4-Hydroxycinnamic acid supplier

Name
p-Hydroxy-cinnamic acid
EINECS 231-000-0
CAS No. 7400-08-0
Article Data284
CAS DataBase
Density 1.33 g/cm³
Solubility
Melting Point 212-214 °C
Formula C₉H₈O₃
Boiling Point 346.052 °C at 760 mmHg
Molecular Weight 164.161
Flash Point 177.284 °C
Transport Information
Appearance Light yellow to beige crystalline powder
Safety 26-36-36/37/39-22
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Cinnamicacid, p-hydroxy-(8CI);3-(4-Hydroxyphenyl)-2-propenoic acid;3-(4-Hydroxyphenyl)acrylic acid;4-Coumaric acid;
PSA 57.53000
LogP 1.49000

Synthetic route

: 141-82-2
malonic acid

: 123-08-0
4-hydroxy-benzaldehyde

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With piperidine; pyridine for 1h; Knoevenagel-Doebner-Stobbe Reaction; Reflux;	98%
With ammonium acetate for 0.05h; Irradiation;	97%
With aluminum oxide; lithium chloride for 0.0833333h; Doebner condensation; microwave irradiation;	97%

: 113641-76-2
(E)-4-iodocinnamic acid

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; sodium hydroxide In water at 100℃; for 6h;	88%

: 1443678-33-8
5-O-(E)-p-coumaroylquinic acid ethyl ester

A: 7400-08-0
p-Coumaric Acid

B: 77-95-2
D-(-)-quinic acid

Conditions

Conditions	Yield
With sulfuric acid; water In 1,4-dioxane at 90℃; for 3h;	A n/a B 2.5 mg

: 2'-O-acetyl-3-O-(E)-p-coumaroylsucrose

A: 57-48-7
D-Fructose

B: 50-99-7
D-glucose

C: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sulfuric acid; water In 1,4-dioxane at 90℃; for 3h;

...Expand

: 3',6'-di-O-acetyl-3-O-(E)-p-coumaroylsucrose

A: 57-48-7
D-Fructose

B: 50-99-7
D-glucose

C: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sulfuric acid; water In 1,4-dioxane at 90℃; for 3h;

...Expand

: 1446205-86-2
4,2',3',6'-tetra-O-acetyl-3-O-(E)-p-coumaroylsucrose

A: 57-48-7
D-Fructose

B: 50-99-7
D-glucose

C: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sulfuric acid; water In 1,4-dioxane at 90℃; for 3h;

...Expand

: 1392307-46-8
1,2',3',4',6'-penta-O-acetyl-3-O-(E)-p-coumaroylsucrose

A: 57-48-7
D-Fructose

B: 50-99-7
D-glucose

C: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sulfuric acid; water In 1,4-dioxane at 90℃; for 3h;

...Expand

: 7400-08-0
para-coumaric acid

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With iodine In d(4)-methanol at 50℃; for 0.166667h; Time; Green chemistry;

: 540-38-5
4-Iodophenol

: 79-10-7
acrylic acid

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate In water at 80℃; for 2h;	94%
With potassium carbonate In 1,4-dioxane; water at 80℃; for 12h; Inert atmosphere;	93%
With tetrakis(triphenylphosphine) palladium(0); lithium chloride; potassium hydroxide In water at 85℃; for 3h; Heck Reaction;	95 %Chromat.

: 60-18-4
L-tyrosine

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
Einw. von Bacillus proteus vulgaris in Ringerscher Loesung;
With 1,3-bis[tris(hydroxymethyl)methylamino]-propane; Arabidopsis thaliana phenylalanine ammonia lyase 1 In water at 37℃; pH=8.4; Enzyme kinetics; Further Variations:; Reagents;
free cell extract of Rhodotorula rubra (ATCC 889) In Tris-HCl buffer pH=8.5; Kinetics; Enzymatic reaction;

: kaempferol 3-O-{[(6-O-E-p-coumaroyl)-β-D-glucopyranosyl(1→2)]-α-L-rhamnopyranosyl(1→6)}-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sodium hydroxide; ascorbic acid at 20℃; for 2h; Darkness;

