6-Methoxytetralone supplier

Name
6-Methoxytetralone
EINECS 214-078-0
CAS No. 1078-19-9
Article Data98
CAS DataBase
Density 1.124 g/cm³
Solubility Insoluble in water
Melting Point 77-79 ºC
Formula C₁₁H₁₂O₂
Boiling Point 312.5 ºC at 760 mmHg
Molecular Weight 176.215
Flash Point 153.4 ºC
Transport Information
Appearance yellow crystalline powder
Safety 24/25-36-26
Risk Codes 22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 1 (2H)-Naphthalenone, 3,4-dihydro-6-methoxy-;6-methoxy-1,2,3,4-tetrahydro-1-naphthalenone;6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one;6-methoxytetralin-1-one;1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-;6-Methoxy-3,4-dihydro-2H-naphthalin-1-on;6-Methoxy-3,4-dihydro-1(2H)-naphthalenone;3,4-Dihydro-6-methoxy-1(2H)-naphthalenone;6-Methoxy-3, 4-dihydro-1(2H)-naphthalenone;6-Methoxy-.alpha.-tetralone;6-methoxy-3,4-dihydro-2H-naphthalen-1-one;6-methoxy-3,4-dihydronaphthalen-1(2H)-one;6-Methoxy-alpha-tetralone;6-Methoxy-1-tetralone;6-Methoxy-1-Tetralone 98.5%;6-Methoxy Tetralone;sell:6-Metoxy-1-tetralone;6-methoxy-1-tertralone/6-Methoxytetralone;
PSA 26.30000
LogP 2.21420

Synthetic route

: 180331-07-1
6-methoxy-3,4-dihydro-2H-spiro[naphthalene-1,2'-[1,3]dithiane]

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With periodic acid In tetrahydrofuran; diethyl ether for 0.1h; Ambient temperature;	96%
Stage #1: 6-methoxy-3,4-dihydro-2H-spiro[naphthalene-1,2'-[1,3]dithiane] With chloro-trimethyl-silane; sodium iodide In acetonitrile at 20℃; for 24h; Stage #2: With water In acetonitrile for 0.0833333h;	85%

: 79128-80-6
6-methoxy-3,4-dihydro-2H-naphthalen-1-one-(2,4-dinitro-phenylhydrazone)

A: 615-71-4
benzene-1,2,4-triamine

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With vanadium(II) chloride In tetrahydrofuran for 1h; Heating;	A n/a B 95%

: 111171-80-3
4-(m-methoxyphenyl)-1,1,1-tris(phenylthio)butane

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With silver trifluoromethanesulfonate In dichloromethane for 1h; Ambient temperature;	95%
With DMTSF In dichloromethane for 0.25h; Product distribution; Ambient temperature; effect of various Lewis acids on cyclization followed hydrolyzis;	78%
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; water; silver trifluoromethanesulfonate 1.) C6H6, 70 deg C, 1 h; 2.) CH3CN, 15 min; Yield given. Multistep reaction;

: 16821-32-2
6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With 1-hydroxy-1H-1,2,3-benziodoxathiole 1,3,3-trioxide; Oxone; cetyltrimethylammonim bromide In water at 20℃; for 2h; Green chemistry; chemoselective reaction;	95%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water at 25℃; for 24h; Micellar solution;	93%
With diisopropyl-carbodiimide In toluene at 120℃; for 24h; Inert atmosphere; Sealed tube;	92%

: 73622-41-0
6'-methoxy-3',4'-dihydro-2'H-spiro[1,3-dithiolane-2,1'-naphthalene]

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In methanol; water Heating;	95%
With Oxone; potassium bromide In water; acetonitrile at 20℃; for 2h;	65%

: 57816-04-3
methyl 4-(3-methoxyphenyl)butanoate

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With Eaton’s reagent In 1,2-dichloro-ethane at 75℃; for 2h; Inert atmosphere;	91%

: C13H16O3

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With lithium chloride In water; dimethyl sulfoxide at 90℃; for 6h;	90%

