Butyl lactate supplier | CasNO.138-22-7

Name
Butyl lactate
EINECS 205-316-4
CAS No. 138-22-7
Article Data55
CAS DataBase
Density 1.005 g/cm³
Solubility 42 g/L (25 °C) in water
Melting Point -43 °C
Formula C₇H₁₄O₃
Boiling Point 189.4 °C at 760 mmHg
Molecular Weight 146.186
Flash Point 71 °C
Transport Information
Appearance clear colorless liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms NSC 6533;n-Butyl lactate;a-Hydroxypropionicacid butyl ester;Lacticacid, butyl ester (6CI,7CI,8CI);(?à)-n-Butyl lactate;2-Hydroxypropanoic acid butyl ester;Butyl2-hydroxypropanoate;Butyl 2-hydroxypropionate;Butyl a-hydroxypropionate;
PSA 46.53000
LogP 0.71050

Synthetic route

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
stannous octoate; Nafion-H at 145℃; for 7h; Product distribution / selectivity;	99.5%
With sulfuric acid

: 849585-22-4
LACTIC ACID

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With dichromic acid at 105 - 110℃; for 3h; Green chemistry; Large scale;	99%
With 3H(1+)O40SiW12(4-)C21H22O3PS(1+) Reflux; Dean-Stark;	96.5%
iodine for 20h; Heating;	95%

: 515-98-0
Ammonium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 120℃; under 760.051 Torr; for 12h; Time;	98%
for 6h; Dean-Stark; Reflux;	46 %Chromat.
With tin(II) oxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 120℃; Reagent/catalyst; Dean-Stark;

: 109-65-9
1-bromo-butane

: 849585-22-4
LACTIC ACID

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
Stage #1: LACTIC ACID With potassium carbonate In water at 20 - 90℃; for 1h; Stage #2: 1-bromo-butane at 20 - 40℃; for 8h; Reagent/catalyst; Temperature;	97.5%

: 849585-22-4
LACTIC ACID

: 71-36-3
butan-1-ol

A: 13544-80-4
2-lactoyloxy-propionic acid butyl ester

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
aluminium(III) triflate In iso-tridecanol; di-isopropyl ether; water at 66 - 120℃; under 150.015 - 7500.75 Torr; for 6h; Conversion of starting material;	A 4% B 95%

...Expand

: 2-(Tetrahydro-pyran-2-yloxy)-propionic acid butyl ester

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With dibromotriphenylphosphorane In dichloromethane at -50℃; for 3h;	94%

: 62147-49-3
1,3-dihydroxyacetone dimer

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With tin (IV) chloride pentahydrate at 110℃; for 6h;	88.4%

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
aluminium(III) triflate at 120 - 140℃; under 37.5038 - 7500.75 Torr; for 1.5 - 6h; Conversion of starting material;	70.9%
zirconium(IV) triflate at 120 - 140℃; under 37.5038 - 7500.75 Torr; for 1 - 6h; Conversion of starting material;	46.6%

: 57-50-1
Sucrose

: 71-36-3
butan-1-ol

A: 138-22-7
n-butyl lactate

B: butyl (D,L)-2-hydroxy-3-butenoate

Conditions

Conditions	Yield
Sn-BEA at 160℃; under 15001.5 Torr; Inert atmosphere of argon;	A 26% B 8%
Sn-BEA at 160℃; for 20h; Inert atmosphere; autoclave;	A 26% B 8%

...Expand

: 849585-22-4
LACTIC ACID

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
at 100 - 120℃; unter vermindertem Druck; man kocht 25 Stdn. mit Butylalkohol;

: 78-98-8
2-oxopropanal

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With 2-(diethylamine)ethanethiol
With titanium-silicon molecular sieve TS-1; tin-silicon molecular sieve Sn-Beta at 60℃; for 7h;

: 312-85-6
sodium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With sulfuric acid; benzene unter azeotropem Abdestillieren des Reaktionswassers;
With sulfuric acid; toluene unter azeotropem Abdestillieren des Reaktionswassers;

: 814-80-2
calcium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With sulfuric acid; benzene unter azeotropem Abdestillieren des Reaktionswassers;
With sulfuric acid; toluene unter azeotropem Abdestillieren des Reaktionswassers;

: 506-82-1
dimethylcadmium

: 6295-06-3
butyl glyoxalate

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
In diethyl ether Heating;

: 71-36-3
butan-1-ol

ammonium lactate: ammonium lactate

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With water und Entfernen des entstehenden Wassers und Ammoniaks;

: 56-82-6
Glyceraldehyde

: 71-36-3
butan-1-ol

A: 19255-82-4
1,1-dibutoxy-2-propanone

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
tin(IV) chloride at 90℃; for 1h;	A n/a B 82 % Chromat.

