Chloroacetaldehyde diethyl acetal supplier

Name
Chloroacetaldehyde diethyl acetal
EINECS 210-695-4
CAS No. 621-62-5
Article Data46
CAS DataBase
Density 1.018g/cm³
Solubility 1.8 g/L (20 °C )
Melting Point -45 °C
Formula C₆H₁₃ClO₂
Boiling Point 157.4 °C at 760 mmHg
Molecular Weight 152.621
Flash Point 29.4 °C
Transport Information UN 1993
Appearance Clear, colorless liquid.
Safety 28A-26-16-36-23-7/9
Risk Codes 10-22-36/37/38
Molecular Structure
Hazard Symbols Xi; Xn
Synonyms Acetaldehyde,chloro-, diethyl acetal (6CI,7CI,8CI);1-Chloro-2,2-diethoxyethane;2-Chloro-1,1-diethoxyethane;2-Chloroacetaldehyde diethyl acetal;Chloroacetaldehyde diethyl acetal;Chloroethanal diethyl acetal;Diethoxyethylchloride;Monochloroacetaldehyde diethyl acetal;NSC 8436;
PSA 18.46000
LogP 1.62430

Synthetic route

: 64-17-5
ethanol

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium ethanolate at 20℃; for 1h; Cooling with ice; Green chemistry;	96.7%

: 107-20-0
2-chloroethanal

: 64-17-5
ethanol

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform Reflux; Large scale;	93%

: 108-05-4
vinyl acetate

: 64-17-5
ethanol

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With chlorine at 1 - 4℃; for 2h; Chlorination; Acetalization;	64%
With chlorine im Dunkeln unter Kuehlung mit CO2-Aceton;
With chlorine im Dunkeln unter Kuehlung mit CO2-Aceton;

: 100-64-1
Cyclohexanone oxime

A: 371-89-1
chlorofluorocyclohexane

B: 2108-92-1
1,1-dichlrocyclohexane

C: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With hydrogen fluoride; chlorine In ethanol at -10℃; for 4h;	A 59% B 32% C n/a

...Expand

: 64-17-5
ethanol

: 75-07-0
acetaldehyde

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
Stage #1: acetaldehyde With chlorine Chlorination; Stage #2: ethanol With calcium chloride at 20 - 30℃; for 4h; Acetalization;	48%

: 105-57-7
diethyl acetal

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
beim Chlorieren;
beim Chlorieren;
With chlorine Versetzen des Reaktionsgemisches mit Natriumaethylat bei 50grad;

: 10140-87-1
1,2-dichloroethyl acetate

: 64-17-5
ethanol

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
at 55℃;

: 64-17-5
ethanol

: 75-01-4
chloroethylene

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With chlorine

: 64-17-5
ethanol

: 75-35-4
1,1-Dichloroethylene

: 141-52-6
sodium ethanolate

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
at 40 - 50℃;

...Expand

: 64-17-5
ethanol

: 928-56-3
E/Z-2-chlorovinyl ethyl ether

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With sulfuric acid
With hydrogenchloride

: 64-17-5
ethanol

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With chlorine
With chlorine dann Erhitzen auf 55grad und laesst man mit Marmor in der Kaelte Stehen, faellt dann mit Wasser und fraktioniert das gefaellte Oel;

: 64-17-5
ethanol

A: 619-33-0
dichloroacetaldehyde diethyl acetal

B: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With chlorine; calcium carbonate

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 141-52-6
sodium ethanolate

: 621-62-5
chloroacetaldehyde diethyl acetal

: 64-17-5
ethanol

: 109-92-2
ethyl vinyl ether

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With chlorine
With tert-butylhypochlorite
(i) SO2Cl2, Et2O, (ii) /BRN= 1718733/, H2SO4; Multistep reaction;
With tert-butylhypochlorite; potassium carbonate In diethyl ether at -50℃;

: 123-63-7
paracetaldehyde

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With hydrogenchloride; potassium permanganate at 20 - 25℃; moeglichst im Sonnelicht, dann mit Alkohol und Wasser;

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1730-25-2
allylmagnesium bromide

A: 2-ethoxy-4,5-dibromo-1-chloro-pentane

B: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
Behandeln des Reaktiongemischs mit Brom;

...Expand

: 64-17-5
ethanol

: 123-63-7
paracetaldehyde

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
(i) Cl2, (ii) /BRN= 1718733/; Multistep reaction;

