Carzenide supplier | CasNO.138-41-0

Name
Carzenide
EINECS 205-327-4
CAS No. 138-41-0
Article Data37
CAS DataBase
Density 1.536 g/cm³
Solubility 453 mg/L (25 ºC)
Melting Point 285-295 °C(lit.)
Formula C₇H₇NO₄S
Boiling Point 449 °C at 760 mmHg
Molecular Weight 201.203
Flash Point 225.4 °C
Transport Information
Appearance White powder
Safety 22-24/25-36/37/39-26
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Benzoicacid, p-sulfamoyl- (6CI,7CI,8CI);Benzoic acid, p-sulfamyl- (4CI);4-Carboxybenzenesulfonamide;Benzoic acid p-sulfamide;Dirnate;NSC 22976;NSC 683540;p-Aminobenzoic acid sulfamide;p-Carboxybenzenesulfonamide;p-Sulfamoylbenzoic acid;p-Sulfonamidobenzoic acid;
PSA 105.84000
LogP 1.81330

Synthetic route

: 17202-49-2
p-carboxybenzenesulfonyl azide

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate; cetyltrimethylammonim bromide; cobalt(II) chloride In water at 25℃; for 0.166667h; Reduction;	97%
With ethyl acetoacetate; triethylamine In acetonitrile

: 70-55-3
toluene-4-sulfonamide

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With oxygen; cobalt(II) acetate; 3,5-dinitro-N-hydroxy-N-methylbenzamide; acetic acid at 100℃; under 760.051 Torr; for 10h; Temperature; Reagent/catalyst;	94.05%
With sodium hydroxide; potassium permanganate In water at 70 - 90℃; for 2h;	90%
Stage #1: toluene-4-sulfonamide With potassium permanganate In water for 12h; Reflux; Stage #2: With sulfuric acid In water at 0℃;	66%

: C7H9NO5S

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With gadolinium(III) oxide; 2-methyl-4-hydroxy-3,6-dimethyloltoluene; acetylacetone at 50 - 78℃; for 1.83333h; Temperature;	94%

: 456-25-7
p-carboxyphenyl diazonium tetrafluoroborate

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 12h; Inert atmosphere;	60%
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 4h; Inert atmosphere; Schlenk technique;	60%

: 10130-89-9
p-carboxyphenylsulfonyl chloride

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With ammonia In methanol at -5℃;	53%
With ammonia
Multi-step reaction with 2 steps 1: NaN3 / acetone; H2O 2: 3-oxo-butanoic acid ethyl ester, Et3N / acetonitrile View Scheme
With hydrogenchloride; ammonium hydroxide

: 3240-35-5
4-formyl-benzenesulfonamide

A: 138-41-0
4-(aminosulfonyl)-benzoic acid

B: 67472-44-0
4-(hydroxymethyl)benzenesulfonamide

Conditions

Conditions	Yield
With potassium hydroxide

: 701-34-8
4-bromo-benzenesulfonic acid amide

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With n-butyllithium; diethyl ether anschliessend mit Kohlendixid;

: 657-84-1
sodium tosylate

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
With phosphorus pentachloride und Erhitzen des Reaktionsprodukts mit wss.Ammoniumpolysulfid in Dioxan;

: 6435-78-5
N-tosylpyrrolidine

: 7732-18-5
water

potassium permanganate: potassium permanganate

A: 110-15-6
succinic acid

B: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
Erhitzen;

...Expand

: 3240-35-5
4-formyl-benzenesulfonamide

concentrated KOH-solution: concentrated KOH-solution

A: 138-41-0
4-(aminosulfonyl)-benzoic acid

B: 67472-44-0
4-(hydroxymethyl)benzenesulfonamide

...Expand

: 3119-02-6
4-cyanobenzenesulfonamide

: 7732-18-5
water

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 3119-02-6
4-cyanobenzenesulfonamide

alkali: alkali

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 98555-79-4
4-(trichlorophosphoranylidene-sulfamoyl)-benzoyl chloride

: 7732-18-5
water

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1146-43-6
N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide

alkaline potassium permanganate: alkaline potassium permanganate

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 834-04-8
4-sulfamoyl-cinnamic acid amide

chromic acid: chromic acid

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 147723-92-0
4-sulfamoyl-cinnamic acid

chromic acid: chromic acid

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 6306-24-7
4-amidobenzylsulfonamide

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 138-41-0
4-(aminosulfonyl)-benzoic acid

B: 7664-41-7
ammonia

...Expand

: 1132-18-9
4-propylbenzene-1-sulfonamide

KMnO4: KMnO4

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1135-00-8
(4-n-butylbenzene)sulfonamide

permanganate: permanganate

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 7732-18-5
water

: 7080-50-4
chloramine T trihydrate

A: 138-41-0
4-(aminosulfonyl)-benzoic acid

B: 70-55-3
toluene-4-sulfonamide

Conditions

Conditions	Yield
am Licht;