: 54951-36-9
6-methoxy-1-tetralone oxime

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With sodium bismuthate; water; silica gel for 0.05h;	88%
With iodine; sodium dodecyl-sulfate In water at 25 - 40℃; for 4.5h;	69.8%

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With oxygen; 9,10-Dicyanoanthracene; Paraquat; iron(II) chloride In methanol; acetonitrile for 2h; Ambient temperature; Irradiation;	87%
With tetrabutylammonium perchlorate; water; sodium acetate In acetonitrile Electrochemical reaction; Green chemistry;	84.9%
With Bromotrichloromethane; Ir[2-(2,4-difluorophenyl)-5-(trifluoromethyl)pyridine]2(4,4'-di-tert-butyl-2,2'-bipyridine)PF6; water; potassium carbonate In acetonitrile at 20℃; Irradiation; Inert atmosphere; regioselective reaction;	78%

: 6-methoxy-1-(methoxymethylene)-1,2,3,4-tetrahydronaphthalene

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper (II) carbonate hydroxide; TPGS-750-M In water at 20℃; Green chemistry;	83%

: 436155-55-4
methyl 2-[4-(3-methoxyphenyl)butanoyl]hydrazinecarboxylate

A: methyl (7-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)carbamate

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
Stage #1: methyl 2-[4-(3-methoxyphenyl)butanoyl]hydrazinecarboxylate With bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; Stage #2: With boron trifluoride diethyl etherate In dichloromethane Further stages.;	A 82% B 6%

: 129225-85-0
4-(m-methoxyphenyl)-1,1,1-tris(methylthio)butane

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With silver trifluoromethanesulfonate In dichloromethane for 2h; Ambient temperature;	78%

: 7-Methoxy-4-phenylsulfanyl-1,2-dihydro-naphthalene

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With chloro-trimethyl-silane; water; sodium iodide; mercury dichloride In acetonitrile for 2h; Ambient temperature;	77%

: C13H16O2S

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With aluminium trichloride; potassium iodide In water; acetonitrile at 80℃; for 6h;	77%

: 6132-86-1
6-Methoxy-<1>tetralon-phenylhydrazon

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With hexamethylenetetramine; water for 0.0222222h; microwave irradiation;	76%

: 57700-25-1
6-methoxytetralone semicarbazone

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With sodium bismuthate; silica gel for 0.133333h; Hydrolysis; microwave irradiation, solid phase reaction;	73%

: 86770-53-8
(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)hydrazine

A: 86770-56-1
4-iodo-7-methoxy-1,2-dihydronaphthalene

B: 86770-58-3
N,N'-Bis-[6-methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-hydrazine

C: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With tert-butyl-tetramethyl-guanidine; iodine In toluene for 0.25h; Product distribution; Ambient temperature; variation of solvent and base, optimize the yield of iodide;	A 68% B 15% C 12%

...Expand

: 86770-53-8
6-methoxy-α-tetralone hydrazone

A: 86770-58-3
1,2-bis((E)-6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)hydrazine

B: 86770-56-1
4-iodo-7-methoxy-1,2-dihydronaphthalene

C: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; iodine In tetrahydrofuran at 20℃; for 0.5h;	A 15% B 68% C 12%
With N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; iodine In toluene at 20℃; for 0.5h;	A 15% B 68% C 12%
Product distribution; effect of solvents (ether, THF, toluene, acetonitrile, DMF, DMSO);

...Expand

: 83390-26-5
6-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carbaldehyde

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water for 22h; Heating;	67%
With alkaline tetrahydrofuran for 22h; Heating; Yield given;

: 114423-18-6
(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-methanol

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With molecular sieve; pyridinium chlorochromate In dichloromethane at 20℃; for 15h;	67%
With dipyridinium dichromate; Celite In dichloromethane at 25℃; for 14h;	60%

: 164171-80-6
1-(4-methoxyphenyl)cyclobutan-1-ol

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver nitrate In dichloromethane; water at 20℃; for 3h; Inert atmosphere; regioselective reaction;	66%
With lithium perchlorate In acetonitrile at 0 - 20℃; for 3h; Electrochemical reaction; Sealed tube; Green chemistry; regioselective reaction;	25%

