Cortisone acetate supplier

Name
Cortisone acetate
EINECS 200-006-5
CAS No. 50-04-4
Article Data50
CAS DataBase
Density 1.28 g/cm³
Solubility 19mg/L(25 oC)
Melting Point 237-240 °C(lit.)
Formula C₂₃H₃₀O₆
Boiling Point 567.8 °C at 760 mmHg
Molecular Weight 402.488
Flash Point 311.2 °C
Transport Information
Appearance solid
Safety 22-36/37
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Cortisone-21-acetate;21-Acetoxypregnen-17a-ol-3,11,20-trione;
PSA 97.74000
LogP 2.56060

Synthetic route

: 7753-60-8
anecortave

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Stage #1: anecortave With tetrafluoroboric acid In dichloromethane; acetone at -5 - 0℃; for 5h; Inert atmosphere; Stage #2: With Jones reagent In dichloromethane; acetone at 0 - 5℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	95.8%

: Acetic acid 2-hydroxy-2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl ester

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 50℃; for 3h;	93%

: hydrocortisone acetate

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With [2,2]bipyridinyl; trimethylsilyl trifluoromethanesulfonate; bis(acetoxy)iodylbenzene In dichloromethane at 20℃; for 0.5h;	93%

: 50733-54-5
21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With di-tert-butyl peroxide In tetrahydrofuran Inert atmosphere; Reflux;	90%

: C23H29BrO6

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With acetic acid; zinc In dichloromethane at 10℃; for 3h; Temperature;	79.5%

: 50-03-3
hydrocortisone acetate

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid
With pyridine; magnesium sulfate; pyridinium chlorochromate at 0 - 25℃; for 12h;
With chromium(VI) oxide; acetic acid; manganese(ll) chloride In chloroform; water at 30℃; Solvent; Reagent/catalyst; Temperature;	19.2 g

: 1499-59-8
21-acetoxy-17-hydroxy-5β-pregnane-3,11,20-trione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With bromine durch aufeinanderfolgende Umsetzung mit Semicarbazid und mit Brenztraubensaeure;

: 988-16-9
21-acetoxy-3,3-ethanediyldioxy-17-hydroxy-pregn-5-ene-11,20-dione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid

: 50-03-3
hydrocortisone acetate

A: 382-44-5
(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione

B: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Product distribution; Rate constant; Irradiation; radiolytic degradation;

21-acetoxy-11α,17-dihydroxy-pregn-4-ene-3,20-dione: 21-acetoxy-11α,17-dihydroxy-pregn-4-ene-3,20-dione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With chromium(VI) oxide

21-acetoxy-pregna-4,17(2O)c-diene-3,11-dione: 21-acetoxy-pregna-4,17(2O)c-diene-3,11-dione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With osmium(VIII) oxide; triethylamine N-oxide; dihydrogen peroxide

: 50-03-3
hydrocortisone acetate

: 64-19-7
acetic acid

CrO3: CrO3

: 50-04-4
Cortisone acetate

...Expand

: 111615-16-8
21-acetoxy-17,20βF-dihydroxy-pregn-4-ene-3,11-dione

: 64-19-7
acetic acid

CrO3: CrO3

A: 50-04-4
Cortisone acetate

B: 382-45-6
adrenosterone

...Expand

: 50-23-7
HYDROCORTISONE

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine 2: CrO3; acetic acid View Scheme

: 3684-83-1, 19427-36-2, 95975-59-0
11α-hydroxy-16α,17α-epoxyprogesterone

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: hydrogen bromide / 5 h / 5 - 10 °C 2: hydrogen; acetic acid / ethanol / 3 h / 40 - 45 °C 3: bromine; hydrogenchloride / ethanol; chloroform / 1 h / 20 - 25 °C 4: N,N-dimethyl-formamide / 0.5 h / 35 - 40 °C 5: manganese(ll) chloride; acetic anhydride; acetic acid / water / 4 h / 5 - 10 °C View Scheme

