Product Name

  • Name

    Cytidine 5'-monophosphate disodium salt

  • EINECS 229-819-3
  • CAS No. 6757-06-8
  • Article Data1
  • CAS DataBase
  • Density 2.15g/cm3
  • Solubility
  • Melting Point 300 °C
  • Formula C9H12N3Na2O8P
  • Boiling Point 678.1oC at 760 mmHg
  • Molecular Weight 367.163
  • Flash Point 363.9oC
  • Transport Information
  • Appearance White crystalline powder
  • Safety 24/25
  • Risk Codes 20/21/22-36/37/38
  • Molecular Structure Molecular Structure of 6757-06-8 (Cytidine 5'-monophosphate disodium salt)
  • Hazard Symbols Xn,Xi
  • Synonyms 5'-Cytidylicacid, disodium salt (7CI,8CI,9CI);5'-CMP disodium salt;CMP disodium salt;Cytidine 5'-monophosphate sodium;Cytidine monophosphate disodium salt;Disodium 5'-CMP;Disodium 5'-cytidylate;Disodium CMP;Disodium cytidine 5'-monophosphate;Disodium cytidine5'-phosphate;NSC 20259;Sodium 5'-cytidylate;
  • PSA 192.83000
  • LogP -0.98840

Synthetic route

C9H14N4O10P2(2-)*2Na(1+)

C9H14N4O10P2(2-)*2Na(1+)

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

Conditions
ConditionsYield
With water; zinc(II) cation pH=5.5;
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

copper(II) nitrate hexahydrate

copper(II) nitrate hexahydrate

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

water
7732-18-5

water

[Cu7(1,10-phenanthroline)6(cytidine 5'-monophosphate)4]*(NO3)6*(H2O)46

[Cu7(1,10-phenanthroline)6(cytidine 5'-monophosphate)4]*(NO3)6*(H2O)46

Conditions
ConditionsYield
In ethanol at 40℃;76%
...Expand
Cu(NO3)2*2(ethylenediamine)

Cu(NO3)2*2(ethylenediamine)

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

water
7732-18-5

water

[Cu2(ethylenediamine)2(cytidine 5'-monophosphate)2]*5H2O

[Cu2(ethylenediamine)2(cytidine 5'-monophosphate)2]*5H2O

Conditions
ConditionsYield
In methanol for 0.5h; pH=4;75%
...Expand
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

water
7732-18-5

water

trans-1,2-bis(4-pyridyl)ethylene
1135-32-6

trans-1,2-bis(4-pyridyl)ethylene

[Co(HCMP)2(bis(4-pyridyl)ethylene)(H2O)2]·3.5H2O

[Co(HCMP)2(bis(4-pyridyl)ethylene)(H2O)2]·3.5H2O

Conditions
ConditionsYield
Stage #1: cobalt(II) nitrate hexahydrate; cytidine-5'-monophosphate disodium salt; water for 0.5h;
Stage #2: trans-1,2-bis(4-pyridyl)ethylene With nitric acid In ethanol at 20℃; for 0.5h; pH=5;		72%
...Expand
manganese(II) perchlorate hexahydrate

manganese(II) perchlorate hexahydrate

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

water
7732-18-5

water

trans-1,2-bis(4-pyridyl)ethylene
1135-32-6

trans-1,2-bis(4-pyridyl)ethylene

[Mn(bis(4-pyridyl)ethylene)(H2O)4]·(CMP)·3H2O

[Mn(bis(4-pyridyl)ethylene)(H2O)4]·(CMP)·3H2O

Conditions
ConditionsYield
Stage #1: manganese(II) perchlorate hexahydrate; cytidine-5'-monophosphate disodium salt; water for 0.5h;
Stage #2: trans-1,2-bis(4-pyridyl)ethylene With sodium hydroxide In ethanol at 20℃; for 0.5h; pH=6;		68%
...Expand
manganese(II) perchlorate hexahydrate

