4-Methoxybenzylchloride supplier

Name
4-Methoxybenzylchloride
EINECS 212-540-6
CAS No. 824-94-2
Article Data170
CAS DataBase
Density 1.109 g/cm³
Solubility slowly decomposes in water
Melting Point -1 °C(lit.)
Formula C₈H₉ClO
Boiling Point 243.6 °C at 760 mmHg
Molecular Weight 156.612
Flash Point 109.4 °C
Transport Information UN 3265 8/PG 3
Appearance Colorless liquid
Safety 26-27-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols
Synonyms Anisole,p-(chloromethyl)- (6CI,7CI,8CI);1-(Chloromethyl)-4-(methyloxy)benzene;1-(Chloromethyl)-4-methoxybenzene;4-(Chloromethyl)-1-methoxybenzene;4-(Chloromethyl)anisole;4-(Chloromethyl)phenyl methyl ether;4-Methyloxybenzyl chloride;NSC 172955;p-(Chloromethyl)(methoxy)benzene;p-(Chloromethyl)anisole;p-Anisyl chloride;a-Chloro-4-methoxytoluene;a-Chloro-p-methoxytoluene;p-Methoxybenzyl chloride;
PSA 9.23000
LogP 2.43400

Synthetic route

: 105-13-5
4-Methoxybenzyl alcohol

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With 1,2,3-Benzotriazole; thionyl chloride In dichloromethane at 20℃; Substitution;	100%
With thionyl chloride; triethylamine In dichloromethane at -10 - 0℃; for 4.25h; Large scale;	99%
With oxalyl dichloride; 1-methyl-3-(2-(3-methyl-2-oxoimidazolidin-1-yl)ethyl)-1H-imidazol-3-ium hexafluorophosphate at 20 - 60℃; for 24h; Reagent/catalyst;	99%

: 15733-09-2
1-methoxy-4-((methylsulfinyl)methyl)benzene

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With hydrogenchloride In tetrachloromethane for 0.25h; Heating;	100%

: 15733-09-2
1-methoxy-4-((methylsulfinyl)methyl)benzene

HCl gas: HCl gas

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
In tetrachloromethane for 15h; Heating;	100%

: 27979-81-3
Methyl-thiocarbamic acid S-(4-methoxy-benzyl) ester

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃;	98%

: 34820-80-9
p-methoxybenzylmercuric chloride

A: 824-94-2
p-methoxybenzyl chloride

B: mercury

Conditions

Conditions	Yield
In nitromethane byproducts: Hg2Cl2; vacuum-sealed ampule, 65°C for 50h; separation of Hg, analysis of decanted soln. by TLC and GLC;	A 90% B 97%

: 14629-56-2
trimethyl(4-methoxybenzyloxy)silane

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With 4-aminophenyl diphenylphosphinite; N-chloro-succinimide In dichloromethane for 1h; Heating;	96%

: 18494-82-1
2-(4-methoxy-benzyloxy)-tetrahydro-pyran

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With 4-aminophenyl diphenylphosphinite; N-chloro-succinimide In dichloromethane for 1.5h; Heating;	95%

: 34820-80-9
p-methoxybenzylmercuric chloride

A: 824-94-2
p-methoxybenzyl chloride

B mercury: mercury

Conditions

Conditions	Yield
In nitromethane at 65℃; for 50h;	A 90% B n/a

: 5405-95-8
4,4'-dimethoxydibenzyl ether

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With tetrachlorosilane; NbCl3(N,N′-bis-(2,6-diisopropylphenyl)-1,4-diaza-2,3-dimethyl-1,3-butadiene) In chloroform-d1 at 20℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;	85%

: 75-62-7
Bromotrichloromethane

: 105-13-5
4-Methoxybenzyl alcohol

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
Stage #1: Bromotrichloromethane With triphenylphosphine In dichloromethane at 20℃; for 0.666667h; Appel reaction; in air; Stage #2: 4-Methoxybenzyl alcohol In dichloromethane at 20℃; Appel reaction; in air;	84%