...Expand

: 78-98-8
2-oxopropanal

: 71-36-3
butan-1-ol

A: 19255-82-4
1,1-dibutoxy-2-propanone

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
tin(ll) chloride at 90℃; for 3h;	A n/a B 78 % Chromat.

...Expand

: 96-26-4
dihydroxyacetone

: 71-36-3
butan-1-ol

A: 19255-82-4
1,1-dibutoxy-2-propanone

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
tin(IV) chloride at 90℃; for 1h;	A n/a B 91 % Chromat.
With Zeolite USY CBV 600 at 109.84℃; for 4h; Autoclave;	A 28 %Chromat. B 71 %Chromat.

...Expand

: 617-51-6
isopropyl lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
aluminium(III) triflate at 125 - 145℃; under 37.5038 - 7500.75 Torr; Conversion of starting material;

: 62147-49-3
1,3-dihydroxyacetone dimer

aqueous titanium lactate: aqueous titanium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
In diethylene glycol dimethyl ether

...Expand

: 20279-44-1
n-butyl pyruvate

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With Streptomyces avermitilis α-keto ester reductase I, Mr 71.6 kDa by gel filtration; NAD at 37℃; for 6h; aq. phosphate buffer;

: 10326-41-7
D-Lactic acid

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
for 24h;

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
stannous octoate; Nafion-H at 145℃; for 7h; Product distribution / selectivity;	99.5%
With sulfuric acid

: 849585-22-4
LACTIC ACID

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With dichromic acid at 105 - 110℃; for 3h; Green chemistry; Large scale;	99%
With 3H(1+)O40SiW12(4-)C21H22O3PS(1+) Reflux; Dean-Stark;	96.5%
iodine for 20h; Heating;	95%

: 515-98-0
Ammonium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 120℃; under 760.051 Torr; for 12h; Time;	98%
for 6h; Dean-Stark; Reflux;	46 %Chromat.
With tin(II) oxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 120℃; Reagent/catalyst; Dean-Stark;

: 109-65-9
1-bromo-butane

: 849585-22-4
LACTIC ACID

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
Stage #1: LACTIC ACID With potassium carbonate In water at 20 - 90℃; for 1h; Stage #2: 1-bromo-butane at 20 - 40℃; for 8h; Reagent/catalyst; Temperature;	97.5%

: 849585-22-4
LACTIC ACID

: 71-36-3
butan-1-ol

A: 13544-80-4
2-lactoyloxy-propionic acid butyl ester

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
aluminium(III) triflate In iso-tridecanol; di-isopropyl ether; water at 66 - 120℃; under 150.015 - 7500.75 Torr; for 6h; Conversion of starting material;	A 4% B 95%

...Expand

: 2-(Tetrahydro-pyran-2-yloxy)-propionic acid butyl ester

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With dibromotriphenylphosphorane In dichloromethane at -50℃; for 3h;	94%

: 62147-49-3
1,3-dihydroxyacetone dimer

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With tin (IV) chloride pentahydrate at 110℃; for 6h;	88.4%

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
aluminium(III) triflate at 120 - 140℃; under 37.5038 - 7500.75 Torr; for 1.5 - 6h; Conversion of starting material;	70.9%
zirconium(IV) triflate at 120 - 140℃; under 37.5038 - 7500.75 Torr; for 1 - 6h; Conversion of starting material;	46.6%

: 57-50-1
Sucrose

: 71-36-3
butan-1-ol

A: 138-22-7
n-butyl lactate

B: butyl (D,L)-2-hydroxy-3-butenoate

Conditions

Conditions	Yield
Sn-BEA at 160℃; under 15001.5 Torr; Inert atmosphere of argon;	A 26% B 8%
Sn-BEA at 160℃; for 20h; Inert atmosphere; autoclave;	A 26% B 8%

...Expand

: 849585-22-4
LACTIC ACID

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
at 100 - 120℃; unter vermindertem Druck; man kocht 25 Stdn. mit Butylalkohol;

: 78-98-8
2-oxopropanal

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With 2-(diethylamine)ethanethiol
With titanium-silicon molecular sieve TS-1; tin-silicon molecular sieve Sn-Beta at 60℃; for 7h;

: 312-85-6
sodium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With sulfuric acid; benzene unter azeotropem Abdestillieren des Reaktionswassers;
With sulfuric acid; toluene unter azeotropem Abdestillieren des Reaktionswassers;

: 814-80-2
calcium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With sulfuric acid; benzene unter azeotropem Abdestillieren des Reaktionswassers;
With sulfuric acid; toluene unter azeotropem Abdestillieren des Reaktionswassers;

: 506-82-1
dimethylcadmium

: 6295-06-3
butyl glyoxalate

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
In diethyl ether Heating;

: 71-36-3
butan-1-ol

ammonium lactate: ammonium lactate

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With water und Entfernen des entstehenden Wassers und Ammoniaks;

: 56-82-6
Glyceraldehyde

: 71-36-3
butan-1-ol

A: 19255-82-4
1,1-dibutoxy-2-propanone

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
tin(IV) chloride at 90℃; for 1h;	A n/a B 82 % Chromat.

