Betamipron supplier | CasNO.3440-28-6

Name
Betamipron
EINECS
CAS No. 3440-28-6
Article Data24
CAS DataBase
Density 1.227 g/cm³
Solubility
Melting Point 132 °C
Formula C10H11 N O3
Boiling Point 469.2 °C at 760 mmHg
Molecular Weight 193.202
Flash Point 237.6 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 3-(Benzoylamino)propanoicacid; 3-(Benzoylamino)propionic acid; 3-Benzamidopropionic acid; Benzoyl-b-alanine; Betamipron; CS 443;N-Benzoyl-b-alanine; N-Benzoyl-b-aminopropionic acid; NSC 192714
PSA 66.40000
LogP 1.28200

Synthetic route

: 1-benzoyldeoxyvasicinone chloride

: 107-95-9
3-amino propanoic acid

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
In benzene	88.5%

: 17966-68-6
N-benzoylaspartic acid

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
In acetone for 3h; Ambient temperature; Irradiation;	80%

: 98-88-4
benzoyl chloride

: 107-95-9
3-amino propanoic acid

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With sodium hydroxide for 6h;	72.5%
With hydroxide	64%
With sodium hydroxide; sodium carbonate

: 3440-29-7
3-(Benzoylamino)propansaeureamid

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With ammonium hydroxide at 150℃;

: 20897-15-8
N-<2-Carboxy-ethyl>-α-phenyl-nitron

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With thionyl chloride

: 124-38-9
carbon dioxide

: 26385-07-9
N-(2-chloro-ethyl)-benzamide

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With n-butyllithium; naphthalen-1-yl-lithium 1.) THF, ether, -78 deg C, 20 min 2.) THF, 5 h, -78 deg C; 3.) 20 deg C; Yield given. Multistep reaction;

: 124-38-9
carbon dioxide

: 150932-87-9
N-lithio-N-(2-lithioethyl)benzamide

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With water at -78 - 20℃; Yield given;

: 7647-01-0
hydrogenchloride

: 6-ethoxy-2-phenyl-4H-[1,3]oxazine

A: 3440-28-6
N-benzoyl-beta-alanine

B: 107-95-9
3-amino propanoic acid

...Expand

: 114645-09-9
3-Benzoylamino-propionic acid tert-butyl ester

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With trifluoroacetic acid for 0.5h;

: 69689-45-8
N-benzoyl-β-lactam

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With sodium hydroxide at 30℃; Kinetics;
With P99 β-lactamase from Enterobacter cloacae In various solvent(s) at 30℃; pH=7; Enzyme kinetics;

: 98-88-4
benzoyl chloride

tetrabutyl ammonium [Zn(2-thione-1,3-dithiole-4,5-dithiolate)2]: tetrabutyl ammonium [Zn(2-thione-1,3-dithiole-4,5-dithiolate)2]

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / 0.17 h / 20 °C 2: CF3CO2H / 0.5 h View Scheme

: 26385-07-9
N-(2-chloro-ethyl)-benzamide

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: n-buthyl-lithium, lithium naphthalenide / tetrahydrofuran; diethyl ether / 4 h / -78 °C 2: H2O / -78 - 20 °C View Scheme

: 932-90-1, 622-31-1, 140461-24-1, 140461-25-2, 622-32-2
syn-benzaldehyde oxime

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Et3N 2: NaOH / methanol 3: SOCl2 View Scheme

: 20897-16-9
N-<2-Carbomethoxy-ethyl>-α-phenyl-nitron

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOH / methanol 2: SOCl2 View Scheme

: N-benzoyl-2-tert-butyl-6-oxo-1,3-oxazinane

A: 3440-28-6
N-benzoyl-beta-alanine

B: 630-19-3
pivalaldehyde

Conditions

Conditions	Yield
With water

: 49615-28-3
ethyl 3-benzamidopropanoate

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 0 - 20℃; for 3h;

: 98-88-4
benzoyl chloride

: 3440-28-6
N-benzoyl-beta-alanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 3 h / 0 - 20 °C View Scheme

: 3440-28-6
N-benzoyl-beta-alanine

: 41621-85-6
Phorbol 13,20-diacetate

: 3-Benzoylamino-propionic acid (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-3-acetoxymethyl-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	99%

: 67-56-1
methanol

: 3440-28-6
N-benzoyl-beta-alanine

: 89928-06-3
methyl ester of 3-(N-benzoyl)aminopropionic acid

Conditions

Conditions	Yield
With tert.-butylnitrite at 40℃; for 48h; Green chemistry;	97%
With hydrogenchloride