: 67-56-1
methanol

: 105-13-5
4-Methoxybenzyl alcohol

A: 1515-81-7
1-methoxy-4-(methoxymethyl)benzene

B: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
Stage #1: 4-Methoxybenzyl alcohol With titanium tetrachloride In chloroform at 20℃; for 0.0166667h; Molecular sieve; Stage #2: methanol In chloroform for 9h; Reflux;	A 82% B 10%
Stage #1: 4-Methoxybenzyl alcohol With titanium tetrachloride In chloroform at 20℃; for 0.0166667h; Molecular sieve; Stage #2: methanol In chloroform for 1h; Reflux;	A 5% B 12%

...Expand

: 93394-70-8
cyclohexyl(4-methoxybenzyl)sulfane

A: 2550-40-5
1,2-dicyclohexyl disulfide

B: 123-11-5
4-methoxy-benzaldehyde

C: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; tris-(4-bromophenyl)aminium hexachloroantimonate In dichloromethane; acetonitrile for 1h; Mechanism;	A 80% B n/a C 80%

...Expand

: 50-00-0
formaldehyd

: 100-66-3
methoxybenzene

A: 25445-34-5
1-methoxy-2,4-bis(chloromethyl)benzene

B: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; 1-ethyl-3-methylimidazolium hexafluorophosphate at 70℃; for 5h; Ionic liquid;	A 79% B 16%
With hydrogenchloride; 1-ethyl-3-methylimidazolium tetrafluoroborate at 70℃; for 5h;	A 76% B 17%

...Expand

: 98-88-4
benzoyl chloride

: 105-13-5
4-Methoxybenzyl alcohol

A: 24318-41-0
p-methoxybenzyl benzoate

B: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With racemic methyl phenyl sulfoxide In acetonitrile at 0 - 20℃; for 14.25h; Sealed tube;	A n/a B 78%
In tert-butyl methyl ether at 20℃; for 24h;	A n/a B 32 %Spectr.

...Expand

: 102607-00-1
S-(4-methoxybenzyl) ethanethioate

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃;	74%

: 123-11-5
4-methoxy-benzaldehyde

A: 5405-95-8
4,4'-dimethoxydibenzyl ether

B: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane; thionyl chloride; 1,1,3,3-Tetramethyldisiloxane; zinc(II) iodide at -70℃; for 2.5h;	A 40% B 60%

: 105-13-5
4-Methoxybenzyl alcohol

A: 123-11-5
4-methoxy-benzaldehyde

B: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With N-chloro-succinimide; N-(phenylthio)-N-(tert-butyl)amine; potassium carbonate; 4 A molecular sieve In dichloromethane at 0℃; for 1h;	A 29% B 60%

: 123-11-5
4-methoxy-benzaldehyde

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With dichloromethylsilane; iron(III) chloride In 1,2-dimethoxyethane for 4h; Heating;	55%
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C 2: thionyl chloride / dichloromethane / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 2: thionyl chloride / Inert atmosphere View Scheme

: 32315-10-9
bis(trichloromethyl) carbonate

: 148120-38-1
1-(phenylmethyl)-4-[(4'-methoxyphenyl)methyl]piperazine

A: 63763-66-6
4-(phenylmethyl)-1-piperazine carbonyl chloride

B: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
In dichloromethane	A 53% B n/a

...Expand

: 64-17-5
ethanol

: 17988-20-4
(4-methoxy-benzyl)-trimethyl-silane

A: 55249-73-5
1-ethoxymethyl-4-methoxybenzene

B: 123-11-5
4-methoxy-benzaldehyde

C: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With oxovanadium(V) ethoxydichloride; oxygen at 20℃; for 6h;	A 51% B 40% C 5%

...Expand

: 74260-40-5
4-methoxybenzyltri-n-butylstannane

A: 123-11-5
4-methoxy-benzaldehyde

B: 824-94-2
p-methoxybenzyl chloride

C: 105-13-5
4-Methoxybenzyl alcohol

Conditions

Conditions	Yield
With C2H2Cl2F3O2V; oxygen In tert-butyl alcohol at 20℃; for 2h;	A 48% B 38% C 14%