: quercetin 3-O-[(6-O-E-p-coumaroyl)-β-D-glucopyranosyl(1→2)]-β-D-galactopyranoside-7-O-(2-O-E-caffeoyl)-β-D-glucuropyranoside

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sodium hydroxide; ascorbic acid at 20℃; for 2h; Darkness;

quercetin 3-O-[(6-O-E-p-coumaroyl)-β-D-glucopyranosyl-(1→2)]-β-D-galactopyranoside-7-O-β-D-glucuropyranoside: quercetin 3-O-[(6-O-E-p-coumaroyl)-β-D-glucopyranosyl-(1→2)]-β-D-galactopyranoside-7-O-β-D-glucuropyranoside

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sodium hydroxide; ascorbic acid at 20℃; for 2h; Darkness;

: kaempferol 3-O-[(6-O-E-p-coumaroyl)-β-D-glucopyranosyl-(1→2)]-β-D-galactopyranoside-7-O-β-D-glucuropyranoside

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sodium hydroxide; ascorbic acid at 20℃; for 2h; Darkness;

: juglanoside J

A: 7400-08-0
p-Coumaric Acid

B: (1S)-1,2,3,4-tetrahydro-8-hydroxy-4-oxonaphthalen-1-yl 6-O-[(3,4,5-trihydroxyphenyl)carbonyl]-β-D-glucopyranoside

Conditions

Conditions	Yield
With sodium hydroxide at 20℃; for 6h;	A 1.5 mg B 2.8 mg

: 106-41-2
4-bromo-phenol

: 79-10-7
acrylic acid

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With sodium carbonate; palladium dichloride In water at 100℃; for 2h;	65%
With sodium carbonate; palladium dichloride at 100℃; for 2h;	65%

: 123-08-0
4-hydroxy-benzaldehyde

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With hydrogenchloride; malonic acid; aniline In pyridine

: 1-O-(E)-caffeoyl-2-O-p-(E)-coumaroyl-β-D-glucopyranose

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With hydrogenchloride; water at 90℃; for 3h; Sealed tube;

: 3943-97-3
methyl 4-hydroxycinnamate

: 7400-08-0
p-Coumaric Acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 20℃; for 18h; Inert atmosphere; Schlenk technique; Glovebox;	92%

: peonidin 3-O-[2-O-(2-O-(trans-sinapoyl)-glucosyl)-6-O-(trans-p-coumaroyl)-glucoside]-5-O-[6-O-(malonyl)-glucoside]

A: 2280-44-6
D-Glucose

B: 141-82-2
malonic acid

C: 7400-08-0
p-Coumaric Acid

D: 530-59-6
trans-3,5-dimethoxy-4-hydroxycinnamic acid

E: 134-01-0
peonidin chloride

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 1h;

...Expand

: cyanidin 3-O-[2-O-(2-O-(trans-feruloyl)-glucosyl)-6-O-(trans-p-coumaroyl)-glucoside]-5-O-[6-O-(malonyl)-glucoside]

A: 2280-44-6
D-Glucose

B: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

C: 141-82-2
malonic acid

D: 7400-08-0
p-Coumaric Acid

E: 528-58-5
cyanidin chloride

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 1h;

...Expand

: peonidin 3-O-[2-O-(2-O-(trans-feruloyl)-glucosyl)-6-O-(trans-p-coumaroyl)-glucoside]-5-O-[6-O-(malonyl)-glucoside]

A: 2280-44-6
D-Glucose

B: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

C: 141-82-2
malonic acid

D: 7400-08-0
p-Coumaric Acid

E: 134-01-0
peonidin chloride

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 1h;

...Expand

: allivictoside C

A: 7400-08-0
p-Coumaric Acid

B: kaempferol 3,7,4'-tri-O-β-D-glucopyranoside

Conditions

Conditions	Yield
With potassium hydroxide at 20℃; for 12h;

: allivictoside E

A: 7400-08-0
p-Coumaric Acid

B: kaempferol 3,7,4'-tri-O-β-D-glucopyranoside

Conditions

Conditions	Yield
With potassium hydroxide at 20℃; for 12h;

