4-Hydroxypyridine supplier

Name
4-Hydroxypyridine
EINECS 210-958-3
CAS No. 626-64-2
Article Data66
CAS DataBase
Density 1.111 g/cm³
Solubility soluble in water
Melting Point 150-151 °C(lit.)
Formula C₅H₅NO
Boiling Point 204.3 °C at 760 mmHg
Molecular Weight 95.1008
Flash Point 107.8 °C
Transport Information
Appearance beige crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 5-21-07-00152 (Beilstein Handbook Reference);4-Pyridinol;gamma-Hydroxypyridine;1H-Pyridin-4-one;4-hydropyridine;Pyridin-4-ol;
PSA 33.12000
LogP 0.78720

Synthetic route

: 1692-15-5
4-pyridylboronic acid

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With fullerene (C60); oxygen; N-ethyl-N,N-diisopropylamine In ethanol; toluene Irradiation; Flow reactor;	99%
With water; oxygen; sodium sulfite at 50℃; for 1h; Green chemistry;	90%
With dihydrogen peroxide In ethanol at 20℃; for 0.166667h;	79%

: 1338215-40-9
4-(2-trimethylsilanylethoxy)pyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
Stage #1: 4-(2-trimethylsilanylethoxy)pyridine With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere; Stage #2: With water In N,N-dimethyl-formamide Inert atmosphere;	95%

: 3,5-dichloropiperidin-4-one

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 40 - 45℃; for 3h;	93.3%

: 620-08-6
4-methoxypyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran for 2h; Reagent/catalyst; Solvent; Reflux; Inert atmosphere; chemoselective reaction;	87%
With toluene-4-sulfonic acid; lithium chloride In 1-methyl-pyrrolidin-2-one at 180℃; for 1h;	85%
With hexamethyldisilathiane; sodium methylate In various solvent(s) at 180℃; for 24h;	60%

: 1417816-42-2
benzyl 4-pyridyl carbonate

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction;	81%

: 80937-33-3
oxygen

: 1692-15-5
4-pyridylboronic acid

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With triethanolamine In water at 20℃; for 18h; Sonication; Irradiation; Green chemistry;	76%

: 15854-87-2
4-iodopyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere;	73%
With oxygen; triethylamine In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;	39%
Multi-step reaction with 2 steps 1.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 14 h / 110 °C / Inert atmosphere; Sealed tube 2.1: cesium fluoride / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere 2.2: Inert atmosphere View Scheme

: C7H9NO2

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;	57%

: 40504-49-2
4-allyloxy-pyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;	57%

: 513-81-5
2,3-dimethyl-buta-1,3-diene

: 178620-85-4
4-pyridyl phenacyl sulfoxide

A: 626-64-2
pyridin-4-ol

B: 80738-10-9
2-Benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiopyran

Conditions

Conditions	Yield
In 1,4-dioxane at 100℃; for 24h;	A n/a B 36%

...Expand

: C13H13NO2

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;	20%

: 49826-70-2
4-(benzyloxy)pyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;	19%
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 21h; Schlenk technique; Irradiation; Inert atmosphere; chemoselective reaction;	0.0188 g

: 33399-46-1
4-ethoxypyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;	11%

: 110-86-1
pyridine

A: 626-64-2
pyridin-4-ol

B: 553-26-4
4,4'-bipyridine

Conditions

Conditions	Yield
With oxygen; trifluoroacetic anhydride for 72h; Ambient temperature;	A 0.18% B 2.3%

: 108-97-4
4-pyrone

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With ammonia
With ammonia at 120 - 140℃;

: 504-24-5
4-aminopyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With sulfuric acid Diazotization;

: 626-61-9
4-Chloropyridine

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
Destillation;

: 6890-62-6
4-hydroxypyridine N-oxide

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With hydrogenchloride; palladium on activated charcoal; ethanol; water Hydrogenation;
With methanol; nickel at 120℃; under 51485.6 Torr; Hydrogenation;
With 1,4-dioxane; phosphorus trichloride
With acetic anhydride; ethyl acetate
With palladium on activated charcoal; ethanol Hydrogenation;

: 2683-66-1
4-benzyloxypyridine-N-oxide

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With methanol; palladium on activated charcoal; nickel Hydrogenation;
With palladium on activated charcoal; ethanol Hydrogenation;