: 1,3-dioxoisoindolin-2-yl 5-(4-methoxyphenyl)-5-oxopentanoate

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; trifluoroacetic acid In dimethyl sulfoxide at 20℃; for 7h; Irradiation;	65%

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 16821-24-2
1,6-dimethoxy-tetralin

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In methanol for 0.0833333h; Ambient temperature;	A 19% B 63%

: 87543-03-1
6'-methoxy-3',4'-dihydrospiro<1,3-benzodithiole-2,1'(2'H)naphthalene>

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; mercury(II) oxide In tetrahydrofuran; water	62%
With tetrahydrofuran; mercury(II) oxide; boron trifluoride diethyl etherate	62%

: 436155-56-5
phenyl 2-[4-(3-methoxyphenyl)butanoyl]hydrazinecarboxylate

A: 436155-78-1
phenyl (7-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)carbamate

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
Stage #1: phenyl 2-[4-(3-methoxyphenyl)butanoyl]hydrazinecarboxylate With bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; Stage #2: With boron trifluoride diethyl etherate In dichloromethane Further stages.;	A 55% B 4.7%

: 2564-83-2, 45842-10-2
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: 164171-80-6
1-(4-methoxyphenyl)cyclobutan-1-ol

A: 1-(4-methoxyphenyl)-4-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-butan-1-one

B: 4160-51-4
1-(4-methoxyphenyl)-1-butanone

C: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With sodium persulfate; silver nitrate In water; dimethyl sulfoxide at 50℃; for 16h; Inert atmosphere;	A 54% B 7 mg C 16%

...Expand

: 75-91-2
tert.-butylhydroperoxide

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 6836-19-7
7-Methoxy-1-tetralone

B: 6-methoxy-2,3-dihydronaphthalene-1,4-dione

C: 1-tert-butylperoxy-6-methoxytetralin

D: 1-tert-butylperoxy-7-methoxytetralin

E: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With copper(II) choride dihydrate; tetrabutyl-ammonium chloride; sodium carbonate; 2,2′‐biquinoline‐4,4′‐dicarboxylic acid dipotassium salt In water at 20℃; for 17h; Green chemistry;	A 8% B 12% C n/a D n/a E 50%

...Expand

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 93-04-9
2-Methoxynaphthalene

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(I) sulfate In water; acetonitrile at 65 - 70℃; for 3h;	A 10% B 45%

: 75-91-2
tert.-butylhydroperoxide

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

B: 6836-19-7
7-Methoxy-1-tetralone

C: 16821-32-2
6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

D: 1-tert-butylperoxy-6-methoxytetralin

E: 1-tert-butylperoxy-7-methoxytetralin

F: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With copper(II) choride dihydrate; tetrabutyl-ammonium chloride; sodium carbonate; 2,2′‐biquinoline‐4,4′‐dicarboxylic acid dipotassium salt In water at 20℃; for 17h; Green chemistry;	A n/a B 17% C n/a D n/a E n/a F 39%

...Expand

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 6836-19-7
7-Methoxy-1-tetralone

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; chromium(VI) oxide In dichloromethane for 9h; Ambient temperature;	A 17% B 36%
With tert.-butylhydroperoxide; bis-(tributyltin oxide) dioxochromium(VI) In dichloromethane at 40℃; for 7.5h;	A 15% B 32%
With tert.-butylhydroperoxide; 2,4-dimethyl-2,4-pentanediol cyclic Cr(VI) ester In tetrachloromethane; dichloromethane at 0℃; for 8h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With potassium permanganate; copper(II) sulfate In dichloromethane for 72h; Heating;	A 5 % Chromat. B 85 % Chromat.

