Product Name

  • Name

    4-HYDROXYCYCLOPHOSPHAMIDE

  • EINECS
  • CAS No. 67292-62-0
  • Density
  • Solubility
  • Melting Point
  • Formula C7H15Cl2N2O3P
  • Boiling Point 351.4°C at 760 mmHg
  • Molecular Weight 277.11
  • Flash Point 166.3°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl−, POx, and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 67292-62-0 (4-HYDROXYCYCLOPHOSPHAMIDE)
  • Hazard Symbols
  • Synonyms 4-OH-CP;
  • PSA 58.32000
  • LogP 1.65000

4-Hydroxycyclophosphamide Chemical Properties

Molecular Formula: C7H15Cl2N2O2P
Molar mass: 261.085961 g/mol
Flash Point: 166.3 °C
Boiling Point: 351.4 °C at 760 mmHg
Vapour Pressure: 2.43E-06 mmHg at 25°C
Structure of 4-Hydroxycyclophosphamide (67292-62-0):
 
XLogP3-AA: 0.8
H-Bond Donor: 2
H-Bond Acceptor: 4
Systematic Name of 4-Hydroxycyclophosphamide (67292-62-0): 2-Bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-ol 
SMILES: ClCCN(P1OCCC(O)N1)CCCl 
InChI: InChI=1/C7H15Cl2N2O2P/c8-2-4-11(5-3-9)14-10-7(12)1-6-13-14/h7,10,12H,1-6H2 
InChIKey: UGYXAZPJFUKXSM-UHFFFAOYAV 
Std. InChI: InChI=1S/C7H15Cl2N2O2P/c8-2-4-11(5-3-9)14-10-7(12)1-6-13-14/h7,10,12H,1-6H2 
Std. InChIKey: UGYXAZPJFUKXSM-UHFFFAOYSA-N

4-Hydroxycyclophosphamide Toxicity Data With Reference

1.    

mmo-sat 10 µg/plate

     CNREA8    Cancer Research. 42 (1982),3016.
2.    

mma-sat 10 µg/plate

     CNREA8    Cancer Research. 42 (1982),3016.
3.    

sce-hmn:lym 1 µmol/L

     MUREAV    Mutation Research. 129 (1984),47.
4.    

dnd-mus:leu 50 µmol/L

     CNREA8    Cancer Research. 44 (1984),5156.
5.    

ivn-rat LD50:139 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 18 (1975),376.
6.    

ipr-mus LD50:141 mg/kg

     INNDDK    Investigational New Drugs. The Journal of New Anticancer Agents. 2 (1984),253.

4-Hydroxycyclophosphamide Safety Profile

Poison by intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl−, POx, and NOx.

4-Hydroxycyclophosphamide Specification

 4-Hydroxycyclophosphamide (67292-62-0) also can be called 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroxytetrahydro-, 2-oxide ; 4-OH-CP ;and ; 2-(Bis(2-chloroethyl)amino)-4-hydroxytetrahydro-2H-1,3,2-oxazaphosphorine .

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