NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 82.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 82.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 82.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
The IUPAC name of Adriamycin is (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione. With the CAS registry number 23214-92-8 and EINECS 245-495-6, it is also named as Doxorubicin. The classification codes are Antibiotics, Antineoplastic; Antineoplastic; Antineoplastic agents; Drug / Therapeutic Agent; Human Data; Mutation data; Natural Product; Reproductive Effect; Skin / Eye Irritant; Tumor data. It is highly toxic and flammable. When heated to decomposition it emits very toxic fumes of NOx and HCl. So the storage environment should be well-ventilated, low-temperature and dry. Keep Adriamycin separate from raw materials of food. What's more, this drug is photosensitive, and containers are often covered by an aluminum bag and/or brown wax paper to prevent light from affecting it.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.24; (2)# of Rule of 5 Violations: 3; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 12; (8)#H bond donors: 7; (9)#Freely Rotating Bonds: 11; (10)Polar Surface Area: 206.07 Å2; (11)Index of Refraction: 1.71; (12)Molar Refractivity: 131.521 cm3; (13)Molar Volume: 336.639 cm3; (14)Surface Tension: 96.438 dyne/cm; (15)Enthalpy of Vaporization: 123.508 kJ/mol; (16)Vapour Pressure: 0 mmHg at 25°C; (17)Rotatable Bond Count: 5; (18)Tautomer Count: 81; (19)Exact Mass: 543.174061; (20)MonoIsotopic Mass: 543.174061; (21)Topological Polar Surface Area: 206; (22)Heavy Atom Count: 39; (23)Complexity: 977.
Preparation and Uses of Adriamycin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas. The most serious adverse effect of this drug is life-threatening heart damage. In addition, this chemical can react with formaldehyde to get doxoform. This reaction needs reagent Et3N*AcOH and AcOH at temperature of 25 °C. The reaction time is 15 hours. The yield is 70%.
People can use the following data to convert to the molecule structure.
1. SMILES:C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](Cc3c2c(c4c(c3O)C(=O)c5cccc(c5C4=O)OC)O)(C(=O)CO)O)N)O
2. InChI:InChI=1/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
3. InChIKey:AOJJSUZBOXZQNB-TZSSRYMLBG
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 2400ug/kg (2.4mg/kg) | Drug and Chemical Toxicology. Vol. 6, Pg. 21, 1983. | |
hamster | LD10 | parenteral | 3500ug/kg (3.5mg/kg) | Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980. | |
human | LDLo | intravenous | 400ug/kg (0.4mg/kg) | GASTROINTESTINAL: OTHER CHANGES BLOOD: LEUKOPENIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Cancer Chemotherapy Reports, Part 3. Vol. 3, Pg. 33, 1972. |
human | TDLo | intravenous | 15mg/kg/D (15mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Cancer Vol. 34, Pg. 518, 1974. |
human | TDLo | intravenous | 380mg/kg/31W (380mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Cancer Vol. 34, Pg. 518, 1974. |
mammal (species unspecified) | LD50 | intraperitoneal | 8500ug/kg (8.5mg/kg) | Antibiotiki. Vol. 29, Pg. 748, 1984. | |
man | LDLo | unreported | 243ug/kg (0.243mg/kg) | CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Postgraduate Medical Journal. Vol. 68, Pg. 69, 1992. |
mouse | LD50 | intraperitoneal | 10700ug/kg (10.7mg/kg) | Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. Vol. 20, Pg. 303, 1989. | |
mouse | LD50 | intravenous | 10mg/kg (10mg/kg) | Journal of Antibiotics. Vol. 45, Pg. 1373, 1992. | |
mouse | LD50 | oral | 570mg/kg (570mg/kg) | Antibiotiki. Vol. 28, Pg. 298, 1983. | |
mouse | LD50 | unreported | 21900ug/kg (21.9mg/kg) | Biochemical Pharmacology. Vol. 38, Pg. 167, 1989. | |
mouse | LDLo | intratracheal | 2400ug/kg (2.4mg/kg) | Toxicology Letters. Vol. 30, Pg. 63, 1986. | |
rabbit | LD50 | intravenous | 5mg/kg (5mg/kg) | Yiyao Gongye. Pharmaceutical Industry. Vol. 17, Pg. 72, 1986. | |
rabbit | LDLo | intrapleural | 400ug/kg (0.4mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" | Pharmacology and Toxicology Vol. 62, Pg. 84, 1988. |
rat | LD50 | intraperitoneal | 16mg/kg (16mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1075, 1972. | |
rat | LD50 | intravenous | 10510ug/kg (10.51mg/kg) | Toxicology and Applied Pharmacology. Vol. 79, Pg. 412, 1985. | |
rat | LD50 | unreported | 7mg/kg (7mg/kg) | Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 34, Pg. 216, 1989. |
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