: 7400-08-0
p-Coumaric Acid

: 501-97-3
4-hydroxyphenylpropionic acid

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In methanol under 760 Torr; Ambient temperature;	100%
With hydrogen; palladium on activated charcoal In methanol	100%
With hydrogen; palladium on activated charcoal In ethyl acetate at 20℃;	99%

: 67-56-1
methanol

: 7400-08-0
p-Coumaric Acid

: 3943-97-3
methyl 4-hydroxycinnamate

Conditions

Conditions	Yield
With sulfuric acid for 24h; Reflux;	100%
With sulfuric acid for 7h; Heating;	99%
With sulfuric acid for 24h; Reflux;	99%

: 7400-08-0
p-Coumaric Acid

: 108-24-7
acetic anhydride

: 27542-85-4
4-acetoxycinnamic acid

Conditions

Conditions	Yield
With pyridine at 20℃;	100%
With pyridine; dmap for 1.5h;	97%
With pyridine at 25℃; for 24h;	95%

: 7400-08-0
p-Coumaric Acid

: 77-78-1
dimethyl sulfate

: 3901-07-3
3-(4-methoxy-phenyl)acrylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: p-Coumaric Acid With potassium carbonate In acetone at 20℃; for 0.25h; Stage #2: dimethyl sulfate In acetone at 20℃; for 8h; Heating / reflux;	99%
With potassium carbonate In acetone at 25℃; for 24h;	92%
With potassium carbonate In acetone for 3h; Reflux;	68%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 7400-08-0
p-Coumaric Acid

: 88492-43-7
4-hydroxycinnamic acid N-hydroxysuccinimide ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;	95%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h; Ambient temperature;	59%
With diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 2h;	58%

: 7400-08-0
p-Coumaric Acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 141222-28-8
(E)-3-(4'-((tert-butyldimethylsilyl)oxy)phenyl)acrylic acid

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 3h;	98%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h;	98%

: 7400-08-0
p-Coumaric Acid

: trans-p-coumaric acid-4-O-sulfate

Conditions

Conditions	Yield
With sulfur trioxide trimethylamine complex; sodium hydrogencarbonate; sodium hydroxide In water at 20℃; for 96h;	99%
With chlorosulfonic acid In pyridine at 20℃;	63%
With D-glucose; aryl sulfotransferase SULT1A1 Rattus norvegicus; isopropyl β-D-thiogalactopyranoside for 96h; Reagent/catalyst; Enzymatic reaction;

: 7400-08-0
p-Coumaric Acid

: 3943-97-3
methyl 4-hydroxycinnamate

Conditions

Conditions	Yield
With sulfuric acid In methanol Heating / reflux;	98%
With sulfuric acid In methanol; ethanol; water	61%
With methanol; sulfuric acid

: 7400-08-0
p-Coumaric Acid

: 2628-17-3
4-Vinylphenol

Conditions

Conditions	Yield
With 4-methoxy-phenol In water; N,N-dimethyl-formamide at 150℃; for 4h; Solvent;	97%
With 1-methyl-1H-imidazole; sodium hydrogencarbonate for 0.333333h; Heating; microwave irradiation;	94%
With bis(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)sebacate; potassium acetate In DMF (N,N-dimethyl-formamide) at 150℃; for 1.5h; Product distribution / selectivity;	94%

: 31252-42-3
4-benzylpyperidine

: 7400-08-0
p-Coumaric Acid

: (E)-1-(4-benzylpiperidin-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	56.5%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	47.7%
Stage #1: p-Coumaric Acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.5h; Condensation; Stage #2: 4-benzylpyperidine In tetrahydrofuran at 20℃; Acylation;	19%

: 7400-08-0
p-Coumaric Acid

: 10597-60-1
hydroxytyrosol

: (2E)-3-(4-hydroxyphenyl)-2-propenoic acid 2-(3,4-dihydroxyphenyl)ethyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 48h;	73%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h; Mitsunobu Displacement; chemoselective reaction;	66%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h; Schlenk technique; Inert atmosphere;	54%
With Escherichia coli strain B-CP1 at 30℃; for 24h; Microbiological reaction; Enzymatic reaction;