: 11α,17α-dihydroxy-16β-bromo progesterone

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogen; acetic acid / ethanol / 3 h / 40 - 45 °C 2: bromine; hydrogenchloride / ethanol; chloroform / 1 h / 20 - 25 °C 3: N,N-dimethyl-formamide / 0.5 h / 35 - 40 °C 4: manganese(ll) chloride; acetic anhydride; acetic acid / water / 4 h / 5 - 10 °C View Scheme

: 603-98-5
11α,17α-dihydroxypregn-4-ene-3,20-dione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: bromine; hydrogenchloride / ethanol; chloroform / 1 h / 20 - 25 °C 2: N,N-dimethyl-formamide / 0.5 h / 35 - 40 °C 3: manganese(ll) chloride; acetic anhydride; acetic acid / water / 4 h / 5 - 10 °C View Scheme

: 1250-97-1
11α,17α-dihydroxyprogesterone-21-acetate

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With acetic anhydride; acetic acid; manganese(ll) chloride In water at 5 - 10℃; for 4h;	29.1 g

: 2206-03-3
21-acetoxy-9-bromo-17-hydroxy-pregn-4-ene-3,11,20-trione

: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
With acetic acid; zinc In chloroform at 10 - 15℃; for 10h; Solvent; Inert atmosphere;	32.6 g

: 1249-67-8
17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate

A: 640-87-9
cortexolone 21-acetate

B: 50-04-4
Cortisone acetate

Conditions

Conditions	Yield
Stage #1: 17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate With potassium carbonate; sodium hydroxide In methanol; chloroform at -5 - 5℃; for 0.333333h; Inert atmosphere; Stage #2: With acetic acid In methanol; chloroform Inert atmosphere; Stage #3: With methanol; acetic anhydride; triethylamine In dichloromethane Reagent/catalyst; Solvent; Temperature;

: 50-04-4
Cortisone acetate

: 382-45-6
adrenosterone

Conditions

Conditions	Yield
Stage #1: Cortisone acetate With sodium tetrahydroborate In ethanol; dichloromethane for 1.5h; Inert atmosphere; Stage #2: With sodium periodate In water; acetone at 20℃; for 0.75h; Inert atmosphere;	86%
Product distribution; Rate constant; Irradiation; radiolytic degradation;

: 50-04-4
Cortisone acetate

: 21-acetoxy-17α-hydroxypregna-3,5-diene-11,20-dione

Conditions

Conditions	Yield
Stage #1: Cortisone acetate With C19H26ClIrN3O(1+)*Cl(1-) In water; acetonitrile at 80℃; for 0.166667h; Green chemistry; Stage #2: With formic acid In water; acetonitrile at 80℃; for 8h; Green chemistry; regioselective reaction;	81%

: 50-04-4
Cortisone acetate

: 149-73-5
trimethyl orthoformate

: (2R,3aR,3bS,5aS,6R,8aS,8bS)-6-(2-Acetoxy-acetyl)-6-hydroxy-3a,5a-dimethyl-4-oxo-2,3,3a,3b,4,5,5a,6,7,8,8a,8b,9,10-tetradecahydro-dicyclopenta[a,f]naphthalene-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With thallium(III) nitrate In methanol at 0℃; for 0.5h;	66%

: 50-04-4
Cortisone acetate

: 53-06-5
Cortisone

Conditions

Conditions	Yield
With lipase from Candida cylindracea; octanol In water; acetonitrile at 37℃; for 144h;	62%
With potassium hydrogencarbonate
With potassium hydroxide
With sodium methylate

: 50-00-0
formaldehyd

: 50-04-4
Cortisone acetate

: 3607-68-9
17α,20;20,21-bismethylenedioxypregn-4-ene-3,11-dione

Conditions

Conditions	Yield
With hydrogenchloride In chloroform; water at 23℃; for 12h; Inert atmosphere;	61%