: 5421-92-1
1-(4-pyridyl)pyridinium chloride hydrochloride

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With water

: 110-86-1
pyridine

A: 109-00-2
3-HYDROXYPYRIDINE

B: 142-08-5
2-hydroxypyridin

C: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With nitrous oxide saturated solution; hexachloroiridate(IV) Product distribution; Irradiation; in presence and absence of var. oxidants ;

...Expand

: 108-96-3
4-pyridone

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
In chloroform Equilibrium constant; Ambient temperature;
In water at 20℃; Equilibrium constant; polar - non-polar tautomer equilibrium;
In gaseous matrix Thermodynamic data; Equilibrium constant; ΔRGo, ΔRH, tests in solvents of different polarity;

: 36228-61-2
4-(Benzoyloxy)pyridine

A: 626-64-2
pyridin-4-ol

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide In water; acetonitrile at 25℃; Rate constant; k=200 sec-1M-1;

4-oxy-pyridine-carboxylic acid-(2): 4-oxy-pyridine-carboxylic acid-(2)

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
ueber den Schmelzpunkt;

4-oxy-pyridine-carboxylic acid-(3): 4-oxy-pyridine-carboxylic acid-(3)

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
at 260℃;

4-oxy-pyridine-dicarboxylic acid-(2.6): 4-oxy-pyridine-dicarboxylic acid-(2.6)

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
at 230 - 250℃;
With water at 196℃;

4-oxy-pyridine-dicarboxylic acid-(3.5): 4-oxy-pyridine-dicarboxylic acid-(3.5)

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With hydrogenchloride at 210 - 215℃;

: 101349-88-6
1-hydroxy-1H-pyridin-4-one

: 67-66-3
chloroform

: 7719-12-2, 52843-90-0
phosphorus trichloride

: 626-64-2
pyridin-4-ol

...Expand

<1,4'>bipyridylium bromide hydrobromide: <1,4'>bipyridylium bromide hydrobromide

: 626-64-2
pyridin-4-ol

Conditions

Conditions	Yield
With water

: 626-64-2
pyridin-4-ol

: 5382-16-1
4-HYDROXYPIPERIDINE

Conditions

Conditions	Yield
In methanol; water	100%
With water; ruthenium Hydrogenation;
With water; pyrographite; ruthenium at 140℃; under 87525.4 Torr; Hydrogenation;
With hydrogenchloride; 5% active carbon-supported ruthenium; hydrogen In water at 95℃; under 26252.6 Torr; for 24h; Reagent/catalyst; Time; Autoclave;	99.5 %Chromat.
With palladium on activated charcoal; hydrogen; acetic acid at 20℃; under 760.051 Torr; for 21h; Time;	55 %Spectr.

: 626-64-2
pyridin-4-ol

: 25813-25-6
3,5-dibromo-4-hydroxypyridine

Conditions

Conditions	Yield
With N-Bromosuccinimide In tetrachloromethane at 20℃; for 24h;	100%
With N-Bromosuccinimide In tetrachloromethane at 20℃; for 24h;	95%
With N-Bromosuccinimide In tetrachloromethane at 25℃; for 30h; Inert atmosphere;	88%

: 626-64-2
pyridin-4-ol

: 350-46-9
4-Fluoronitrobenzene

: 79228-85-6
1-(4-nitrophenyl)-4-pyridone

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 1.5h; Substitution;	100%
With caesium carbonate In DMF (N,N-dimethyl-formamide)
With caesium carbonate In N,N-dimethyl-formamide

: 626-64-2
pyridin-4-ol

: 88-88-0
2,4,6-trinitrochlorobenzene

: N-(2,4,6-trinitrophenyl)-4-pyridone

Conditions

Conditions	Yield
In acetonitrile at 30℃; Product distribution; Kinetics; Further Variations:; Solvents;	100%

: 626-64-2
pyridin-4-ol

: 76899-07-5, 78963-47-0, 78963-48-1, 78963-60-7, 80951-41-3, 81275-02-7, 85647-75-2, 85954-95-6, 92217-74-8, 104527-11-9, 76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: (3R,4R)-3-{(R)-1-[(tert-butyldimethylsilyl)oxy]ethyl}-4-(pyridin-4-yloxy)azetidin-2-one

