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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Methoxyindole

Cas:4837-90-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

4-Methoxyindole Basic information Product Name: 4-Methoxyindole Synonyms: Indole, 4-methoxy-;1H-INDOL-4-YL METHYL ETHER;4-METHOXY-1H-INDOLE;4-METHOXYLINDOLE;4-METHOXYINDOLE;AKOS JY208261

4-Methoxyindole ,98%

Cas:4837-90-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 4837-90-5 with fast shipping

Cas:4837-90-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

4-Methoxyindole CAS4837-90-5

Cas:4837-90-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla

4-Methoxyindole CAS 4837-90-5

Cas:4837-90-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Methoxyindole 4837-90-5

Cas:4837-90-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Methoxyindole

Cas:4837-90-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

4-Methoxy-1H-indole

Cas:4837-90-5

Min.Order:1 Gram

FOB Price: $483.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Methoxyindole

Cas:4837-90-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Methoxyindole

Cas:4837-90-5

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:light brown to grey crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Appli

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

4-Methoxyindole

Cas:4837-90-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Methoxyindole CAS No.:4837-90-5 Molecule Formula:C9H9NO Molecule Weight:147.17 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPEC

Best Quality 4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

4-Methoxyindole Chemical Properties Melting point 69-70 °C (lit.) Boiling point 181-183 °C/24 mmHg (lit.) density 1.1135 (rough estimate) refractive index 1.5310 (estimate) Fp 181-183°C/24mm storage temp. Keep Cold

4-Methoxyindole

Cas:4837-90-5

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

4-Methoxyindole

Cas:4837-90-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

4-Methoxyindole

Cas:4837-90-5

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

4-Methoxyindole

Cas:4837-90-5

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Methoxyindole

Cas:4837-90-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Methoxyindole

Cas:4837-90-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Synthetic route

4-methoxy-1H-indole-2-carboxylic acid
103260-65-7

4-methoxy-1H-indole-2-carboxylic acid

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
In quinoline for 0.2h; microwave;97%
With quinoline; copper for 2h; Heating;94%
copper In quinoline for 2h; Heating / reflux;94%
With quinoline; copper oxide-chromium oxide at 200 - 210℃;
(6-methoxy-2-nitrophenyl)acetonitrile
20876-27-1

(6-methoxy-2-nitrophenyl)acetonitrile

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With hydrogen; acetic acid; 10% palladium on active carbon In ethanol under 2280 Torr; for 2h; Ambient temperature;96%
With palladium 10% on activated carbon; hydrogen; acetic acid at 20℃; for 12h;
4-methoxy-1-<(4-methylphenyl)sulfonyl>indole
112970-67-9

4-methoxy-1-<(4-methylphenyl)sulfonyl>indole

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With sodium hydroxide In methanol for 12h; Heating;96%
With sodium hydride In N,N-dimethyl acetamide at 60℃; for 3h; Inert atmosphere;74%
1H-indol-4-ol
2380-94-1

1H-indol-4-ol

methyl iodide
74-88-4

methyl iodide

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With potassium carbonate In methanol; butanone for 6h; Heating;95%
Stage #1: 1H-indol-4-ol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 1h;
92%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;91%
2-ethenyl-3-methoxynitrobenzene

2-ethenyl-3-methoxynitrobenzene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With carbon monoxide; triphenylphosphine; palladium diacetate In acetonitrile under 3040 Torr; for 20h; Heating;89%
acetaldehyde 3-methoxyphenylhydrazone
34158-98-0

acetaldehyde 3-methoxyphenylhydrazone

A

6-methoxylindole
3189-13-7

6-methoxylindole

B

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
GIPKh-115 In benzene at 260 - 280℃; (g) phase;A n/a
B 85%
GIPKh-115 In benzene at 180 - 320℃; (g) phase. Object of study: effect of electronic factors;A n/a
B 85%
GIPKh-115 at 260 - 280℃; Yield given. Yields of byproduct given;
2-methoxy-6-nitrophenylacetaldehyde semicarbazone

2-methoxy-6-nitrophenylacetaldehyde semicarbazone

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 3102.9 Torr; for 6h;82%
2,3-dihydro-4-methoxy-1H-indole
7555-94-4

2,3-dihydro-4-methoxy-1H-indole

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With C55H49N4OP2Ru In o-xylene at 140℃; under 750.075 Torr; for 48h; Inert atmosphere; Schlenk technique; Green chemistry;82%
With potassium tert-butylate In o-xylene at 140℃; for 36h; Inert atmosphere;55%
3-methoxy-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene
96631-91-3

