5-Aminoisophthalic acid supplier

Name
5-Aminoisophthalic acid
EINECS 202-748-5
CAS No. 99-31-0
Article Data20
CAS DataBase
Density 1.551 g/cm³
Solubility insoluble in water
Melting Point >300 °C(lit.)
Formula C₈H₇NO₄
Boiling Point 514.9 °C at 760 mmHg
Molecular Weight 181.148
Flash Point 265.2 °C
Transport Information
Appearance Off-white crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,3-Benzenedicarboxylic acid, 5-amino-;Isophthalic acid, 5-amino-;5-aminobenzene-1,3-dicarboxylic acid;Isophthalic acid, 5-amino- (8CI);5-aminobenzene-1,3-dicarboxylate;5-Amino isophthalic acid;5-Aminoisophthalicacid;
PSA 100.62000
LogP 1.24640

Synthetic route

: 618-88-2
5-nitrobenzene-1,3-dicarboxylic acid

: 99-31-0
5-aminoisophthalic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 760 Torr; for 1h;	95%
Stage #1: 5-nitrobenzene-1,3-dicarboxylic acid With sodium hydroxide In water for 1h; Stage #2: With hydrazine hydrate In water at 30 - 35℃; for 1h; Concentration; Temperature;	95%
With hydrogenchloride; tin

: 618-88-2
5-nitrobenzene-1,3-dicarboxylic acid

Na2S2O4: Na2S2O4

: 99-31-0
5-aminoisophthalic acid

: 7647-01-0
hydrogenchloride

: 618-88-2
5-nitrobenzene-1,3-dicarboxylic acid

tin: tin

: 99-31-0
5-aminoisophthalic acid

...Expand

: 618-88-2
5-nitrobenzene-1,3-dicarboxylic acid

: 7440-44-0
pyrographite

: 99-31-0
5-aminoisophthalic acid

Conditions

Conditions	Yield
With sodium hydroxide; nitrogen; hydrogen; palladium-carbon In water
With sodium hydroxide; nitrogen; hydrogen; palladium-carbon In water
With sodium hydroxide; nitrogen; hydrogen; palladium-carbon In water

: N,N'-bis(3,5-dicarboxylatophenyl)pyromelliticdiimide

A: 89-05-4
1,2,4,5-benzenetetracarboxylic acid

B: 99-31-0
5-aminoisophthalic acid

Conditions

Conditions	Yield
Heating;

: 64-17-5
ethanol

: 99-31-0
5-aminoisophthalic acid

: 42122-73-6
diethyl 5-aminoisophthalate

Conditions

Conditions	Yield
With sulfuryl dichloride at 0℃; for 5h; Reflux;	100%
With thionyl chloride In ethanol at 0 - 85℃; for 5h;	98%
With thionyl chloride at 0℃; Inert atmosphere; Reflux;	97%

(BOC)20: (BOC)20

: 99-31-0
5-aminoisophthalic acid

: 497-19-8
sodium carbonate

: 5-tert-butyloxycarbamyl-benzene-1,3-dicarboxylic acid

Conditions

Conditions	Yield
With potassium hydrogensulfate In 1,4-dioxane; water; ethyl acetate	100%

...Expand

(Boc)2 O: (Boc)2 O

: 99-31-0
5-aminoisophthalic acid

: 497-19-8
sodium carbonate

: 5-tert-butyloxycarbamyl-benzene-1,3-dicarboxylic acid

Conditions

Conditions	Yield
With potassium hydrogensulfate In 1,4-dioxane; water; ethyl acetate	100%

...Expand

: 86-90-8
4-bromophthalic anhydride

: 99-31-0
5-aminoisophthalic acid

: C16H8BrNO6

Conditions

Conditions	Yield
Stage #1: 4-bromophthalic anhydride; 5-aminoisophthalic acid In N,N-dimethyl acetamide at 60 - 100℃; for 1h; Stage #2: With pyridine; acetic anhydride In N,N-dimethyl acetamide for 2h;	100%

