Product Name

  • Name

    Crotamiton

  • EINECS 207-596-3
  • CAS No. 483-63-6
  • Density 1.014 g/cm3
  • Solubility Soluble in water (1:500), alcohol, methanol, ether, and ethanol.
  • Melting Point 25°C
  • Formula C13H17NO
  • Boiling Point 282.7 °C at 760 mmHg
  • Molecular Weight 203.284
  • Flash Point 115.5 °C
  • Transport Information
  • Appearance
  • Safety 26-36
  • Risk Codes 22-36/38-43
  • Molecular Structure Molecular Structure of 483-63-6 (Crotamiton)
  • Hazard Symbols HarmfulXn
  • Synonyms o-Crotonotoluidide,N-ethyl- (6CI,7CI,8CI);Crotalgin;Crotamitex;Crotamitone;Crotonyl N-ethyl-o-toluidine;Eurax;Euraxil;N-Crotonyl-N-ethyl-o-toluidine;N-Ethyl-o-crotonotoluidide;Veteusan;
  • PSA 20.31000
  • LogP 2.92400

Synthetic route

N-ethyl-N-(2-methylphenyl)but-2-enamide
483-63-6

N-ethyl-N-(2-methylphenyl)but-2-enamide

N-ethyl-N-(2-methylphenyl)butanamide

N-ethyl-N-(2-methylphenyl)butanamide

Conditions
ConditionsYield
With O,N-bis-(trifluoroacetyl)-hydroxylamine; hydroxylamine In 1,4-dioxane; water at 140℃; for 0.333333h;

Crotamiton Chemical Properties

The molecular formula of Crotamiton(483-63-6) is C13H17NO and its formula weight is 203.28.
The density of Crotamiton(483-63-6) is 0.987 g/mL at 25 °C(lit.) and it has a boiling point of  153-155 °C13 mm Hg(lit.). The refractive index is about  1.54(lit.). Its flash point is  115.5 °C .
The chemical synonyms of Crotamiton(483-63-6) are (2E)-N-Ethyl-N-(2-methylphenyl)-2-butenamide;2-Butenamide, N-ethyl-N-(2-methylphenyl)-;component of Eurax;Crotalgin;Crotamitex;Crotamitone;Eurasil;Eurax
The molecular structure of Crotamiton(483-63-6):

Crotamiton Toxicity Data With Reference

1.   

orl-rat LD50:1500 mg/kg

   29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,35.
2.   

orl-mus LD50:1600 mg/kg

   29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,35.

Crotamiton Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes  Xn
Risk Statements  22-36/38-43
Safety Statements  26-36
WGK Germany  3
RTECS  GQ7000000

Crotamiton Specification

Incompatibilities
Oxidizing agents.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.
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