-
Name
Clemizole hydrochloride
- EINECS 214-605-4
- CAS No. 1163-36-6
- Article Data1
- CAS DataBase
- Density 1.25 g/cm3
- Solubility 16.84mg/L at 25℃
- Melting Point 239-241°
- Formula C19H20ClN3.HCl
- Boiling Point 506.1 °C at 760 mmHg
- Molecular Weight 362.302
- Flash Point 259.9 °C
- Transport Information
- Appearance
- Safety 36
- Risk Codes 22
-
Molecular Structure
-
Hazard Symbols
Xn
- Synonyms 1H-Benzimidazole,1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, monohydrochloride (9CI);Benzimidazole, 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-, monohydrochloride(8CI);1-(4-Chlorobenzyl)-2-(pyrrolidinylmethyl)-1,3-benzimidazolehydrochloride;1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride;1-p-Chlorobenzyl-2-pyrrolidylmethyl benzimidazole hydrochloride;AL 20;Allercur;Histacuran;Klemidox;Reactrol;
- PSA 21.06000
- LogP 5.07370
CLEMIZOLE HYDROCHLORIDE Chemical Properties
MF: C19H21Cl2N3
MW: 362.3
EINECS: 214-605-4
MS: 
Mol File: 1163-36-6.mol
Flash Point: 259.9 °C
Enthalpy of Vaporization: 77.59 kJ/mol
Boiling Point: 506.1 °C at 760 mmHg
Vapour Pressure: 2.29E-10 mmHg at 25°C
Merck: 13,2368
CLEMIZOLE HYDROCHLORIDE Uses
1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole hydrochloride (1163-36-6)
is used as pharmaceutical intermediates of chloroimidazo penicillin.
CLEMIZOLE HYDROCHLORIDE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 26mg/kg (26mg/kg) | autonomic nervous system: "smooth muscle relaxant (mechanism undefined, spasmolytic)" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. |
| mouse | LD50 | intraperitoneal | 290mg/kg (290mg/kg) | Farmaco, Edizione Scientifica. Vol. 14, Pg. 194, 1959. | |
| mouse | LD50 | intravenous | 75mg/kg (75mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 49, Pg. 18, 1960. | |
| mouse | LD50 | oral | 837mg/kg (837mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 49, Pg. 18, 1960. | |
| rat | LD50 | intravenous | 74mg/kg (74mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 49, Pg. 18, 1960. | |
| rat | LD50 | oral | 1950mg/kg (1950mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 49, Pg. 18, 1960. |
CLEMIZOLE HYDROCHLORIDE Safety Profile
Hazard Codes: Xn .gif){kind=small}
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36:When using1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole hydrochloride (1163-36-6),please wear suitable protective clothing .
WGK Germany: 3
RTECS: DD6730000
CLEMIZOLE HYDROCHLORIDE Specification
IUPAC Name: 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole hydrochloride (1163-36-6)
CAS: 1163-36-6
Synonyms: 1-(p-chlorobenzil)-2-Pirrolidil-metil-benzimidazolocloridato ; 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-Benzimidazolmonohydrochloride ; 1-P-chlorobenzyl-pyrrolidyl-methylene-benzimidazolehydrochloride ; Allercur ; Allercurehydrochloride ; P48 ; 1-P-chlorobenzyl-2-[1-pyrrolidinyl]-methylbenzimidazole hydrochloride ; 1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)Benzoimidazole hydrochloride
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