Arginyl-glycyl-aspartic acid supplier

Name
ARG-GLY-ASP
EINECS
CAS No. 99896-85-2
Article Data5
CAS DataBase
Density 1.61 g/cm³
Solubility
Melting Point 153-155℃ (ethyl ether )
Formula C₁₂H₂₂N₆O₆
Boiling Point 597.205°C at 760 mmHg
Molecular Weight 346.343
Flash Point 314.979°C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms L-Asparticacid, N-(N-L-arginylglycyl)-;10: PN: JP2003189848 PAGE: 2 claimed protein;1337: PN: US20090258017 SEQID: 1353claimed protein;13: PN:US6147189 SEQID: 1 claimed protein;1: PN: JP2009072081 PAGE: 7 claimed protein;1: PN: US20080262614 SEQID: 1unclaimed protein;1: PN: WO0004941PAGE: 31 claimed protein;1: PN:WO0147553 PAGE: 13 claimed protein;1: PN: WO2008150101 SEQID: 1claimed protein;24: PN: US6797807PAGE: 59-60 claimed protein;2:PN: JP2004344469 SEQID: 2 claimed protein;
PSA 220.72000
LogP -0.58970

Synthetic route

: Arg(Pbf)-Gly-Asp(OtBu)

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
With methanol; triethylsilane; water; trifluoroacetic acid at 20℃; for 2h;	72%

: 4685-12-5
glycyl-L-aspartic acid

: 108787-79-7
Nα,NG,NG'-tri-Boc-L-arginine N-hydroxysuccinimide ester

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
Stage #1: glycyl-L-aspartic acid; Nα,NG,NG'-tri-Boc-L-arginine N-hydroxysuccinimide ester With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 24h; Addition; Stage #2: With trifluoroacetic acid In chloroform Hydrolysis; deprotection;	54%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-14-5
Fmoc-(tBu)Asp-OH

: N-α-Fmoc-N-γ-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 131668-52-5
Z-Gly-Asp(OBu)-OH

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 4-toluenesulfonic acid; H2 / Pd/C / dimethylformamide / 48 h 2.1: N-methylmorpholine / dimethylformamide / 24 h / 20 °C 2.2: 54 percent / TFA, 50 percent / CHCl3 View Scheme

: 106-44-5
p-cresol

: 108-98-5
thiophenol

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
In hydrogen fluoride

: 35737-10-1
N-Fmoc-β-alanine

: 99896-85-2
Arg-Gly-Asp

: β-Alanine pNb ester hydrochloride

: 188970-92-5
N-α-Fmoc-N-β-alloc-L-diaminopropionic acid

: c[L-Dapa(RGD)-βAla-L-Dapa(RGD)-βAla]

Conditions

Conditions	Yield
Multistep reaction;	100%

...Expand

α-acryloyl-ω-N-succinimidyl-acetate-PEG: α-acryloyl-ω-N-succinimidyl-acetate-PEG

: 99896-85-2
Arg-Gly-Asp

Ac-PEG-RGD: Ac-PEG-RGD

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 17h; Product distribution / selectivity; Sonographic reaction;	59%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1h; Product distribution / selectivity;

1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate, PEG MW = 3400: 1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate, PEG MW = 3400

: 99896-85-2
Arg-Gly-Asp

1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate : Arg-Gly-Asp conjugate, 2:1 molar ratio, PEG MW = 3400: 1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate : Arg-Gly-Asp conjugate, 2:1 molar ratio, PEG MW = 3400

Conditions

Conditions	Yield
In various solvent(s) at 4℃; for 4h; pH=7.5;

α-hydroxy-ω-N-succinimidyl-acetate-PEG: α-hydroxy-ω-N-succinimidyl-acetate-PEG

: 99896-85-2
Arg-Gly-Asp

HO-PEG-RGD: HO-PEG-RGD

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 19h;

: Arg(Pbf)-Gly-Asp(OtBu)

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
With methanol; triethylsilane; water; trifluoroacetic acid at 20℃; for 2h;	72%

: 4685-12-5
glycyl-L-aspartic acid

: 108787-79-7
Nα,NG,NG'-tri-Boc-L-arginine N-hydroxysuccinimide ester

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
Stage #1: glycyl-L-aspartic acid; Nα,NG,NG'-tri-Boc-L-arginine N-hydroxysuccinimide ester With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 24h; Addition; Stage #2: With trifluoroacetic acid In chloroform Hydrolysis; deprotection;	54%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-14-5
Fmoc-(tBu)Asp-OH

: N-α-Fmoc-N-γ-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 131668-52-5
Z-Gly-Asp(OBu)-OH

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 4-toluenesulfonic acid; H2 / Pd/C / dimethylformamide / 48 h 2.1: N-methylmorpholine / dimethylformamide / 24 h / 20 °C 2.2: 54 percent / TFA, 50 percent / CHCl3 View Scheme

: 106-44-5
p-cresol

: 108-98-5
thiophenol

: 99896-85-2
Arg-Gly-Asp

Conditions

Conditions	Yield
In hydrogen fluoride

: 35737-10-1
N-Fmoc-β-alanine

: 99896-85-2
Arg-Gly-Asp

: β-Alanine pNb ester hydrochloride

: 188970-92-5
N-α-Fmoc-N-β-alloc-L-diaminopropionic acid

: c[L-Dapa(RGD)-βAla-L-Dapa(RGD)-βAla]