manganese(II) perchlorate hexahydrate

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

water
7732-18-5

water

trans-1,2-bis(4-pyridyl)ethylene
1135-32-6

trans-1,2-bis(4-pyridyl)ethylene

[Mn(bis(4-pyridyl)ethylene)3(H2O)2]·(ClO4)2·(bis(4-pyridyl)ethylene)2·5H2O

[Mn(bis(4-pyridyl)ethylene)3(H2O)2]·(ClO4)2·(bis(4-pyridyl)ethylene)2·5H2O

Conditions
ConditionsYield
Stage #1: manganese(II) perchlorate hexahydrate; cytidine-5'-monophosphate disodium salt; water for 0.5h;
Stage #2: trans-1,2-bis(4-pyridyl)ethylene With sodium hydroxide In ethanol at 20℃; for 0.5h; pH=7;		68%
...Expand
cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In methanol at 0 - 20℃; for 24.25h;42%
chromium(III)(L-ser)2(H2O)2Cl*H2O

chromium(III)(L-ser)2(H2O)2Cl*H2O

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

(chromium(III))2(L-ser)2(5'-CMP)(OH)Cl*7H2O

(chromium(III))2(L-ser)2(5'-CMP)(OH)Cl*7H2O

Conditions
ConditionsYield
In water soln. of nucleotide (pH=7) is added dropwise to a soln. of amino acid chromium complex, soln. is placed in a thermostated bath at 50°C with const. stirring for 8 h; soln. is concd. to 5 ml, chromy. (Sephadex), addn. of ethanol to the first (blue) fraction, further evapn., ppt. is vac. dried (P4O10); elem. anal.;
chromium(III)(L-met)(L-metH)Cl2*3H2O

chromium(III)(L-met)(L-metH)Cl2*3H2O

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

(chromium(III))2(L-met)(5'-CMP)2(OH)*10H2O

(chromium(III))2(L-met)(5'-CMP)2(OH)*10H2O

Conditions
ConditionsYield
In water soln. of nucleotide (pH approx. 7) is added dropwise to a soln. of amino acid chromium complex (pH 3.9-4.2), mixt. is maintained at 50°C with const. stirring for 1.5-2.5 h; ppt. is filtered off, washed with cold water and vac. dried (P4O10); elem. anal.;
trans-{CrCl2(C2H4(NH2)2)2}Cl
14240-29-0, 14301-97-4, 59109-96-5, 66653-37-0

trans-{CrCl2(C2H4(NH2)2)2}Cl

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

Cr(3+)*NH2CH2CH2NH2*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3)O)(2-)*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3H)O)(1-)*8H2O

Cr(3+)*NH2CH2CH2NH2*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3)O)(2-)*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3H)O)(1-)*8H2O

Conditions
ConditionsYield
In water aq. soln. of Cr compd. mixed with aq. soln. of org. compd. (mole ratio Cr : org. compd. = 1 : 1); soln. heated at ca. 55 °C for 5-7 h; soln. concd. at 50 °C and passed through a colomn; ethanol addedto eluate; resulting ppt. filtered, washed (EtOH), and dried over silica gel; elem. anal.;
cis-[chromium(1,2-diaminoethane)2Cl2]Cl

cis-[chromium(1,2-diaminoethane)2Cl2]Cl

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

Cr(3+)*NH2CH2CH2NH2*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3)O)(2-)*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3H)O)(1-)*C2H5OH*6H2O

Cr(3+)*NH2CH2CH2NH2*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3)O)(2-)*CONC(NH2)CHCHN(CHCHOHCHOHCH(CH2OPO3H)O)(1-)*C2H5OH*6H2O