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile for 1h;	100%

: 626-64-2
pyridin-4-ol

: 942152-80-9
7-bromo-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid methyl ester

: 4-hydroxy-1-methyl-2-oxo-7-(pyridin-4-yloxy)-1,2-dihydroquinoline-3-carboxylic acid methyl ester

Conditions

Conditions	Yield
With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate In N,N-dimethyl-formamide at 140℃; for 12h; Inert atmosphere;	100%

: 626-64-2
pyridin-4-ol

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 308386-35-8
1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃;	99%
	75%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 55℃; for 14h; Mitsunobu reaction;	67%

: 626-64-2
pyridin-4-ol

: 548770-64-5
methyl-phenyl-carbamic acid 4-(2-hydroxy-ethyl)-phenyl ester

: 811435-86-6
methyl-phenyl-carbamic acid 4-[2-(pyridin-4-yloxy)-ethyl]-phenyl ester

Conditions

Conditions	Yield
With tributylphosphine; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 20℃; for 16h;	99%

: 626-64-2
pyridin-4-ol

: 663164-11-2
chloro(2,6-bis(dimethylaminomethyl)phenyl-N,C,N)platinum(II)

: 881887-98-5
[2,6-bis(dimethylaminomethyl)phenylplatinum]-4-pyridone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol under N2 atm. Pt complex, 4-hydroxypyridine, and NaOH in EtOH were stirred for 2 h; solvent was evapd. in vacuo, residue was dissolved in CH2Cl2 in air and filtered, filtrate was evapd.; elem. anal.;	99%

: 626-64-2
pyridin-4-ol

: 134450-56-9
4,5-difluoro-1,2-dicyanobenzene

: 4,5-bis(4-oxopyridin-1(4H)-yl)phthalonitrile

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 5h; Inert atmosphere;	99%

: 626-64-2
pyridin-4-ol

: 948859-48-1
1-(4-fluorophenyl)prop-2-ynyl acetate

: C14H10FNO

Conditions

Conditions	Yield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

: 626-64-2
pyridin-4-ol

: 1191267-32-9
1-(3-methylphenyl)-2-propynyl acetate

: C15H13NO

Conditions

Conditions	Yield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

: 626-64-2
pyridin-4-ol

: 1015083-64-3
1-(3,4-dimethoxyphenyl)prop-2-ynyl acetate

: C16H15NO3

Conditions

Conditions	Yield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

: 626-64-2
pyridin-4-ol

: 1240238-60-1
1-(2-methylphenyl)-2-propynyl acetate

: C15H13NO

Conditions

Conditions	Yield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

: 626-64-2
pyridin-4-ol

: 952686-35-0
methyl p-methylphenylallyl carbonate

: C15H15NO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;	99%

: 626-64-2
pyridin-4-ol

: 952686-36-1
p-bromophenylpropene methyl carbonate

: C14H12BrNO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;	99%

: 626-64-2
pyridin-4-ol

: (1r,3r)-3-(benzyloxy)cyclobutan-1-ol

: 4-[(1s,3s)-(3-benzyloxy)cyclobutoxy]pyridine

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 110℃; Temperature; Solvent;	99%

: 626-64-2
pyridin-4-ol

: 24424-99-5
di-tert-butyl dicarbonate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: pyridin-4-ol With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex In 2,2,2-trifluoroethanol at 50℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: di-tert-butyl dicarbonate With triethylamine In 2,2,2-trifluoroethanol at 20℃; Inert atmosphere; Schlenk technique; Sealed tube;	99%

: 626-64-2
pyridin-4-ol

: 5435-54-1
4-hydroxy-3-nitropyridine

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate at 0 - 100℃; for 1h; Inert atmosphere;	98%
With fuming sulphuric acid; nitric acid for 2h; Reflux;	92%
With sulfuric acid; potassium nitrate at 100℃;	92%

: 626-64-2
pyridin-4-ol

: 2398-37-0
3-methoxyphenyl bromide

: 1-(3-methoxyphenyl)pyridin-4(1H)-one

Conditions

Conditions	Yield
With potassium carbonate; copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline In N,N-dimethyl-formamide at 110℃; for 24h;	98%