3-methoxy-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In tetrahydrofuran for 1h;70%
With hydrogen; palladium on activated charcoal In methanol; dichloromethane at 20℃;63%
(3-Methoxy-2-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester

(3-Methoxy-2-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 5h; Heating;70%
[(E)-2-(2-Methoxy-6-nitro-phenyl)-vinyl]-dimethyl-amine

[(E)-2-(2-Methoxy-6-nitro-phenyl)-vinyl]-dimethyl-amine

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With titanium(III) chloride; ammonium acetate buffer for 0.166667h;61%
N-(3-methoxyphenyl)ethenesulfinamide
105896-37-5

N-(3-methoxyphenyl)ethenesulfinamide

A

6-methoxylindole
3189-13-7

6-methoxylindole

B

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
In toluene at 110℃; for 1h;A 25%
B 5%
tris(piperidino)-methane
22630-08-6

tris(piperidino)-methane

6-methoxy-2-nitrotoluene
4837-88-1

6-methoxy-2-nitrotoluene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With iron; silica gel 1) 120 deg C, 4 h, under vacuum 2) 1 h reflux in toluene-acetic acid; Yield given. Multistep reaction;
(2-Methoxy-6-nitro-phenyl)-acetaldehyde
85355-48-2

(2-Methoxy-6-nitro-phenyl)-acetaldehyde

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With sodium acetate; iron; acetic acid In ethanol; water for 2h; Heating; Yield given;
1-[(E)-2-(2-Methoxy-6-nitro-phenyl)-vinyl]-piperidine
117609-03-7

1-[(E)-2-(2-Methoxy-6-nitro-phenyl)-vinyl]-piperidine

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With titanium(III) chloride; ammonium acetate In acetone Yield given;
Acetic acid 1-chloro-2-(2-methoxy-6-nitro-phenyl)-ethyl ester
85355-37-9

Acetic acid 1-chloro-2-(2-methoxy-6-nitro-phenyl)-ethyl ester

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With sodium acetate; iron; acetic acid In ethanol; water for 2h; Heating;
N-(2,2-Diethoxy-ethyl)-2,2,2-trifluoro-N-(3-methoxy-phenyl)-acetamide
75934-38-2

N-(2,2-Diethoxy-ethyl)-2,2,2-trifluoro-N-(3-methoxy-phenyl)-acetamide

A

6-methoxylindole
3189-13-7

6-methoxylindole

B

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With potassium hydroxide; trifluoroacetic anhydride 1) CF3COOH, 56 deg C, 56 h; 2) methanol, room temperature; Yield given. Multistep reaction. Yields of byproduct given;
6-methoxy-2-nitrotoluene
4837-88-1

6-methoxy-2-nitrotoluene

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With pyrrolidine; hydrazine hydrate; nickel 1.) DMF, 125 deg C, 3 h; 2.) methanol, 50-60 deg C, 3 h; Yield given. Multistep reaction;
triethanolamine
102-71-6

triethanolamine

m-Anisidine
536-90-3

m-Anisidine

A

6-methoxylindole
3189-13-7

6-methoxylindole

B

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
With tin(ll) chloride; ruthenium trichloride; triphenylphosphine In 1,4-dioxane at 180℃; for 20h; Yield given. Yields of byproduct given;
4-methoxy-indole-carboxylic acid-(2)

4-methoxy-indole-carboxylic acid-(2)

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
at 245 - 250℃;
methyl 4-methoxy-1H-indole-2-carboxylate
111258-23-2

methyl 4-methoxy-1H-indole-2-carboxylate

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / aq. NaOH / 0.5 h / Heating
2: 94 percent / Cu; quinoline / 2 h / Heating
View Scheme
(Z)-2-azido-3-(2-methoxyphenyl)acrylic acid methyl ester
143702-35-6

(Z)-2-azido-3-(2-methoxyphenyl)acrylic acid methyl ester

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / xylene / 1 h / Heating
2: 99 percent / aq. NaOH / 0.5 h / Heating
3: 94 percent / Cu; quinoline / 2 h / Heating
View Scheme
ortho-anisaldehyde
135-02-4

ortho-anisaldehyde

(S)-(Fmoc-amino)-cyclohexyl-acetic acid on Wang resin

(S)-(Fmoc-amino)-cyclohexyl-acetic acid on Wang resin

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 68 percent / methanol / 1.5 h / -10 °C
2: 88 percent / xylene / 1 h / Heating
3: 99 percent / aq. NaOH / 0.5 h / Heating
4: 94 percent / Cu; quinoline / 2 h / Heating
View Scheme
3-nitro-o-cresol
5460-31-1