: 64-17-5
ethanol

: 7782-50-5
chlorine

: 109-92-2
ethyl vinyl ether

: 621-62-5
chloroacetaldehyde diethyl acetal

...Expand

: 64-17-5
ethanol

<1.2-dichloro-ethyl>-acetate: <1.2-dichloro-ethyl>-acetate

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
at 64℃;
at 64℃;

: 64-17-5
ethanol

chloroaldehyde alcoholate: chloroaldehyde alcoholate

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With hydrogenchloride

: 623-46-1
1,2-dichloro-2-ethoxyethane

sodium alcoholate (1 mol ): sodium alcoholate (1 mol )

: 621-62-5
chloroacetaldehyde diethyl acetal

: 60-29-7
diethyl ether

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1730-25-2
allylmagnesium bromide

A: 621-62-5
chloroacetaldehyde diethyl acetal

B α-chloro-δ.ε-dibromo-β-ethoxy-pentane: α-chloro-δ.ε-dibromo-β-ethoxy-pentane

Conditions

Conditions	Yield
nachfolgenden Behandlung mit Brom;

...Expand

: 64-17-5
ethanol

: 7782-50-5
chlorine

A: 619-33-0
dichloroacetaldehyde diethyl acetal

B: 79-02-7
2,2-dichloroacetaldehyde

C: 75-87-6
chloral

D: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
at 80 - 90℃; unter der Einwirkung von stillen elektrischen Entladungen; weitere Prod.: Trichloracetaldehyd-diaethylacetal und Hexachloraethan;

...Expand

: 74283-45-7
1-chloro-2-ethoxy-2-ethanol

A: 621-62-5
chloroacetaldehyde diethyl acetal

B monochloroaldehyde hydrate: monochloroaldehyde hydrate

Conditions

Conditions	Yield
bei der Destillation;

: 108-05-4
vinyl acetate

A: 10140-87-1
1,2-dichloroethyl acetate

B: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
	A n/a B 790 grams (56 % pure)

: 621-62-5
chloroacetaldehyde diethyl acetal

: 108-95-2
phenol

: 32438-31-6
(2,2-diethoxy-ethoxy)-benzene

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 175℃; for 1h; Microwave irradiation;	100%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 100℃;	58%
With potassium hydroxide 1.) H2O, 90 to 100 deg C, 2.) reflux, 6 h; Multistep reaction;

: 75-64-9
tert-butylamine

: 621-62-5
chloroacetaldehyde diethyl acetal

: 84500-89-0
N-(tert-butylamino)acetaldehyde diethyl acetal

Conditions

Conditions	Yield
at 140℃; for 20h;	99%

: 446273-59-2
4-bromo-6-chloro-3-pyridazineamine

: 621-62-5
chloroacetaldehyde diethyl acetal

: 933190-51-3
8-bromo-6-chloro-imidazo[1,2-b]pyridazine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In isopropyl alcohol at 80℃; for 20h;	98%
Stage #1: 4-bromo-6-chloro-3-pyridazineamine; chloroacetaldehyde diethyl acetal With toluene-4-sulfonic acid In isopropyl alcohol at 80℃; for 20h; Stage #2: With sodium hydrogencarbonate	98%
With toluene-4-sulfonic acid In isopropyl alcohol at 80℃; for 20h;	98%
With toluene-4-sulfonic acid In isopropyl alcohol at 80℃; for 16h;	15%

: 60811-24-7
3,4-difluorobenzenethiol

: 621-62-5
chloroacetaldehyde diethyl acetal

: 847684-97-3
(2,2-diethoxyethyl)(3,4-difluorophenyl)sulfane

Conditions

Conditions	Yield
With sodium ethanolate for 36h; Heating;	95%
Stage #1: 3,4-difluorobenzenethiol With sodium ethanolate In ethanol Stage #2: chloroacetaldehyde diethyl acetal In ethanol at 20℃;

: 35877-37-3
1-benzyl-5-(2,2-diethoxyethyl)-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1392411-81-2
5-(2,2-diethoxyethyl)-1-methyl-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile for 7h; Reflux;	94%

: 64-04-0
phenethylamine

: 621-62-5
chloroacetaldehyde diethyl acetal

: 94508-09-5
N-(2-phenylethyl)aminoacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide for 18h; Heating;	92%