...Expand

: 17988-20-4
(4-methoxy-benzyl)-trimethyl-silane

: 67-63-0
isopropyl alcohol

A: 98446-83-4
1-methoxy-4-[(propan-2-yloxy)methyl]benzene

B: 123-11-5
4-methoxy-benzaldehyde

C: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With oxovanadium(V) ethoxydichloride; oxygen at 0℃; for 24h;	A 8% B 44% C 4%

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: 37931-52-5
4-methoxy-N-methyl-N-phenylbenzenemethanamine

A: 4285-42-1
N-phenyl-N-methylcarbamoyl chloride

B: 824-94-2
p-methoxybenzyl chloride

C: C16H17ClNO2(1+)*Cl(1-)

Conditions

Conditions	Yield
for 0.5h;	A 44% B n/a C n/a

...Expand

: 70887-29-5
4-methoxybenzyl iodide

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With FeCl2(phen)3 In acetonitrile at 60℃; for 0.5h;	34%
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;	27 % Spectr.

: 117309-25-8
(4-Methoxy-benzyl)-phosphonic acid isopropyl ester 2-thioxo-2H-pyridin-1-yl ester

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With tetrachloromethane; 2,2'-azobis(isobutyronitrile) In benzene Heating;	27%

: 51755-57-8
(4-Methoxybenzyl)trimethylstannane

A: 1657-55-2
1,2-bis(4-methoxyphenyl)ethane

B: 123-11-5
4-methoxy-benzaldehyde

C: 824-94-2
p-methoxybenzyl chloride

D: 105-13-5
4-Methoxybenzyl alcohol

Conditions

Conditions	Yield
With iodosylbenzene; (5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)iron(III) chloride In benzene at 25℃; for 3h;	A 5% B 16% C 3% D 13%
With iodosylbenzene; (5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)iron(III) chloride In dichloromethane at 25℃; for 3h;	A 4% B 12% C 8% D 11%

...Expand

: 74260-40-5
4-methoxybenzyltri-n-butylstannane

A: 1657-55-2
1,2-bis(4-methoxyphenyl)ethane

B: 123-11-5
4-methoxy-benzaldehyde

C: 824-94-2
p-methoxybenzyl chloride

D: 105-13-5
4-Methoxybenzyl alcohol

Conditions

Conditions	Yield
With iodosylbenzene; (5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)iron(III) chloride In methanol; dichloromethane; water at 25℃; for 3h;	A 5% B 16% C 6% D 11%

...Expand

: 104-93-8
4-Methylanisole

: 824-94-2
p-methoxybenzyl chloride

Conditions

Conditions	Yield
With chlorine Einwirkung von Sonnenlicht;

: 107-30-2
chloromethyl methyl ether

: 100-66-3
methoxybenzene

: 824-94-2
p-methoxybenzyl chloride

: 824-94-2
p-methoxybenzyl chloride

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

Conditions

Conditions	Yield
With sodium azide In tetrahydrofuran Inert atmosphere;	100%
With sodium azide In N,N-dimethyl-formamide at 70℃;	100%
With sodium azide In N,N-dimethyl-formamide at 65℃; for 4h;	100%

: 824-94-2
p-methoxybenzyl chloride

: 79929-17-2
4-methoxybenzyl nitrate

Conditions

Conditions	Yield
With silver nitrate In acetonitrile for 0.166667h;	100%
With diethyl ether; silver nitrate; calcium carbonate
Multi-step reaction with 2 steps 1: 83 percent / potassium carbonate / acetone / 5 h / Heating 2: cerium(IV) ammonium nitrate / acetonitrile View Scheme

: 675-20-7
piperidin-2-one

: 824-94-2
p-methoxybenzyl chloride

: 128773-73-9
N-(4-Methoxybenzyl)-δ-valerolactam

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Reflux; Inert atmosphere;	100%
With sodium hydride In tetrahydrofuran for 23h; Heating;	94%
With sodium t-butanolate In dimethyl sulfoxide at 20℃; for 3h;	78%
With potassium hydroxide; tetrabutylammomium bromide In toluene for 8h; Heating;	52%
With tetrabutylammomium bromide; potassium hydroxide In toluene for 8h; Dean-Stark;	28.8 g

