Chlorpromazine supplier | CasNO.50-53-3

Name
Chlorpromazine
EINECS 200-045-8
CAS No. 50-53-3
Article Data36
CAS DataBase
Density 1.212g/cm³
Solubility Soluble
Hazard Symbols 6.1 (Packing Group: III) UN NO.
Synonyms Phenothiazine,2-chloro-10-[3-(dimethylamino)propyl]- (7CI,8CI);2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine; 2-Chloropromazine; 2601A;Aminazin; Aminazine; Ampliactil; Amplictil; BC 135; CPZ; Chlor-Promanyl;Chlordelazin; Chlorderazin; Chlorpromados; Chlorpromazine; Chlropromados;Contomin; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746;Largactilothiazine; Largactyl; Megaphen; NSC 167745; NSC 226514; Noiafren;Novomazina; Phenactyl; Proma; Promactil; Promazil; Propaphenin; Prozil; RP4560; SKF 2601A; Sanopron; Sedatil; Thorazin; Thorazine; Wintermin
PSA 31.78000
LogP 4.95940

Synthetic route

: 1219602-20-6
C11H16ClIN2

: 6320-02-1
2-bromothiophenol

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; L-proline In ethyl methyl ether at 90 - 110℃; Inert atmosphere;	78%

: 50-00-0
formaldehyd

: 2095-17-2
2-chloro-10-(3-aminopropyl)phenothiazine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With formic acid In water at 80℃; for 8h; Eschweiler-Clark Amine Methylation; Microwave irradiation;	66%

: 31928-44-6
2-bromo-4-chloroiodobenzene

: 6320-02-1
2-bromothiophenol

: 109-55-7
1-amino-3-(dimethylamino)propane

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate In toluene at 60 - 160℃; for 2.33333h; Microwave irradiation;	50%

...Expand

: 92-39-7
2-chlorophenothiazine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With sodium amide
(i) NaNH2, toluene, (ii) /BRN= 605294/; Multistep reaction;
With potassium hydroxide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate toluene 1.) room temp., 2 h, 2.) reflux, 18 h; Yield given. Multistep reaction;

: 3179-63-3
3-Dimethylamino-1-propanol

: 36798-98-8
2-chloro-phenothiazine-10-carbonyl chloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With toluene Erhitzen des Reaktionsprodukts unter vermindertem Druck auf 210-220grad;

: 4414-83-9
3-(2-chloro-10H-phenothiazin-10-yl)propanonitrile

A: 2095-17-2
2-chloro-10-(3-aminopropyl)phenothiazine

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With nickel; dimethyl amine; benzene at 110 - 116℃; under 58840.6 Torr; Hydrogenation;

: 109454-48-0
N'-[2-(2-bromo-phenylsulfanyl)-5-chloro-phenyl]-N,N-dimethyl-propanediyldiamine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With copper; potassium carbonate; N,N-dimethyl-formamide

: 969-99-3
chlorpromazine sulfoxide

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With iron; acetic acid; xylene

: 41951-57-9
1-(2-chloro-phenothiazin-10-yl)-3-methanesulfonyloxy-propane

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With dimethyl amine

: 103278-35-9
bis-[3-(2-chloro-phenothiazin-10-yl)-propyl]-methyl-amine

A: 63615-79-2
10-Allyl-2-chlorophenothiazine

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With sodium hydroxide; methyl iodide

: 2765-59-5
2-chloro-10-(3-chloropropyl)-10H-phenothiazine

: 124-40-3
dimethyl amine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
In ethanol

: 51-61-6
dopamine

: 50-53-3
chloropromazine cation radical

A: 50673-96-6
dopaminoquinone

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
In hydrogenchloride Rate constant; pH=1.5;

...Expand

: 92-39-7
2-chlorophenothiazine

: 109-54-6
3-(Dimethylamino)propyl chloride

A: 19607-03-5
2-chloro-10-methyl-10H-phenothiazine

B: 63615-79-2
10-Allyl-2-chlorophenothiazine

C: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With sodium hydroxide In chlorobenzene; toluene for 4.5h; Heating; Yield given. Yields of byproduct given;

...Expand

: 124-38-9
carbon dioxide

: 2-chloro-10-<3-N-trimethylsilyl, 3-N-methylaminopropyl> phenothiazine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride 1.) THF, -45 deg C - 60 deg C, 2.) 60 deg C, 10 min; Yield given. Multistep reaction;

: 138-65-8
Norepinephrine

: 50-53-3
chloropromazine cation radical

A: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

B: 14309-96-7
4-(2-Amino-1-hydroxy-ethyl)-[1,2]benzoquinone

Conditions

Conditions	Yield
In hydrogenchloride Rate constant; pH=7;

