Conditions | Yield |
---|---|
With Iron(III) nitrate nonahydrate; acetic acid at 35℃; for 5h; Reagent/catalyst; Temperature; | 96% |
With bismuth(III) nitrate; acetic anhydride; acetic acid at 20℃; for 6h; Reagent/catalyst; Temperature; | 96.5% |
With nitric acid In dichloromethane at 10℃; for 1.33333h; | 90% |
6-nitro-acenaphthen-5-ylamine
4-nitroacenaphthene
Conditions | Yield |
---|---|
(i) aq. HCl, NaNO2, (ii) Cu2O, aq. NH3; Multistep reaction; |
Conditions | Yield |
---|---|
With nitric acid; perfluoro-o-phenylenemercury trimer; sodium chloride; sodium nitrite In nitrobenzene; benzene at 21℃; for 0.666667h; Product distribution; various reaction conditions; | |
With Hg5(C(CF3)2)5; cis-nitrous acid; sodium chloride In nitrobenzene; benzene at 21℃; Yield given. Yields of byproduct given; | |
With nitric acid In acetic anhydride for 3h; Overall yield = 98 %; Overall yield = 0.78 g; |
Conditions | Yield |
---|---|
at 15℃; |
Conditions | Yield |
---|---|
at 20 - 25℃; |
Conditions | Yield |
---|---|
at 20 - 25℃; |
Conditions | Yield |
---|---|
at -10℃; |
nitric acid
acetic anhydride
acenaphthene
A
3-nitroacenaphthene
B
4-nitroacenaphthene
C
4-nitro-acenaphthene
Conditions | Yield |
---|---|
With Petroleum ether at -10℃; |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol under 3102.9 Torr; for 1h; | 91% |
With ethanol; platinum Hydrogenation; | |
With hydrogenchloride; tin |
Conditions | Yield |
---|---|
With sodium dichromate; acetic acid at 80 - 95℃; | 91% |
With sodium dichromate In acetic acid for 5h; Reflux; | 90% |
With sodium dichromate; acetic acid for 5h; Reflux; | 87% |
4-nitroacenaphthene
methylmagnesium chloride
5-Chloro-4-methyl-acenaphthene
Conditions | Yield |
---|---|
With potassium hydroxide; sodium hypochlorite In tetrahydrofuran; ethanol; water for 0.166667h; Ambient temperature; | 89% |
4-nitroacenaphthene
2-nitro-1,8-naphthalic anhydride
Conditions | Yield |
---|---|
With sodium dichromate In acetic acid at 65 - 100℃; for 8.5h; | 74% |
4-nitroacenaphthene
perfluoro-o-phenylenemercury trimer
[(o-C6F4Hg)3](5-nitroacenaphthene)
Conditions | Yield |
---|---|
In dichloromethane soln. of nitroacenaphthene in CH2Cl2 was added to soln. of Hg compd. in CH2Cl2; slowly evapd. at 20°C for 2 d; filtered; washed (ether); dried (vac., 20°C, 3 h); elem. anal.; | 66% |
4-nitroacenaphthene
vinyl magnesium bromide
5,6-dihydroindeno<1,7-fg>indole
Conditions | Yield |
---|---|
In tetrahydrofuran at -40℃; | 59% |
Conditions | Yield |
---|---|
auf dem Dampfbad; |
Conditions | Yield |
---|---|
bei der Oxydation; | |
With sodium dichromate; acetic acid man faellt mit Wasser und kocht den Niederschlag mit Sodaloesung; |
Conditions | Yield |
---|---|
With nitric acid; acetic anhydride at -20℃; |
Conditions | Yield |
---|---|
With sodium dithionite; ethanol Kochen der Reaktionsloesung mit verd. Salzsaeure; |
4-nitroacenaphthene
1-bromo-5-nitro-acenaphthene
Conditions | Yield |
---|---|
With tetrachloromethane; N-Bromosuccinimide; dibenzoyl peroxide | |
With bromine; dibenzoyl peroxide In tetrachloromethane Irradiation; |
4-nitroacenaphthene
6-nitro-acenaphthene-4-sulfonic acid
Conditions | Yield |
---|---|
With chlorosulfonic acid; nitrobenzene |
4-nitroacenaphthene
Conditions | Yield |
---|---|
With ethanol; calcium chloride; zinc |
Conditions | Yield |
---|---|
With pyridine |
Conditions | Yield |
---|---|
With piperidine at 130℃; |
Conditions | Yield |
---|---|
With piperidine Erwaermen auf dem Dampfbad und anschliessendes Behandeln mit Acetanhydrid; |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid |
Conditions | Yield |
---|---|
With bromine |
4-nitroacenaphthene
A
1-hydroxy-5-nitroacenaphthene
B
2-hydroxy-5-nitroacenaphthene