...Expand

: 98-59-9
p-toluenesulfonyl chloride

: 138-41-0
4-(aminosulfonyl)-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: pyridine; ammonium hydroxide / dichloromethane / 4 h / 0 - 20 °C 2.1: potassium permanganate / water / 12 h / Reflux 2.2: 0 °C View Scheme

: 67-56-1
methanol

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 22808-73-7
methyl 4-sulfamoylbenzoate

Conditions

Conditions	Yield
With thionyl chloride at 20℃; for 2h;	100%
Stage #1: methanol With thionyl chloride at 0℃; for 0.5h; Stage #2: 4-(aminosulfonyl)-benzoic acid at 20℃; for 3h;	100%
With sulfuric acid for 8h; Reflux;	95%

: 64-17-5
ethanol

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 5446-77-5
4-sulfamoylbenzoic acid ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride at 20℃;	98%
With hydrogenchloride In water for 20h; Reflux;	52%
With hydrogenchloride
With sulfuric acid for 24h; Reflux;

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 22808-73-7
methyl 4-sulfamoylbenzoate

Conditions

Conditions	Yield
In methanol; hexane; chloroform at 20℃; for 0.0833333h;	98%
In methanol; hexane; dichloromethane at 20℃; for 2h;	95%
Stage #1: 4-(aminosulfonyl)-benzoic acid; diazomethyl-trimethyl-silane In methanol; hexane; dichloromethane for 2h; Stage #2: With sodium hydroxide In methanol; hexane; dichloromethane; water	95%
In methanol; hexane; dichloromethane for 2h;

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 298-14-6
potassium hydrogencarbonate

: 117662-91-6
potassium 4-sulfamoylbenzoate

Conditions

Conditions	Yield
In water at 45℃; for 0.5h;	98%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 194920-62-2
tert-butyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate

: C22H37N3O8S

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In chloroform; N,N-dimethyl-formamide	97%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 579-75-9
2-Methoxybenzoic acid

: 4-[[(2-methoxybenzoyl)amino]sulphonyl]benzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride In Isopropyl acetate at 80 - 90℃; Solvent; Temperature;	96%
Stage #1: 4-(aminosulfonyl)-benzoic acid; 2-Methoxybenzoic acid With p-nitrobenzenesulfonic acid In toluene for 4h; Reflux; Stage #2: With thionyl chloride In toluene at 50℃; for 5h; Temperature; Reagent/catalyst;

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 1315482-72-4
C17H27N3O5S

Conditions

Conditions	Yield
Stage #1: 4-(aminosulfonyl)-benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide Inert atmosphere; Stage #2: 5-tert-butoxycarbonylamino-1-aminopentane With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	94%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 2450-71-7
Propargylamine

: 912345-32-5
N-(prop-2-yn-1-yl)-4-sulfamoylbenzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;	93%
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;	82%
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate	82%
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	82%
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide	74%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: tert-butyl (4-(4-sulfamoylbenzamido)butyl)carbamate

Conditions

Conditions	Yield
Stage #1: 4-(aminosulfonyl)-benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 1-amino-4-[(tert-butyloxycarbonyl)amino]butane In N,N-dimethyl-formamide at 20℃; for 16h;	93%

: N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)pent-4-ynamide

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: C18H25N3O6S

Conditions

Conditions	Yield
Stage #1: 4-(aminosulfonyl)-benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)pent-4-ynamide With triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;	92%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 84859-26-7
1-Ethyl-2,2-dimethoxy-pyrrolidine

: 4-[1-Ethyl-pyrrolidin-(2Z)-ylidenesulfamoyl]-benzoic acid methyl ester

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	91%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 4-([(2-methoxy-5-chlorobenzoyl)amino]sulfonyl)benzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride In chlorobenzene at 120℃; for 7 - 9h;	91%

: 78197-27-0
4-fluoropiperidine

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1050514-21-0
4-[(4-fluoropiperidin-1-yl)carbonyl]benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: 4-(aminosulfonyl)-benzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 3h; Stage #2: 4-fluoropiperidine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h;	91%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: (3aS,6aS)-tert-butyl 5-(4-sulfamoylbenzoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide at 0℃;	91%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 51594-97-9
4-sulfamoylbenzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride for 5h; Heating;	90%
With thionyl chloride for 0.5h; Heating;
With thionyl chloride Heating / reflux;

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 66095-18-9
N-benzyloxycarbonyl-1,6-hexanediamine

: 1294354-58-7
benzyl (6-(4-sulfamoylbenzamido)hexyl)carbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	90%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 14h;	73.8 mg

: 1603-40-3
3-methylpyridin-2-ylamine

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: C6H8N2*C7H7NO4S

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	90%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 2-((S)-2-{[(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyryl)-benzooxazole-5-carboxylic acid methyl ester

: 2-[(S)-3-Methyl-2-({(S)-1-[(S)-3-methyl-2-(4-sulfamoyl-benzoylamino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-butyryl]-benzooxazole-5-carboxylic acid methyl ester