...Expand

: 78-98-8
2-oxopropanal

: 71-36-3
butan-1-ol

A: 19255-82-4
1,1-dibutoxy-2-propanone

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
tin(ll) chloride at 90℃; for 3h;	A n/a B 78 % Chromat.

...Expand

: 96-26-4
dihydroxyacetone

: 71-36-3
butan-1-ol

A: 19255-82-4
1,1-dibutoxy-2-propanone

B: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
tin(IV) chloride at 90℃; for 1h;	A n/a B 91 % Chromat.
With Zeolite USY CBV 600 at 109.84℃; for 4h; Autoclave;	A 28 %Chromat. B 71 %Chromat.

...Expand

: 617-51-6
isopropyl lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
aluminium(III) triflate at 125 - 145℃; under 37.5038 - 7500.75 Torr; Conversion of starting material;

: 62147-49-3
1,3-dihydroxyacetone dimer

aqueous titanium lactate: aqueous titanium lactate

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
In diethylene glycol dimethyl ether

...Expand

: 20279-44-1
n-butyl pyruvate

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With Streptomyces avermitilis α-keto ester reductase I, Mr 71.6 kDa by gel filtration; NAD at 37℃; for 6h; aq. phosphate buffer;

: 10326-41-7
D-Lactic acid

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
for 24h;

cellulose: cellulose

A: 98-01-1
furfural

B: 620-02-0
5-Methylfurfural

C: 1192-51-4, 69841-77-6
3-methyl-furan-2,4-dione

D: 13529-27-6
2-(diethoxymethyl)furan

E: 138-22-7
n-butyl lactate

F: 123-86-4
acetic acid butyl ester

G: 624-45-3
levulinic acid methyl ester

H: 21188-58-9
methyl 3-hydroxyhexanoate

I: 37575-80-7
methyl 3-methylenecyclopentane-1-carboxylate

J: 123-76-2
levulinic acid

Conditions

Conditions	Yield
With 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate; 1-butyl-3-methylimidazolium chloride In methanol; hexane at 19.84 - 199.84℃; pH=0.09; Mechanism; Reagent/catalyst; Temperature; pH-value; Autoclave; Inert atmosphere; chemoselective reaction;	A n/a B n/a C n/a D 45.8 %Chromat. E n/a F n/a G n/a H n/a I n/a J n/a

...Expand

: 58-86-6
D-xylose

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
Stage #1: D-xylose With sodium hydroxide In water for 4h; Heating; Stage #2: butan-1-ol With hydrogenchloride In water at 106℃; for 4h; pH=1; Dean-Stark; Reflux;	35.6 %Chromat.

: 25878-57-3
1,6-anhydro-2,2',3,3',4',6'-hexa-O-acetyl-β-D-lactose

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
In [(2)H6]acetone

: n-butyl lactyllactate

: 138-22-7
n-butyl lactate

: 56669-88-6
lactic acid-triethylamine complex

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
Stage #1: lactic acid-triethylamine complex at 170℃; Dean-Stark; Stage #2: butan-1-ol for 24h; Reflux;	42 %Chromat.

: 50-99-7
D-glucose

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
With tungsten(VI) oxide at 160℃; under 3750.38 Torr; for 5h; Reagent/catalyst; Inert atmosphere; Autoclave;	23 %Chromat.

: 57-55-6
propylene glycol

: 71-36-3
butan-1-ol

: 138-22-7
n-butyl lactate

Conditions

Conditions	Yield
at 180℃; for 8h; Time;

: 138-22-7
n-butyl lactate

: 20279-44-1
n-butyl pyruvate

Conditions

Conditions	Yield
With hydrogenchloride; sodium hypobromide In dichloromethane; water at 25℃; for 5h;	96%
With silica gel supported bis(trimethylsilyl) chromate In dichloromethane at 25℃; for 0.333333h;	83%
With air at 180℃;
Oxidation;

Na2S2O3·5H2O: Na2S2O3·5H2O

: 138-22-7
n-butyl lactate

: 20279-44-1
n-butyl pyruvate

Conditions

Conditions	Yield
With hydrogenchloride; sodium thiosulfate In dichloromethane	94%
With sodium hydrogencarbonate; sodium thiosulfate In dichloromethane; water	132.5g (92%yield)

