COMPOUND 48/80 supplier | CasNO.4091-50-3

Name
[2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINE
EINECS
CAS No. 4091-50-3
Article Data22
CAS DataBase
Density 0.963g/cm³
Solubility
Melting Point
Formula C10H15 N O
Boiling Point 251.2°Cat760mmHg
Molecular Weight 165.235
Flash Point 99.3°C
Transport Information
Appearance
Safety Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Phenethylamine,p-methoxy-N-methyl- (6CI,8CI); (p-Methoxyphenethyl)methylamine;4-Methoxy-N-methylbenzeneethanamine; 4-Methoxy-N-methylphenethylamine;N-(p-Methoxyphenethyl)methylamine; N-Methyl-(p-methoxyphenethyl)amine;N-Methyl-2-(4-methoxyphenyl)ethylamine; N-Methyl-4-methoxy-b-phenethylamine;N-Methyl-4-methoxyphenethylamine; N-Methyl-N-(4-methoxyphenethyl)amine; N-Methyl-b-(4-methoxyphenyl)ethylamine;[2-(4-Methoxyphenyl)ethyl]methylamine; p-Methoxy-N-methylphenethylamine
PSA 21.26000
LogP 1.84800

Synthetic route

: 136390-01-7
ethyl-N-<2-(4-methoxyphenyl)ethyl>-carbamate

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	99%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 50℃; Inert atmosphere;	27%

: 91247-71-1
2-4-methoxyphenylethylcarbamic acid methyl ester

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux;	93%
With lithium aluminium tetrahydride

: 74-89-5
methylamine

: 18217-00-0
1-(2-Chloroethyl)-4-methoxybenzene

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
In methanol for 168h; Ambient temperature;	73%
Stage #1: methylamine; 1-(2-Chloroethyl)-4-methoxybenzene In ethanol at 20℃; for 1h; Stage #2: With triisobutylaluminum In ethanol at 60℃; for 24h;	72%

: 74-89-5
methylamine

: 768-60-5
4-methoxyphenylacetylen

A: 4091-50-3
N-methylhomoanisylamine

B: 41684-13-3
4-methoxy-N-methyl-α-methylbenzylamine

Conditions

Conditions	Yield
Stage #1: methylamine; 4-methoxyphenylacetylen; Ind2TiMe2 In toluene at 80℃; under 760 Torr; for 7h; Stage #2: With sodium cyanoborohydride; zinc(II) chloride In methanol; toluene at 25℃; for 16h;	A 20% B 19%

...Expand

: 100-52-7
benzaldehyde

: 55-81-2
4-Methoxyphenethylamine

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
anschliessend mit Dimethylsulfat und dann mit wss. Aethanol;

: 14425-64-0
4-methoxyphenethyl bromide

: 74-89-5
methylamine

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With methanol at 100℃;

: 59907-36-7
2-(4-methoxyphenyl)-N-methylacetamide

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran
With borane-THF In tetrahydrofuran for 4h; Inert atmosphere; Reflux;

: 56100-69-7
N-[2-(4-methoxyphenyl)ethyl]formamide

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran

: 55-81-2
4-Methoxyphenethylamine

: 7693-46-1
4-Nitrophenyl chloroformate

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With 4-methyl-morpholine; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; Wang resin 1.) 0 deg C, 2 h; room temp., overnight, 2.) DMF, room temp., overnight, 3.) THF, 60 deg C, 14 h; Yield given. Multistep reaction;

: 13139-86-1
4-methoxyphenyl magnesium bromide

methyl-<2-chloro-ethyl>-amine hydrochloride: methyl-<2-chloro-ethyl>-amine hydrochloride

: 4091-50-3
N-methylhomoanisylamine

: 702-23-8
2-(4-Methoxyphenyl)ethanol

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / 0.5 h / Heating 2: 73 percent / methanol / 168 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1.1: phosphorus pentachloride; calcium carbonate / toluene / 3.67 h / 0 - 20 °C / Inert atmosphere 2.1: ethanol / 1 h / 20 °C 2.2: 24 h / 60 °C View Scheme

: 55-81-2
4-Methoxyphenethylamine

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / K2CO3 / tetrahydrofuran / 25 °C 2: 99 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
Multi-step reaction with 2 steps 1: Et3N / CHCl3 2: LiAlH4 / tetrahydrofuran View Scheme
Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere View Scheme

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (catalytic hydrogenation) 2: Et3N / CHCl3 3: LiAlH4 / tetrahydrofuran View Scheme

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene; water / 0.5 h / 0 - 22 °C / Inert atmosphere 2: borane-THF / tetrahydrofuran / 4 h / Inert atmosphere; Reflux View Scheme

: 104-01-8
4-Methoxyphenylacetic acid

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; thionyl chloride / toluene / 0.5 h / 40 °C / Inert atmosphere 2: toluene; water / 0.5 h / 0 - 22 °C / Inert atmosphere 3: borane-THF / tetrahydrofuran / 4 h / Inert atmosphere; Reflux View Scheme

: 50-00-0
formaldehyd

: 55-81-2
4-Methoxyphenethylamine

A: 775-33-7
4-methoxyphenethyl-dimethylamine

B: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With calcium hydride; 5%-palladium/activated carbon In toluene at 30℃; for 16h; Sealed tube;	A n/a B 38 %Spectr.

