Product Name

  • Name

    Clindamycin phosphate

  • EINECS 246-433-0
  • CAS No. 24729-96-2
  • Article Data6
  • CAS DataBase
  • Density 1.41 g/cm3
  • Solubility Soluble in water
  • Melting Point 114 °C
  • Formula C18H34ClN2O8PS
  • Boiling Point 159°C
  • Molecular Weight 504.969
  • Flash Point
  • Transport Information
  • Appearance White solid
  • Safety 36-26
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 24729-96-2 (Clindamycin phosphate)
  • Hazard Symbols IrritantXi,HarmfulXn
  • Synonyms U 28508;Dalacin-S;Cleocin phosphate;Dalacin T;Cleocin T (TN);L-threo-R-D-galacto-Octopyranoside,methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1- methyl-4-propyl-2-pyrrolidinyl]carbonyl]- amino]-1-thio-,2-(dihydrogen phosphate);Dalacin P;[6-[2-chloro-1-[(1-methyl-4-propyl-pyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-oxan-3-yl]oxyphosphonic acid;Cleocin T;Clindamycin 2-phosphate;
  • PSA 183.90000
  • LogP 0.83530

Synthetic route

C25H40ClN8O6PS

C25H40ClN8O6PS

clindamycin phosphate
24729-96-2

clindamycin phosphate

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water at 50 - 55℃; for 10h;96.15%
C21H36Cl3N2O7PS

C21H36Cl3N2O7PS

clindamycin phosphate
24729-96-2

clindamycin phosphate

Conditions
ConditionsYield
In water at 20℃; for 8h; Temperature; Acidic conditions; Green chemistry;92%
C35H50ClN2O8PS

C35H50ClN2O8PS

clindamycin phosphate
24729-96-2

clindamycin phosphate

Conditions
ConditionsYield
Stage #1: C35H50ClN2O8PS With palladium 10% on activated carbon; hydrogen In methanol at 20 - 30℃; under 2585.81 Torr; for 15h;
Stage #2: With hydrogenchloride at 60 - 70℃; for 24h; Time;		84.2%
clindamycin hydrochloride
21462-39-5

clindamycin hydrochloride

clindamycin phosphate
24729-96-2

clindamycin phosphate

lincomycin hydrochloride
859-18-7

lincomycin hydrochloride

clindamycin phosphate
24729-96-2

clindamycin phosphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: phosgene / chloroform; N,N-dimethyl-formamide / 2 h / 5 - 71 °C / Large scale
1.2: 10 °C / Alkaline conditions; Large scale
2.1: toluene-4-sulfonic acid / acetone / 6 h / 35 °C / Large scale
3.1: triethylamine; trichlorophosphate; 1H-imidazole / acetone / 4 h / 22 °C / Large scale
3.2: 30 °C / Large scale
View Scheme
C21H37ClN2O5S

C21H37ClN2O5S

clindamycin phosphate
24729-96-2

clindamycin phosphate

Conditions
ConditionsYield
Stage #1: C21H37ClN2O5S With 1H-imidazole; triethylamine; trichlorophosphate In acetone at 22℃; for 4h; Large scale;
Stage #2: With water In acetone at 30℃; Temperature; Reagent/catalyst; Large scale;

Clindamycin phosphate Chemical Properties

IUPAC Name: [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-Chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate
Synonyms of Clindamycin-2-phosphate (CAS NO.24729-96-2): 2-(Dihydrogenphosphate ; 7(S)-Chloro-7-deoxylincomycin2-phosphate ; Ceocinphosphate ; Dalacinp ; Clindamycin-2-dihydrogenphosphat ; Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside 2-(dihydrogen phosphate)
CAS NO: 24729-96-2
Molecular Formula:C18H34ClN2O8PS
Molecular Weight:505.02
Molecular Structure:
EINECS:246-433-0
H bond acceptors: 10
H bond donors: 5
Freely Rotating Bonds: 11
Polar Surface Area: 131.11 Å2
Index of Refraction: 1.577
Molar Refractivity: 117.96 cm3
Molar Volume: 355.9 cm3
Surface Tension: 63.5 dyne/cm
Density:1.41 g/cm3
Melting Point:114 °C
Solubility: Soluble in water
Storage temp: 2-8°C
Appearance: White solid
Stability: Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
Product Categories of Clindamycin-2-phosphate (CAS NO.24729-96-2): Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);API's

Clindamycin phosphate Uses

 Clindamycin-2-phosphate (CAS NO.24729-96-2) is used as pharmaceutical intermediate.

Clindamycin phosphate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1100mg/kg (1100mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 intraperitoneal 784mg/kg (784mg/kg)   Drugs under Experimental and Clinical Research. Vol. 3, Pg. 79, 1977.
mouse LD50 intravenous 820mg/kg (820mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 oral 2539mg/kg (2539mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 subcutaneous 1036mg/kg (1036mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 intramuscular > 3500mg/kg (3500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 691, 1983.
rat LD50 intraperitoneal 745mg/kg (745mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 intravenous 321mg/kg (321mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 oral 1832mg/kg (1832mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toxicology and Applied Pharmacology. Vol. 27, Pg. 308, 1974.
rat LD50 subcutaneous 3861mg/kg (3861mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
women TDLo intravenous 12mg/kg (12mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Southern Medical Journal. Vol. 75, Pg. 768, 1982.

Clindamycin phosphate Safety Profile

Safety Information of Clindamycin-2-phosphate (CAS NO.24729-96-2): 
Hazard Codes: HarmfulXn,Xi
Risk Statements: 22-36/37/38
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 36-26 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: GF2625000
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human systemic effects by intravenous route: pulse rate increase, blood pressure lowering. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl−, POx, SOx, and NOx.

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