3-nitro-o-cresol

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 54 percent / CuI; DMF / acetonitrile / 10 h / 180 °C / 6000.6 - 7500.75 Torr / microwave irradiation
2: 63 percent / H2 / Pd/C / methanol; CH2Cl2 / 20 °C
View Scheme
6-methoxy-2-nitrotoluene
4837-88-1

6-methoxy-2-nitrotoluene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 83 percent / CuI; DMF / 3 h / 180 °C / 6000.6 - 7500.75 Torr / microwave irradiation
2: 63 percent / H2 / Pd/C / methanol; CH2Cl2 / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: pyrrolidine / dimethylformamide / 3 h / 125 °C
2: 61 percent / aq. TiCl3, ammonium acetate buffer / 0.17 h
View Scheme
Multi-step reaction with 2 steps
1: 4 h / 110 °C
2: TiCl3, 4M NH4OAc / acetone
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 3 h / Reflux
2: zinc; acetic acid; hydrogenchloride / water / 0.5 h / 20 °C
View Scheme
2-bromo-1-methoxy-3-nitrobenzene
67853-37-6

2-bromo-1-methoxy-3-nitrobenzene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / PPh3 / Pd(dba)2 / toluene / 23.5 h / Heating
2: 89 percent / PPh3, CO / Pd(OAc)2 / acetonitrile / 20 h / 3040 Torr / Heating
View Scheme
Multi-step reaction with 5 steps
1: 88 percent / iron / ethanol; acetic acid / 3.5 h / Heating
2: 72 percent / pyridine / 6 h / Ambient temperature
3: tetrakis(triphenylphosphine)palladium(0) / toluene / 36 h / Heating
4: 68 percent / bis(acetonitrile)palladium chloride, p-benzoquinone, lithium chloride / dimethylformamide / 28 h / 100 - 110 °C
5: 96 percent / 20percent aq. NaOH / methanol / 12 h / Heating
View Scheme
1-tert-butoxycarbonyl-2-iodo-3-methoxyaniline
194869-14-2

1-tert-butoxycarbonyl-2-iodo-3-methoxyaniline

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / CuI, Pd(PPh3)2Cl2 / triethylamine / 24 h / 80 °C
2: 70 percent / t-BuOK / 2-methyl-propan-2-ol / 5 h / Heating
View Scheme
3-nitroanisole
555-03-3

3-nitroanisole

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 41 percent / tBuOK / dimethylformamide / 0.5 h / -20 - -10 °C
2: 96 percent / H2, acetic acid / Pd/C (10percent Pd) / ethanol / 2 h / 2280 Torr / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / -20 °C
2: acetic acid; palladium 10% on activated carbon; hydrogen / 12 h / 20 °C
View Scheme
2-Amino-3-nitrophenol
603-85-0

2-Amino-3-nitrophenol

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) hydrobromic acid, sodium nitrite, 2.) coopper(I) bromide / 1.) water, 1,4-dioxane, 0 deg C, 15 min, 2.) a) 0 deg C, 15 min, b) 60 deg C, 15 min
2: sodium hydroxide, / aq. ethanol / 14 h / Ambient temperature
3: 88 percent / iron / ethanol; acetic acid / 3.5 h / Heating
4: 72 percent / pyridine / 6 h / Ambient temperature
5: tetrakis(triphenylphosphine)palladium(0) / toluene / 36 h / Heating
6: 68 percent / bis(acetonitrile)palladium chloride, p-benzoquinone, lithium chloride / dimethylformamide / 28 h / 100 - 110 °C
7: 96 percent / 20percent aq. NaOH / methanol / 12 h / Heating
View Scheme
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

