4-Piperidinopiperidine supplier

Name
4-Piperidinopiperidine
EINECS 225-522-8
CAS No. 4897-50-1
Article Data6
CAS DataBase
Density 0.969 g/cm³
Solubility
Melting Point 64-66 °C(lit.)
Formula C₁₀H₂₀N₂
Boiling Point 251.4 °C at 760 mmHg
Molecular Weight 168.282
Flash Point 99.9 °C
Transport Information
Appearance light yellow to yellow-brown crystalline solid
Safety 24/25-26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,4-Bipiperidyl;1,4'-bipiperidine;1-(3,4,5,6-tetrahydro-2H-pyridin-4-yl)-3,4,5,6-tetrahydro-2H-pyridine;4-(1-piperidinyl)piperidine;[1,4']Bipiperidinyl;4-(1-Piperidino)piperidine;1-(4-piperidyl)piperidine;
PSA 15.27000
LogP 1.49100

Synthetic route

: 110-89-4
piperidine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 4897-50-1
4-piperidinopiperidin

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h;	80%

: 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A: 4897-50-1
4-piperidinopiperidin

B: [1,4']Bipiperidinyl-1'-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Conditions

Conditions	Yield
	A n/a B 35%

: 97682-44-5, 130144-33-1
irinotecan

A: 4897-50-1
4-piperidinopiperidin

B: 86639-52-3, 110714-48-2, 130144-34-2
7-ethyl-10-hydroxycamptothecin

Conditions

Conditions	Yield
With carboxylesterase at 37℃; for 0.0833333h; pH=7.4;

: 944411-93-2
[1,4']bipiperidinyl-1'-carboxylic acid (4-bromo-phenyl)amide

A: 4897-50-1
4-piperidinopiperidin

B: [1,4']bipiperidinyl-1'-carboxylic acid (3'-acetylamino-biphenyl-4-yl)amide

C: 1608129-84-5
C14H14N2O

D: 106-40-1
4-bromo-aniline

Conditions

Conditions	Yield
Suzuki-Miyaura Coupling;

...Expand

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 4897-50-1
4-piperidinopiperidin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme

: 125541-12-0
tert-butyl 1,4’-bipiperidine-1’-carboxylate

: 4897-50-1
4-piperidinopiperidin

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 40℃; for 12h;	2.04 g

: 4897-50-1
4-piperidinopiperidin

: 2369-11-1
5-fluoro-2-nitroaniline

: 900506-32-3
2-nitro-5-(4-(piperidin-1-yl)piperidin-1-yl)benzenamine

Conditions

Conditions	Yield
With triethylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 2.5h;	100%
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 4h;	75%

: 4897-50-1
4-piperidinopiperidin

: 5147-80-8
[Bis(methylthio)methylene]malononitrile

: 904677-87-8
[(methylthio)(4-piperidinopiperidino)methylene]malononitrile

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 0.25h;	100%

: 4897-50-1
4-piperidinopiperidin

: 185321-62-4
2-tert-butyloxycarbonylamino-3-(3,4-dichlorophenyl)propionic acid

: C24H35Cl2N3O3

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	100%

: 4897-50-1
4-piperidinopiperidin

: 215595-66-7
N6-Boc-N2-Cbz-lysine

: C29H46N4O5

Conditions

Conditions	Yield
	100%

: 4897-50-1
4-piperidinopiperidin

: 1361214-48-3
(R)-3-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-4-(((R)-1-phenylethyl)amino)butanoic acid

: 1361214-50-7
(R)-4-([1,4'-bipiperidin]-1'-yl)-2-((2R,3S)-2-((E)-3-fluorostyryl)-4-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)azetidin-1-yl)-4-oxo-N-((R)-1-phenylethyl)butanamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h;	100%

: 4897-50-1
4-piperidinopiperidin

: 32315-10-9
bis(trichloromethyl) carbonate

: 103816-19-9
4-piperidinopiperidine-1-carbonyl chloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -10 - 20℃; for 4h;	99%
Stage #1: 4-piperidinopiperidin; bis(trichloromethyl) carbonate In dichloromethane; acetonitrile at 20 - 70℃; Stage #2: With potassium carbonate In dichloromethane at 20℃;	98.5%
Stage #1: 4-piperidinopiperidin; bis(trichloromethyl) carbonate In hexane; dichloromethane; acetonitrile at 20 - 25℃; Stage #2: With potassium carbonate In dichloromethane at 20℃;	98.5%