: lanthanide(III)chloride heptahydrate

: 99-31-0
5-aminoisophthalic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 95-54-5
1,2-diamino-benzene

: La(3+)*C6H8N2*2H2O*2C3H7NO*2Cl(1-)*C8H6NO4(1-)

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 48.5h; Temperature; High pressure; Autoclave;	98.5%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 99-31-0
5-aminoisophthalic acid

: 178446-63-4
5-[(tert-butyloxycarbonyl)amino]-isophthalic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃;	98%
With triethylamine In dichloromethane at 20℃; for 2h;	85%
With sodium hydroxide In water; N,N-dimethyl-formamide at 0 - 20℃; for 30h;	67%

: 99-31-0
5-aminoisophthalic acid

: 552-30-7
trimellitic Anhydride

: 51222-09-4
C17H9NO8

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 6h; Heating;	98%

: 99-31-0
5-aminoisophthalic acid

: 51839-16-8
5-iodoisophthalic acid

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With potassium iodide In water at 0 - 20℃;	96%
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium nitrite Stage #2: With potassium iodide In water Further stages.;	95%
Stage #1: 5-aminoisophthalic acid With hydrogenchloride In water Stage #2: With sodium nitrite In water at 0℃; for 0.5h; Stage #3: With potassium iodide In water at 0 - 20℃; for 24h;	83%

: 99-31-0
5-aminoisophthalic acid

: 35453-30-6
2,4,6-tribromo-5-amino-isophthalic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium dithionite; bromine In water	96%

: 99-31-0
5-aminoisophthalic acid

: 4422-95-1
1,3,5-benzene tris(carbonyl chloride)

: 404018-62-8
5,5’,5’’-((benzene-1,3,5-tricarbonyl)tris(azanediyl))triisophthalic acid

Conditions

Conditions	Yield
With dmap In N,N-dimethyl acetamide for 96h;	95.8%
With dmap In N,N-dimethyl acetamide at 25℃; for 12h; Inert atmosphere;	95%
With triethylamine In acetone for 16h;	88%

: 99-31-0
5-aminoisophthalic acid

: 35453-19-1
2,4,6-triiodo-5-aminoisophthalic acid

Conditions

Conditions	Yield
With potassium iodate; sulfuric acid; potassium iodide In water at 30 - 75℃; for 5h; pH=< 0.5; Reagent/catalyst; Temperature; pH-value;	95.3%
With sulfuric acid; iodine; iodic acid In water at 72℃; for 6.2h; pH=1; Product distribution / selectivity;	82.6%
With K(1+)*Cl2I(1-) In water at 60 - 90℃; for 25h;	75%

: 85-44-9
phthalic anhydride

: 99-31-0
5-aminoisophthalic acid

: 5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)isophthalic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 6h; Heating;	95%
With acetic acid Heating;
In N,N-dimethyl-formamide for 3h; Reflux;
With acetic acid for 8h; Reflux;

: 99-31-0
5-aminoisophthalic acid

: 121385-69-1
5-hydrazinyl-1,3-benzene dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With hydrogenchloride In water at 0 - 5℃; for 0.25h; Stage #2: With sodium nitrite In water at 0 - 5℃; for 1h; Stage #3: With hydrogenchloride; sodium sulfite In water at 0 - 60℃;	95%
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: With tin(II) chloride dihdyrate In water for 1h;	93%
Product distribution / selectivity;	68.8%

: 6326-83-6
bis(carboxymethyl)trithiocarbonate

: 99-31-0
5-aminoisophthalic acid

: 5-(4-oxo-2-thioxothiazolidin-3-yl)isophthalic acid

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid In water at 95℃; Stage #2: bis(carboxymethyl)trithiocarbonate In water at 100℃;	95%
With sodium carbonate
In water at 100℃;

: 81-30-1
1,4,5,8-naphthalenetetracarboxylic dianhydride

: 99-31-0
5-aminoisophthalic acid

: 350024-36-1
5,5′-(1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diyl)bis-1,3-benzenedicarboxylic acid