: 2034-22-2
2,4,5-tribromo-1H-imidazole

: 824-94-2
p-methoxybenzyl chloride

: 101901-58-0
2,4,5-tribromo-1-(4-methoxybenzyl)-1H-imidazole

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 55℃; for 18h;	100%
With sodium carbonate In N,N-dimethyl-formamide Heating;	90%
With sodium carbonate In N,N-dimethyl-formamide	90%
Stage #1: 2,4,5-tribromo-1H-imidazole With sodium hydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: p-methoxybenzyl chloride In tetrahydrofuran for 6h; Inert atmosphere; Reflux;	53%

: 75-64-9
tert-butylamine

: 824-94-2
p-methoxybenzyl chloride

: 22675-83-8
N-(p-methoxybenzyl)-N-tert-butylamine

Conditions

Conditions	Yield
	100%
With sodium carbonate; sodium iodide In N,N-dimethyl-formamide at 65℃; for 4h; Inert atmosphere;	56%
In N,N-dimethyl-formamide for 6h; Yield given;

: 329899-64-1
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 824-94-2
p-methoxybenzyl chloride

: 329899-60-7
(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; dimethyl sulfoxide Ambient temperature;	100%

: 114114-36-2
(2R,3S,4R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-[1,3]dithian-2-yl-pentan-3-ol

: 824-94-2
p-methoxybenzyl chloride

: 114130-12-0
(S)-4-[(1R,2S,3R)-3-[1,3]Dithian-2-yl-2-(4-methoxy-benzyloxy)-1-methyl-butyl]-2,2-dimethyl-[1,3]dioxolane

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	100%
With sodium hydride In N,N-dimethyl-formamide for 1h;	87%
With sodium hydride 1.) DMF, room temp., 5 min, 2.) DMF, 1 h; Yield given. Multistep reaction;

: 113296-75-6
(Z)-1-acetyl-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 824-94-2
p-methoxybenzyl chloride

: 1-Acetyl-4-(4-methoxy-benzyl)-6-(2,4,5-trimethoxy-3-methyl-benzyl)-3-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 25℃; for 2h;	100%
With sodium hydride 1.) DMF, 0 deg C, 30 min, 2.) DMF, 25 deg C, 2 h; Multistep reaction;

: 1-(3-chloro-4-methoxybenzyl)-4-chloro-1,2,3-triazole

: 824-94-2
p-methoxybenzyl chloride

: 5-Chloro-3-(3-chloro-4-methoxy-benzyl)-1-(4-methoxy-benzyl)-3H-[1,2,3]triazol-1-ium; chloride

Conditions

Conditions	Yield
	100%

: 116932-57-1
1-benzyl-4-chloro-1,2,3-triazole

: 824-94-2
p-methoxybenzyl chloride

: 3-Benzyl-5-chloro-1-(4-methoxy-benzyl)-3H-[1,2,3]triazol-1-ium; chloride

Conditions

Conditions	Yield
	100%

: 824-94-2
p-methoxybenzyl chloride

: 70887-29-5
4-methoxybenzyl iodide

Conditions

Conditions	Yield
With sodium iodide In acetone at 20℃; for 1.5h;	100%
With sodium iodide In acetone for 16h; Ambient temperature;	91%
With sodium iodide In acetone at 25℃; for 16h; Darkness;	85%

: 824-94-2
p-methoxybenzyl chloride

: 123-11-5
4-methoxy-benzaldehyde

Conditions

Conditions	Yield
With water; sodium hydroxide at 20℃; for 0.05h; Microwave irradiation;	100%
hydrotalcite In dimethyl sulfoxide at 140℃; for 1.5h; Kornblum reaction;	96%
With 1-dodecyl-3-methylimidazolium iron chloride; periodic acid at 30℃; for 1.5h;	95%