: 4897-50-1
4-piperidinopiperidin

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 761440-29-3
1'-[3-(methyloxy)-4-nitrophenyl]-1,4'-bipiperidine

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 72h;	99%

: 4897-50-1
4-piperidinopiperidin

: 169205-95-2
2-(methylthio)oxazolo[4,5-b]pyridine

: 1231933-81-5
C16H22N4O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃;	99%
In N,N-dimethyl-formamide at 100℃;	90%

: 4897-50-1
4-piperidinopiperidin

: 955084-10-3
5,5-difluoro-10-(p-tolyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

: C26H31BF2N4

Conditions

Conditions	Yield
With silver(I) acetate In dimethyl sulfoxide at 80℃; for 12h; Schlenk technique; Inert atmosphere; regioselective reaction;	99%

: 4897-50-1
4-piperidinopiperidin

: 616-38-6
carbonic acid dimethyl ester

: 4-piperidylpiperidine methyl carbonate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60 - 65℃; for 3h;	98.5%

: 4897-50-1
4-piperidinopiperidin

: 76-05-1
trifluoroacetic acid

N-Boc pyroglutamic acid-Wang resin: N-Boc pyroglutamic acid-Wang resin

: (S)-2-Amino-5-[1,4']bipiperidinyl-1'-yl-5-oxo-pentanoic acid; compound with trifluoro-acetic acid

Conditions

Conditions	Yield
Stage #1: 4-piperidinopiperidin; N-Boc pyroglutamic acid-Wang resin In tetrahydrofuran Addition; Stage #2: trifluoroacetic acid In water for 2.5h; Hydrolysis;	98%

...Expand

: 82278-95-3
rac-(3-(3-bromophenyl)-2-tert-butoxycarbonylamino)propionic acid

: 4897-50-1
4-piperidinopiperidin

: C24H36BrN3O3

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	98%

: 4897-50-1
4-piperidinopiperidin

: 2-{4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl}acetaldehyde

: 3-iodo-1-[2-[4-(1-piperidyl)-1-piperidyl]ethyl]pyrazolo[3,4-d]pyrimidin-4-amine

Conditions

Conditions	Yield
Stage #1: 4-piperidinopiperidin; 2-{4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl}acetaldehyde With acetic acid In dichloromethane for 0.166667h; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane for 17h;	97.5%
Stage #1: 4-piperidinopiperidin; 2-{4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl}acetaldehyde With acetic acid In dichloromethane for 0.166667h; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane for 17h;	191.6 mg

: 4897-50-1
4-piperidinopiperidin

: 1269606-87-2
2-[1,4']bipiperidinyl-1'-yl-1-(3-methoxy-phenyl)-ethanol

Conditions

Conditions	Yield
	97%

: 4897-50-1
4-piperidinopiperidin

: C26H20ClN3O

: 4-(((1,4'-bipiperidin)-1'-yl)methyl)-N-(1-(p-methylphenyl)-9H-pyrido[3,4-b]indol-3-yl)benzamide

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 10h;	97%

: 4897-50-1
4-piperidinopiperidin

: 49627-27-2
sulindac sulfide

: (Z)-1-([1,4'-bipiperidin]-1'-yl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)ethanone

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 20℃; Inert atmosphere;	97%

: 4897-50-1
4-piperidinopiperidin

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 1-(4-chloromethylbenzoyl)-4-piperidinopiperidine hydrochloride

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 2h;	96%

: 4897-50-1
4-piperidinopiperidin

: 865626-93-3
(R)-2-(4-(8-Fluoro-2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carbonyloxy)-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)propanoic acid

: 865626-94-4
(R)-3-(7-Methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl 4-(8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: (R)-2-(4-(8-Fluoro-2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carbonyloxy)-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)propanoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 0.0833333h; Stage #2: 4-piperidinopiperidin In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;	96%

Yield

Stage #1: (R)-2-(4-(8-Fluoro-2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carbonyloxy)-3-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)propanoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 0.0833333h;
Stage #2: 4-piperidinopiperidin In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;