: 7400-08-0
p-Coumaric Acid

: 100-39-0
benzyl bromide

: 6272-45-3
(E)-4-benzyloxycinnamic acid

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide	92%
With potassium carbonate In acetone for 12h; Reflux;	92%
With sodium hydroxide In ethanol	82%
With potassium hydroxide In ethanol; water at 20℃; for 72h;	41%
With sodium hydroxide

: 64-17-5
ethanol

: 7400-08-0
p-Coumaric Acid

: 2979-06-8, 7361-92-4, 7362-39-2
ethyl (E)-4-hydroxycinnamate

Conditions

Conditions	Yield
With sulfuric acid at 60℃;	100%
With sulfuric acid at 65℃; for 18h;	95%
With hydrogenchloride	92%

: 7400-08-0
p-Coumaric Acid

: 90557-60-1
(E)-3-(4-hydroxyphenyl)acryloylhydrazide

Conditions

Conditions	Yield
Stage #1: p-Coumaric Acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 25℃; for 2h; Stage #2: With hydrazine hydrate In acetonitrile at 0 - 10℃;	79%
Stage #1: p-Coumaric Acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 2h; Stage #2: With hydrazine hydrate In acetonitrile; cyclohexene at 0 - 10℃;	46%
Stage #1: p-Coumaric Acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 2h; Stage #2: With hydrazine; cyclohexene In acetonitrile at 0 - 20℃; for 1.33333h;	36%
Multi-step reaction with 2 steps 1: 74 percent / Et3N / ethyl acetate / 6 h / Heating 2: 55 percent / N2H4 / CHCl3 / Heating View Scheme

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 7400-08-0
p-Coumaric Acid

: (E)-1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	76.7%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	62.7%

: 60-12-8
2-phenylethanol

: 7400-08-0
p-Coumaric Acid

: (2E)-3-(4-hydroxyphenyl)-2-propenoic acid 2-phenylethyl ester

Conditions

Conditions	Yield
With ytterbium(III) triflate In nitromethane at 120℃; for 1h;	70.6%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 48h;	40%
With Escherichia coli strain B-CP1 at 30℃; for 24h; Microbiological reaction; Enzymatic reaction;

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 7400-08-0
p-Coumaric Acid

: (E)-3-(4-hydroxyphenyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)acrylamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	84%

: 71-23-8
propan-1-ol

: 7400-08-0
p-Coumaric Acid

: 94530-69-5
(E)-propyl 3-(4-hydroxyphenyl)acrylate

Conditions

Conditions	Yield
With sulfuric acid for 3h;	72%
With dmap; dicyclohexyl-carbodiimide at 50℃; for 24h;	71%
With sulfuric acid Reflux;	58.43%
	16%
With sulfuric acid

: 7400-08-0
p-Coumaric Acid

: 3188-13-4
ethyl chloromethyl ether

: 642471-45-2
ethoxymethyl 4-hydroxycinnamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	84%
With triethylamine In dichloromethane at 0℃;	84%

: 2009-83-8
6-chloro-1-hexanol

: 7400-08-0
p-Coumaric Acid

: 503000-67-7
4-(6-hydroxyhexyloxy)cinnamic acid

Conditions

Conditions	Yield
Stage #1: p-Coumaric Acid With potassium hydroxide; potassium iodide In ethanol; water for 0.166667h; Stage #2: 6-chloro-1-hexanol In ethanol; water at 30 - 40℃; Heating / reflux;	62%
With 1,3-dimethyl-2-imidazolidinone; potassium carbonate; potassium iodide at 130℃; for 17h;	47%
Stage #1: p-Coumaric Acid With potassium iodide; potassium hydroxide In ethanol; water for 0.166667h; Reflux; Stage #2: 6-chloro-1-hexanol In ethanol; water for 48h; Reflux; Stage #3: With hydrogenchloride In ethanol; water	46.8%

: 7400-08-0
p-Coumaric Acid

: 104-94-9
4-methoxy-aniline

: C16H15NO3

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane; N,N-dimethyl-formamide for 6h;	85%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 23℃; for 24h;	78.5%