...Expand

: 329-65-7
Epinephrine

: 50-53-3
chloropromazine cation radical

A: 672-73-1, 162706-73-2
adrenaline o-quinone

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
In hydrogenchloride Rate constant; pH=7;

...Expand

: 58-15-1
aminopyrine

: chlorpromazine semiquinone cation radical

A: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

B: 58-15-1
aminopyrine radical cation

Conditions

Conditions	Yield
Rate constant; pH 6;

...Expand

: 76637-15-5
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-(2-methyl-acryloyloxymethyl)-ammonium; chloride

A: 50-00-0
formaldehyd

B: 79-41-4
poly(methacrylic acid)

C: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
In water at 21℃; pH=8.8, ionic strength 0.1 M KCl; other pH, other temp.; hydrolysis rate;

...Expand

: 76637-14-4
Benzoyloxymethyl-[3-(2-chloro-phenothiazin-10-yl)-propyl]-dimethyl-ammonium; chloride

A: 50-00-0
formaldehyd

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
In water at 21℃; pH=8.2, ionic strength 0.1 M KCl; other pH; hydrolysis rate;

...Expand

: 51-61-6
dopamine

: chlorpromazine semiquinone cation radical

A: 50673-96-6
dopaminoquinone

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
Kinetics; Rate constant; in constant ionic strength (0.8 M) mixtures of HClO4 and NaClO4 in 40percent MeO/H2O (w/w) with a pH between 0.1 and 1.5;

...Expand

: 50-53-3
chloropromazine cation radical

: 452-86-8
4-methyl-1,2-dihydroxybenzene

A: 3131-54-2
4-methylbenzo-1,2-quinone

B: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
In hydrogenchloride Rate constant; pH=7;

...Expand

benzyl-<3-(2-chloro-phenothiazin-10-yl)-propyl>-dimethyl-ammonium-methanesulfonate: benzyl-<3-(2-chloro-phenothiazin-10-yl)-propyl>-dimethyl-ammonium-methanesulfonate

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

: 92-39-7
2-chlorophenothiazine

methanesulfonic acid-<3-dimethylamino-propyl ester: methanesulfonic acid-<3-dimethylamino-propyl ester

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With n-butyllithium; diethyl ether

: 92-39-7
2-chlorophenothiazine

toluene-4-sulfonic acid-<3-dimethylamino-propyl ester>-hydrochloride: toluene-4-sulfonic acid-<3-dimethylamino-propyl ester>-hydrochloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
With xylene

: 3953-65-9
2-chloro-N-methyl-10H-phenothiazine-10-propanamine hydrochloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (NH4)2SO4 / 110 °C 2: 2.) LiAlH4 / 1.) THF, -45 deg C - 60 deg C, 2.) 60 deg C, 10 min View Scheme

: 69-09-0
chlorpromazine hydrochloride

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous H2O2; ethanol 2: iron-powder; acetic acid; xylene View Scheme
With potassium carbonate In water pH=10; Inert atmosphere;

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: tert-butyl (2-(2-((4-(chloromethyl)benzyl)oxy)ethoxy)ethyl)carbamate

: 3-(2-chloro-10H-phenothiazin-10-yl)-N-(4-(11,11-dimethyl-9-oxo-2,5,10-trioxa-8-azadodecyl)benzyl)-N,N-dimethylpropan-1-aminium chloride

Conditions

Conditions	Yield
In acetone at 40℃; for 48h; Inert atmosphere; Reflux;	97%

: 504-29-0
2-aminopyridine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 10-(3-(dimethylamino)propyl)-N-(pyridin-2-yl)-10H-phenothiazin-2-amine

Conditions

Conditions	Yield
With methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II); potassium hydroxide In water; toluene at 110℃; Flow reactor;	95%

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: chlorpromazine semiquinone cation radical

Conditions

Conditions	Yield
With GLUTATHIONE; isopropyl alcohol; acetone In water Rate constant; Product distribution; Irradiation; pH=3; pulse radiolysis; other thiol reagents and CPZ concentrations;	91%
With halothane peroxyl radical In various solvent(s) Rate constant; Ambient temperature; Irradiation; pH=7; pulse radiolysis; different CZ concentrations;	54 % Spectr.
With dihydrogen peroxide; horseradish peroxidase In acetate buffer pH=4.5; Kinetics; Further Variations:; Reagents; Oxidation;
With hydroxyl pH=7; Kinetics; aq. phosphate buffer;

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 3926-64-5
10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol

Conditions

Conditions	Yield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 14h; Schlenk technique; Inert atmosphere;	87%
With water for 120h; Irradiation;

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 969-99-3
chlorpromazine sulfoxide

Conditions

Conditions	Yield
In acetonitrile Electrolysis;	83%
With hydrogenchloride; sodium nitrite In water for 2h; Product distribution; oxidation of phenothiazine salts to their sulfoxides with aqueous nitrous acid; hydrogen peroxide oxidation;	74%
With hydrogenchloride; sodium nitrite In water for 2h;	74%

