• Name

  Amylamine

• EINECS 203-780-2
• CAS No. 110-58-7
• Article Data130
• CAS DataBase
• Density 0.755 g/cm³
• Solubility soluble
• Melting Point -55 °C(lit.)
• Formula C₅H₁₃N
• Boiling Point 105.5 °C at 760 mmHg
• Molecular Weight 87.1649
• Flash Point 4.4 °C
• Transport Information UN 1106 3/PG 2
• Appearance clear colourless to very slightly yellow liquid
• Safety 16-26-36/37/39-45-33
• Risk Codes 11-22-34-42/43-20/21/22
• Molecular Structure
• Hazard Symbols F,C
• Synonyms Pentylamine(8CI);1-Aminopentane;1-Pentylamine;Monoamylamine;Monopentylamine;NSC 7906;Norleucamine;n-Amylamine;n-Pentylamine;1-Pentanamine;
• PSA 26.02000
• LogP 1.83560

Synthetic route

110-59-8

pentanonitrile

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With borane-ammonia complex; C15H30Cl2CoN3P In hexane at 120℃; for 16h; Sealed tube; Inert atmosphere; chemoselective reaction;	86%
With hydrogen; sodium methylate; nickel In methanol hydrogen generated in situ electrochemically on Raney nickel electrode;	72%
With lithium aluminium tetrahydride	71%

110-62-3

pentanal

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With ammonia; hydrogen In methanol at 30℃; for 15h; Autoclave;	94%
With ammonium hydroxide; ammonium acetate; hydrogen; [Ru(cod)Cl]2; trisodium tris(3-sulfophenyl)phosphine In toluene at 145℃; under 48754.9 Torr; for 10h;	47 % Chromat.
With ammonium hydroxide; hydrogen at 65℃; under 11251.1 Torr; for 12h; Autoclave; Green chemistry;
With pyridoxal 5'-phosphate; Amine transaminase 117; rac-methylbenzylamine; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water; dimethyl sulfoxide at 30℃; Reagent/catalyst; Enzymatic reaction;

26330-06-3

pentyl azide

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With hydrogen; MCM-silylamine Pd(II) In methanol at 20℃; for 2h; Reduction;	90%

1119-46-6

5-chloro-valeric acid

A

110-89-4

piperidine

B

675-20-7

piperidin-2-one

C

110-58-7

1-pentanamine

D

109-73-9

N-butylamine

Conditions

Conditions	Yield
Stage #1: 5-chloro-valeric acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 85% B 9% C 2% D 2%

...Expand

628-02-4

Caproamide

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With sodium hydroxide; benzyltrimethylazanium tribroman-2-uide In water at 70℃; for 2h;	80%
With sodium hydroxide; sodium bromite In water at 75℃; for 0.5h;	60%
With sodium hypochlorite

71-41-0

pentan-1-ol

A

110-58-7

1-pentanamine

B

109-52-4

valeric acid

Conditions

Conditions	Yield
With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia; water In 1,4-dioxane at 135℃; under 5700.38 Torr; for 30h; Inert atmosphere;	A 70.0 %Chromat. B n/a

60169-95-1

N,N'-dipentyl-oxalamide

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With potassium tert-butylate; hydrogen; [Ru(PtBuNNHBn)H(CO)Cl] In toluene at 135℃; under 30003 Torr; for 24h;	97 %Spectr.

5775-76-8, 5780-42-7, 628-79-5

valeraldoxime

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With ethanol; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation;
With diethyl ether; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation;
With palladium on activated charcoal; acetic acid Hydrogenation;

5775-76-8, 5780-42-7, 628-79-5

valeraldoxime

A

110-58-7

1-pentanamine

B

2050-92-2

Di-n-amylamine

Conditions

Conditions	Yield
With nickel kieselguhr; methyl cyclohexane at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation;
With diethyl ether; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation;
With ethanol; nickel kieselguhr at 100 - 125℃; under 73550.8 - 110326 Torr; Hydrogenation;

628-02-4

Caproamide

A

110-58-7

1-pentanamine

B

142-62-1

hexanoic acid

Conditions

Conditions	Yield
With sodium hydroxide; sodium persulfate; sodium chloride In water at 85 - 90℃; for 7h;	A 36% B 56%
With sodium hydroxide; sodium persulfate; copper dichloride In water at 85 - 90℃; for 7h;	A 36% B 56%
With sodium hydroxide; sodium persulfate; sodium chloride In water at 85 - 90℃; for 7h;	A 36% B 52%
With sodium hydroxide; sodium persulfate; sodium chloride In water at 85 - 90℃; for 7h;	A 36% B 52%