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 54951-36-9
6-methoxy-1-tetralone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride	100%
With hydroxylamine hydrochloride; sodium acetate In methanol at 70℃; for 1.5h;	96%
With hydroxylamine hydrochloride; sodium acetate In methanol; water at 60℃; for 12h;	95%

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16821-32-2
6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol for 4h;	100%
With lithium aluminium tetrahydride In tetrahydrofuran for 18h; Heating;	99%
With methanol; sodium tetrahydroborate at 0 - 20℃;	99%

: 74-88-4
methyl iodide

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 21568-65-0
2,2-dimethyl-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

Conditions

Conditions	Yield
With sodium hydride In benzene Heating;	100%
In benzene	100%
With sodium hydride In benzene Heating / reflux;	100%

: 7677-24-9
trimethylsilyl cyanide

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 80859-07-0
6-methoxy-1-(trimethylsilanyloxy)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile

Conditions

Conditions	Yield
With zinc(II) chloride	100%
With zinc(II) iodide for 48h; Ambient temperature;	64%
With zinc(II) iodide In toluene; acetonitrile at 60℃; for 5h;	56%
With zinc(II) iodide

: 358-23-6
trifluoromethylsulfonic anhydride

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 115375-59-2
6-methoxy-3,4-dihydronaphthalene-1-yl triflate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 40℃; for 24h; Solvent; Sealed tube; Inert atmosphere;	100%
Stage #1: 6-methoxy-3,4-dihydro-1(2H)-naphthalenone With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at 0 - 20℃;	70%
With triethylamine In dichloromethane at 0℃; for 22h; Inert atmosphere; Reflux;	69%
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane for 7h; Ambient temperature;	62%

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 35609-43-9
2-chloro-6-methoxy-1-tetralone

Conditions

Conditions	Yield
With N-chloro-succinimide; thiourea In methanol at 23℃; for 0.333333h;	100%
With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one In ethanol for 6h; Heating;	71%
Stage #1: 6-methoxy-3,4-dihydro-1(2H)-naphthalenone With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With p-toluenesulfonyl chloride In tetrahydrofuran at -78 - 20℃; for 1.33333h;
With N-chloro-succinimide; O,O-bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrazine-1,2-bis(carbothioate) In methanol at 25℃; for 0.666667h;	99 %Chromat.
With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one In ethanol for 4h; Reflux;

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 115375-59-2
6-methoxy-3,4-dihydronaphthalene-1-yl triflate

Conditions

Conditions	Yield
Stage #1: 6-methoxy-3,4-dihydro-1(2H)-naphthalenone With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.75h; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 0℃; for 3h;	100%
With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; for 16h; Inert atmosphere;	89%
Stage #1: 6-methoxy-3,4-dihydro-1(2H)-naphthalenone With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	80%

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: (1R)-6-methoxy-1,2,3,4-tetrahydronaphthalene-1-ol

Conditions

Conditions	Yield
With formic acid; C38H40ClN2O2RhS; triethylamine In neat (no solvent) at 24 - 30℃; for 24h; Reagent/catalyst; Inert atmosphere; enantioselective reaction;	100%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C49H64FeNOP; hydrogen; sodium t-butanolate In isopropyl alcohol at 25 - 30℃; under 38002.6 Torr; for 12h; Autoclave; enantioselective reaction;	99%
With C32H39BrMnN2O2P; potassium tert-butylate; hydrogen In methanol at 20℃; under 37503.8 Torr; for 16h; Glovebox; Autoclave; enantioselective reaction;	99%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 582300-13-8
[(6-methoxy-3,4-dihydro-1-naphthalenyl)oxy](dimethyl)-tert-butylsilane

Conditions

Conditions	Yield
With triethylamine; sodium iodide In acetonitrile at 20℃;	100%

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 111221-68-2
1-allyl-1,2,3,4-tetrahydro-6-methoxynaphthalen-1-ol

Conditions

Conditions	Yield
With methanol; indium (III) tris(hexamethyldisilyl) amide In toluene at 20℃; for 6h; Inert atmosphere;	100%
With indium iodide In tetrahydrofuran at 40℃; for 24h;	70%

: 593-56-6
N-methoxylamine hydrochloride

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: (E)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one O-methyloxime

