IUPAC Name: (1R)-1-[[(3R)-3-Ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydropyrido[2,1-a]isoquinolin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol dichloride
Synonyms of Cephaeline hydrochloride (CAS NO.5853-29-2) : (-)-Cephaeline dihydrochloride ; 7',10,11-Trimethoxyemetan-6'-ol dihydrochloride ; Cephaeline HCL ; Cephaleine hydrochloride
CAS NO:5853-29-2
Molecular Formula: C28H40Cl2N2O4
Molecular Weight :539.5342
Molecular Structure :
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | subcutaneous | 8mg/kg (8mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 10, Pg. 73, 1917/1918. | |
mouse | LD50 | intraperitoneal | 20530ug/kg (20.53mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
mouse | LD50 | oral | 74970ug/kg (74.97mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
rat | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 421, 1952. | |
rat | LDLo | subcutaneous | 6500ug/kg (6.5mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 10, Pg. 73, 1917/1918. |
Poison by ingestion and intraperitoneal routes. When Cephaeline hydrochloride (CAS NO.5853-29-2) is heated to decomposition, it emits toxic fumes of NOx and HCl.
RIDADR 1544
HazardClass 6.1(b)
PackingGroup III
Category: Toxic Substances
Toxicity classification: Cephaeline hydrochloride (CAS NO.5853-29-2) is highly toxic.
Acute toxicity: abdominal - rat LD50: 10 mg / kg; Oral - Mouse LD50: 74.97 mg / kg
Flammable hazardous characteristics: thermal decomposition of toxic emissions of nitrogen oxides, hydrogen chloride fumes
Storage features: Treasury temperature, ventilation, drying; and keep separately from food raw materials
Fire-extinguishing agent: water, carbon dioxide, foam, dry powder
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