: 138-22-7
n-butyl lactate

: 617-35-6
2-oxo-propionic acid ethyl ester

Conditions

Conditions	Yield
With oxalic acid diethyl ester at 130℃; under 760.051 Torr; for 5h; Reagent/catalyst; Temperature;	90.2%

: 67-56-1
methanol

: 138-22-7
n-butyl lactate

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
iodine for 15h; Heating;	90%

: 138-22-7
n-butyl lactate

: 64-19-7
acetic acid

: 5422-69-5
butyl 2-acetoxypropionic acid

Conditions

Conditions	Yield
With Amberlyst 15 hydrogen form for 2h; Reagent/catalyst; Reflux;	88%

: 138-22-7
n-butyl lactate

: 590-01-2
propionic acid butyl ester

Conditions

Conditions	Yield
With hydrogen In ethanol at 220℃; under 37503.8 Torr; for 12h; Catalytic behavior;	67%
With hydrogen at 220℃; under 37503.8 Torr; for 12h;	67%

: 138-22-7
n-butyl lactate

: 201230-82-2
carbon monoxide

: 1-cyclopropyl-1,3,3-trimethylurea

: 1-butoxy-1-oxopropan-2-yl 4-(1,3,3-trimethylureido)butanoate

Conditions

Conditions	Yield
With di(rhodium)tetracarbonyl dichloride; tris(pentafluorophenyl)phosphine In 1,2-dichloro-benzene at 130℃; under 760.051 Torr; for 36h; Glovebox;	67%

...Expand

: 138-22-7
n-butyl lactate

: 123-86-4
acetic acid butyl ester

: 5422-69-5
butyl 2-acetoxypropionic acid

Conditions

Conditions	Yield
With tin(II) chloride dihdyrate at 200℃; under 20627.1 Torr; for 3h;	60%

: 138-22-7
n-butyl lactate

: 123-20-6
vinyl n-butyrate

A: 34451-19-9
butyl (S)-(-)-lactate

B: (R)-O-butanoyl-(n-butyl)lactate

Conditions

Conditions	Yield
With immobilized lipase B from Candida antarctica In neat (no solvent) at 65℃; for 9h; Temperature; Resolution of racemate; Large scale; Enzymatic reaction; enantioselective reaction;	A 48% B 48%

...Expand

Butyl lactate Chemical Properties

Molecular Formula: C₇H₁₄O₃
Molecular Weight: 146.18
EINECS: 205-316-4
Melting point: -28 °C(lit.)
Boiling point: 185-187 °C(lit.)
Density: 0.984 g/mL at 25 °C(lit.)
Vapor density: 5.04 (vs air)
Refractive index: n20/D 1.421(lit.)
Flash point: 157 °F
Water Solubility: 42 g/L (25 °C)
n-Butyl lactate's(138-22-7) Synonyms: BUTYL LACTATE;1-hydroxyethanecarboxylicacid,butylester;2-Hydroxypropanoic acid butyl ester;2-hydroxy-propanoicacibutylester;2-hydroxypropanoicacid,butylester;2-hydroxy-propanoicacidbutylester;2-hydroxypropionicacid,butylester;2-hydroxy-propionicacidbutylester
n-Butyl lactate's(138-22-7) structural formula:

Butyl lactate Uses

n-Butyl lactate(138-22-7) can be used as food and feed additive.

Butyl lactate Toxicity Data With Reference

1.	skn-rbt 500 mg/24H MOD	FCTXAV Food and Cosmetics Toxicology. 17 (1979),727.
2.	scu-rat LD50:12 g/kg	NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. 1 (1974),15.
3.	ipr-mus LDLo:200 mg/kg	CBCCT* “Summary Tables of Biological Tests“ National Research Council Chemical-Biological Coordination Center. 7 (1955),690.
4.	scu-mus LD50:11,000 mg/kg	FCTXAV Food and Cosmetics Toxicology. 17 (1979),727.

Butyl lactate Consensus Reports

Reported in EPA TSCA Inventory.

Butyl lactate Safety Profile

Poison by intraperitoneal route. A skin irritant. Toxic concentration in air for humans is about 4 ppm. Flammable when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, foam, CO₂, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS, n-BUTYL ALCOHOL, and LACTIC ACIDLACTIC ACID.

Safety Information for n-Butyl lactate(138-22-7)
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 2
RTECS OD4025000

Butyl lactate Standards and Recommendations

OSHA PEL: TWA 5 ppm
ACGIH TLV: TWA 5 ppm

Product Name

Butyl lactate

Synthetic route

Butyl lactate Chemical Properties

Butyl lactate Uses

Butyl lactate Toxicity Data With Reference

Butyl lactate Consensus Reports

Butyl lactate Safety Profile

Butyl lactate Standards and Recommendations

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