: 22323-82-6
(S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol

: 824-94-2
p-methoxybenzyl chloride

: 109786-73-4
(S)-4-[(4-methoxybenzyloxy)methyl]-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;	100%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	100%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	100%

: 824-94-2
p-methoxybenzyl chloride

: 10111-08-7
2-imidazolecarbaldehyde

: 95460-12-1
1-(4-methoxybenzyl)-1H-imidazole-2-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	100%
With tetrabutylammomium bromide; potassium carbonate at 120℃; for 2h;	34%

: 824-94-2
p-methoxybenzyl chloride

: (3S,3aR,6aS)-6-Benzyloxymethyl-3-(4-methoxy-benzyloxymethyl)-hexahydro-1,2,4-trioxa-6-aza-cyclopropa[e]inden-5-one

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane In dichloromethane at 0℃;	100%

: 824-94-2
p-methoxybenzyl chloride

: (4E,6E)-2,4,6-trimethyl-1,4,6-nonatrien-3-ol

: (4E,6E)-3-(p-methoxybenzyloxy)-2,4,6-trimethyl-1,4,6-nonatriene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 3h;	100%

: 111-29-5
1 ,5-pentanediol

: 824-94-2
p-methoxybenzyl chloride

: 131375-63-8
5-(4-methoxybenzyloxy)-1-pentanol

Conditions

Conditions	Yield
Stage #1: 1 ,5-pentanediol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 3h; Inert atmosphere; Reflux; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; mineral oil at 20℃; for 12h; Inert atmosphere; Reflux;	100%
Stage #1: 1 ,5-pentanediol With sodium hydride In tetrahydrofuran for 3h; Heating; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran for 15h;	99%
Stage #1: 1 ,5-pentanediol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 4.5h; Reflux; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; mineral oil for 17h; Reflux;	97%

: 824-94-2
p-methoxybenzyl chloride

: 190777-77-6
5-bromo-2H-isoquinolin-1-one

: 5-bromo-2-(4-methoxyphenylmethyl)isoquinoline-1(2H)-one

Conditions

Conditions	Yield
With sodium iodide; lithium hexamethyldisilazane In tetrahydrofuran 1.) 2 h, 2.) 5 d;	100%

: 824-94-2
p-methoxybenzyl chloride

: 195134-70-4
tert-butyl (3,5-dibromophenyl)carbamate

: 195134-80-6
3,5-dibromo-N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)aniline

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide 1.) 20 min, 2.) 21 h;	100%

: 143571-61-3
N-{(4aR,6S,7R,8R,8aS)-6-[(2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-acetamide

: 824-94-2
p-methoxybenzyl chloride

: N-[(4aR,6S,7R,8R,8aS)-6-[(2R,3S,4S,5R,6R)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-4-yloxy]-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide 1.) 0 deg C, 20 min, 2.) room temperature, 10 h;	100%

: 824-94-2
p-methoxybenzyl chloride

: 199792-19-3
2-[(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-ethanol

: 199792-20-6
(4aR,6S,7S,8R,8aR)-7,8-Bis-benzyloxy-6-[2-(4-methoxy-benzyloxy)-ethyl]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

Conditions

Conditions	Yield
With potassium hydride In tetrahydrofuran for 3h; Ambient temperature;	100%
With tetra-(n-butyl)ammonium iodide; potassium hydride In tetrahydrofuran for 3h; Ambient temperature; Yield given;

: 67320-20-1, 83692-41-5, 94292-91-8, 64722-95-8
1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-bis-ethylsulfanyl-propan-1-ol

: 824-94-2
p-methoxybenzyl chloride

: 152453-71-9
(1'S,4R)-4-(3',3'-bisethylthio-1'-p-methoxybenzyloxypropyl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With sodium hydride; dimethyl sulfoxide for 4h; Ambient temperature;	100%
With sodium hydride In N,N-dimethyl-formamide	100%
With sodium hydride In N,N-dimethyl-formamide for 2h;	100%
Stage #1: 1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-bis-ethylsulfanyl-propan-1-ol With sodium hydride In DMF (N,N-dimethyl-formamide) for 0.5h; Stage #2: p-methoxybenzyl chloride In DMF (N,N-dimethyl-formamide) at 20℃; for 4h;