: 954-92-7
3,4-dimethyl-pyrrole-2-carboxylic acid benzyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 156726-87-3
dibenzyl 5-(chloromethyl)-2,3,7,8-tetramethyldipyrromethane-1,9-dicarboxylate

Conditions

Conditions	Yield
With Montmorillonite K-10 clay; trifluoroacetic acid In dichloromethane	91%
With Montmorillonite K-10 clay; trifluoroacetic acid In dichloromethane	91%

: 50551-10-5
ethyl amidinoacetate

: 621-62-5
chloroacetaldehyde diethyl acetal

: 108290-86-4
2-amino-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: chloroacetaldehyde diethyl acetal With hydrogenchloride In water; toluene at 10℃; for 0.333333h; Stage #2: ethyl amidinoacetate In water; toluene at 80℃; for 3h;	91%

: 51-79-6
urethane

: 621-62-5
chloroacetaldehyde diethyl acetal

: 5336-13-0
1-chloro-2-di(ethoxycarbonylamino)ethane

Conditions

Conditions	Yield
With sulfuric acid at 75 - 80℃; for 5h;	90%
With hydrogenchloride

: 598-55-0
methyl carbamate

: 621-62-5
chloroacetaldehyde diethyl acetal

: 76934-25-3
1-chloro-2-di(methoxycarbonylamino)ethane

Conditions

Conditions	Yield
With sulfuric acid at 75 - 80℃; for 5h;	90%

: 93914-69-3
2-Methyl-2-(3-methyl-4-thiocarbamoyloxy-phenyl)-malonic acid diethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 2-[3-Methyl-4-(thiazol-2-yloxy)-phenyl]-propionic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid at 90 - 95℃; for 1.5h;	89%

: 289651-72-5
1-benzyl-5-(2,2-diethoxyethyl)-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1392411-82-3
5-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile for 7h; Reflux;	89%

: 2-Methyl-2-(2-methyl-4-thiocarbamoyloxy-phenyl)-malonic acid diethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 93914-44-4
2-[2-Methyl-4-(thiazol-2-yloxy)-phenyl]-propionic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid at 90 - 95℃; for 1.5h;	88%

: 93914-70-6
2-(3-Fluoro-4-thiocarbamoyloxy-phenyl)-2-methyl-malonic acid diethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 2-[3-Fluoro-4-(thiazol-2-yloxy)-phenyl]-propionic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid at 90 - 95℃; for 1.5h;	88%

: 2-(2-Fluoro-4-thiocarbamoyloxy-phenyl)-2-methyl-malonic acid diethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 93914-45-5
2-[2-Fluoro-4-(thiazol-2-yloxy)-phenyl]-propionic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid at 90 - 95℃; for 1.5h;	87%

: 1162648-73-8
ethyl 3-[2-formyl-N-(methoxymethyl)indol-3-yl]acrylate

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1162648-74-9
ethyl 3-[2-(3-ethoxy-1-hydroxyprop-2-yn-1-yl)-N-(methoxymethyl)indol-3-yl]acrylate

Conditions

Conditions	Yield
Stage #1: chloroacetaldehyde diethyl acetal With n-butyllithium; diethylamine In tetrahydrofuran; hexane for 1.66667h; Cooling with ice; Stage #2: ethyl 3-[2-formyl-N-(methoxymethyl)indol-3-yl]acrylate In tetrahydrofuran for 1.5h; Cooling with ice;	87%

: 21314-17-0
1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1060548-22-2
5-(2,2-diethoxyethyl)-1-phenyl-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile for 7h; Reflux;	87%

: 88975-84-2
2-Methyl-2-(4-thiocarbamoyloxy-phenyl)-malonic acid diethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 56355-16-9
ethyl 2-[4-(2-thiazolyloxy)-phenyl]propionate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid at 90 - 95℃; for 1.5h;	85.3%

: 126080-81-7
[4-phenyl-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

: 621-62-5
chloroacetaldehyde diethyl acetal

: 126080-87-3
{[2-(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-hydrazono}-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating;	85%

: 93914-68-2
2-(2-Chloro-4-thiocarbamoyloxy-phenyl)-2-methyl-malonic acid diethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 2-[2-Chloro-4-(thiazol-2-yloxy)-phenyl]-propionic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid at 90 - 95℃; for 1.5h;	85%

