Synthetic route
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483-63-6
N-ethyl-N-(2-methylphenyl)but-2-enamide
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N-ethyl-N-(2-methylphenyl)butanamide
Conditions
Conditions | Yield |
With O,N-bis-(trifluoroacetyl)-hydroxylamine; hydroxylamine In 1,4-dioxane; water at 140℃; for 0.333333h; | |
Crotamiton Chemical Properties
The molecular formula of Crotamiton(483-63-6) is C
13H
17NO and its formula weight is 203.28.
The density of Crotamiton(483-63-6) is 0.987 g/mL at 25 °C(lit.) and it has a boiling point of 153-155 °C13 mm Hg(lit.). The refractive index is about 1.54(lit.). Its flash point is 115.5 °C .
The chemical synonyms of Crotamiton(483-63-6) are (2E)-N-Ethyl-N-(2-methylphenyl)-2-butenamide;2-Butenamide, N-ethyl-N-(2-methylphenyl)-;component of Eurax;Crotalgin;Crotamitex;Crotamitone;Eurasil;Eurax
The molecular structure of Crotamiton(483-63-6):
Crotamiton Toxicity Data With Reference
1. | | orl-rat LD50:1500 mg/kg | | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,35. |
2. | | orl-mus LD50:1600 mg/kg | | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,35. |
Crotamiton Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes Xn
Risk Statements 22-36/38-43
Safety Statements 26-36
WGK Germany 3
RTECS GQ7000000
Crotamiton Specification
Incompatibilities
Oxidizing agents.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.