: 50-04-4
Cortisone acetate

: 2435-02-1
17α,21-dihydroxy-pregna-4,6-diene-3,11,20-trione 21-acetate

Conditions

Conditions	Yield
With chloranil In tert-butyl alcohol for 7h; Heating;	60%
With chloranil; xylene
Multi-step reaction with 3 steps 1: N-bromo-succinimide 2: salicylic acid 3: 4-hydroxy-benzaldehyde View Scheme

: 186581-53-3, 908094-01-9
diazomethane

: 50-04-4
Cortisone acetate

: 115388-24-4
20,21-epoxy-17,22-dihydroxy-23,24-dinor-20ξH-chol-4-ene-3,11-dione

Conditions

Conditions	Yield
With methanol; diethyl ether

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 50-04-4
Cortisone acetate

: 988-16-9
21-acetoxy-3,3-ethanediyldioxy-17-hydroxy-pregn-5-ene-11,20-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid

: 67-62-9
O-Methylhydroxylamin

: 50-04-4
Cortisone acetate

: 125496-85-7
21-acetoxy-17-hydroxy-pregn-4-ene-3,11,20-trione-3,20-bis-(O-methyl oxime )

: 4362-28-1
2-methallyl-2-methyl-[1,3]dioxolane

: 50-04-4
Cortisone acetate

: 988-16-9
21-acetoxy-3,3-ethanediyldioxy-17-hydroxy-pregn-5-ene-11,20-dione

Conditions

Conditions	Yield
With tetrahydrofuran; sulfuric acid

: 50-04-4
Cortisone acetate

: 125-10-0
prednisone acetate

Conditions

Conditions	Yield
With selenium(IV) oxide
With periodic acid
With iodine pentoxide
With Arthrobacter simplex By-2-13	17 g

: 50-04-4
Cortisone acetate

: 28444-83-9
21-acetoxy-4-chloro-17-hydroxy-pregn-4-ene-3,11,20-trione

Conditions

Conditions	Yield
With hypochloric acid
Multi-step reaction with 2 steps 1: diethyl ether; propionic acid; chlorine 2: pyridine View Scheme
Multi-step reaction with 2 steps 1: aqueous perchloric acid / Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton und danach mit Acetanhydrid und Pyridin 2: HCl View Scheme

: 50-04-4
Cortisone acetate

: 68599-17-7
21,21-dimethoxy-pregn-4-ene-3,11,20-trione

Conditions

Conditions	Yield
With hydrogenchloride

: 50-04-4
Cortisone acetate

A: 17-acetoxy-D-homo-androsta-4,16-diene-3,11,17a-trione

B: 102084-08-2
17β-acetoxymethyl-17α-hydroxy-D-homo-androst-4-ene-3,11,17a-trione

Conditions

Conditions	Yield
With cyclohexanone; aluminum isopropoxide; toluene beim anschliessender Acetylierung;

: 50-04-4
Cortisone acetate

: 102084-08-2
17β-acetoxymethyl-17α-hydroxy-D-homo-androst-4-ene-3,11,17a-trione

Conditions

Conditions	Yield
With cyclohexanone; aluminum isopropoxide; toluene
With cyclohexanone; aluminum isopropoxide In toluene