: 824-94-2
p-methoxybenzyl chloride

: 513-42-8
3-hydroxy-2-methyl-1-propene

: 189366-67-4
1-((methallyloxy)methyl)-4-methoxybenzene

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃;	100%
With sodium hydroxide 1.) THF, mineral oil, DMF, 0 deg C, 30 min; 2.) THF, 2 h;	97%
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; 1.) 30 min, 2.) 2 h;

: 123-56-8
Succinimide

: 824-94-2
p-methoxybenzyl chloride

: 108640-66-0
1-[(4-methoxyphenyl)methyl]-2,5-pyrrolidinedione

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile	100%
With potassium carbonate In acetonitrile at 25℃; for 16h;
With potassium carbonate In acetonitrile at 25℃; for 16h;
With potassium carbonate In acetonitrile at 25℃; for 16h;

: 824-94-2
p-methoxybenzyl chloride

: 72904-78-0
methyl 3-deoxy-4,6-O-phenylmethylene-α-D-arabinohexopyranoside

: 226885-87-6
methyl 4,6-O-benzylidene-3-deoxy-2-O-(4-methoxybenzyl)-α-D-arabinopyranoside

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃;	100%
With sodium hydride 1) DMF, 0 deg C, 30 min; 2) DMF, 0 deg C, 3 h; Yield given; Multistep reaction;

: 824-94-2
p-methoxybenzyl chloride

: 100-79-8
(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

: 156147-59-0
4-(((4-methoxybenzyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 20h;	100%
Stage #1: (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Stage #2: p-methoxybenzyl chloride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 20℃;	100%
With tetra-(n-butyl)ammonium iodide; sodium hydride In tetrahydrofuran at 0℃; Inert atmosphere; Reflux;	89%

: 824-94-2
p-methoxybenzyl chloride

: (+/-)-1,4,5-tri-O-allyl-2,3-O-cyclohexylidene-myo-inositol

: (+/-)-1,4,5-tri-O-allyl-2,3-O-cyclohexylidene-6-O-p-methoxybenzyl-myo-inositol

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; Arylation;	100%

4-Methoxybenzylchloride Specification

The 4-Methoxybenzylchloride, with the CAS registry number 824-94-2,is also known as 4-(1,1,3,3-Tetramethylbutyl)phenol. It belongs to the product categories of Biochemistry;Reagents for Oligosaccharide Synthesis. This chemical's molecular formula is C₈H₉ClO and molecular weight is 156.61.Its EINECS number is 212-540-6. What's more,Its systematic name is p-Methoxybenzyl chloride.It is a colorless liquid

Physical properties about 4-Methoxybenzylchloride are:
(1)ACD/LogP: 2.468; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.47; (4)ACD/LogD (pH 7.4): 2.47; (5)ACD/BCF (pH 5.5): 44.21; (6)ACD/BCF (pH 7.4): 44.21; (7)ACD/KOC (pH 5.5): 524.15; (8)ACD/KOC (pH 7.4): 524.15; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.517; (13)Molar Refractivity: 42.697 cm3; (14)Molar Volume: 141.131 cm3; (15)Surface Tension: 33.367000579834 dyne/cm; (16)Density: 1.11 g/cm3; (17)Flash Point: 109.444 °C; (18)Enthalpy of Vaporization: 46.119 kJ/mol; (19)Boiling Point: 243.639 °C at 760 mmHg; (20)Vapour Pressure: 0.0500000007450581 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:ClCc1ccc(OC)cc1;
(2)Std. InChI:InChI=1S/C8H9ClO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3;
(3)Std. InChIKey:MOHYOXXOKFQHDC-UHFFFAOYSA-N.

Safety Information of 4-Methoxybenzylchloride:
The 4-Methoxybenzylchloride can causes burns .In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .When you use it ,wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) and take off immediately all contaminated clothing.

Product Name

4-Methoxybenzylchloride

Synthetic route

4-Methoxybenzylchloride Specification

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