Product Name

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  • Name

    BUPRENORPHINE HYDROCHLORIDE

  • EINECS
  • CAS No. 53152-21-9
  • Density 1.26g/cm3
  • Solubility
  • Melting Point 260-262?C (dec.)
  • Formula C29H41 N O4 . Cl H
  • Boiling Point °Cat760mmHg
  • Molecular Weight 504.17
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
  • Risk Codes 22-62-63-39/23/24/25-23/24/25-11
  • Molecular Structure Molecular Structure of 53152-21-9 (BUPRENORPHINE HYDROCHLORIDE)
  • Hazard Symbols Xn,T,F
  • Synonyms 6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, hydrochloride, (aS,5a,7a)- (9CI); 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, hydrochloride, [5a,7a(S)]-; Buprederm; Buprenex; Buprenorphinehydrochloride; CL 112302; Lepetan; M 6029; MR 56; NIH 8805; UM 952; Vetergesic
  • PSA 62.16000
  • LogP 5.15370

Buprenorphine hydrochloride Chemical Properties

Molecular Structure:

Molecular Formula: C29H42ClNO4
Molecular Weight: 504.1011
IUPAC Name: 2-Methoxy-2-methylpropane
Synonyms of Buprenorphine hydrochloride (CAS NO.53152-21-9): 21-Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine hydrochloride ; Buprenex ; Buprenorphine HCl ; CL 112,302 ; CL 112302 ; EINECS 258-396-8 ; Finibron ; MR 56 ; NIH 8805 ; RX 6029-M ; Subutex ; Temgesic ; UM 952 ; UNII-56W8MW3EN1 ; (5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol hydrochloride ; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (5alpha,7alpha(S))-
CAS NO: 53152-21-9
Classification Code: Analgesic ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect 
H bond acceptors: 5
H bond donors: 2
Freely Rotating Bonds: 7
Polar Surface Area: 40.16 Å2

Buprenorphine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 79mg/kg (79mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1351, 1984.
mammal (species unspecified) LD50 intravenous 40mg/kg (40mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1351, 1984.
man TDLo oral 2857ug/kg (2.857mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT		 British Medical Journal. Vol. 296, Pg. 214, 1988.
mouse LD50 intramuscular > 600mg/kg (600mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: ATAXIA

BLOOD: CHANGES IN SPLEEN		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
mouse LD50 intravenous 72mg/kg (72mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
mouse LD50 oral 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LIVER: OTHER CHANGES		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: CHANGES IN SPLEEN		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat LD50 intramuscular > 600mg/kg (600mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ATAXIA		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat LD50 intravenous 62mg/kg (62mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat LD50 oral > 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: CHANGES IN SPLEEN		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.

Buprenorphine hydrochloride Safety Profile

Hazard Codes of Buprenorphine hydrochloride (CAS NO.53152-21-9): HarmfulXn
Risk Statements: 22 
R22: Harmful if swallowed.
WGK Germany: 3
RTECS: KM7758000
Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.

Buprenorphine hydrochloride Specification

Storage Features of Buprenorphine hydrochloride (CAS NO.53152-21-9).
 Treasury ventilated low-temperature drying
 

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