: 7400-08-0
p-Coumaric Acid

: Carvacryl chloroacetate

: 2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate

Conditions

Conditions	Yield
With triethylamine; potassium iodide In N,N-dimethyl-formamide at 20℃; for 24h;	80%

: 2759-28-6
1-phenylmethylpiperazine

: 7400-08-0
p-Coumaric Acid

: (E)-1-(4-benzylpiperazin-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	63.7%

: 7400-08-0
p-Coumaric Acid

: 93930-15-5
hydroxymethylparthenolide

: ((1aR,7aS,10aS,10bS,E)-1a-methyl-8-methylene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[2′,3′:9,10]cyclodeca[1,2-b]furan-5-yl)methyl (E)-3-(4-hydroxyphenyl)acrylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; Inert atmosphere;	76%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h; Inert atmosphere; Cooling with ice;	69%

: 7400-08-0
p-Coumaric Acid

: 111-27-3
hexan-1-ol

: trans-hexyl 3-(4-hydroxyphenyl)propenoate

Conditions

Conditions	Yield
Stage #1: p-Coumaric Acid; hexan-1-ol In tetrahydrofuran at 0℃; for 0.5h; Mitsunobu Displacement; Stage #2: With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; Mitsunobu Displacement;	36.88%
With di-isopropyl azodicarboxylate; triphenylphosphine In N,N-dimethyl-formamide for 12h; Ambient temperature;	15 mg

4-Hydroxycinnamic acid Chemical Properties

IUPAC Name: (E)-3-(4-Hydroxyphenyl)prop-2-enoic acid
Synonyms of 4-Coumaric acid (CAS NO.7400-08-0): 3-(4-Hydroxyphenyl)-2-propenoic acid ; 4-Hydroxycinnamic acid ; Hydroxycinnamic acid ; beta-(4-Hydroxyphenyl)acrylic acid ; p-Hydroxyphenylacrylic acid ; 2-Propenoic acid, 3-(4-hydroxyphenyl)-
CAS NO: 7400-08-0
Molecular Formula: C₉H₈O₃
Molecular Weight: 164.16
Molecular Structure:
EINECS: 231-000-0
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 3
Polar Surface Area: 35.53 Å²
Index of Refraction: 1.66
Molar Refractivity: 45.58 cm³
Molar Volume: 123.4 cm³
Surface Tension: 62.4 dyne/cm
Density: 1.329 g/cm³
Flash Point: 177.3 °C
Enthalpy of Vaporization: 62.28 kJ/mol
Boiling Point: 346.1 °C at 760 mmHg
Vapour Pressure: 2.24E-05 mmHg at 25°C
Melting point: 212-214°C
Appearance: Light yellow to beige crystalline powder
SMILES: O=C(O)/C=C/c1ccc(O)cc1
InChI: InChI=1/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
InChIKey: NGSWKAQJJWESNS-ZZXKWVIFBJ
Std. InChI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
Std. InChIKey: NGSWKAQJJWESNS-ZZXKWVIFSA-N
Product Categories of 4-Coumaric acid (CAS NO.7400-08-0): Cinnamic acid

4-Hydroxycinnamic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	657mg/kg (657mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 104, Pg. 793, 1984.

4-Hydroxycinnamic acid Consensus Reports

Reported in EPA TSCA Inventory.

4-Hydroxycinnamic acid Safety Profile

Safety Information of 4-Coumaric acid (CAS NO.7400-08-0):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-22
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 2
RTECS: GD9095000
Moderately toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes. See also COUMARIN

4-Hydroxycinnamic acid Specification

Stability and Reactivity :
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide.
Hazardous Polymerization Has not been reported.
First Aid Measures:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

p-Hydroxy-cinnamic acid

Synthetic route

4-Hydroxycinnamic acid Chemical Properties

4-Hydroxycinnamic acid Toxicity Data With Reference

4-Hydroxycinnamic acid Consensus Reports

4-Hydroxycinnamic acid Safety Profile

4-Hydroxycinnamic acid Specification

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