Product Name

  • Name

    1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate

  • EINECS 230-011-8
  • CAS No. 6903-79-3
  • Article Data7
  • CAS DataBase
  • Density 1.65 g/cm3
  • Solubility
  • Melting Point 244 °C(dec.)
  • Formula C4H12N3O4P
  • Boiling Point 384.1 °C at 760 mmHg
  • Molecular Weight 197.131
  • Flash Point 186.1 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 6903-79-3 (1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate)
  • Hazard Symbols
  • Synonyms Guanidine,1-(2-hydroxyethyl)-1-methyl-, dihydrogen phosphate (7CI);Guanidine,1-(2-hydroxyethyl)-1-methyl-, dihydrogen phosphate (ester) (8CI);2-(1-Methylguanidino)ethyl phosphate;Aplodan;Creatinol O-phosphate;Creatinolphosphate;Creatinolfosfate;N-Methyl-N-(b-hydroxyethyl)guanidine O-phosphate;O-Phosphate ofN-methyl-N-(b-hydroxyethyl)guanidine;
  • PSA 129.68000
  • LogP -0.27900

Synthetic route

C8H22N6O7P2

C8H22N6O7P2

Aplodan
6903-79-3

Aplodan

Conditions
ConditionsYield
With water at 90℃; for 5h;

Creatinol phosphate Chemical Properties


IUPAC Name: 2-[Carbamimidoyl(methyl)amino]ethyl dihydrogen phosphate
Molecular Weight: 197.129541 [g/mol]
Molecular Formula: C4H12N3O4P
XLogP3-AA: -2.5
H-Bond Donor: 4
H-Bond Acceptor: 7 
EINECS: 230-011-8 
Index of Refraction: 1.574
Molar Refractivity: 39.37 cm3
Molar Volume: 119.1 cm3
Surface Tension: 81.5 dyne/cm
Density: 1.65 g/cm3
Flash Point: 186.1 °C
Enthalpy of Vaporization: 69.46 kJ/mol
Boiling Point: 384.1 °C at 760 mmHg
Vapour Pressure: 5.78E-07 mmHg at 25 °C
Classification Code of Guanidine,N-methyl-N-[2-(phosphonooxy)ethyl]- (CAS NO.6903-79-3): Drug / Therapeutic Agent

Creatinol phosphate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 3200mg/kg (3200mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
guinea pig LD50 intravenous 1500mg/kg (1500mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
guinea pig LD50 oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
mouse LD50 intraperitoneal 3gm/kg (3000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
mouse LD50 intravenous 1200mg/kg (1200mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
rat LD50 intraperitoneal 4800mg/kg (4800mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
rat LD50 intravenous 1300mg/kg (1300mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.
rat LD50 oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1449, 1979.

Creatinol phosphate Specification

 Guanidine,N-methyl-N-[2-(phosphonooxy)ethyl]- (CAS NO.6903-79-3), its Synonyms are Creatinol phosphate ; Creatinolfosfate ; 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate (ester) ; 2-(1-Methylguanidino)ethyl dihydrogenphosphat ; Aplodan ; Creatinol O-phosphate ; Creatinolfosfatum ; Gipron ; N-Methyl-N-(2-(phosphonooxy)ethyl)guanidine ; N-Methyl-N-(beta-hydroxyaethyl)guanidine-O-phosphat ; N-Methyl-N-(beta-hydroxyethyl)guanidine O-phosphate ; Nergize .

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