Beauvericin supplier | CasNO.26048-05-5

Name
Beauvericin
EINECS
CAS No. 26048-05-5
Article Data1
CAS DataBase
Density 1.126 g/cm³
Solubility
Melting Point 93-94℃
Formula C₄₅H₅₇N₃O₉
Boiling Point 975.6 °C at 760 mmHg
Molecular Weight 783.962
Flash Point 543.8 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl];
PSA 139.83000
LogP 4.72620

Synthetic route

: Boc-Me-Phe-D-Hiv-Me-Phe-D-Hiv-Me-Phe-D-Hiv-OBn

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 3: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 4 steps
1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
3: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere
View Scheme

: 17407-56-6
(R)-2-Hydroxy-3-methylbutyric acid

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 °C / Inert atmosphere 1.2: 15 h / 0 - 20 °C / Inert atmosphere 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 5.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 7.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 8.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 9.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 11 steps 1.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 °C / Inert atmosphere 1.2: 15 h / 0 - 20 °C / Inert atmosphere 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 6.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 8.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 9.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 10.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 9 steps 1.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 °C / Inert atmosphere 1.2: 15 h / 0 - 20 °C / Inert atmosphere 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 6.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 7.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 8.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

: 640-68-6
D-Val-OH

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: sulfuric acid; sodium nitrite / water / 60 °C / 5171.62 Torr / Inert atmosphere 2.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 °C / Inert atmosphere 2.2: 15 h / 0 - 20 °C / Inert atmosphere 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 4.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 5.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 7.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 8.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 9.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 11 steps 1.1: sulfuric acid; sodium nitrite / water / 60 °C / 5171.62 Torr / Inert atmosphere 2.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 °C / Inert atmosphere 2.2: 15 h / 0 - 20 °C / Inert atmosphere 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 6.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 8.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 9.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 10.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 12 steps 1.1: sulfuric acid; sodium nitrite / water / 60 °C / 5171.62 Torr / Inert atmosphere 2.1: caesium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 °C / Inert atmosphere 2.2: 15 h / 0 - 20 °C / Inert atmosphere 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 4.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 5.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 7.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 9.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 10.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 11.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 12.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

: 2441-07-8, 65138-05-8, 14487-24-2
benzyl (R)-2-hydroxy-3-methylbutanoate

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 3: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 5: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 7: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 8: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 9: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 10: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 8 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 3: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 5: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 6: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 7: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 8: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 9 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 6: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 7: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 8: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 9: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

: C22H27NO4*ClH

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 5: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 6: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 7: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 7 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
5: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
6: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere
View Scheme

: C20H29NO6

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 5: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 8 steps 1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 5: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 6: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 7: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 8: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
5: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere
View Scheme

Multi-step reaction with 8 steps
1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
5: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
6: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
7: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere
View Scheme

: C37H46N2O7*(x)ClH

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 4: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
4: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere
View Scheme

: C50H67N3O12

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

: C45H59N3O10

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

: C20H28ClNO5

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 4: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 7 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 5: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 6: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 7: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

Yield

: Boc-Me-Phe-D-Hiv-OBn

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 5: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 6: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 7: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 8 steps 1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 5: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 6: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 7: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 8: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 9 steps 1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere 2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.33 h / 0 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 6: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 7: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 8: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 9: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

: C45H58ClN3O9

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 18.5h; Inert atmosphere;	46 mg

: Boc-Me-Phe-D-Hiv-Me-Phe-D-Hiv-OBn

: 26048-05-5
beauvericin

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere 5: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C / Inert atmosphere
5: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 18.5 h / 0 - 20 °C / Inert atmosphere
View Scheme

: 26048-05-5
beauvericin

: 1398380-27-2
C45H57N3O9*Na(1+)

Conditions

Conditions	Yield
With sodium picrate In water; nitrobenzene at 25℃; for 2h;

Beauvericin Specification

The CAS registry number of Beauvericin is 26048-05-5. It belongs to the product category of Peptide. This chemical is also named as Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl]. In addition, its molecular formula is C₄₅H₅₇N₃O₉ and molecular weight is 783.95. Its systematic name and IUPAC name are the same which is called 3,9,15-tribenzyl-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone.

Physical properties about Beauvericin are: (1)ACD/LogP: 5.49; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): 5.49; (4)ACD/LogD (pH 7.4): 5.49; (5)ACD/BCF (pH 5.5): 8794.53; (6)ACD/BCF (pH 7.4): 8794.54; (7)ACD/KOC (pH 5.5): 23166.35; (8)ACD/KOC (pH 7.4): 23166.35; (9)#H bond acceptors: 12; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 9; (12)Index of Refraction: 1.529; (13)Molar Refractivity: 214.85 cm³; (14)Molar Volume: 695.8 cm³; (15)Surface Tension: 40.5 dyne/cm; (16)Density: 1.126 g/cm³; (17)Flash Point: 543.8 °C; (18)Enthalpy of Vaporization: 142.33 kJ/mol; (19)Boiling Point: 975.6 °C at 760 mmHg.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C1N(C)C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC1C(C)C)Cc2ccccc2)C)C(C)C)Cc3ccccc3)C)C(C)C)Cc4ccccc4
(2)InChI: InChI=1/C45H57N3O9/c1-28(2)37-40(49)46(7)35(26-32-21-15-11-16-22-32)44(53)56-39(30(5)6)42(51)48(9)36(27-33-23-17-12-18-24-33)45(54)57-38(29(3)4)41(50)47(8)34(43(52)55-37)25-31-19-13-10-14-20-31/h10-24,28-30,34-39H,25-27H2,1-9H3
(3)InChIKey: GYSCAQFHASJXRS-UHFFFAOYAE

Product Name

Beauvericin

Synthetic route

Beauvericin Specification

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