Cefuroxime

The Cefuroxim is an organic compound with the formula C₁₆H₁₆N₄O₈S. The IUPAC name of this chemical is (6R, 7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl] amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. With the CAS registry number 55268-75-2, the product's categories are Antibiotics; Bacteriostatic Antibiotics; beta-Lactam StructureAlphabetic; C; CA - CG; Chemical Structure; Principle.

The Cefuroxim is the second-generation cephalosporin antibiotics against Gram-positive bacteria and-negative bacteria have a strong antibacterial or bactericidal effect on the β-lactamase stability, and injection administration. It is used to susceptible ones caused by urinary tract infections, respiratory infections, soft tissue infections, obstetrics and gynecology diseases, infections, gonorrhea, meningitis.

Physical properties about Cefuroxim are: (1)ACD/LogP: 0.84; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -2.07; (4)ACD/LogD (pH 7.4): -2.91; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 12; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 156.49 Å²; (13)Index of Refraction: 1.734; (14)Molar Refractivity: 96.66 cm³; (15)Molar Volume: 241 cm3; (16)Polarizability: 38.32×10^-24cm³; (17)Surface Tension: 78 dyne/cm; (18)Density: 1.76 g/cm³.

Uses of Cefuroxim: it can be used to produce 3-carbamoyloxymethyl-7-(2-furan-2-yl-2-methoxyimino-acetylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester at ambient temperature. It will need reagent NaHCO₃ and solvent dimethylformamide, dioxane . The yield is about 75%.

When you are using this chemical, please be cautious about it as the following:
It may cause sensitisation by inhalation and skin contact. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves, do not breathe dustand avoid contact with skin. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=NOC)c3occc3)COC(=O)N)C(=O)O
(2)InChI: InChI=1/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/t10-,14-/m1/s1
(3)InChIKey: JFPVXVDWJQMJEE-QMTHXVAHBS
(4)Std. InChI: InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/t10-,14-/m1/s1
(5)Std. InChIKey: JFPVXVDWJQMJEE-QMTHXVAHSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	64mg/kg/16H-I (64mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Lancet. Vol. 1, Pg. 965, 1984.
mouse	LD50	intramuscular	> 2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA	Chemotherapy Vol. 27(Suppl,
mouse	LD50	intraperitoneal	> 10gm/kg (10000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Chemotherapy Vol. 27(Suppl,
mouse	LD50	intravenous	10400mg/kg (10400mg/kg)		Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 17, Pg. 233, 1979.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA	Chemotherapy Vol. 27(Suppl,
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA	Chemotherapy Vol. 27(Suppl,
rabbit	LD50	intramuscular	> 300mg/kg (300mg/kg)		Chemotherapy Vol. 27(Suppl,
rabbit	LD50	intravenous	> 1500mg/kg (1500mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Chemotherapy Vol. 27(Suppl,
rat	LD50	intramuscular	> 2gm/kg (2000mg/kg)		Chemotherapy Vol. 27(Suppl,
rat	LD50	intraperitoneal	> 10gm/kg (10000mg/kg)		Chemotherapy Vol. 27(Suppl,
rat	LD50	intravenous	> 8gm/kg (8000mg/kg)		Chemotherapy Vol. 27(Suppl,
rat	LD50	oral	10gm/kg (10000mg/kg)		Chemotherapy Vol. 27(Suppl,
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Chemotherapy Vol. 27(Suppl,