...Expand

: C15H23NO3

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
With hydrogenchloride In water; ethyl acetate for 3h;	685 mg

: 121778-75-4
N-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-ethylamine

: 4091-50-3
N-methylhomoanisylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 5 h / Inert atmosphere 2.1: hydrogenchloride / water; ethyl acetate / 3 h View Scheme

: 4091-50-3
N-methylhomoanisylamine

: 2-Chloro-N-(cyclopropylmethyl)-6-morpholinopyrimidine-4-carboxamide

: N-(cyclopropylmethyl)-2-((4-methoxyphenethyl)(methyl)amino)-6-morpholinopyrimidine-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 120℃; for 168h; Inert atmosphere;	90%

: 4206-67-1
iodo(trimethylsilyl)methane

: 4091-50-3
N-methylhomoanisylamine

: [2-(4-Methoxy-phenyl)-ethyl]-methyl-trimethylsilanylmethyl-amine

Conditions

Conditions	Yield
In acetonitrile Heating;	88%

: 4091-50-3
N-methylhomoanisylamine

: 85175-59-3
3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one

: 85175-68-4
1-[7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{4-methoxy-phenyl}-ethyl)-amino]-propane hydrochloride

Conditions

Conditions	Yield
	76.2%

: 67793-85-5
2-methyl-3-[4-(3-chloropropoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one

: 4091-50-3
N-methylhomoanisylamine

: 2-Methyl-3-[4-(3-(N-4-methoxyphenethyl-N-methyl-amino)-propoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one hydrochloride

Conditions

Conditions	Yield
In acetone	75%

: 67794-31-4
6-methyl-7-[4-(2,3-epoxypropoxy)-phenyl]-1,6-naphthyridin-5(6H)-one

: 4091-50-3
N-methylhomoanisylamine

: 67794-37-0
6-Methyl-7-[4-(2-hydroxy-3-(4-methoxyphenethyl-N-methyl-amino)-propoxy)-phenyl]-1,6-naphthyridin-5(6H)-one oxalate

Conditions

Conditions	Yield
	61%

: 58-54-8
ethacrynic acid

: 4091-50-3
N-methylhomoanisylamine

: 2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(4-methoxyphenethyl)-N-methylacetamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	58%

: 4091-50-3
N-methylhomoanisylamine

: 140-88-5
ethyl acrylate

A: ethyl 2-(7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

B: ethyl (E)-3-(1-(2-ethoxy-2-oxoethyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)acrylate

Conditions

Conditions	Yield
With 2-Pyridone; silver(I) acetate; palladium diacetate; bis(trifluoromethanesulfonyl)amide In dichloromethane at 90℃; for 12h; Sealed tube;	A 55% B 13%

...Expand

: 4091-50-3
N-methylhomoanisylamine

: 140-88-5
ethyl acrylate

A: ethyl 2-(7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

B: C20H27NO5

Conditions

Conditions	Yield
With 2-hydroxypyridin; silver(I) acetate; palladium diacetate; bis(trifluoromethanesulfonyl)amide In dichloromethane at 90℃; for 12h; Sealed tube;	A 55% B 13%

...Expand

: 4091-50-3
N-methylhomoanisylamine

: 91833-10-2
2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(4H)-thione

: 117427-82-4
2,3-dihydro-2-[2-[[2-(4-methoxyphenyl)ethyl]methylamino]ethyl]-4-methylpyrido[3,2-f]-1,4-oxazepine-5(4H)-thione

Conditions

Conditions	Yield
In ethanol Heating;	37%

: 50-00-0
formaldehyd

: 4091-50-3
N-methylhomoanisylamine

: 5839-66-7
p-methoxy-N-methylphenethylamine dimer

Conditions

Conditions	Yield
With perchloric acid

: 1647-26-3
1-bromo-2-cyclohexylethane

: 4091-50-3
N-methylhomoanisylamine

: (2-cyclohexyl-ethyl)-(4-methoxy-phenethyl)-methyl-amine

Conditions

Conditions	Yield
With ethanol; sodium carbonate at 150℃;