: 87121-29-7
(5,6-diphenyl-1,2,4-triazin-3-yl)oxyacetyl hydrazide

: 621-62-5
chloroacetaldehyde diethyl acetal

: {[2-(5,6-Diphenyl-[1,2,4]triazin-3-yloxy)-acetyl]-hydrazono}-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating;	85%

: 621-62-5
chloroacetaldehyde diethyl acetal

: 117204-61-2
ethanol ethyl acetate

Conditions

Conditions	Yield
	85%

: 1269103-70-9
N-(phenylsulfonyl)-2-styrylindole-3-carbaldehyde

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1269103-71-0
3-(3-ethoxy-1-hydroxyprop-2-yn-1-yl)-N-(phenylsulfonyl)-2-styrylindole

Conditions

Conditions	Yield
Stage #1: chloroacetaldehyde diethyl acetal With n-butyllithium; diethylamine In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #2: N-(phenylsulfonyl)-2-styrylindole-3-carbaldehyde In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	85%

: 103-85-5
monophenylthiourea

: 621-62-5
chloroacetaldehyde diethyl acetal

: 33142-18-6
2-phenylaminothiazole

Conditions

Conditions	Yield
With hydrogenchloride In water for 4h; Hantzsch cyclization; Reflux;	84%

: 111-24-0
1,5-dibromo-pentane

: 621-62-5
chloroacetaldehyde diethyl acetal

: 159756-65-7
7-bromo-1-ethoxyhept-1-yne

Conditions

Conditions	Yield
With n-butyllithium; diethylamine In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide 0 deg C, 2 h, RT, 12 h;	84%

: 87-42-3
6-chloropurine

: 621-62-5
chloroacetaldehyde diethyl acetal

: 6-chloro-9-(2-chloro-1-ethoxyethyl)-9H-purine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; acetic anhydride In acetonitrile at 20℃; for 0.25h; regioselective reaction;	82%

: 5334-56-5
1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1392411-80-1
1-benzyl-5-(2,2-diethoxyethyl)-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile for 7h; Reflux;	81%

Chloroacetaldehyde diethyl acetal Specification

The Ethane,2-chloro-1,1-diethoxy-, with CAS registry number 621-62-5, belongs to the following product category: Pharmaceutical Intermediates. It has the systematic name of Ethane, 2-chloro-1,1-diethoxy-. This chemical is a kind of clear colourless to slightly yellowish liquid. And this chemical can be prepared by the chlorination of Acetaldehyde diethylacetal. And the main use of this chemical is for organic intermediate.

Physical properties of Ethane,2-chloro-1,1-diethoxy-: (1)ACD/LogP: 1.67; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.67; (4)ACD/LogD (pH 7.4): 1.67; (5)#H bond acceptors: 2; (6)#H bond donors: 0; (7)#Freely Rotating Bonds: 5; (8)Polar Surface Area: 18.46 Å²; (9)Index of Refraction: 1.415; (10)Molar Refractivity: 38.14 cm³; (11)Molar Volume: 152 cm³; (12)Polarizability: 15.12×10^-24cm³; (13)Surface Tension: 26.8 dyne/cm; (14)Enthalpy of Vaporization: 37.79 kJ/mol; (15)Vapour Pressure: 3.57 mmHg at 25°C.

Uses of p-Chloropropiophenone: it can be used to produce ethoxyethyne. This reaction will need reagents Fe(NO₃)₃^.9H₂O, NH₃ liquid, Na. The reaction time is 30 min with reaction temperature of -80 ℃. The yield is about 65%.

When you are using this chemical, please be cautious about it as the following:
The Ethane,2-chloro-1,1-diethoxy- is flammable, so keep it away from sources of ignition. This chemical is harmful if swallowed. And it also irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.And you should keep its container tightly closed and in a well-ventilated place.

You can still convert the following datas into molecular structure:
(1)SMILES: ClCC(OCC)OCC
(2)InChI: InChI=1/C6H13ClO2/c1-3-8-6(5-7)9-4-2/h6H,3-5H2,1-2H3
(3)InChIKey: OVXJWSYBABKZMD-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C6H13ClO2/c1-3-8-6(5-7)9-4-2/h6H,3-5H2,1-2H3
(5)Std. InChIKey: OVXJWSYBABKZMD-UHFFFAOYSA-N

Product Name

Chloroacetaldehyde diethyl acetal

Synthetic route

Chloroacetaldehyde diethyl acetal Specification

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