4-N-Boc-aminopiperidine supplier

Name
4-N-Boc-aminopiperidine
EINECS 616-026-6
CAS No. 73874-95-0
Article Data42
CAS DataBase
Density 1.02 g/cm³
Solubility
Melting Point 162-166 °C
Formula C₁₀H₂₀N₂O₂
Boiling Point 304.8 °C at 760 mmHg
Molecular Weight 236.742
Flash Point 138.2 °C
Transport Information
Appearance Off-white solid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-N-Boc-amino-piperidine;4-(N-tert-Butoxycarbonylamino)piperidine;4-Boc-AminoPiperidine;4-tert-Butoxycarbonyl-aminopiperidine;4-(N-BOC-amino) piperidine;4-N-Boc-Amino Piperidine;4-(Boc-amino)piperidine;tert-butyl piperidin-4-ylcarbamate;4-(N-Boc-amino)piperidine;4-Boc-amino piperidine;4-Boc-aminopiperindine;4-N-(tert-Butoxycarbonyl)aminopiperidine;N-Boc-piperidin-4-amine;tert-butyl N-(3,4,5,6-tetrahydro-2H-pyridin-4-yl)carbamate;
PSA 50.36000
LogP 1.98280

Synthetic route

: 73889-19-7
tert-butyl (1-benzylpiperidin-4-yl)carbamate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In methanol for 12h;	99%
With hydrogen; palladium 10% on activated carbon In methanol for 12h;	99%
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 18h;	97%

: C17H24N2O2

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 70℃; under 6000.6 - 7500.75 Torr; for 4h; Reagent/catalyst; Temperature;	90.7%

: 159874-20-1
1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopiperidine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2068.59 Torr;
palladium In ethanol	1.8 g (100%)

: 50541-93-0
4-amino-1-benzylpiperidine

4-formylimidazole on 2-Cl-Trityl cross-linked PS-resin: 4-formylimidazole on 2-Cl-Trityl cross-linked PS-resin

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / NaOH / 2-methyl-propan-2-ol / 20 °C 2: 95 percent / H2 / Pd/C / methanol / 20 °C View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

1.) NaH; 2.) SOCl2: 1.) NaH; 2.) SOCl2

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / NaOH / 2-methyl-propan-2-ol / 20 °C 2: 95 percent / H2 / Pd/C / methanol / 20 °C View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / acetonitrile / 1 h / 20 °C 2: 92 percent / cyclohexene / 20 percent Pd(OH)2/C / ethanol / 3.5 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 99 percent / CH2Cl2 / 18 h / Ambient temperature 2: 97 percent / H2 / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / ethanol View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / acetonitrile / 1 h / 20 °C 2: 92 percent / cyclohexene / 20 percent Pd(OH)2/C / ethanol / 3.5 h / Heating View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / ethanol View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; 1,4-dioxane / 25 h / 5 - 20 °C 2: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 65 °C / Reflux View Scheme
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 12 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 24 h View Scheme

: 220394-91-2
benzyl 4-isocyanatotetrahydro-1(2H)-pyridinecarboxylate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CuCl2 / 20 °C 2: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium: pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / CH2Cl2 / 18 h / Ambient temperature 2: 97 percent / H2 / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine; palladium dihydroxide; hydrogen In dichloromethane; water
Stage #1: 4-amino-1-benzylpiperidine; di-tert-butyl dicarbonate With triethylamine Stage #2: With palladium on activated charcoal; hydrogen
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 12 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 24 h View Scheme
Multi-step reaction with 2 steps 1: chloroform 2: acetic acid / palladium-carbon catalyst / methanol View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 73889-19-7
tert-butyl (1-benzylpiperidin-4-yl)carbamate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
In tetrahydrofuran; palladium-carbon; ethanol; n-heptane

...Expand

: 60211-57-6
3,5-dichlorobenzyl alcohol

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 1,1'-carbonyldiimidazole In ethyl acetate; N,N-dimethyl-formamide

: C13H18N2O

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 5 °C / Reflux; Inert atmosphere 2: triethylamine / dichloromethane / 20 °C 3: formic acid; potassium hydroxide; / ethanol / 1 h / 70 °C View Scheme

: 3612-20-2
1-phenylmethyl-4-piperidone

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate; hydroxylamine hydrochloride / methanol / 4 h / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 5 °C / Reflux; Inert atmosphere 3: triethylamine / dichloromethane / 20 °C 4: formic acid; potassium hydroxide; / ethanol / 1 h / 70 °C View Scheme

: 757982-39-1
2-(4-chloro-7-methylquinazolin-2-yl)-phenol

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl 1-(2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-4-yl-carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 6h;	100%
With triethylamine In dichloromethane at 20℃;	69%