: 590-28-3
potassium cyanate

: 4091-50-3
N-methylhomoanisylamine

: 92547-62-1
N-(4-methoxy-phenethyl)-N-methyl-urea

Conditions

Conditions	Yield
With sulfuric acid

: 4091-50-3
N-methylhomoanisylamine

: 370-98-9
N-methyltyramine

Conditions

Conditions	Yield
With hydrogen bromide

: 4091-50-3
N-methylhomoanisylamine

: 7569-90-6
(3-chloro-4-methoxy-phenethyl)-methyl-amine

Conditions

Conditions	Yield
With hydrogenchloride; chlorine

: 4091-50-3
N-methylhomoanisylamine

: 861199-14-6
(3-bromo-4-methoxy-phenethyl)-methyl-amine

Conditions

Conditions	Yield
With hydrogenchloride; bromine

: 4091-50-3
N-methylhomoanisylamine

: 292638-85-8
acrylic acid methyl ester

: 56100-74-4
N-(4-methoxy-phenethyl)-N-methyl-β-alanine methyl ester

: 4091-50-3
N-methylhomoanisylamine

: 102-92-1
Cinnamoyl chloride

: 539-18-4
herclavine

Conditions

Conditions	Yield
With potassium hydroxide; benzene

: 5437-82-1
3-bromo-N,N-diethylpropionylamide

: 4091-50-3
N-methylhomoanisylamine

: (+/-)-β-<α.N-Dimethyl-4-methoxy-benzylamino>-N'.N'-diaethyl-propionamid

: 50-00-0
formaldehyd

: 4091-50-3
N-methylhomoanisylamine

A: 5839-66-7
p-methoxy-N-methylphenethylamine dimer

B: 94724-12-6
compound 48/80

Conditions

Conditions	Yield
With perchloric acid In water at 90℃; for 4h; Yield given. Yields of byproduct given;

...Expand

: 4091-50-3
N-methylhomoanisylamine

: 85175-59-3
3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one

: 85175-70-8
7,8-Dimethoxy-3-(3-{[2-(4-methoxy-phenyl)-ethyl]-methyl-amino}-propyl)-1,3-dihydro-benzo[d]azepin-2-one

Conditions

Conditions	Yield
at 90 - 95℃; for 2h;

: 4091-50-3
N-methylhomoanisylamine

: 114432-17-6
2-Isopropyl-1-[4-(3-bromopropyloxy)benzenesulphonyl]indolizine

: 114433-00-0
{3-[4-(2-Isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-[2-(4-methoxy-phenyl)-ethyl]-methyl-amine

Conditions

Conditions	Yield
With triethylamine In toluene for 24h; Heating;

COMPOUND 48/80 Chemical Properties

Product Name: Compound 48/80 (CAS NO.4091-50-3)

Molecular Formula: C₁₀H₁₅NO
Molecular Weight: 165.23g/mol
Mol File: 4091-50-3.mol
Boiling point: 251.2 °C at 760 mmHg
Storage Temperature:
Flash Point: 99.3 °C
Density: 0.963 g/cm³
Surface Tension: 32 dyne/cm
Enthalpy of Vaporization: 48.85 kJ/mol
Vapour Pressure: 0.0208 mmHg at 25°C
XLogP3-AA: 1.7
H-Bond Donor: 1
H-Bond Acceptor: 2
Product Categories: Amines and Anilines

COMPOUND 48/80 Uses

Compound 48/80 (CAS NO.4091-50-3) promotes histamine release. In biochemical research, compound 48/80 is used to promote mast cell degranulation.

COMPOUND 48/80 Production

Compound 48/80 (CAS NO.4091-50-3) is a polymer produced by the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.

COMPOUND 48/80 Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intravenous	1290ug/kg (1.29mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959.
mouse	LD50	intravenous	1950ug/kg (1.95mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959.
rabbit	LD50	intravenous	1500ug/kg (1.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959.
rat	LD50	intravenous	2400ug/kg (2.4mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959.

COMPOUND 48/80 Safety Profile

Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.

COMPOUND 48/80 Specification

Compound 48/80 ,its CAS NO. is 4091-50-3,the synonyms is 4-Methoxy-n-methyl-benzeneethanamin ; p-Methoxy-n-methyl-phenethylamin ; [2-(4-Methoxy-phenyl)-ethyl]-methyl-amine ; p-Methoxy-n-methylphenethylamine ; n-Methyl 4-methoxyphenethylamine ; 2-(4-Methoxyphenyl)-n-methylethanamine ; 4-Methoxy-n-methylbenzeneethanamine ; n-Methyl-2-(4-methoxyphenyl)ethylamine .

Product Name

[2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINE

Synthetic route

COMPOUND 48/80 Chemical Properties

COMPOUND 48/80 Uses

COMPOUND 48/80 Production

COMPOUND 48/80 Toxicity Data With Reference

COMPOUND 48/80 Safety Profile

COMPOUND 48/80 Specification

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