Conditions
ConditionsYield
In water aq. soln. of Cr compd. mixed with aq. soln. of org. compd. (mole ratio Cr : org. compd. = 1 : 1); soln. heated at ca. 55 °C for 5-7 h; soln. concd. at 50 °C and passed through a colomn; ethanol addedto eluate; resulting ppt. filtered, washed (EtOH), and dried over silica gel; elem. anal.;
pentaaminechlorocobalt(III) dichloride
13859-51-3

pentaaminechlorocobalt(III) dichloride

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

(Co(NH3)4(NH2C4H2ON2C4H4(OH)2OCH2PO4H)2)(1+)*Cl(1-)*2H2O=(Co(NH3)4(NH2C4H2ON2C4H4(OH)2OCH2PO4H)2)Cl*2H2O

(Co(NH3)4(NH2C4H2ON2C4H4(OH)2OCH2PO4H)2)(1+)*Cl(1-)*2H2O=(Co(NH3)4(NH2C4H2ON2C4H4(OH)2OCH2PO4H)2)Cl*2H2O

Conditions
ConditionsYield
With H2O; HClO4 In water Co-compd. (1 mmol) was dissolved in the min. amt. of H2O and 1 mmol of org. compd. in H2O; both solns. were mixed and brought to pH 4.5 by means of HClO4; the resulting soln. was concd. at 70°C for 5 min, then heated at 50°C for 20 h;; column chromy., the first fraction was pptd. with EtOH; the complex waswashed with ethanol and dried over P4O10; elem. anal.;;
trans-dichlorobis(ethylenediamine)cobalt(III) chloride
13408-72-5, 14040-32-5, 14040-33-6, 20594-10-9, 20594-11-0

trans-dichlorobis(ethylenediamine)cobalt(III) chloride

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

(Co(NH2CH2CH2NH2)2(NH2C4H2ON2C4H4(OH)2OCH2PO4)(NH2C4H2ON2C4H4(OH)2OCH2PO4H))*6H2O

(Co(NH2CH2CH2NH2)2(NH2C4H2ON2C4H4(OH)2OCH2PO4)(NH2C4H2ON2C4H4(OH)2OCH2PO4H))*6H2O

Conditions
ConditionsYield
With H2O In water Co-compd. (0.5 mmol) was dissolved in H2O and 1 mmol of org. compd. in H2O; both solns. were mixed and heated at 50°C with const. stirring for about 7 h;; column chromy., the first fraction was pptd. with EtOH; the complex waswashed with ethanol and dried over P4O10; elem. anal.;;
[(η6-biphenyl)(ethylenediamine)chlororuthenium(II)] hexafluorophosphate

[(η6-biphenyl)(ethylenediamine)chlororuthenium(II)] hexafluorophosphate

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

A

(C6H5C6H5)Ru(H2NCH2CH2NH2)OPO3CH2C4H4O(OH)2C4H2N2(NH2)(O)

(C6H5C6H5)Ru(H2NCH2CH2NH2)OPO3CH2C4H4O(OH)2C4H2N2(NH2)(O)

B

(C6H5C6H5)Ru(H2NCH2CH2NH2)(OPO3CH2C4H4O(OH)2C4H2N2(NH2)(O))

(C6H5C6H5)Ru(H2NCH2CH2NH2)(OPO3CH2C4H4O(OH)2C4H2N2(NH2)(O))

Conditions
ConditionsYield
With H2O In water pH 7.23, 310 K, 3 d; reaction was monitored by (1)H and (31)P NMR spectroscopy; (1)H and (31)P NMR data;
...Expand
deuteriated sodium hydroxide
14014-06-3

deuteriated sodium hydroxide

uranyl nirate hexahydrate

uranyl nirate hexahydrate

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

A

(UO2(cytidine monophosphate(4-)))3(O)(8-)

(UO2(cytidine monophosphate(4-)))3(O)(8-)

B

(UO2)6(cytidine monophosphate(4-))4(OH)2(O)2(10-)

(UO2)6(cytidine monophosphate(4-))4(OH)2(O)2(10-)

Conditions
ConditionsYield
In water; water-d2 concd. NaOD soln. added to stirred suspn. of Na salt of nucleotide and UO2(NO2)2*6H2O in H2O-D2O; pH 8.5-12; not isoalted; detd. by NMR spectra; two UO2 complexes obtained in soln.;
In water-d2 concd. NaOD soln. added to stirred suspn. of Na salt of nucleotide and UO2(NO2)2*6H2O in D2O; pH 8.5-12; not isoalted; detd. by NMR spectra; two UO2 complexes obtained in soln.;
...Expand
disodium[(bis(5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]

disodium[(bis(5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

disodium[(bis(5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]*cytidine-5'-monophosphate disodium salt

disodium[(bis(5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]*cytidine-5'-monophosphate disodium salt