: 98-88-4
benzoyl chloride

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 429677-00-9
tert-butyl N-(1-benzoylpiperidin-4-yl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Ice cooling;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	96%
With triethylamine In dichloromethane for 18h;	91%
With triethylamine In dichloromethane at 20℃; for 2h;
With triethylamine In dichloromethane at 20℃; for 2h;

: 16269-66-2
4-chlorothieno[3,2-d]pyrimidine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: (1-thieno[2,3-d]pyrimidin-4-yl-piperidin-4-yl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In butan-1-ol at 100℃; for 48h;	100%

: 1556-18-9
cyclopentyl iodide

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 936221-73-7
4-(N-(tert-butyloxycarbonyl)amino)piperidine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 48h;	100%

: 1003944-27-1
(7-fluoro-2-oxo-1(2H)-quinolinyl)acetaldehyde

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 917341-51-6
1,1-dimethylethyl {1-[2-(7-fluoro-2-oxo-1(2H)-quinolinyl)ethyl]-4-piperidinyl}carbamate

Conditions

Conditions	Yield
Stage #1: (7-fluoro-2-oxo-1(2H)-quinolinyl)acetaldehyde; (piperidin-4-yl)carbamic acid tert-butyl ester In methanol; chloroform at 20℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In methanol; chloroform at 20℃; for 2.83333h;	100%

: 1118-68-9
dimethylaminoacetic acid

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 864246-28-6
tert-butyl [1-(2-dimethylaminoacetyl)piperidin-4-yl]carbamate

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid; (piperidin-4-yl)carbamic acid tert-butyl ester With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 46h; Stage #2: With sodium hydroxide In water; ethyl acetate; N,N-dimethyl-formamide; sodium chloride at 20℃; for 0.5h;	100%
With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 46h;	100%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 540-51-2
2-bromoethanol

: 558443-53-1
[1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 5h; Inert atmosphere; Reflux;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h; Inert atmosphere;	97%
With potassium carbonate In acetonitrile for 5h; Heating;	94%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 182198-35-2
4-chloro-5-phenyl-thieno[2,3-d]pyrimidine

: [1-(5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethylene glycol at 110℃; for 3h;	100%
With triethylamine In isopropyl alcohol for 2h; Heating / reflux;	75%
In ethylene glycol at 110℃; for 4h;

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 672324-63-9
C18H23F3N2O3

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃; for 3.25h;	100%

: 364-74-9
1,4-difluoro-2-nitrobenzene

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 885115-60-6
tert-butyl 1-(4-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 70℃; for 3.5h;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1-(pyridin-2-ylmethyl)piperidin-4-amine tris(hydrochloride)

Conditions

Conditions	Yield
Stage #1: pyridine-2-carbaldehyde; (piperidin-4-yl)carbamic acid tert-butyl ester With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; Stage #2: With hydrogenchloride In methanol; diethyl ether at 20℃;	100%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 25171-36-2
4-chloro-2-(2'-hydroxyphenyl)quinazoline

: tert-butyl 1-(2-(2-hydroxyphenyl)quinazolin-4-yl)piperidin-4-ylcarbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	100%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 6-{4-[2-(4-Amino-piperidin-1-yl)-ethyl]-phenyl}-pyridin-2-ylamine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane	100%

: 929095-40-9
methyl 5-[6-(chloromethyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: methyl 5-(6-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 20℃; for 18h;	100%

: 944407-62-9
9-fluoro-1-(hydroxymethyl)-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl 4-methylbenzenesulfonate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 944407-63-0
1,1-dimethylethyl {1-[(9-fluoro-1-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)methyl]-4-piperidinyl}carbamate

Conditions

Conditions	Yield
With sodium carbonate In ethanol; water	100%
With sodium carbonate In ethanol at 20℃; for 16h;	100%
With sodium carbonate In ethanol at 20℃; for 16h;	100%

: 4-Chloro-5-(thien-2-yl)thieno[2,3-d]pyrimidine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: C20H24N4O2S2

Conditions

Conditions	Yield
In ethylene glycol at 110℃; for 6h;	100%
In ethylene glycol at 110℃; for 4h;

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: (4-aminopiperidin-1-yl)acetonitrile dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 40℃;	100%

: 863250-63-9
4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 863252-14-6
4-{[4-(benzofuran-3-ylmethoxy)-1H-indole-2-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 0℃; for 0.166667h; Stage #2: (piperidin-4-yl)carbamic acid tert-butyl ester With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 96-09-3
styrene oxide

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1269606-74-7
[1-(2-Hydroxy-2-phenyl-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
	100%