: 3440-28-6
N-benzoyl-beta-alanine

: 69320-89-4
L-isoleucine tert-butyl ester hydrochloride

: Bz-β-HoGly-L-Ile-O-t-Bu

Conditions

Conditions	Yield
With pentamethoxy tantalum; 1-(Trimethylsilyl)imidazole In neat (no solvent) at 40℃; for 48h; Inert atmosphere; Sealed tube;	97%

: 16874-08-1
L-Isoleucin-tert-butylester

: 3440-28-6
N-benzoyl-beta-alanine

: Bz-β-HoGly-L-Ile-O-t-Bu

Conditions

Conditions	Yield
With pentamethoxy tantalum; 1-(Trimethylsilyl)imidazole In neat (no solvent) at 40℃; for 48h; Inert atmosphere; Sealed tube;	97%

: 3440-28-6
N-benzoyl-beta-alanine

: 7758-99-8
copper(II) sulfate

: 409108-35-6, 60487-57-2
[Cu2(μ(2)-O2CCH2CH2NHCOC6H5)4]

Conditions

Conditions	Yield
With NaOH In water org. ligand dissolved in H2O with NaOH; CuSO4 in H2O added; mixt. heatedfor 12 h at 50°C; ppt. filtered; washed (EtOH, Et2O); dried (vac.); elem. anal.;	93%

: 524-38-9
N-hydroxyphthalimide

: 3440-28-6
N-benzoyl-beta-alanine

: 1,3-dioxoisoindolin-2-yl 3-benzamidopropanoate

Conditions

Conditions	Yield
With dmap; diisopropyl-carbodiimide In tetrahydrofuran at 20℃; for 18h;	91%

: 3440-28-6
N-benzoyl-beta-alanine

: 94594-90-8
(2R)-bornane-10,2-sultam

: N-(3-benzoylaminopropionyl) sultam

Conditions

Conditions	Yield
With 4-methyl-morpholine; sodium hydride; isobutyl chloroformate In 1,2-dimethoxyethane Acylation;	81%

: 3440-28-6
N-benzoyl-beta-alanine

: 20427-59-2
copper hydroxide

: diaquatetrakis(μ-benzoyl-α-alaninato)-dicopper(II)

Conditions

Conditions	Yield
In propan-1-ol; water addn. of Cu(OH)2 to hot soln. of amino acid (water/n-propanol 1:3), heating (water-bath, 1 h); filtration, crystn. on standing (72 h);	80%

: 1190-73-4
2-(acetylamino)ethanethiol

: 3440-28-6
N-benzoyl-beta-alanine

: 1147756-00-0
S-2-acetamidoethyl 3-benzamidopropanethioate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 22 - 24℃; for 18h; Inert atmosphere;	76.7%

: 3440-28-6
N-benzoyl-beta-alanine

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: C24H31N3O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	72%

: 78539-98-7
(E)-pyridin-2-ylmethylene-hydrazine

: 3440-28-6
N-benzoyl-beta-alanine

: pyridine-2-carbaldehyde 2-(N-benzoylamino)ethylcarbohydrazone

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	71%

: 3440-28-6
N-benzoyl-beta-alanine

: 14529-00-1
benzyl 3-aminopropionate

: 351352-70-0
benzyl N-(N-benzoyl-β-alanyl)-β-alaninate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃;	70%

: 3440-28-6
N-benzoyl-beta-alanine

: 4720-29-0
3-(benzylamino)propan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) room temperature, overnight, 3.) reflux, 9 h;	67%
With lithium aluminium tetrahydride	67%

: 141-30-0
3,6-dichlorpyridazine

: 3440-28-6
N-benzoyl-beta-alanine

: N-[2-(3,6-dichloropyridazin-4-yl)ethyl]benzamide

Conditions

Conditions	Yield
With ammonium persulfate; silver nitrate; trifluoroacetic acid In water at 75℃; Minisci reaction;	67%

: 118-58-1
benzyl salicylate

: 3440-28-6
N-benzoyl-beta-alanine

: 2-benzyloxycarbonylphenyl N-benzoyl-β-alaninate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 12h;	57%

: 58-27-5
menadione

: 3440-28-6
N-benzoyl-beta-alanine

: N-(2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)ethyl)benzamide

Conditions

Conditions	Yield
With ammonium peroxydisulfate; silver nitrate In water; acetonitrile	42%