96%

: 4897-50-1
4-piperidinopiperidin

: 19313-88-3
3-chloro-N-(4-nitrophenyl)propanamide

: 1586764-66-0
3-([1,4'-bipiperidin]-1'-yl)-N-(4-nitrophenyl)propanamide

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃;	96%

: 4897-50-1
4-piperidinopiperidin

: 4-chloromethyl-N-(9H-pyrido[3,4-b]indol-3-yl)benzamide

: 4-(((1,4'-bipiperidin)-1'-yl)methyl)-N-(9H-pyrido[3,4-b]indol-3-yl)benzamide

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 10h;	96%

: 4897-50-1
4-piperidinopiperidin

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1'-(4-nitrobenzyl)-1,4'-bipiperidine

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 2h;	96%
With potassium carbonate; potassium iodide In acetonitrile for 5h;	92%

: 4897-50-1
4-piperidinopiperidin

: 89336-46-9
2-{2[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetic acid

: tert-butyl {4-[2-(1,4’-bipiperidin-1‘-yl)-2-oxoethyl]-1,3-thiazol-2-yl}carbamate

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃;	96%

: 4897-50-1
4-piperidinopiperidin

: C18H17Cl3N6

: 5-(4-(piperidin-1-yl)piperidin-1-yl)methyl-7-(4-(bis(2-chloroethyl)amino)phenylamino)-3-cyanopyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 40℃;	95.3%

: 4897-50-1
4-piperidinopiperidin

: 6-((3-fluorobenzyl)amino)imidazo[1,2-b]pyridazine-3-carboxylic acid

: [1,4'-bipiperidin]-1'-yl(6-((3-fluorobenzyl)amino)imidazo[1,2-b]pyridazin-3-yl)methanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 60℃; for 1h;	95.1%

: 4897-50-1
4-piperidinopiperidin

: 583051-10-9
7-chloro-3,6-dicyano-2-ethoxy-4-phenyl-1,8-naphthyridine

: 3,6-dicyano-2-ethoxy-4-phenyl-7-(4-piperidylpiperidino)-1,8-naphthyridine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 16h; Heating;	95%

: 4897-50-1
4-piperidinopiperidin

: C14H18Br2N2O4

: C24H36Br2N4O3

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	95%

: 873090-18-7
5-(3-bromophenyl)-3H-1,3,4-oxadiazol-2-one

: 4897-50-1
4-piperidinopiperidin

: 1024613-87-3
1'-[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]-1,4'-bipiperidinyl

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h;	95%

4-Piperidinopiperidine Specification

The 4-Piperidinopiperidine, with the CAS registry number 4897-50-1, is also known as 1,4'-Bipiperidin. It belongs to the product categories of Nitrogen Cyclic Compounds; Pharmaceutical Intermediates; Heterocycles; Piperidine; Heterocyclic Compounds; Piperidine Series; Piperidines. Its EINECS registry number is 225-522-8. This chemical's molecular formula is C₁₀H₂₀N₂ and molecular weight is 168.2792. Its IUPAC name is called 1-piperidin-4-ylpiperidine. What's more, the product should be sealed and stored in cool and dry place.

Physical properties of 4-Piperidinopiperidine: (1)ACD/LogP: 1.53; (2)ACD/LogD (pH 5.5): -2.57; (3)ACD/LogD (pH 7.4): -2.18; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.5; (12)Molar Refractivity: 51.07 cm³; (13)Molar Volume: 173.6 cm³; (14)Surface Tension: 35.5 dyne/cm; (15)Density: 0.969 g/cm³; (16)Flash Point: 99.9 °C; (17)Enthalpy of Vaporization: 48.88 kJ/mol; (18)Boiling Point: 251.4 °C at 760 mmHg; (19)Vapour Pressure: 0.0205 mmHg at 25°C.

Uses of 4-Piperidinopiperidine: it can be used to produce 4-Oxo-4-phenyl-2-(4-piperidinopiperidino)-butansaeure with 4-oxo-4-phenyl-but-2-enoic acid. This reaction will need solvents toluene and ethanol. The yield is about 68%.

4-Piperidinopiperidine can be used to produce 4-Oxo-4-phenyl-2-(4-piperidinopiperidino)-butansaeure with 4-oxo-4-phenyl-but-2-enoic acid

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CCN(CC1)C2CCNCC2
(2)InChI: InChI=1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2
(3)InChIKey: QDVBKXJMLILLLB-UHFFFAOYSA-N

Product Name

4-Piperidinopiperidine

Synthetic route

4-Piperidinopiperidine Specification

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