: 23378-88-3
3,5-dichloro-2-hydroxybenzenesulfonyl chloride

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1417652-18-6
C16H22Cl2N2O5S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane	100%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 107-13-1
acrylonitrile

: 898271-16-4
[1-(2-cyano-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
In ethanol at 80℃; for 2h;	100%

: 1401066-79-2
(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1581704-69-9
tert-butyl 1-(((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl 2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)methyl)piperidin-4-yl carbamate

Conditions

Conditions	Yield
With formaldehyd In ethanol at 75℃; for 18h;	100%

: 4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzaldehyde

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl 1-(4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzyl)piperidin-4-ylcarbamate

Conditions

Conditions	Yield
Stage #1: 4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzaldehyde; (piperidin-4-yl)carbamic acid tert-butyl ester With acetic acid In dichloromethane at 50℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 2h; Cooling with ice;	100%

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1.5h; Inert atmosphere;	100%

: 2-(4-cyano-3-fluorophenyl)-5-methyl-1-(2-methylindazol-5-yl)imidazole-4-carboxylic acid

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: C30H32FN7O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;	100%

: 163083-48-5
6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl (1-(6-methyl-2-nitropyridin-3-yl)piperidin-4-yl)carbamate

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 8h; Reflux;	100%

: 35857-89-7
6-chloropyridazine-3-carbonitrile

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: (1-(6-cyano-pyridazin-3-yl)piperidin-4-yl)-carbamic acid tert-butylester

Conditions

Conditions	Yield
With triethylamine In ethanol at 20℃;	100%
With triethylamine In ethanol at 20℃;	100%
With triethylamine In ethanol at 20℃;	100%

: 31872-63-6
3-bromo-4-chloro-5-nitropyridine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl N-(1-(3-bromo-5-nitro-4-pyridinyl)-4-piperidinyl)carbamate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;	100%
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;	59.7 g
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;	59.78 g

: 2746-25-0
p-Methoxybenzyl bromide

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl (1-(4-methoxybenzyl)piperidin-4-yl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	100%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 1h;	81%
With triethylamine In ethanol

: 1008451-58-8
4-chloro-2-methoxynicotinic aldehyde

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: tert-butyl N-[1-(3-formyl-2-methoxypyridin-4-yl)piperidin-4-yl]carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 100℃; for 0.666667h;	100%

4-N-Boc-aminopiperidine Specification

The 4-N-Boc-aminopiperidine, with the CAS registry number 73874-95-0, is also known as Boc-4-aminopiperidine. It belongs to the product categories of Amines; Blocks; Pharmacetical; Pyridine Series; Pyrans, Piperidines & Piperazines; Piperidine; Piperidines; Pyrans, Piperidines & Piperazines; Building Blocks; Heterocyclic Building Blocks. This chemical's molecular formula is C₁₀H₂₀N₂O₂ and molecular weight is 200.278. Its IUPAC name is called tert-butyl N-piperidin-4-ylcarbamate. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides. 4-N-Boc-aminopiperidine is used for pharmaceutical intermediates.

Physical properties of 4-N-Boc-aminopiperidine: (1)ACD/LogP: 1.16; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 4; (7)#H bond donors: 2; (8)#Freely Rotating Bonds: 3; (9)Index of Refraction: 1.48; (10)Molar Refractivity: 55.446 cm³; (11)Molar Volume: 195.2 cm³; (12)Surface Tension: 35.73 dyne/cm; (13)Density: 1.026 g/cm³; (14)Flash Point: 138.152 °C; (15)Enthalpy of Vaporization: 54.522 kJ/mol; (16)Boiling Point: 304.823 °C at 760 mmHg; (17)Vapour Pressure: 0.001 mmHg at 25°C.

Preparation of 4-N-Boc-aminopiperidine: this chemical can be prepared by (1-benzyl-piperidin-4-yl)-carbamic acid tert-butyl ester. This reaction will need reagent cyclohexene and solvent ethanol. The reaction time is 3.5 hours. The yield is about 92%.

4-N-Boc-aminopiperidine can be prepared by (1-benzyl-piperidin-4-yl)-carbamic acid tert-butyl ester

Uses of 4-N-Boc-aminopiperidine: it can be used to produce [1-(4-nitro-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester at temperature of 20 °C. This reaction will need reagents acetic acid, sodium triacetoxyborohydride and solvent tetrahydrofuran with reaction time of 20 hours. The yield is about 78%.

4-N-Boc-aminopiperidine can be used to produce [1-(4-nitro-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(C)OC(=O)NC1CCNCC1
(2)InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)
(3)InChIKey: CKXZPVPIDOJLLM-UHFFFAOYSA-N

Product Name

4-N-Boc-aminopiperidine

Synthetic route

4-N-Boc-aminopiperidine Specification

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