4-methoxyindole-3-carboxaldehyde
90734-97-7

4-methoxyindole-3-carboxaldehyde

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With N-chloro-succinimide; triphenylphosphine In tetrahydrofuran for 1h; Reflux;
Stage #2: 4-methoxy-1H-indole In tetrahydrofuran for 1h; Reflux;
100%
Stage #1: N,N-dimethyl-formamide With N-chloro-succinimide; triphenylphosphine In tetrahydrofuran at 20℃; Reflux;
Stage #2: 4-methoxy-1H-indole In tetrahydrofuran for 1h; Reflux;
100%
Stage #1: 4-methoxy-1H-indole; N,N-dimethyl-formamide With trichlorophosphate at 0 - 45℃; for 1.08333h; Inert atmosphere;
Stage #2: With sodium hydroxide In water Inert atmosphere;
95%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

2,3-dihydro-4-methoxy-1H-indole
7555-94-4

2,3-dihydro-4-methoxy-1H-indole

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid100%
With sodium cyanoborohydride; acetic acid for 0.5h; Ambient temperature;98%
With sodium cyanoborohydride; acetic acid at 20℃; for 0.833333h;98%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

bromopentene
1119-51-3

bromopentene

4-methoxy-1-(pent-4-en-1-yl)-1H-indole

4-methoxy-1-(pent-4-en-1-yl)-1H-indole

Conditions
ConditionsYield
Stage #1: 4-methoxy-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: bromopentene In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;
100%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

methyl iodide
74-88-4

methyl iodide

4-methoxy-1-methyl-1H-indole
7556-35-6

4-methoxy-1-methyl-1H-indole

Conditions
ConditionsYield
Stage #1: 4-methoxy-1H-indole With sodium hydride In acetonitrile at 0℃; for 0.5h;
Stage #2: methyl iodide In acetonitrile at 0 - 20℃; for 16h;
99%
With sodium hydride In tetrahydrofuran at 0 - 20℃;95%
With sodium hydride In tetrahydrofuran for 4h;82%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

eschenmoser's salt
33797-51-2

eschenmoser's salt

(4-methoxy-1H-indol-3-ylmethyl)dimethylamine
52335-75-8

(4-methoxy-1H-indol-3-ylmethyl)dimethylamine

Conditions
ConditionsYield
In acetic acid; acetonitrile at 20℃; for 2h;99%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

4-methoxy-3-thiocyanato-1H-indole

4-methoxy-3-thiocyanato-1H-indole

Conditions
ConditionsYield
In acetonitrile at 20℃; for 3h; Electrochemical reaction; Inert atmosphere;99%
With copper(II) choride dihydrate; oxygen In ethanol at 20℃; for 24h; Irradiation;98%
With iodine In methanol for 1h;75%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-methoxyindole-1-carboxylic acid tert-butyl ester
1093759-59-1

4-methoxyindole-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃; for 1h;99%
With dmap; triethylamine In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; for 11h;97%
With dmap In dichloromethane at 20℃; for 8h; Inert atmosphere;95%
nitrostyrene
5153-67-3

nitrostyrene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

4-methoxy-3-(2-nitro-1-phenylethyl)-1H-indole
1187817-63-5, 1236277-14-7

4-methoxy-3-(2-nitro-1-phenylethyl)-1H-indole

Conditions
ConditionsYield
With pyrrolidinium 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate at 50℃; for 12h; Friedel Crafts alkylation;99%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

tert-butyl (1,3-dioxo-2-phenyl-2,3-dihydroisoquinolin-4(1H)-ylidene)carbamate

tert-butyl (1,3-dioxo-2-phenyl-2,3-dihydroisoquinolin-4(1H)-ylidene)carbamate

(S)-tert-butyl (4-(4-methoxy-1H-indol-3-yl)-1,3-dioxo-2-phenyl-1,2,3,4-tetrahydroisoquinolin-4-yl)carbamate

(S)-tert-butyl (4-(4-methoxy-1H-indol-3-yl)-1,3-dioxo-2-phenyl-1,2,3,4-tetrahydroisoquinolin-4-yl)carbamate

Conditions
ConditionsYield
With (11aR)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin In toluene at 60℃; for 3h; enantioselective reaction;99%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

2-(4-methoxy-1H-indol-3-yl)naphthalene-1,4-dione

2-(4-methoxy-1H-indol-3-yl)naphthalene-1,4-dione

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 0.0708333h; Flow reactor;99%
With tris(pentafluorophenyl)borate In water at 60℃; for 2h;52%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethane-1,1-diol
1033591-96-6

1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethane-1,1-diol

(R)-1-(benzo[d]thiazol-2-yl)-2,2,2-trifluoro-1-(4-methoxy-1H-indol-3-yl)ethan-1-ol