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 70℃; for 2h;	100%

: 1950-68-1
4-methoxybenzenesulfonyl hydrazide

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 4-methoxy-N'-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)benzenesulfonohydrazide

Conditions

Conditions	Yield
With acetic acid In ethanol Reflux;	100%

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 3470-50-6
6-Hydroxy-1-tetralone

Conditions

Conditions	Yield
With hydrogen bromide for 3h; Heating;	99%
With hydrogen bromide; acetic acid at 120℃; for 12h;	98%
With aluminum (III) chloride In toluene for 1.08333h; Inert atmosphere; Sealed tube; Reflux;	96%

: 105-58-8
Diethyl carbonate

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16425-80-2
ethyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Conditions

Conditions	Yield
Stage #1: Diethyl carbonate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Schlenk technique; Stage #2: 6-methoxy-3,4-dihydro-1(2H)-naphthalenone In tetrahydrofuran; mineral oil at 0 - 80℃; for 12h; Inert atmosphere; Schlenk technique;	99%
With sodium hydride In tetrahydrofuran for 48h; Heating / reflux;	91.8%
With sodium hydride	85%

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16821-32-2, 42246-05-9, 120523-15-1
(1S)-6-methoxy-1,2,3,4-tetrahydronaphthalene-1-ol

Conditions

Conditions	Yield
With Tetrahydrofurfuryl alcohol; sodium tetrahydroborate In ethanol; chloroform at -20℃; for 0.333333h;	99%
With RuCl[(S)-daipena][(R)-dm-segphos]; potassium tert-butylate; hydrogen In ethanol; isopropyl alcohol at 15℃; under 7600.51 Torr; for 21h; optical yield given as %ee; enantioselective reaction;	96%
With Tetrahydrofurfuryl alcohol; sodium tetrahydroborate; (1S,2S)-1,2-bis(3,5-dimethylphenyl)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]ethylenediaminatocobalt(II) In methanol; chloroform at -30 - 10℃; for 9.75h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	96%

: 57-14-7
1,1-dimethylhydrazine

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16388-08-2
2-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-1,1-dimethylhydrazine

Conditions

Conditions	Yield
With acetic acid In benzene for 18h; Reflux;	99%
With trifluoroacetic acid In benzene Reflux; Dean-Stark; Inert atmosphere;	91%

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 86770-53-8
(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)hydrazine

Conditions

Conditions	Yield
With hydrazine In ethanol for 8h; Reflux;	99%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: (E)-6-methoxy-2-(4-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2H)-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 4h;	99%

: 106-21-8, 59204-02-3
tetrahydrogeraniol

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: C21H32O2

Conditions

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; lithium tert-butoxide In hexane; pentan-1-ol at 100℃; for 24h;	99%

: 608-05-9
5-methyl-indole-2,3-dione

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 3-methoxy-5'-methyl-9-phenyl-6,9,10,11-tetrahydrospiro[benzo[h]pyrazolo[3,4-b]quinoline-7,3'-indoline]-2',8(5H)-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 7h; Green chemistry;	99%

...Expand

: 70201-43-3
3-bromo-pyridine-4-carbaldehyde

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 1620646-31-2
(E)-2-((3-bromopyridin-4-yl)methylene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 35℃; for 4h;	99%

: 109-94-4
formic acid ethyl ester

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 851486-82-3
2-(hydroxymethylene)-6-methoxy-1-tetralone

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at -78 - -5℃; for 1h;	98%
With sodium methylate In pyridine for 18h; Ambient temperature;

: 109-94-4
formic acid ethyl ester

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 16252-53-2
6-Methoxy-2-hydroxymethylen-1-tetralon

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at -78 - -5℃; Inert atmosphere;	98%
Stage #1: formic acid ethyl ester; 6-methoxy-3,4-dihydro-1(2H)-naphthalenone With potassium tert-butylate at -78 - -5℃; Inert atmosphere; Stage #2: With hydrogenchloride In water	98%
With potassium tert-butylate In toluene at -78 - -5℃; Inert atmosphere;	98%