: 5335-05-7
chloromethyl benzoate

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 76637-14-4
Benzoyloxymethyl-[3-(2-chloro-phenothiazin-10-yl)-propyl]-dimethyl-ammonium; chloride

Conditions

Conditions	Yield
In acetone	81.5%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 2-chloro-N-(1-chloroethoxycarbonyl)-N-methyl-10H-phenothiazine-10-propanamine

Conditions

Conditions	Yield
In 1,2-dichloro-ethane for 1h; Substitution; Heating;	81%

: 27550-73-8
Chloromethyl methacrylate

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 76637-15-5
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-(2-methyl-acryloyloxymethyl)-ammonium; chloride

Conditions

Conditions	Yield
In acetone	79%

: 120-72-9
indole

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 3-(2-(1H-indol-3-yl)-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
With Cy-DHTP*HBF4; palladium diacetate; lithium tert-butoxide In toluene at 20 - 110℃; for 21h; Inert atmosphere; Sealed tube;	65%

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 21085-72-3
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

: 86492-49-1
chlorpromazine N+-glucuronide chloride

Conditions

Conditions	Yield
With XAD-2 ion-exchange resin; sodium hydrogencarbonate In water; benzene for 72h; Ambient temperature;	46%

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 21085-72-3
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

A: 86492-49-1
chlorpromazine N+-glucuronide chloride

B: 145823-11-6
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-((2R,3R,4S,5S,6S)-3,4,5-triacetoxy-6-methoxycarbonyl-tetrahydro-pyran-2-yl)-ammonium; bromide

C: 145823-13-8
Hydrogen carbonate[3-(2-chloro-phenothiazin-10-yl)-propyl]-dimethyl-((2R,3R,4S,5S,6S)-3,4,5-triacetoxy-6-carboxy-tetrahydro-pyran-2-yl)-ammonium;

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; benzene for 72h; Ambient temperature;	A 46% B n/a C n/a

...Expand

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

A: 1672-76-0
Chlorpromazine oxide

B: 969-99-3
chlorpromazine sulfoxide

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid; sodium hydroxide In dichloromethane at 0℃; for 4h;	A 40% B 10%

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

A: 2095-62-7
7-hydroxychlorpromazine

B: 3926-66-7
2-chloro-10-(3-dimethylamino-propyl)-10H-phenothiazin-1-ol

C: 3930-47-0
3-hydroxyl CPZ

D: 969-99-3
chlorpromazine sulfoxide

Conditions

Conditions	Yield
Stage #1: 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine With ethylenediaminetetraacetic acid trisodium salt; oxygen; manganese (II) acetate tetrahydrate; ascorbic acid In water pH=4; Udenfriend reaction; Stage #2: With ferrous(II) sulfate heptahydrate; ethylenediaminetetraacetic acid trisodium salt; oxygen In water at 45℃; for 2h; Udenfriend reaction;	A n/a B 0.4% C 0.84% D 0.58%

...Expand

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 10404-90-7
chlorpromazine N',S-dioxide

Conditions

Conditions	Yield
With ethanol; dihydrogen peroxide
With dihydrogen peroxide In ethanol
With dihydrogen peroxide In ethanol for 24h; Ambient temperature;
Multi-step reaction with 2 steps 1: aq. H2O2, NH3 / ethanol / 60 h 2: aq. H2O2 / ethanol / 84 h View Scheme
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid; sodium hydroxide / dichloromethane / 4 h / 0 °C 2: 3-chloro-benzenecarboperoxoic acid; sodium hydroxide / dichloromethane / 4 h / 0 °C View Scheme

: 1556-34-9
9-(bromomethyl)acridine

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 56265-45-3
acridin-9-ylmethyl-[3-(2-chloro-phenothiazin-10-yl)-propyl]-dimethyl-ammonium; bromide

Conditions

Conditions	Yield
In acetonitrile Ambient temperature;

: 14181-72-7, 17082-13-2, 17082-14-3
2-bromo-1-phenyl-ethanone oxime

: 50-53-3
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

: 19337-44-1
[3-(2-chloro-phenothiazin-10-yl)-propyl]-(2-hydroxyimino-2-phenyl-ethyl)-dimethyl-ammonium; bromide

Conditions

Conditions	Yield
In diethyl ether

Chlorpromazine Chemical Properties

MF: C₁₇H₁₉ClN₂S
MW: 318.86416
MS:
EINECS: 200-045-8
Product Categories:
Mol File: 50-53-3.mol
Surface Tension: 46.6 dyne/cm
Density: 1.212 g/cm3
Flash Point: 226 °C
Enthalpy of Vaporization: 70.89 kJ/mol
Boiling Point: 450.1 °C at 760 mmHg
Vapour Pressure: 2.72E-08 mmHg at 25°C

Chlorpromazine Uses

3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine(50-53-3) have good effect on have good effect on schizophrenia, severe depression and anxiety, hyperactive children, you can also use 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine(50-53-3) to relieve nausea, belching.