(R)-1-(benzo[d]thiazol-2-yl)-2,2,2-trifluoro-1-(4-methoxy-1H-indol-3-yl)ethan-1-ol

Conditions
ConditionsYield
With (R)-6,6'-bis(2,4,6-triisopropylphenyl)-1,1'-spirobiindanyl-7,7'-diyl hydrogen phosphate In dichloromethane at 20℃; Friedel-Crafts Alkylation; Molecular sieve; enantioselective reaction;99%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

1-(tert-Butyldimethylsilyl)-4-methoxyindole

1-(tert-Butyldimethylsilyl)-4-methoxyindole

Conditions
ConditionsYield
Stage #1: 4-methoxy-1H-indole With n-butyllithium In tetrahydrofuran; hexane at -78 - -10℃; for 0.25h;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; hexane at 0℃; for 3h;
98%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

diethyl benzalmalonate
5292-53-5

diethyl benzalmalonate

(+)-ethyl 2-ethoxycarbonyl-3-[3-(4-methoxyindolyl)]-3-phenylpropanoate

(+)-ethyl 2-ethoxycarbonyl-3-[3-(4-methoxyindolyl)]-3-phenylpropanoate

Conditions
ConditionsYield
With 1,2,2-tris[(4S)-4-iPr-4,5-dihydro-1,3-oxazol-2-yl]propane; copper(II) bis(trifluoromethanesulfonate) In 2-methyl-propan-1-ol at -25℃; for 50h; Friedel-Crafts alkylation of indoles;98%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

diethyl benzalmalonate
5292-53-5

diethyl benzalmalonate

(S)-ethyl-2-ethoxycarbonyl-3-[3-(4-methoxyindolyl)]-3-phenyl-propanoate
458563-96-7

(S)-ethyl-2-ethoxycarbonyl-3-[3-(4-methoxyindolyl)]-3-phenyl-propanoate

Conditions
ConditionsYield
Stage #1: diethyl benzalmalonate With (3aR,8aS)-2-(3-(3,5-di-tert-butylphenyl)-2,2-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)propyl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole; copper(II) bis(trifluoromethanesulfonate) In iso-butanol at -25℃; for 0.25h; Friedel Crafts alkylation;
Stage #2: 4-methoxy-1H-indole In iso-butanol at -25℃; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
98%
1,1'-bis(4-(S)-isopropyl-1,3-oxazolin-2-yl)ethane*Cu(OTf)2 In water; iso-butanol at -15 - 0℃;90%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

sodium 1-(tert-butoxycarbonyl) azetidine-3-sulfinate

sodium 1-(tert-butoxycarbonyl) azetidine-3-sulfinate

tert-butyl 3-((4-methoxy-1H-indol-2-yl)sulfonyl)azetidine-1-carboxylate

tert-butyl 3-((4-methoxy-1H-indol-2-yl)sulfonyl)azetidine-1-carboxylate

Conditions
ConditionsYield
With iodine In methanol at 20℃; for 24h; regioselective reaction;98%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

trifluoromethane sulfonyl chloride
421-83-0

trifluoromethane sulfonyl chloride

4-methoxy-3-((trifluoromethyl)thio)-1H-indole

4-methoxy-3-((trifluoromethyl)thio)-1H-indole

Conditions
ConditionsYield
With triphenylphosphine; sodium iodide In acetonitrile at 60℃; for 1.5h; Schlenk technique; Inert atmosphere;98%
With phosphonic acid diethyl ester In acetonitrile at 90℃; for 10h;90%
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; phenylsilane In 1,4-dioxane at 40℃; for 1h; Schlenk technique; Sealed tube; Inert atmosphere;89%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

S-(difluoromethyl) benzenesulfonothioate

S-(difluoromethyl) benzenesulfonothioate

3-((difluoromethyl)thio)-4-methoxy-1H-indole

3-((difluoromethyl)thio)-4-methoxy-1H-indole

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 16h; Inert atmosphere; Irradiation; regioselective reaction;98%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