Conditions

Conditions	Yield
Multistep reaction;	100%

...Expand

α-acryloyl-ω-N-succinimidyl-acetate-PEG: α-acryloyl-ω-N-succinimidyl-acetate-PEG

: 99896-85-2
Arg-Gly-Asp

Ac-PEG-RGD: Ac-PEG-RGD

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 17h; Product distribution / selectivity; Sonographic reaction;	59%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1h; Product distribution / selectivity;

: 28122-14-7
1-(vinylsulfonyl)-4-fluorobenzene

: 99896-85-2
Arg-Gly-Asp

: C20H29FN6O8S

Conditions

Conditions	Yield
In methanol at 50℃; pH=8.5;	55%

1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate, PEG MW = 3400: 1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate, PEG MW = 3400

: 99896-85-2
Arg-Gly-Asp

1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate : Arg-Gly-Asp conjugate, 2:1 molar ratio, PEG MW = 3400: 1,2-dioleyol-sn-glycero-3-phosphoethanolamine-n-[poly(ethyleneglycol)]-N-benzotriazole carbonate : Arg-Gly-Asp conjugate, 2:1 molar ratio, PEG MW = 3400

Conditions

Conditions	Yield
In various solvent(s) at 4℃; for 4h; pH=7.5;

α-hydroxy-ω-N-succinimidyl-acetate-PEG: α-hydroxy-ω-N-succinimidyl-acetate-PEG

: 99896-85-2
Arg-Gly-Asp

HO-PEG-RGD: HO-PEG-RGD

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 19h;

: 99896-85-2
Arg-Gly-Asp

collagen: collagen

arginine-glycine-aspartic acid peptide modified 3D collagen matrix: arginine-glycine-aspartic acid peptide modified 3D collagen matrix

Conditions

Conditions	Yield
With 1,2-dichloro-ethane In water at 37℃; for 18h;

: isoleucinyllysinylvalylalanylvaline

: 99896-85-2
Arg-Gly-Asp

collagen: collagen

arginine-glycine-aspartic acid-isoleucine-lysine-valine-alanine-valine peptides modified 3D collagen matrix: arginine-glycine-aspartic acid-isoleucine-lysine-valine-alanine-valine peptides modified 3D collagen matrix

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; 1,2-dichloro-ethane In water at 37℃; for 18h;

...Expand

: 99896-85-2
Arg-Gly-Asp

A: 2174-58-5
L-malic acid

B: 74-79-3
L-arginine

C: 56-40-6
glycine

Conditions

Conditions	Yield
With hydrogenchloride In water for 24h; Reflux;

...Expand

: 99896-85-2
Arg-Gly-Asp

: 127290-62-4
α-D-L-arginine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 24 h / Reflux 2: deuterium / water-d2 / 36 h / 55 °C / 1500.15 Torr / Inert atmosphere View Scheme

: 99896-85-2
Arg-Gly-Asp

: Arg-Gly-Asp

Conditions

Conditions	Yield
With deuterium In water-d2 at 55℃; under 1500.15 Torr; for 36h; Inert atmosphere; enantiospecific reaction;

: C8H13N3O4S

: 99896-85-2
Arg-Gly-Asp

: C20H33N9O10

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; potassium hexacyanoferrate(III) In water; water-d2 at 20℃; for 0.333333h; pH=9;	76 %Spectr.

: [18F]-1-fluoro-4-(vinylsulfonyl)benzene

: 99896-85-2
Arg-Gly-Asp

: C20H29(18)FN6O8S

Conditions

Conditions	Yield
In methanol at 35℃; for 0.5h;

Arginyl-glycyl-aspartic acid Chemical Properties

Product Name: Arg-gly-asp (CAS NO.99896-85-2)

Molecular Formula: C₁₂H₂₂N₆O₆
Molecular Weight: 346.34g/mol
Mol File: 99896-85-2.mol
Storage Temperature: −20°C
Density: 1.61 g/cm³
Surface Tension: 76.3 dyne/cm
Structure Descriptors of Arg-gly-asp (CAS NO.99896-85-2):
InChI : InChI=1/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1
Smiles: NC(=N)NCCC[C@@H](C(NCC(=O)N[C@@H](CC(=O)O)C(O)=O)=O)N
Product Categories: Peptide; Cell Signaling Enzymes; ECM ProteinsCytoskeleton and Extracellular Matrix; Extracellular Matrix; Extracellular Matrix Peptides (ECM); Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology; Fibronectin Fragments and Analogs; Matrix Metalloproteinases Products; Various Peptides

Arginyl-glycyl-aspartic acid Specification

Arg-gly-asp ,its CAS NO. is 99896-85-2,the synonyms is Arginyl-glycyl-asparagilin ; Arginyl-glycyl-aspartic acid ; F-336 ; N-(N-L-Arginylglycyl)-L-aspartic acid ; Rgd peptide ; Rgd tripeptide sequence ; L-Aspartic acid, N-(N-L-arginylglycyl)- .

Product Name

ARG-GLY-ASP

Synthetic route

Arginyl-glycyl-aspartic acid Chemical Properties

Arginyl-glycyl-aspartic acid Specification

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