Conditions | Yield |
---|---|
With iodosylbenzene; CrIII(TPP)(Cl) In dichloromethane for 0.5h; Product distribution; Mechanism; selectivity parameter; biomimetic hydroxylation; | A 52.8 % Chromat. B 17.7 % Chromat. C 16.5 % Chromat. D 4.6 % Chromat. |
With iodosylbenzene; meso-tetrakis(tetraphenyl)porphyrin iron(III) chloride In dichloromethane for 0.5h; Product distribution; Mechanism; selectivity parameter; biomimetic hydroxylation; | A 50.3 % Chromat. B 22.0 % Chromat. C 14.3 % Chromat. D 5.5 % Chromat. |
With iodosylbenzene; 5,10,15,20-tetraphenyl-21 H,23-H-porphine manganese(III)chloride In dichloromethane for 0.5h; Product distribution; Mechanism; selectivity parameter; biomimetic hydroxylation; | A 22.1 % Chromat. B 11.4 % Chromat. C 34.3 % Chromat. D 20.6 % Chromat. |
4-nitroacenaphthene
4,5-Dihydro-1,2,4,5-tetrabrom-6-nitro-acenaphthen
Conditions | Yield |
---|---|
With bromine In chloroform |
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of chemicals to Man . 16 ,1978,p. 319.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); Clear Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-118 ,1978. . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
The IUPAC name of 5-Nitroacenaphthene is 5-nitro-1,2-dihydroacenaphthylene. With the CAS registry number 602-87-9, it is also named as 1,2-Dihydro-5-nitro-acenaphthylene. The product's categories are Intermediates of Dyes and Pigments; Aromatic Compounds. It is yellow powder which is soluble in water, ethanol, ether and petroleum ether. This chemical is also stable, combustible and incompatible with strong oxidizing agents. Additionally, it should be sealed in the container and stored in the cool and dry place.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.92; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.92; (4)ACD/LogD (pH 7.4): 3.92; (5)ACD/BCF (pH 5.5): 558.93; (6)ACD/BCF (pH 7.4): 558.93; (7)ACD/KOC (pH 5.5): 3222.28; (8)ACD/KOC (pH 7.4): 3222.28; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.723; (13)Molar Refractivity: 58.2 cm3; (14)Molar Volume: 146.7 cm3; (15)Polarizability: 23.07×10-24 cm3; (16)Surface Tension: 62.6 dyne/cm; (17)Enthalpy of Vaporization: 60.07 kJ/mol; (18)Vapour Pressure: 1.46E-05 mmHg at 25°C; (19)Exact Mass: 199.063329; (20)MonoIsotopic Mass: 199.063329; (21)Topological Polar Surface Area: 45.8; (22)Heavy Atom Count: 15; (23)Complexity: 273.
Preparation of 5-Nitroacenaphthene: It can be derived from nitration of acenaphthene. Adding glacial acetic acid into the dry glass-lined reactor and adding industrial acenaphthene (melting point: 92-94 °C) with the stirring. Stirring 10min at 70 °C. Then cooling to 23 °C. Adding 65% nitric acid dropwise at the temperature of 23-26 °C and stirring 1h at 23-26 °C. At last, we can get the product.
Uses of 5-Nitroacenaphthene: It is used as intermediate of dyes. And it is also used as chemical reagent. In addition, it can react with methylmagnesium chloride to get 5-chloro-4-methyl-acenaphthene. This reaction needs reagent sodium hypochlorite, potassium hydroxide and solvent tetrahydrofuran, H2O, ethanol at ambient temperature. The reaction time is 10 min. The yield is 89%.
When you are using this chemical, please be cautious about it as the following:
It may cause cancer. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) And avoid exposure - obtain special instructions before use.
People can use the following data to convert to the molecule structure.
1. SMILES:[O-][N+](=O)c1ccc3c2c1cccc2CC3
2. InChI:InChI=1/C12H9NO2/c14-13(15)11-7-6-9-5-4-8-2-1-3-10(11)12(8)9/h1-3,6-7H,4-5H2
3. InChIKey:CUARLQDWYSRQDF-UHFFFAOYAL
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