: 626-64-2
pyridin-4-ol

: 947169-76-8
C15H14O3

: C18H15NO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 24h; Mechanism; Inert atmosphere; stereoselective reaction;	98%

: 626-64-2
pyridin-4-ol

: 776296-22-1
3-(4-chlorophenyl)allyl methyl carbonate

: C14H12ClNO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;	98%

: 626-64-2
pyridin-4-ol

: 626-55-1
3-Bromopyridine

: 34847-11-5
1-(pyridin-3-yl)pyridin-4(1H)-one

Conditions

Conditions	Yield
With potassium carbonate; copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline In dimethyl sulfoxide at 110℃; for 24h;	97%

: 626-64-2
pyridin-4-ol

: 91652-00-5
4-{[6-(methacryloyloxy)hexyl]oxy}benzoic acid

: C22H25NO5

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 23℃;	97%

: 626-64-2
pyridin-4-ol

: 1222181-25-0
m-methylphenylallyl methyl carbonate

: C15H15NO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;	97%

: 626-64-2
pyridin-4-ol

: C11H10F2O3

: C14H11F2NO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;	97%

: 626-64-2
pyridin-4-ol

: 1186634-65-0
2-bromocinnamyl methyl carbonate

: C14H12BrNO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 24h; Inert atmosphere; stereoselective reaction;	97%

: 626-64-2
pyridin-4-ol

: 1356240-34-0
C39H35BrN2O6

: 1356240-42-0
C44H39N3O7

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	96%

: 626-64-2
pyridin-4-ol

: 99520-55-5
3-acetoxy-3-(4-methoxyphenyl)prop-1-yne

: C15H13NO2

Conditions

Conditions	Yield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere; Schlenk technique; enantioselective reaction;	96%

4-Hydroxypyridine Specification

The 4-Hydroxypyridine, with the CAS registry number of 626-64-2, is also known as 4-Pyridinol. It belongs to the product categories of Pyridine; Heterocyclic Compounds; Pyridines. Its EINECS registry number is 210-958-3. This chemical's molecular formula is C₅H₅NO and molecular weight is 95.1. What's more, its IUPAC name is 1H-Pyridin-4-one. In addition, it should be stored in dry, cool, airtight place. And it should avoid contact with oxidant, otherwise it would decompose.

Physical properties about 4-Hydroxypyridine are: (1)ACD/LogP: -0.99; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1; (4)ACD/LogD (pH 7.4): -0.99; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 6.82; (8)ACD/KOC (pH 7.4): 6.86; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 20.31 Å²; (13)Index of Refraction: 1.513; (14)Molar Refractivity: 25.74 cm³; (15)Molar Volume: 85.5 cm³; (16)Polarizability: 10.2×10^-24 cm³; (17)Surface Tension: 35.7 dyne/cm; (18)Density: 1.111 g/cm³; (19)Flash Point: 107.8 °C; (20)Enthalpy of Vaporization: 44.06 kJ/mol; (21)Boiling Point: 204.3 °C at 760 mmHg; (22)Melting Point: 150-151 °C(lit. ); (23)Vapour Pressure: 0.265 mmHg at 25 °C.

Preparation: this chemical is prepared by 4-Methoxy-pyridine. The reaction needs reagents Hexamethyldisilathiane and Sodium methoxide. The reaction time is 24 hours with reaction temperature of 180 °C. The yield is about 60 %.

Uses: (1)it can be used as intermediate to synthetic diuretic drug Torasemide or other drugs; (2)it is used to produce other chemicals. For example, it is used to produce 3-Nitro-pyridin-4-ol at heating. This reaction needs reagents HNO₃, H₂SO₄ and SO₃. Other condition of this reaction is reaction time of 1 hour. The yield is about 72 %.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes, respiratory system and skin. In addition, this chemical may cause inflammation to the skin or other mucous membranes. During using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C\1\C=C/N/C=C/1
(2) InChI: InChI=1/C5H5NO/c7-5-1-3-6-4-2-5/h1-4H,(H,6,7)
(3) InChIKey: GCNTZFIIOFTKIY-UHFFFAOYAB

Product Name

4-Hydroxypyridine

Synthetic route

4-Hydroxypyridine Specification

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