: 917-54-4
methyllithium

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 85035-85-4
1,2,3,4-tetrahydro-6-methoxy-1-methyl-1-naphthalenol

Conditions

Conditions	Yield
With lithium bromide In tetrahydrofuran; diethyl ether Ambient temperature;	98%

: 616-38-6
carbonic acid dimethyl ester

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 40153-87-5
methyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Conditions

Conditions	Yield
With sodium hydride Inert atmosphere; Reflux;	98%
With sodium hydride Inert atmosphere; Reflux;	98%
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; acetic acid; mineral oil	96%

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 5'-bromo-3-methoxy-9-phenyl-6,9,10,11-tetrahydrospiro[benzo[h]pyrazolo[3,4-b]quinoline-7,3'-indoline]-2',8(5H)-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 6h; Green chemistry;	98%

...Expand

: 456-48-4
3-Fluorobenzaldehyde

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 304459-30-1
(3-fluorobenzylidene)-6-methoxy-1-tetralone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 4h;	97.8%

: 638-38-0, 993-02-2, 2180-18-9, 15411-95-7, 22981-23-3, 27004-39-3
manganese triacetate

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 66049-51-2
1,2,3,4-tetrahydro-6-methoxy-1-oxonaphthalen-2-yl acetate

Conditions

Conditions	Yield
With acetic acid In benzene for 5h; Heating;	97%

: 104-88-1
4-chlorobenzaldehyde

: 57-13-6
urea

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 4-(4-chlorophenyl)-3,4,5,6-tetrahydro-8-methoxybenzo[h]quinazolin-2-(1H)-one

Conditions

Conditions	Yield
With (4-sulfobutyl)-tris(4-sulfophenyl)phosphonium hydrogen sulfate at 80℃; for 0.166667h;	97%

...Expand

: 7477-63-6
7-chloroisatin

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 7'-chloro-3-methoxy-9-phenyl-6,9,10,11-tetrahydrospiro[benzo[h]pyrazolo[3,4-b]quinoline-7,3'-indoline]-2',8(5H)-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 6h; Green chemistry;	97%

...Expand

6-Methoxytetralone Chemical Properties

IUPAC Name: 6-Methoxy-3,4-dihydro-2H-naphthalen-1-one
Molecular Formula: C₁₁H₁₂O₂
Molecular Weight: 176.21 g/mol
SMILES: O=C2c1c(cc(OC)cc1)CCC2 Copy
InChI: InChI=1/C11H12O2/c1-13-9-5-6-10-8(7-9)3-2-4-11(10)12/h5-7H,2-4H2,1H3
EINECS: 214-078-0
Product Categories: Carbonyl Compounds; Ketone; C11 to C12; Carbonyl Compounds; Ketones
Melting Point: 77-79 °C(lit.)
storage temperature: 0-6 °C
Index of Refraction: 1.548
Molar Refractivity: 49.84 cm³
Molar Volume: 156.7 cm³
Surface Tension: 40.8 dyne/cm
Density: 1.124 g/cm³
Flash Point: 153.4 °C
Enthalpy of Vaporization: 55.35 kJ/mol
Boiling Point: 312.5 °C at 760 mmHg
Vapour Pressure of 6-Methoxytetralone (CAS NO.1078-19-9): 0.000528 mmHg at 25 °C

6-Methoxytetralone Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38-20/21/22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note of 6-Methoxytetralone (CAS NO.1078-19-9): Irritant

6-Methoxytetralone Specification

6-Methoxytetralone (CAS NO.1078-19-9), its Synonyms are 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy- ; 6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one ; 6-Methoxy-1-tetralone ; 6-Methoxy-3,4-dihydro-1(2H)-naphthalenone ; 6-Methoxy-alpha-tetralone . It is yellow to light brown fine crystalline powder.

Product Name

6-Methoxytetralone

Synthetic route

6-Methoxytetralone Chemical Properties

6-Methoxytetralone Safety Profile

6-Methoxytetralone Specification

Related Products

Hot Products