2-fluorobenzenesulfonyl chloride
2905-21-7

2-fluorobenzenesulfonyl chloride

C15H12FNO3S
530116-16-6

C15H12FNO3S

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water at 20℃;97%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

silver trifluoromethanesulfonate
2923-28-6

silver trifluoromethanesulfonate

2-phenylethynylbenzaldehyde p-toluenesulphonylhydrazone
75586-32-2

2-phenylethynylbenzaldehyde p-toluenesulphonylhydrazone

1-(4-methoxyindol-3-yl)-2-amino-3-phenylisoquinolinium triflate
1198746-32-5

1-(4-methoxyindol-3-yl)-2-amino-3-phenylisoquinolinium triflate

Conditions
ConditionsYield
With dysprosium(III) trifluoromethanesulfonate In 1,2-dichloro-ethane at 70℃; Inert atmosphere;97%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(R)-ethyl 3,3,3-trifluoro-2-hydroxy-2-(4-methoxy-1H-indol-3-yl)-propanoate

(R)-ethyl 3,3,3-trifluoro-2-hydroxy-2-(4-methoxy-1H-indol-3-yl)-propanoate

Conditions
ConditionsYield
Stage #1: 4-methoxy-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
97%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

methyldiphenylsilane
776-76-1

methyldiphenylsilane

4-methoxy-1-(methyldiphenylsilyl)-1H-indole
1343516-70-0

4-methoxy-1-(methyldiphenylsilyl)-1H-indole

Conditions
ConditionsYield
With dodecacarbonyl-triangulo-triruthenium In toluene at 120℃; for 12h; Schlenk technique; Inert atmosphere;97%
With pyridine; zinc trifluoromethanesulfonate In propiononitrile at 80℃; for 15h; Inert atmosphere;94%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

celastrol
34157-83-0

celastrol

(2R,4aS,6aS,12bR,14aS,14bR)-10,11-dihydroxy-8-(4-methoxy-1H-indol-3-yl)-2,4a,6a,9,12b,14a-hexamethyl-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

(2R,4aS,6aS,12bR,14aS,14bR)-10,11-dihydroxy-8-(4-methoxy-1H-indol-3-yl)-2,4a,6a,9,12b,14a-hexamethyl-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

Conditions
ConditionsYield
With aluminium(III) chloride hexahydrate In dichloromethane at 20℃; for 3h; Friedel-Crafts Alkylation; Sealed tube;97%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

benzalacetophenone
94-41-7

benzalacetophenone

3-(4-methoxy-1H-indol-3-yl)-1,3-diphenylpropan-1-one

3-(4-methoxy-1H-indol-3-yl)-1,3-diphenylpropan-1-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetonitrile at 50℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;97%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

1,1,1,3',3',3'-hexafluoro-propanol
920-66-1

1,1,1,3',3',3'-hexafluoro-propanol

1,1,1,3,3,3-hexafluoro-2-(4-methoxy-1H-indol-3-yl)propan-2-ol

1,1,1,3,3,3-hexafluoro-2-(4-methoxy-1H-indol-3-yl)propan-2-ol

Conditions
ConditionsYield
With copper diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine at 90℃; for 24h; Schlenk technique; regioselective reaction;97%
nitrostyrene
5153-67-3

nitrostyrene

4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

4-methoxy-3-(2-nitro-1-phenylethyl)-1H-indole

4-methoxy-3-(2-nitro-1-phenylethyl)-1H-indole

Conditions
ConditionsYield
With piperidine; 2-(((S)-1-hydroxy-1,1,3-triphenylpropan-2-ylimino)methyl)-6-chlorophenol; zinc trifluoromethanesulfonate In toluene at 20℃; for 24h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;96%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

(S)-ethyl 3,3,3-trifluoro-2-hydroxy-2-(4-methoxy-1H-indol-3-yl)-propanoate

(S)-ethyl 3,3,3-trifluoro-2-hydroxy-2-(4-methoxy-1H-indol-3-yl)-propanoate

Conditions
ConditionsYield
Stage #1: 4-methoxy-1H-indole With C33H52N4O4; zinc trifluoromethanesulfonate In dichloromethane at 35℃; for 0.5h;
Stage #2: ethyl-3,3,3-trifluoropyruvate In dichloromethane at 0℃; for 0.5h; Friedel Crafts alkylation; optical yield given as %ee; enantioselective reaction;
96%
4-methoxy-1H-indole
4837-90-5

4-methoxy-1H-indole

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

di-(4-methoxy-1H-indol-3-yl)-4-fluorophenylmethane

di-(4-methoxy-1H-indol-3-yl)-4-fluorophenylmethane

Conditions
ConditionsYield
With sulfuric acid In water at 20℃; for 0.0833333h; Green chemistry;96%

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