Conditions

Conditions	Yield
at 180℃; for 1h;	95%
In N,N-dimethyl-formamide for 6h; Heating;	85%
In N,N-dimethyl-formamide for 24h; Reflux;	84%

: 99-31-0
5-aminoisophthalic acid

: 3807-80-5
3,6-dinitro-1,8-naphthalendicarboxylic anhydride

: 1354701-62-4
N-(3',5'-dicarboxyphenyl)-3,6-dinitro-1,8-naphthalimide

Conditions

Conditions	Yield
With sodium acetate; acetic acid Inert atmosphere; Reflux;	95%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 99-31-0
5-aminoisophthalic acid

: 776242-98-9
5,5’,5’’-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl) triisophthalate

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With sodium hydrogencarbonate; sodium hydroxide In water at 0 - 20℃; for 0.75h; Stage #2: 1,3,5-trichloro-2,4,6-triazine In 1,4-dioxane; water at 100℃; for 24h;	95%
Stage #1: 5-aminoisophthalic acid With sodium hydrogencarbonate; sodium hydroxide In water at 0℃; for 0.5h; Stage #2: 1,3,5-trichloro-2,4,6-triazine In 1,4-dioxane; water at 100℃; for 24h;	94%
Stage #1: 5-aminoisophthalic acid With sodium hydrogencarbonate; sodium hydroxide In water at 0℃; for 0.5h; Stage #2: 1,3,5-trichloro-2,4,6-triazine In 1,4-dioxane; water at 110℃; for 24h;	94%

: 99-31-0
5-aminoisophthalic acid

: 103-71-9
phenyl isocyanate

: 205699-08-7
5-(3-phenylureido)isophthalic acid

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; Inert atmosphere;	95%

: 99-31-0
5-aminoisophthalic acid

: 3,5-dicarboxyphenyl azide

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With hydrogenchloride In water at 0 - 5℃; Stage #2: With sodium nitrite In water for 0.5h; Stage #3: With sodium azide In water at 20℃;	95%
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.666667h; Stage #2: With sodium azide In water at 0 - 5℃; Cooling with ice;	86%
Stage #1: 5-aminoisophthalic acid With sulfuric acid; sodium nitrite In water at 0℃; Stage #2: With sodium azide In water at 0℃; for 0.25h;	84%
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium nitrite In water Stage #2: With sodium azide
Stage #1: 5-aminoisophthalic acid With sodium azide In water at 0 - 5℃; for 0.5h; Stage #2: In water at 20℃;

: 67-56-1
methanol

: 99-31-0
5-aminoisophthalic acid

: 99-27-4
dimethyl 5-aminoisophthalate

Conditions

Conditions	Yield
With sulfuric acid for 24h; Reflux; Solvolysis;	95%
With sulfuric acid at 90℃; for 24h;	88%
With sulfuric acid at 90℃; for 24h;	68%
With sulfuric acid

: C33H15Cl6N3O9

: 99-31-0
5-aminoisophthalic acid

: C81H51N9O33

Conditions

Conditions	Yield
With dmap In N,N-dimethyl acetamide at 25℃; for 12h; Inert atmosphere;	95%

: 99-31-0
5-aminoisophthalic acid

: 1461-22-9
tributyltin chloride

: C32H59NO4Sn2

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With potassium hydroxide In ethanol at 20℃; for 1h; Stage #2: tributyltin chloride In ethanol at 20℃; for 5h;	95%

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 99-31-0
5-aminoisophthalic acid

: 5-((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)isophthalic acid

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With sodium hydrogencarbonate; sodium hydroxide In water at 20℃; for 0.25h; Stage #2: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In 1,4-dioxane; water at 100℃; for 36h;	95%

: 24424-99-5
di-tert-butyl dicarbonate

: 99-31-0
5-aminoisophthalic acid

: 2450-71-7
Propargylamine

: 940005-72-1
(3,5-bis(prop-2-ynylcarbamoyl)phenyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; 5-aminoisophthalic acid With sodium hydroxide In 1,4-dioxane at 0 - 20℃; for 3h; Stage #2: Propargylamine In tetrahydrofuran for 48h;	95%

