquinoline hydrochloride

Conditions

Conditions	Yield
In acetone at 20℃; for 48h;	81%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 71086-99-2
ethyl 5-amino-1H-indole-2-carboxylate

: ethyl 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride In water; butan-1-ol Reflux;	81%
With hydrogenchloride In water; butan-1-ol for 7h; Reflux;	61 mg

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 109-05-7, 3000-79-1
2-Methylpiperidin

: 87602-61-7
8-Methoxy-2-methyl-4-(2-methyl-piperidin-1-yl)-quinoline

Conditions

Conditions	Yield
With pyridine In ethanol for 8h; Heating;	80%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 79-19-6
thiosemicarbazide

: 2-(8-methoxy-2-methylquinolin-4-yl)hydrazinecarbothioamide dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water Heating;	80%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 62-53-3
aniline

: (8-methoxy-2-methyl-[4]quinolyl)-phenyl-amine

Conditions

Conditions	Yield
In ethanol for 6h; Heating;	73%
With acetic acid

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 28507-46-2
4-chloro-8-hydroxy-2-methylquinoline

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -50 - 25℃; for 2h; Inert atmosphere;	73%
With boron tribromide for 2h; Heating;	70.4%
With water; hydrogen bromide
With water; hydrogen bromide

: 462-08-8
pyridin-3-ylamine

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 870621-01-5
(8-methoxy-2-methyl-quinolin-4-yl)-pyridin-3-yl-amine

Conditions

Conditions	Yield
In ethanol for 6.5h; Heating;	73%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 73518-73-7
1-(p-Aminophenyl)-4-(o-tolyl)piperazine

: 87602-44-6
(8-Methoxy-2-methyl-quinolin-4-yl)-[4-(4-o-tolyl-piperazin-1-yl)-phenyl]-amine

Conditions

Conditions	Yield
With pyridine In ethanol for 8h; Heating;	72%

: 50593-73-2
4-chloro-6-methoxy-2-methylquinoline

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 79340-71-9
2-Hydroxy-4-(8-methoxy-2-methyl-quinolin-4-ylamino)-benzoic acid ethyl ester; hydrochloride

Conditions

Conditions	Yield
In ethanol Heating;	65%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 75291-16-6
4-[4-(2-chlorophenyl)piperazin-1-yl]phenylamine

: 87602-46-8
{4-[4-(2-Chloro-phenyl)-piperazin-1-yl]-phenyl}-(8-methoxy-2-methyl-quinolin-4-yl)-amine

Conditions

Conditions	Yield
With pyridine In ethanol for 8h; Heating;	65%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

A: 18004-89-2
2-methyl-4-chloro-5-nitro-8-methoxy quinoline

B: 2-methyl-4-chloro-5,7-dinitro-8-methoxy quinoline

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 5℃; for 12h;	A 64% B 5%

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 87602-60-6
1-(8-Methoxy-2-methyl-quinolin-4-yl)-4-phenyl-piperidin-4-ol

Conditions

Conditions	Yield
With pyridine In ethanol for 8h; Heating;	60%

4-Chloro-8-methoxy-2-methylquinoline Specification

The 4-Chloro-8-methoxy-2-methylquinoline, with the CAS registry number 64951-58-2, is also known as Quinoline, 4-chloro-8-methoxy-2-methyl-. This chemical's molecular formula is C₁₁H₁₀ClNO and molecular weight is 207.66. Its IUPAC name is called 4-chloro-8-methoxy-2-methylquinoline. When you are using this chemical, please be cautious about it: this chemical may cause inflammation to the skin or other mucous membranes.

Physical properties about this chemical are: (1)ACD/LogP: 3.00; (2)#H bond acceptors: 2; (3)#H bond donors: 0; (4)#Freely Rotating Bonds: 1; (5)Polar Surface Area: 22.12 Å²; (6)Index of Refraction: 1.609; (7)Molar Refractivity: 58.58 cm³; (8)Molar Volume: 169 cm³; (9)Surface Tension: 44 dyne/cm; (10)Density: 1.228 g/cm³; (11)Flash Point: 140.6 °C; (12)Enthalpy of Vaporization: 52.76 kJ/mol; (13)Boiling Point: 308.8 °C at 760 mmHg; (14)Vapour Pressure: 0.00121 mmHg at 25°C.

Uses of 4-Chloro-8-methoxy-2-methylquinoline: it can be heated to produce 4-(5-nitro-2-thiazolyl)amino-2-methyl-8-metoxyquinoline. This reaction will need reagent pyridine and solvent xylene. The yield is about 20%.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1=NC2=C(C=CC=C2OC)C(=C1)Cl
(2)InChI: InChI=1S/C11H10ClNO/c1-7-6-9(12)8-4-3-5-10(14-2)11(8)13-7/h3-6H,1-2H3
(3)InChIKey: RHSCPZBPNUZBOA-UHFFFAOYSA-N

Product Name

4-CHLORO-8-METHOXY-2-METHYLQUINOLINE

Synthetic route

4-Chloro-8-methoxy-2-methylquinoline Specification

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