Conditions
ConditionsYield
With potassium nitrate In water (N2); mixing cobalt complex and AMP in 0.2 M aq. KNO3 at pH 7.0; not isolated, detected by UV;
disodium[(bis(4-methoxy-5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]

disodium[(bis(4-methoxy-5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]

cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

disodium[(bis(4-methoxy-5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]*cytidine-5'-monophosphate disodium salt

disodium[(bis(4-methoxy-5-sulfosalicylaldehyde)-4,5-dimethyl-o-phenylenediiminato)cobalt(II)]*cytidine-5'-monophosphate disodium salt

Conditions
ConditionsYield
With potassium nitrate In water (N2); mixing cobalt complex and AMP in 0.2 M aq. KNO3 at pH 7.0; not isolated, detected by UV;
cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

P1-cytidine-P2-adenosine-5’-diphosphate disodium

P1-cytidine-P2-adenosine-5’-diphosphate disodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / acetonitrile / 0.18 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / acetonitrile / 0.17 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / Molecular sieve; Inert atmosphere
3.2: Dowex-50-W ion-exchange resin, Na+ form
View Scheme
cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

C17H16F6N5O9P

C17H16F6N5O9P

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 0.18 h / 0 - 20 °C / Inert atmosphere
2: triethylamine / acetonitrile / 0.17 h / 0 °C / Inert atmosphere
View Scheme
cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

P1-uridine-P2-cytidine-5’-diphosphate disodium

P1-uridine-P2-cytidine-5’-diphosphate disodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / acetonitrile / 0.18 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / acetonitrile / 0.17 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / Molecular sieve; Inert atmosphere
3.2: Dowex-50-W ion-exchange resin, Na+ form
View Scheme
cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

P(1)-cytidine-P(3)-uridine-5'-triphosphate trisodium salt

P(1)-cytidine-P(3)-uridine-5'-triphosphate trisodium salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / acetonitrile / 0.18 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / acetonitrile / 0.17 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / Molecular sieve; Inert atmosphere
3.2: Dowex-50-W ion-exchange resin, Na+ form
View Scheme
cytidine-5'-monophosphate disodium salt
6757-06-8

cytidine-5'-monophosphate disodium salt

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

C13H12F6N3O10P

C13H12F6N3O10P

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 0.183333h; Inert atmosphere;

Cytidine 5'-monophosphate disodium salt Chemical Properties

Molecular Structure of Cytidine 5'-monophosphate disodium salt (CAS NO.6757-06-8):

IUPAC Name: disodium [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate 
Empirical Formula: C9H12N3Na2O8P
Molecular Weight: 367.1602
H bond acceptors: 11
H bond donors: 4
Freely Rotating Bonds: 10
Polar Surface Area: 162.95Å2
EINECS: 229-819-3
Melting point: 300 °C
Product Categories: Amino Acids;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;Nucleic acids
InChI
InChI=1/C9H14N3O8P.2Na/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1
Smiles
n1([C@H]2[C@@H]([C@H](O)[C@H](O2)COP(=O)([O-])[O-])O)c(nc(cc1)N)=O.[Na+].[Na+]

Cytidine 5'-monophosphate disodium salt Safety Profile

Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-36-26
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S37/39:Wear suitable gloves and eye/face protection. 
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
F: 1-10

Cytidine 5'-monophosphate disodium salt Specification

  Cytidine 5'-monophosphate disodium salt , with CAS number of 6757-06-8, can be called 5'-CMP disodium salt ; CMP disodium salt ; Cytidine 5'MP, disodium salt ; Cytidine monophosphate disodium salt ; Disodium 5'-CMP ; Disodium CMP ; Disodium cytidine 5'-monophosphate ; Disodium cytidine 5'-phosphate . It is a white crystalline powder.

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