...Expand

: 99-31-0
5-aminoisophthalic acid

: 108-24-7
acetic anhydride

: 6344-50-9
5-(acetylamino)isophthalic acid

Conditions

Conditions	Yield
With acetic acid In N,N-dimethyl-formamide at 20℃; for 4h;	94%
for 4h; Reflux;	85%
at 90℃; for 4h;	85%
With acetic acid at 180℃;

: 67-52-7
BARBITURIC ACID

: 99-31-0
5-aminoisophthalic acid

: 1400790-44-4
5-[(3,5-dicarboxyphenyl)azo]barbituric acid

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium nitrite In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: BARBITURIC ACID With sodium acetate In N,N-dimethyl-formamide at 0℃; for 3.5h;	94%

: 6710-92-5
2,5,8-trichloro-1,3,4,6,7,9,9b-heptaazaphenalene

: 99-31-0
5-aminoisophthalic acid

: 2,5,8-tris-(3,5-dicarboxylphenylamino)-s-heptazine acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydrogencarbonate; sodium hydroxide In 1,4-dioxane; water at 100℃; for 24h; pH=2;	94%

: 99-31-0
5-aminoisophthalic acid

: 123-54-6
acetylacetone

: 5-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)isophthalic acid

Conditions

Conditions	Yield
Stage #1: 5-aminoisophthalic acid With hydrogenchloride; sodium hydroxide; sodium nitrite In water at -0.16℃; Stage #2: acetylacetone In water at -0.16℃; for 1h;	94%

: 99-31-0
5-aminoisophthalic acid

: 7732-18-5
water

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 4C8H5NO4(2-)*2HO(1-)*5Co(2+)*2H2O

Conditions

Conditions	Yield
In methanol for 8h; Reflux;	94%

...Expand

5-Aminoisophthalic acid Chemical Properties

Molecular Formula: C₈H₇NO₄
Molecular Weight: 181.15
EINECS: 202-748-5
Melting point: >300 °C(lit.)
Boiling Point: 515°C
Water Solubility: Insoluble
Appearance: Beige powder.
5-Aminoisophthalic acid(99-31-0)'s Synonyms: 5-amino-3-benzenedicarboxylicacid;AMINOISOPHTHALIC(5-) ACID;5-AMINO-1,3-ISOPHTHALIC ACID;5-AMINO-1,3-BENZENEDICARBOXYLIC ACID;5-AMINOISOPHTHALIC;5-AMINOISOPHTHALIC ACID;5-AMINOISOPHTHALIC ACID HYDRATE;5-AIPA
5-Aminoisophthalic acid(99-31-0)'s structural formula:

5-Aminoisophthalic acid Uses

5-Aminoisophthalic acid(99-31-0) can be used as contrast agents and dye materials.

5-Aminoisophthalic acid Production

With isophthalic acid as raw materials in sulfuric acid and nitric acid for nitration to generate 5 - nitro-isophthalic acid, and then in the presence of a catalyst, derived from high-pressure hydrogenation.

5-Aminoisophthalic acid Specification

Hazards Identification for 5-Aminoisophthalic acid(99-31-0)
【Inhalation】Causes respiratory tract irritation.
【Skin】Causes skin irritation.
【Eyes】Causes eye irritation. May cause chemical conjunctivitis.
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
【EC Risk Phrase】R 36/37/38
【EC Safety Phrase】S 26 36

Stability and Reactivity 5-Aminoisophthalic acid(99-31-0)
【Disposal Code】4
【Incompatibilities】Oxidizing agents.
【Stability】Stable at room temperature in closed containers under normal storage and handling conditions.
【Decomposition】Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Product Name

5-Aminoisophthalic acid

Synthetic route

5-Aminoisophthalic acid Chemical Properties

5-Aminoisophthalic acid Uses

5-Aminoisophthalic acid Production

5-Aminoisophthalic acid Specification

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