Chlorpromazine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	subcutaneous	> 10mg/kg (10mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
cat	LDLo	oral	100mg/kg (100mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
child	LDLo	oral	37500ug/kg (37.5mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: coma	New England Journal of Medicine. Vol. 256, Pg. 527, 1957.
dog	LD50	intravenous	30mg/kg (30mg/kg)	ungs, thorax, or respiration: emphysema blood: hemorrhage lungs, thorax, or respiration: acute pulmona	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
dog	LD50	subcutaneous	> 20mg/kg (20mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog	LDLo	oral	250mg/kg (250mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
guinea pig	LD50	intraperitoneal	87mg/kg (87mg/kg)		Medicina Experimentalis. Vol. 8, Pg. 237, 1963.
guinea pig	LDLo	oral	250mg/kg (250mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
human	TDLo	oral	8570ug/kg/12D (8.57mg/kg)	behavioral: wakefulness behavioral: muscle weakness behavioral: tremor	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972.
infant	TDLo	oral	20mg/kg (20mg/kg)	vascular: bp lowering not characterized in autonomic section behavioral: somnolence (general depressed activity)	American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976.
mammal (species unspecified)	LD50	oral	500mg/kg (500mg/kg)	behavioral: anticonvulsant behavioral: alteration of classical conditioning	Journal of Medicinal Chemistry. Vol. 8, Pg. 836, 1965.
man	TDLo	oral	8900ug/kg (8.9mg/kg)	lungs, thorax, or respiration: dyspnea	American Journal of Emergency Medicine. Vol. 14, Pg. 467, 1996.
man	TDLo	oral	217mg/kg/19D (217mg/kg)	blood: agranulocytosis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
monkey	LD50	subcutaneous	> 5mg/kg (5mg/kg)	blood: agranulocytosis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LC50	inhalation	209mg/m3/2H (209mg/m3)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968.
mouse	LD50	intraperitoneal	14mg/kg (14mg/kg)		Farmaco, Edizione Scientifica. Vol. 14, Pg. 269, 1959.
mouse	LD50	intravenous	16mg/kg (16mg/kg)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	oral	135mg/kg (135mg/kg)	lbehavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: other changes	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
mouse	LD50	subcutaneous	33mg/kg (33mg/kg)	behavioral: ataxia behavioral: regidity	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	unreported	82500ug/kg (82.5mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 2S, 1957.
mouse	LDLo	intramuscular	300mg/kg (300mg/kg)		Therapie. Vol. 15, Pg. 1064, 1960.
rabbit	LD50	intravenous	16mg/kg (16mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat	LC50	inhalation	209mg/m3/2H (209mg/m3)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968.
rat	LD50	intraperitoneal	137mg/kg (137mg/kg)		German Offenlegungsschrift Patent Document. Vol. #2350222,
rat	LD50	intravenous	23mg/kg (23mg/kg)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
rat	LD50	oral	142mg/kg (142mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
rat	LD50	subcutaneous	75mg/kg (75mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 377, 1960.
women	TDLo	oral	200ug/kg (0.2mg/kg)	behavioral: sleep liver: "jaundice, other or unclassified"	New York State Journal of Medicine. Vol. 57, Pg. 1922, 1957.
women	TDLo	oral	16800ug/kg/3W (16.8mg/kg)	blood: agranulocytosis	Postgraduate Medical Journal. Vol. 69, Pg. 885, 1993.
women	TDLo	oral	166mg/kg/18D- (166mg/kg)	blood: other hemolysis with or without anemia blood: other changes	Postgraduate Medical Journal. Vol. 53, Pg. 278, 1977.
women	TDLo	oral	240mg/kg/30D- (240mg/kg)	blood: agranulocytosis blood: changes in leucocyte (wbc) count blood: agranulocytosis	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
women	TDLo	oral	240mg/kg/30D (240mg/kg)	skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.

Chlorpromazine Specification

IUPAC: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine(50-53-3)
CAS: 50-53-3
Synonyms: 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-;2601-A;2-Chloro-10-[3-(dimethyamino)propyl]phenothiazine;2-Chloropromazine;2-Cloro-10 (3-dimetilaminopropil)fenotiazina;3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine;4560 R.P.;Aminasine

Product Name

Chlorpromazine

Synthetic route

Chlorpromazine Chemical Properties

Chlorpromazine Uses

Chlorpromazine Toxicity Data With Reference

Chlorpromazine Specification

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