Conditions

Conditions	Yield
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran for 16h; Ambient temperature;	89%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1227158-85-1
1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

: 1227158-88-4
1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine 4-sulfamoylbenzoate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	88%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1228371-57-0
C27H48N4O5S

: C34H53N5O8S2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;	88%

: 1023301-84-9
tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 2-(4-sulfamoylbenzoyl)-2,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;	88%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 154715-61-4
4-uulfamoyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	87%
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide	80%
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at -20℃; for 21h;	75%

: 74255-10-0
1-Butyl-2,2-dimethoxy-pyrrolidine

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 4-[1-Butyl-pyrrolidin-(2Z)-ylidenesulfamoyl]-benzoic acid methyl ester

Conditions

Conditions	Yield
In diethyl ether for 6h; Ambient temperature;	87%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 67472-44-0
4-(hydroxymethyl)benzenesulfonamide

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran at 0 - 20℃; for 12h;	86%
With diborane In tetrahydrofuran at 0 - 20℃; for 19h; Inert atmosphere;	74%
Stage #1: 4-(aminosulfonyl)-benzoic acid With diborane In tetrahydrofuran at 0 - 20℃; for 18.5h; Stage #2: With hydrogenchloride In methanol; water at 0℃; for 1.5h; Reflux;	67%
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 10℃; for 12h;	64.47%
Stage #1: 4-(aminosulfonyl)-benzoic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0℃;

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: (13S,17S)-3-(tert-butyldimethylsilyloxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl 2-hydroxyacetate

: 2-((13S,17S)-3-(tert-butyldimethylsilyloxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yloxy)-2-oxoethyl 4-sulfamoylbenzoate

Conditions

Conditions	Yield
With pyridine; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 72h;	86%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 66137-74-4
5-iodooctafluoro-3-oxapentanesulfonyl fluoride

: C11H5F8INO7S2(1-)*K(1+)

Conditions

Conditions	Yield
Stage #1: 4-(aminosulfonyl)-benzoic acid With 19-oxaheptatriacontane; potassium carbonate; potassium hydroxide In water; toluene at 20℃; Stage #2: 5-iodooctafluoro-3-oxapentanesulfonyl fluoride In water; toluene for 0.5h;	86%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 3-bromobenzoylpiperazine

: 4-[4-(3-bromobenzoyl)piperazine-1-carbonyl]benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: 4-(aminosulfonyl)-benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 3-bromobenzoylpiperazine In N,N-dimethyl-formamide at 20℃;	86%

Carzenide Consensus Reports

Reported in EPA TSCA Inventory.

Carzenide Specification

The Benzoic acid,4-(aminosulfonyl)-, with the CAS registry number 138-41-0, is also known as 4-Carboxybenzenesulfonamide. Its EINECS number is 205-327-4. This chemical's molecular formula is C₇H₇NO₄S and molecular weight is 201.21. What's more, its systematic name is 4-sulfamoylbenzoic acid. Its classification code is Drug / Therapeutic Agent. It is used as an organic intermediate and in synthetizing pharmaceuticals.

Physical properties of Benzoic acid,4-(aminosulfonyl)- are: (1)ACD/LogP: 0.50; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.38; (4)ACD/LogD (pH 7.4): -2.56; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 72.06 Å²; (13)Index of Refraction: 1.611; (14)Molar Refractivity: 45.46 cm³; (15)Molar Volume: 130.9 cm³; (16)Polarizability: 18.02×10^-24cm³; (17)Surface Tension: 66.2 dyne/cm; (18)Density: 1.536 g/cm³; (19)Flash Point: 225.4 °C; (20)Enthalpy of Vaporization: 74.57 kJ/mol; (21)Boiling Point: 449 °C at 760 mmHg; (22)Vapour Pressure: 7.56E-09 mmHg at 25°C.

Preparation: this chemical can be prepared by 4-chlorosulfonyl-benzoic acid at the temperature of -5 °C. This reaction will need reagent ammonia and solvent methanol. The yield is about 53%.

Benzoic acid,4-(aminosulfonyl)- can be prepared by 4-chlorosulfonyl-benzoic acid at the temperature of -5 °C

Uses of Benzoic acid,4-(aminosulfonyl)-: it can be used to produce 4-sulfamoyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester. It will need reagent dicyclohexylcarbodiimide and solvent dimethylformamide. The yield is about 80%.

Benzoic acid,4-(aminosulfonyl)- can be used to produce 4-sulfamoyl-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection. You should not breathe dust. When using it, you must avoid contact with eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(N)c1ccc(C(=O)O)cc1
(2)Std. InChI: InChI=1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12)
(3)Std. InChIKey: UCAGLBKTLXCODC-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 1gm/kg (1000mg/kg)		Journal of Medicinal Chemistry. Vol. 8, Pg. 548, 1965.
rat	LD50	intraperitoneal	350mg/kg (350mg/kg)		Pharmazie. Vol. 38, Pg. 102, 1983.

Product Name

Carzenide

Synthetic route

Carzenide Consensus Reports

Carzenide Specification

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