: 3440-28-6
N-benzoyl-beta-alanine

: 95-54-5
1,2-diamino-benzene

: 107313-47-3
N-(2-(1H-benzimidazole-2-yl)ethyl)benzamide

Conditions

Conditions	Yield
at 110℃; for 0.166667h;	41%

: 481-42-5
5-hydroxy-2-methyl-1,4-naphthoquinone

: 3440-28-6
N-benzoyl-beta-alanine

: N-(2'-(8''-hydroxy-3''-methyl-1'',4''-dioxo-1,4-dihydronaphthalen-2''-yl)ethyl)benzamide

Conditions

Conditions	Yield
With ammonium peroxydisulfate; silver nitrate In water; acetonitrile	28%

: 75-77-4
chloro-trimethyl-silane

: 3440-28-6
N-benzoyl-beta-alanine

: 18053-06-0
N-benzoyl-β-alanine trimethylsilanyl ester

Conditions

Conditions	Yield
With pyridine; diethyl ether; formamide

: 64-17-5
ethanol

: 3440-28-6
N-benzoyl-beta-alanine

: 49615-28-3
ethyl 3-benzamidopropanoate

Conditions

Conditions	Yield
With hydrogenchloride

: 24498-31-5
(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate

: 3440-28-6
N-benzoyl-beta-alanine

: N2-(N-benzoyl-β-alanyl)-N6-benzyloxycarbonyl-L-lysine methyl ester

Conditions

Conditions	Yield
With ethyl acetate; triethylamine; isobutyl chloroformate

: 3440-28-6
N-benzoyl-beta-alanine

: phenylmagnesium bromide

: 31537-54-9
N-(3-oxo-3-phenylpropyl)benzamide

: 3440-28-6
N-benzoyl-beta-alanine

: phenylmagnesium bromide

: 60181-44-4
N-(3-hydroxy-3,3-diphenyl-propyl)-benzamide

: 3440-28-6
N-benzoyl-beta-alanine

: 31991-78-3
uvariadiamide

Conditions

Conditions	Yield
With methanol; sodium methylate Electrolysis;

: 3440-28-6
N-benzoyl-beta-alanine

: 3440-29-7
3-(Benzoylamino)propansaeureamid

Conditions

Conditions	Yield
With thionyl chloride Behandeln des erhaltenen Saeurechlorids mit Ammoniak in Chloroform;

: 3440-28-6
N-benzoyl-beta-alanine

: 875838-20-3
N-benzoyl-β-alanine-(3,4-dimethoxy-phenethylamide)

Conditions

Conditions	Yield
With thionyl chloride Behandeln des hergestellten Saeurechlorids mit 3,4-Dimethoxy-phenaethylamin in Aethylacetat;
Multi-step reaction with 3 steps 1: HCl 2: ethanol; N2H4+H2O 3: HNO2 / Behandeln des hergestellten Azids mit 3,4-Dimethoxy-phenaethylamin in Aether und Benzol View Scheme

Betamipron Chemical Properties

Molecular Structure:

Molecular Formula: C₁₀H₁₁NO₃
Molecular Weight: 193.1992
IUPAC Name: 3-Benzamidopropanoic acid
Synonyms of Betamipron (CAS NO.3440-28-6): Betamipron [INN:JAN] ; 3-(Benzoylamino)propionic acid ; 3-Benzamidopropionic acid ; 4-09-00-00796 (Beilstein Handbook Reference) ; BRN 2212769 ; Benzoyl-beta-alanine ; Betamipronum ; Betamipronum [INN-Latin] ; UNII-3W0M245736 ; N-Benzoyl-beta-alanine ; beta-Alanine, N-benzoyl-
CAS NO: 3440-28-6
Product Categories: Drug / Therapeutic Agent
Melting point: 69 °C
Index of Refraction: 1.557
Molar Refractivity: 50.7 cm³
Molar Volume: 157.4 cm³
Surface Tension: 51.5 dyne/cm
Density: 1.227 g/cm³
Flash Point: 237.6 °C
Enthalpy of Vaporization: 77.07 kJ/mol
Boiling Point: 469.2 °C at 760 mmHg
Vapour Pressure of Betamipron (CAS NO.3440-28-6): 1.32E-09 mmHg at 25°C

Betamipron Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	intravenous	3496mg/kg (3496mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Chemotherapy Vol. 39(Suppl,

Betamipron Safety Profile

WGK Germany of Betamipron (CAS NO.3440-28-6): 3
RTECS: AY3272500
HazardClass: IRRITANT

Product Name

Betamipron

Synthetic route

Betamipron Chemical Properties

Betamipron Toxicity Data With Reference

Betamipron Safety Profile

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