18379-77-6

chlorodipentylborane

110-58-7

1-pentanamine

Conditions

Conditions	Yield
Stage #1: chlorodipentylborane With hydroxylamine-O-sulfonic acid In tetrahydrofuran at 60℃; Inert atmosphere; Stage #2: With hydrogenchloride In methanol; diethyl ether; water at 20℃; Inert atmosphere; Stage #3: With sodium hydroxide In methanol; diethyl ether; water at 0℃; Inert atmosphere;	94%

110-86-1

pyridine

A

110-58-7

1-pentanamine

B

109-66-0

pentane

Conditions

Conditions	Yield
With hydrogen In decalin at 349.84℃; under 22502.3 Torr; Catalytic behavior; Reagent/catalyst; Temperature; Flow reactor;
With hydrogen In decalin at 349.84℃; under 22502.3 Torr; Catalytic behavior; Temperature; Flow reactor;

124-04-9

Adipic acid

A

105-60-2

caprolactam

B

111-49-9

hexamethylene imine

C

21920-79-6

6-(azepan-1-yl)hexan-1-amine

D

111-26-2

hexan-1-amine

E

110-58-7

1-pentanamine

Conditions

Conditions	Yield
Stage #1: Adipic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 39% B 53% C 4% D 2% E 2%

...Expand

71-41-0

pentan-1-ol

A

110-58-7

1-pentanamine

B

2050-92-2

Di-n-amylamine

Conditions

Conditions	Yield
With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia In toluene under 5700.38 Torr; for 20h; Inert atmosphere; Reflux;	A 61 %Chromat. B 34.6 %Chromat.

71-41-0

pentan-1-ol

A

65870-64-6

N-pentylidenepentan-1-amine

B

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With ammonia; carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II) In 1,4-dioxane; water under 5700.38 Torr; for 30h; Product distribution / selectivity; Reflux;

71-41-0

pentan-1-ol

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With L-alanin; D-glucose; pyridoxal 5'-phosphate; alanine dehydrogenase from B. subtilis; catalase from M. lysodeikticus; glucose dehydrogenase from DSM; long-chain alcohol oxidase from Aspergillus fumigatus; w-transaminase from Chromobacterium violaceum; NAD; oxygen; ammonium chloride; flavin adenine dinucleotide In aq. phosphate buffer at 20℃; under 1500.15 Torr; for 24h; pH=10; Enzymatic reaction;
With aminedehydrogenase; ammonia; ammonium chloride at 30℃; for 48h; pH=8.7; Enzymatic reaction;
With formate dehydrogenase from Candida boidinii; alcohol dehydrogenase from Thermoanaerobacter ethanolicus I86A W110A variant; chimeric amine dehydrogenase generated through domain shuffling of Bb‐PhAmDH variant and L‐AmDH variant, the latter originated from the leucinedehydrogenase from Bacillus stearothermophilus; NADPH oxidase from Bacillus subtilis; nicotinamide adenine dinucleotide phosphate; nicotinamide adenine dinucleotide; catalase In aq. buffer at 30℃; for 12h; pH=8.5; Enzymatic reaction;

88-14-2

2-furanoic acid

A

109-99-9

tetrahydrofuran

B

110-89-4

piperidine

C

4795-29-3

TETRAHYDROFURFURYLAMINE

D

110-58-7

1-pentanamine

E

109-73-9

N-butylamine

Conditions

Conditions	Yield
Stage #1: 2-furanoic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 13% B 9% C 43% D 6% E 10%

...Expand

109-66-0

pentane

A

110-58-7

1-pentanamine

B

625-30-9

2-pentylamine

C

616-24-0

3-aminopentane

Conditions

Conditions	Yield
Stage #1: pentane With cerium(III) chloride; 1,1,1-trichloroethanol; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride In acetonitrile at 20℃; for 12h; Irradiation; Inert atmosphere; Sealed tube; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Stage #3: With hydrogen In methanol for 12h; Reagent/catalyst;

...Expand

543-59-9

1-Chloropentane

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With ammonia; water; soap at 100℃; unter Druck;
With cis-Octadecenoic acid; ammonia at 100℃; unter Druck;
With ammonia at 135℃; under 22065.2 Torr; und hoehere Temperaturen;