: 50-04-4
Cortisone acetate

: 426833-73-0
21-acetoxy-6ξ-bromo-17-hydroxy-pregn-4-ene-3,11,20-trione

Conditions

Conditions	Yield
With N-Bromosuccinimide

: 50-04-4
Cortisone acetate

: 113862-15-0
21-acetoxy-4β,5-dichloro-17-hydroxy-5α-pregnane-3,11,20-trione

Conditions

Conditions	Yield
With diethyl ether; chlorine; propionic acid

: 50-04-4
Cortisone acetate

: 100437-38-5
21-acetoxy-17-hydroxy-pregn-4-ene-3,11,20-trione-3-oxime

Conditions

Conditions	Yield
With hydrogenchloride; hydroxylamine

: 50-04-4
Cortisone acetate

: 124113-30-0
21-acetoxy-17-hydroxy-pregn-4-ene-3,11,20-trione-3,20-dioxime

Conditions

Conditions	Yield
With hydrogenchloride; hydroxylamine

: 50-04-4
Cortisone acetate

: 111615-16-8
21-acetoxy-17,20βF-dihydroxy-pregn-4-ene-3,11-dione

Conditions

Conditions	Yield
With sodium tetrahydroborate

: 50-04-4
Cortisone acetate

A: 114178-95-9
21-acetoxy-17-hydroxy-5α-pregn-3-ene-11,20-dione

B: 114178-96-0
21-acetoxy-17-hydroxy-5β-pregn-3-ene-11,20-dione

Conditions

Conditions	Yield
With acetic acid; zinc

: 50-04-4
Cortisone acetate

: 3751-02-8
21-acetoxy-17-hydroxy-5α-pregnane-3,11,20-trione

Conditions

Conditions	Yield
With palladium Hydrogenation;

: 50-04-4
Cortisone acetate

A: 17597-29-4
4α,5α-epoxyandrostene-3,11,17-trione

B: 102454-93-3
4ξ,5-epoxy-17α-hydroxy-3,11-dioxo-5ξ-androstane-17β-carboxylic acid

Conditions

Conditions	Yield
With methanol; sodium hydroxide; dihydrogen peroxide

: 50-04-4
Cortisone acetate

: 988-16-9
21-acetoxy-3,3-ethanediyldioxy-17-hydroxy-pregn-5-ene-11,20-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; ethylene glycol; benzene
With toluene-4-sulfonic acid; ethylene glycol unter vermindertem Druck;

Cortisone acetate Specification

The Cortisone acetate is an organic compound with the formula C₂₃H₃₀O₆. The systematic name of this chemical is 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate. With the CAS registry number 50-04-4, it is also named as 2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate. The product's categories are Biochemistry; Hydroxyketosteroids; Steroids. Besides, it should be stored in a closed and dark place. It has been used for prednisone acetate intermediate. As anti-inflammatory agent, it can be used for the treatment of adrenal cortical function with low disease, rheumatoid arthritis, rheumatism, lupus and other diseases.

Physical properties about Cortisone acetate are: (1)ACD/LogP: 2.53; (2)ACD/LogD (pH 5.5): 2.53; (3)ACD/LogD (pH 7.4): 2.53; (4)ACD/BCF (pH 5.5): 48.95; (5)ACD/BCF (pH 7.4): 48.95; (6)ACD/KOC (pH 5.5): 563.79; (7)ACD/KOC (pH 7.4): 563.78; (8)#H bond acceptors: 6; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 5; (11)Polar Surface Area: 86.74 Å²; (12)Index of Refraction: 1.565; (13)Molar Refractivity: 103.75 cm³; (14)Molar Volume: 318.1 cm³; (15)Polarizability: 41.13×10^-24cm³; (16)Surface Tension: 52.8 dyne/cm; (17)Density: 1.26 g/cm³; (18)Flash Point: 197.3 °C; (19)Enthalpy of Vaporization: 99.24 kJ/mol; (20)Boiling Point: 577.3 °C at 760 mmHg; (21)Vapour Pressure: 9.94E-16 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
When you are using it, wear suitable protective clothing and gloves and do not breathe dust.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCC(=O)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)CC[C@]1(C)[C@H]4C(=O)C[C@@]23C)C
(2)InChI: InChI=1/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
(3)InChIKey: ITRJWOMZKQRYTA-RFZYENFJBQ
(4)Std. InChI: InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
(5)Std. InChIKey: ITRJWOMZKQRYTA-RFZYENFJSA-N

Product Name

Cortisone acetate

Synthetic route

Cortisone acetate Specification

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