106-98-9

1-butylene

201230-82-2

carbon monoxide

A

96-15-1

2-Methylbutylamine

B

110-58-7

1-pentanamine

C

2050-92-2

Di-n-amylamine

Conditions

Conditions	Yield
With trisodium tris(3-sulfophenyl)phosphine; ammonia; hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer In various solvent(s) at 130℃; under 58504.7 Torr; for 10h; Product distribution; Further Variations:; Reagents; Hydroaminomethylation;

...Expand

128038-35-7

C7H13NO2

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With hydrogenchloride In water for 2h; Heating;	78%

110-59-8

pentanonitrile

A

110-58-7

1-pentanamine

B

2050-92-2

Di-n-amylamine

Conditions

Conditions	Yield
With diethyl ether; nickel kieselguhr at 100 - 150℃; under 73550.8 - 128714 Torr; Hydrogenation;
With nickel kieselguhr at 110℃; under 73550.8 - 88260.9 Torr; Hydrogenation;
With hydrogen; acetic acid at 50℃; under 1125.11 Torr; for 5h; Catalytic behavior; Reagent/catalyst; chemoselective reaction;
With ammonia; hydrogen at 130℃; under 760.051 Torr; Reagent/catalyst;

110-59-8

pentanonitrile

A

71-41-0

pentan-1-ol

B

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With ammonium hydroxide; nickel phosphide; hydrogen In water at 130℃; under 30003 Torr; for 6h; Reagent/catalyst; Autoclave;	A 10 %Chromat. B 89 %Chromat.

349099-42-9

2-nitro-N-pentyl-benzenesulfonamide

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With potassium carbonate; thiophenol In [D3]acetonitrile at 50℃;	90 % Spectr.

71-41-0

pentan-1-ol

A

65870-64-6

N-pentylidenepentan-1-amine

B

110-58-7

1-pentanamine

C

2050-92-2

Di-n-amylamine

Conditions

Conditions	Yield
With ammonia; carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II) under 5700.38 Torr; for 20h; Product distribution / selectivity; Reflux; Neat (no solvent);

...Expand

18971-59-0

1-pentylisonitrile

110-58-7

1-pentanamine

Conditions

Conditions	Yield
Stage #1: 1-pentylisonitrile In methanol; dichloromethane at 20℃; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;

110-53-2

1-Bromopentane

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With ammonia; water at 100℃; unter Druck;
With ammonia; sodium amide at -50℃;
With cis-Octadecenoic acid; ammonia at 100℃; unter Druck;
With cis-Octadecenoic acid; ammonia at 100℃; unter Druck;
With ammonia; water at 100℃; unter Druck;

106-98-9

1-butylene

carbon monoxide

carbon monoxide

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With manganese; hydrogen; cobalt; iron at 115℃; under 88260.9 Torr; anschliessendes Behandeln mit Ammoniak in Methanol und anschliessendes Hydrieren an Raney-Nickel bei 160grad/200 at;

327-57-1

L-Norleucine

110-58-7

1-pentanamine

Conditions

Conditions	Yield
With 3,5,5-Trimethylcyclohex-2-en-1-one In isopropyl alcohol at 150℃; for 4h; Autoclave;	99 %Chromat.

1180496-63-2

Br(1-)*C16H27N2(1+)

A

1180496-61-0

(4-formylbenzyl)trimethylammonium bromide

B

110-58-7

1-pentanamine

Conditions

Conditions	Yield
at 25℃; pH=11.8; aq. phosphate buffer;

Amylamine Chemical Properties

Molecular Formula: C₅H₁₃N
Molecular Weight: 87.16
Density: 0.755
Melting point: -50 ^oC
Boiling point: 104 ^oC
VAPOR DENSITY: 3.0
AUTOIGNITION: 435 ^oC
FLASH POINT: 20 ^oC
Refractive index: 1.41-1.412
Flash point: 4 ^oC
Water solubility: soluble
Soluble: alcohol
PHYSICAL STATE OF Amylamine (110-58-7): clear liquid
ODOR OF Amylamine (110-58-7): ammonia odor

Amylamine Uses

Amylamine Production

Amylamine Toxicity Data With Reference

Amylamine Consensus Reports

Amylamine Safety Profile

Amylamine Standards and Recommendations

Amylamine Specification